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Scott E. Wolkenberg, Ph.D. - Publications

Affiliations: 
2003 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
synthetic organic chemistry
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24/56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yu W, Liu J, Yu Y, Zhang V, Clausen D, Kelly J, Wolkenberg S, Beshore D, Duffy JL, Chang CC, Myers RW, Klein DJ, Fells J, Holloway K, Wu J, et al. Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation. Bioorganic & Medicinal Chemistry Letters. 127197. PMID 32331932 DOI: 10.1016/J.Bmcl.2020.127197  0.307
2019 Ichiishi N, Moore KP, Wassermann AM, Wolkenberg SE, Krska SW. Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki-Miyaura Cross Coupling Reaction. Acs Medicinal Chemistry Letters. 10: 56-61. PMID 30655947 DOI: 10.1021/Acsmedchemlett.8B00403  0.37
2016 Zhao Z, Harrison ST, Schubert JW, Sanders JM, Polsky-Fisher S, Zhang NR, McLoughlin D, Gibson CR, Robinson RG, Sachs NA, Kandebo M, Yao L, Smith SM, Hutson PH, Wolkenberg SE, et al. Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27133481 DOI: 10.1016/J.Bmcl.2016.03.095  0.341
2009 Zhao Z, Leister WH, O'Brien JA, Lemaire W, Williams DL, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Hartman GD, Lindsley CW, Wolkenberg SE. Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 1488-91. PMID 19179073 DOI: 10.1016/J.Bmcl.2008.12.115  0.324
2008 Brad Nolt M, Zhao Z, Wolkenberg SE. Controlled derivatization of polyhalogenated quinolines utilizing selective cross-coupling reactions Tetrahedron Letters. 49: 3137-3141. DOI: 10.1016/J.Tetlet.2008.03.040  0.39
2007 Tichenor MS, MacMillan KS, Stover JS, Wolkenberg SE, Pavani MG, Zanella L, Zaid AN, Spalluto G, Rayl TJ, Hwang I, Baraldi PG, Boger DL. Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins. Journal of the American Chemical Society. 129: 14092-9. PMID 17948994 DOI: 10.1021/Ja073989Z  0.542
2007 Shipe WD, Yang F, Zhao Z, Wolkenberg SE, Nolt MB, Lindsley CW. Convenient and General Microwave-Assisted Protocols for the Expedient Synthesis of Heterocycles Cheminform. 38. DOI: 10.3987/Rev-06-Sr(W)1  0.414
2007 Boger D, Lawhorn B, Boga S, Wolkenberg S, Colby D, Gauss C, Swingle M, Amable L, Honkanen R. Synthesis of Cytostatin Synfacts. 2007: 0456-0456. DOI: 10.1055/S-2007-968390  0.68
2006 Lawhorn BG, Boga SB, Wolkenberg SE, Colby DA, Gauss CM, Swingle MR, Amable L, Honkanen RE, Boger DL. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. Journal of the American Chemical Society. 128: 16720-32. PMID 17177422 DOI: 10.1021/Ja066477D  0.712
2006 Zhao Z, O'Brien JA, Lemaire W, Williams DL, Jacobson MA, Sur C, Pettibone DJ, Tiller PR, Smith S, Hartman GD, Wolkenberg SE, Lindsley CW. Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides. Bioorganic & Medicinal Chemistry Letters. 16: 5968-72. PMID 16987662 DOI: 10.1016/J.Bmcl.2006.08.131  0.401
2006 Nanda KK, Nolt MB, Cato MJ, Kane SA, Kiss L, Spencer RH, Wang J, Lynch JJ, Regan CP, Stump GL, Li B, White R, Yeh S, Bogusky MJ, Bilodeau MT, ... ... Wolkenberg SE, et al. Potent antagonists of the Kv1.5 potassium channel: synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamides. Bioorganic & Medicinal Chemistry Letters. 16: 5897-901. PMID 16949818 DOI: 10.1016/J.Bmcl.2006.08.054  0.329
2006 Lawhorn BG, Boga SB, Wolkenberg SE, Boger DL. Total synthesis of cytostatin Heterocycles. 70: 65-70. DOI: 10.3987/Com-06-S(W)13  0.615
2006 Nolt MB, Smiley MA, Varga SL, McClain RT, Wolkenberg SE, Lindsley CW. Convenient preparation of substituted 5-aminooxazoles via a microwave-assisted Cornforth rearrangement Tetrahedron. 62: 4698-4704. DOI: 10.1016/J.Tet.2005.12.065  0.395
2005 Shipe WD, Wolkenberg SE, Lindsley CW. Accelerating lead development by microwave-enhanced medicinal chemistry. Drug Discovery Today. Technologies. 2: