Michael A. Trakselis, Ph.D. - Publications

2002 Pennsylvania State University, State College, PA, United States 
 2014- Chemistry and Biochemistry Baylor University, Waco, TX 
mechanistic enzymology

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 McKinzey DR, Li C, Gao Y, Trakselis MA. Activity, substrate preference and structure of the HsMCM8/9 helicase. Nucleic Acids Research. PMID 37309874 DOI: 10.1093/nar/gkad508  0.504
2022 Griffin WC, McKinzey DR, Klinzing KN, Baratam R, Eliyapura A, Trakselis MA. A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress. Nature Communications. 13: 5090. PMID 36042199 DOI: 10.1038/s41467-022-32583-8  0.782
2022 Behrmann MS, Trakselis MA. In vivo fluorescent TUNEL detection of single stranded DNA gaps and breaks induced by dnaB helicase mutants in Escherichia coli. Methods in Enzymology. 672: 125-142. PMID 35934472 DOI: 10.1016/bs.mie.2022.02.021  0.55
2021 Kaszubowski JD, Trakselis MA. Beyond the Lesion: Back to High Fidelity DNA Synthesis. Frontiers in Molecular Biosciences. 8: 811540. PMID 35071328 DOI: 10.3389/fmolb.2021.811540  0.525
2021 Behrmann MS, Perera HM, Hoang JM, Venkat TA, Visser BJ, Bates D, Trakselis MA. Targeted chromosomal Escherichia coli: dnaB exterior surface residues regulate DNA helicase behavior to maintain genomic stability and organismal fitness. Plos Genetics. 17: e1009886. PMID 34767550 DOI: 10.1371/journal.pgen.1009886  0.431
2021 Perera HM, Trakselis MA. Determining translocation orientations of nucleic acid helicases. Methods (San Diego, Calif.). PMID 34758393 DOI: 10.1016/j.ymeth.2021.11.001  0.372
2021 McKinzey DR, Gomathinayagam S, Griffin WC, Klinzing KN, Jeffries EP, Rajkovic A, Trakselis MA. Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment. The Journal of Biological Chemistry. 100355. PMID 33539926 DOI: 10.1016/j.jbc.2021.100355  0.775
2020 Perera HM, Trakselis MA. Site-specific DNA Mapping of Protein Binding Orientation Using Azidophenacyl Bromide (APB). Bio-Protocol. 10: e3649. PMID 33659320 DOI: 10.21769/BioProtoc.3649  0.542
2020 Cranford MT, Kaszubowski JD, Trakselis MA. A hand-off of DNA between archaeal polymerases allows high-fidelity replication to resume at a discrete intermediate three bases past 8-oxoguanine. Nucleic Acids Research. PMID 32997110 DOI: 10.1093/nar/gkaa803  0.435
2020 Klinzing KN, Griffin WC, McKinzey DR, Trakselis MA. Role of MCM8/9 in DNA Fork Protection The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07234  0.594
2020 Trakselis M. Contacts and Confirmations that Regulate Hexameric Helicases at the Replication Fork The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00590  0.399
2019 Perera HM, Trakselis M. Amidst multiple binding orientations on fork DNA, MCM helicase proceeds N-first for unwinding. Elife. 8. PMID 31661075 DOI: 10.7554/Elife.46096  0.61
2019 Perera HM, Behrmann MS, Hoang JM, Griffin WC, Trakselis MA. Contacts and context that regulate DNA helicase unwinding and replisome progression. The Enzymes. 45: 183-223. PMID 31627877 DOI: 10.1016/Bs.Enz.2019.08.001  0.805
2019 Brosh RM, Trakselis MA. Fine-tuning of the replisome: Mcm10 regulates fork progression and regression. Cell Cycle (Georgetown, Tex.). 1-9. PMID 31014174 DOI: 10.1080/15384101.2019.1609833  0.644
2019 Griffin WC, Trakselis MA. The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance. Dna Repair. 76: 1-10. PMID 30743181 DOI: 10.1016/J.Dnarep.2019.02.003  0.747
2019 Perera HM, Trakselis MA. Author response: Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding Elife. DOI: 10.7554/Elife.46096.020  0.494
2018 Graham BW, Bougoulias ME, Dodge KL, Thaxton CT, Olaso D, Tao Y, Young NL, Marshall AG, Trakselis MA. Control of Hexamerization, Assembly, and Excluded Strand Specificity for the Sulfolobus solfataricus MCM Helicase. Biochemistry. PMID 30199238 DOI: 10.1021/Acs.Biochem.8B00766  0.608
2018 van Dongen SFM, Clerx J, van den Boomen OI, Pervaiz M, Trakselis MA, Ritschel T, Schoonen L, Schoenmakers DC, Nolte RJM. Synthetic polymers as substrates for a DNA-sliding clamp protein. Biopolymers. 109: e23119. PMID 29700825 DOI: 10.1002/Bip.23119  0.546
2017 Carney SM, Gomathinayagam S, Leuba SH, Trakselis MA. Bacterial DnaB helicase interacts with the excluded strand to regulate unwinding. The Journal of Biological Chemistry. PMID 28939774 DOI: 10.1074/Jbc.M117.814178  0.631
2017 Trakselis MA, Cranford MT, Chu AM. Coordination and Substitution of DNA Polymerases in Response to Genomic Obstacles. Chemical Research in Toxicology. PMID 28881136 DOI: 10.1021/Acs.Chemrestox.7B00190  0.569
2017 Cranford MT, Chu AM, Baguley JK, Bauer RJ, Trakselis MA. Characterization of a coupled DNA replication and translesion synthesis polymerase supraholoenzyme from archaea. Nucleic Acids Research. PMID 28655184 DOI: 10.1093/Nar/Gkx539  0.654
2017 Trakselis MA, Seidman MM, Brosh RM. Mechanistic insights into how CMG helicase facilitates replication past DNA roadblocks. Dna Repair. 55: 76-82. PMID 28554039 DOI: 10.1016/J.Dnarep.2017.05.005  0.613
2016 Khan I, Crouch JD, Bharti SK, Sommers JA, Carney SM, Yakubovskaya E, Garcia-Diaz M, Trakselis MA, Brosh RM. Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: Substrate Specificity, DNA Branch-Migration, and Ability to Overcome Blockades to DNA Unwinding. The Journal of Biological Chemistry. PMID 27226550 DOI: 10.1074/Jbc.M115.712026  0.63
2016 Carney SM, Trakselis MA. The Excluded DNA Strand is SEW Important for Hexameric Helicase Unwinding. Methods (San Diego, Calif.). PMID 27068657 DOI: 10.1016/J.Ymeth.2016.04.008  0.58
2016 Graham BW, Tao Y, Dodge KL, Thaxton CT, Olaso D, Young NL, Marshall AG, Trakselis MA. DNA Interactions Probed by H/D Exchange FT-ICR Mass Spectrometry Confirm External Binding Sites on the MCM Helicase. The Journal of Biological Chemistry. PMID 27044751 DOI: 10.1074/Jbc.M116.719591  0.559
2016 Trakselis MA. Structural Mechanisms of Hexameric Helicase Loading, Assembly, and Unwinding. F1000research. 5. PMID 26918187 DOI: 10.12688/F1000Research.7509.1  0.568
2016 Carney SM, Leuba SH, Trakselis MA. The Role of the Excluded Strand in Hexameric Helicase Unwinding Biophysical Journal. 110: 62a. DOI: 10.1016/J.Bpj.2015.11.402  0.585
2015 Barnes CO, Calero M, Malik I, Graham BW, Spahr H, Lin G, Cohen AE, Brown IS, Zhang Q, Pullara F, Trakselis MA, Kaplan CD, Calero G. Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble. Molecular Cell. 59: 258-69. PMID 26186291 DOI: 10.1016/J.Molcel.2015.06.034  0.392
2015 AlAsiri S, Basit S, Wood-Trageser MA, Yatsenko SA, Jeffries EP, Surti U, Ketterer DM, Afzal S, Ramzan K, Faiyaz-Ul Haque M, Jiang H, Trakselis MA, Rajkovic A. Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability. The Journal of Clinical Investigation. 125: 258-62. PMID 25437880 DOI: 10.1172/Jci78473  0.393
2015 Carney SM, Leuba S, Trakselis M. Mechanistic Insights of Hexameric Helicase Function Provided by Single-Molecule FRET Biophysical Journal. 108: 67a. DOI: 10.1016/J.Bpj.2014.11.401  0.623
2014 Wood-Trageser MA, Gurbuz F, Yatsenko SA, Jeffries EP, Kotan LD, Surti U, Ketterer DM, Matic J, Chipkin J, Jiang H, Trakselis MA, Topaloglu AK, Rajkovic A. MCM9 mutations are associated with ovarian failure, short stature, and chromosomal instability. American Journal of Human Genetics. 95: 754-62. PMID 25480036 DOI: 10.1016/J.Ajhg.2014.11.002  0.485
2014 Trakselis MA, Bauer RJ, Lin H, Jen-Jacobson L. Complex Temperature Dependent Equilibria Dictate DNA Polymerase Exchange Processes during Synthesis Biophysical Journal. 106: 274a. DOI: 10.1016/J.Bpj.2013.11.1603  0.586
2013 Mohan S, Das D, Bauer RJ, Heroux A, Zalewski JK, Heber S, Dosunmu-Ogunbi AM, Trakselis MA, Hildebrand JD, Vandemark AP. Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology. Plos One. 8: e81075. PMID 24349032 DOI: 10.1371/Journal.Pone.0081075  0.33
2013 van Dongen SF, Clerx J, Nørgaard K, Bloemberg TG, Cornelissen JJ, Trakselis MA, Nelson SW, Benkovic SJ, Rowan AE, Nolte RJ. A clamp-like biohybrid catalyst for DNA oxidation. Nature Chemistry. 5: 945-51. PMID 24153373 DOI: 10.1038/Nchem.1752  0.661
2013 Bauer RJ, Wolff ID, Zuo X, Lin HK, Trakselis MA. Assembly and distributive action of an archaeal DNA polymerase holoenzyme. Journal of Molecular Biology. 425: 4820-36. PMID 24035812 DOI: 10.1016/J.Jmb.2013.09.003  0.642
2013 Jeffries EP, Denq WH, Denq WI, Bartko JC, Trakselis MA. Identification, quantification, and evolutionary analysis of a novel isoform of MCM9. Gene. 519: 41-9. PMID 23403237 DOI: 10.1016/J.Gene.2013.01.054  0.433
2013 Bauer RJ, Graham BW, Trakselis MA. Novel interaction of the bacterial-Like DnaG primase with the MCM helicase in archaea. Journal of Molecular Biology. 425: 1259-73. PMID 23357171 DOI: 10.1016/J.Jmb.2013.01.025  0.63
2012 Trakselis MA, Graham BW. Biochemistry: Molecular hurdles cleared with ease. Nature. 492: 195-7. PMID 23201683 DOI: 10.1038/Nature11758  0.586
2012 Lin HK, Chase SF, Laue TM, Jen-Jacobson L, Trakselis MA. Differential temperature-dependent multimeric assemblies of replication and repair polymerases on DNA increase processivity. Biochemistry. 51: 7367-82. PMID 22906116 DOI: 10.1021/Bi300956T  0.58
2012 Mohan S, Rizaldy R, Das D, Bauer RJ, Heroux A, Trakselis MA, Hildebrand JD, VanDemark AP. Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction. Molecular Biology of the Cell. 23: 2131-42. PMID 22493320 DOI: 10.1091/Mbc.E11-11-0937  0.338
2012 Bauer RJ, Begley MT, Trakselis MA. Kinetics and fidelity of polymerization by DNA polymerase III from Sulfolobus solfataricus. Biochemistry. 51: 1996-2007. PMID 22339170 DOI: 10.1021/Bi201799A  0.566
2011 Graham BW, Schauer GD, Leuba SH, Trakselis MA. Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding. Nucleic Acids Research. 39: 6585-95. PMID 21576224 DOI: 10.1093/Nar/Gkr345  0.646
2011 Zuo Z, Lin HK, Trakselis MA. Strand annealing and terminal transferase activities of a B-family DNA polymerase. Biochemistry. 50: 5379-90. PMID 21545141 DOI: 10.1021/Bi200421G  0.608
2010 Zuo Z, Rodgers CJ, Mikheikin AL, Trakselis MA. Characterization of a functional DnaG-type primase in archaea: implications for a dual-primase system. Journal of Molecular Biology. 397: 664-76. PMID 20122937 DOI: 10.1016/J.Jmb.2010.01.057  0.556
2009 Mikheikin AL, Lin HK, Mehta P, Jen-Jacobson L, Trakselis MA. A trimeric DNA polymerase complex increases the native replication processivity. Nucleic Acids Research. 37: 7194-205. PMID 19773426 DOI: 10.1093/Nar/Gkp767  0.661
2007 Rothenberg E, Trakselis MA, Bell SD, Ha T. MCM forked substrate specificity involves dynamic interaction with the 5'-tail. The Journal of Biological Chemistry. 282: 34229-34. PMID 17884823 DOI: 10.1074/Jbc.M706300200  0.558
2005 McGeoch AT, Trakselis MA, Laskey RA, Bell SD. Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism Nature Structural and Molecular Biology. 12: 756-762. PMID 16116441 DOI: 10.1038/Nsmb974  0.739
2005 Trakselis MA, Alley SC, Ishmael FT. Identification and mapping of protein-protein interactions by a combination of cross-linking, cleavage, and proteomics. Bioconjugate Chemistry. 16: 741-50. PMID 16029014 DOI: 10.1021/Bc050043A  0.333
2005 Norcum MT, Warrington JA, Spiering MM, Ishmael FT, Trakselis MA, Benkovic SJ. Architecture of the bacteriophage T4 primosome: electron microscopy studies of helicase (gp41) and primase (gp61). Proceedings of the National Academy of Sciences of the United States of America. 102: 3623-6. PMID 15738414 DOI: 10.1073/Pnas.0500713102  0.547
2005 Zhang Z, Spiering MM, Trakselis MA, Ishmael FT, Xi J, Benkovic SJ, Hammes GG. Assembly of the bacteriophage T4 primosome: single-molecule and ensemble studies. Proceedings of the National Academy of Sciences of the United States of America. 102: 3254-9. PMID 15728347 DOI: 10.1073/Pnas.0500327102  0.683
2005 Zhang Z, Spiering MM, Trakselis MA, Ishmael F, Xi J, Benkovic S, Hammes GG. Erratum: Assembly of the bacteriophage T4 primosome: Single-molecule and ensemble studies (Proceedings of the National Academy of Sciences of the United States of America (March 1, 2005) 102, 9 (3254-3259)) Proceedings of the National Academy of Sciences of the United States of America. 102: 13349-13350. DOI: 10.1073/Pnas.0506656102  0.437
2004 Millar D, Trakselis MA, Benkovic SJ. On the solution structure of the T4 sliding clamp (gp45). Biochemistry. 43: 12723-7. PMID 15461444 DOI: 10.1021/Bi048349C  0.46
2004 Zhuang Z, Spiering MM, Berdis AJ, Trakselis MA, Benkovic SJ. 'Screw-cap' clamp loader proteins that thread. Nature Structural & Molecular Biology. 11: 580-1. PMID 15221017 DOI: 10.1038/Nsmb0704-580  0.647
2004 Trakselis MA, Bell SD. Molecular biology: the loader of the rings. Nature. 429: 708-9. PMID 15201893 DOI: 10.1038/429708A  0.445
2004 Yang J, Zhuang Z, Roccasecca RM, Trakselis MA, Benkovic SJ. The dynamic processivity of the T4 DNA polymerase during replication. Proceedings of the National Academy of Sciences of the United States of America. 101: 8289-94. PMID 15148377 DOI: 10.1073/Pnas.0402625101  0.699
2003 Trakselis MA, Roccasecca RM, Yang J, Valentine AM, Benkovic SJ. Dissociative properties of the proteins within the bacteriophage T4 replisome. The Journal of Biological Chemistry. 278: 49839-49. PMID 14500719 DOI: 10.1074/Jbc.M307405200  0.781
2003 Yang J, Trakselis MA, Roccasecca RM, Benkovic SJ. The application of a minicircle substrate in the study of the coordinated T4 DNA replication. The Journal of Biological Chemistry. 278: 49828-38. PMID 14500718 DOI: 10.1074/Jbc.M307406200  0.652
2003 Trakselis MA, Berdis AJ, Benkovic SJ. Examination of the role of the clamp-loader and ATP hydrolysis in the formation of the bacteriophage T4 polymerase holoenzyme. Journal of Molecular Biology. 326: 435-51. PMID 12559912 DOI: 10.1016/S0022-2836(02)01330-X  0.688
2003 Ishmael FT, Trakselis MA, Benkovic SJ. Protein-protein interactions in the bacteriophage T4 replisome. The leading strand holoenzyme is physically linked to the lagging strand holoenzyme and the primosome. The Journal of Biological Chemistry. 278: 3145-52. PMID 12427736 DOI: 10.1074/Jbc.M209858200  0.634
2001 Trakselis MA, Benkovic SJ. Intricacies in ATP-dependent clamp loading: variations across replication systems. Structure (London, England : 1993). 9: 999-1004. PMID 11709164 DOI: 10.1016/S0969-2126(01)00676-1  0.662
2001 Trakselis MA, Mayer MU, Ishmael FT, Roccasecca RM, Benkovic SJ. Dynamic protein interactions in the bacteriophage T4 replisome. Trends in Biochemical Sciences. 26: 566-72. PMID 11551794 DOI: 10.1016/S0968-0004(01)01929-6  0.674
2001 Alley SC, Trakselis MA, Mayer MU, Ishmael FT, Jones AD, Benkovic SJ. Building a replisome solution structure by elucidation of protein-protein interactions in the bacteriophage T4 DNA polymerase holoenzyme. The Journal of Biological Chemistry. 276: 39340-9. PMID 11504721 DOI: 10.1074/Jbc.M104956200  0.668
2001 Trakselis MA, Alley SC, Abel-Santos E, Benkovic SJ. Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer. Proceedings of the National Academy of Sciences of the United States of America. 98: 8368-75. PMID 11459977 DOI: 10.1073/Pnas.111006698  0.584
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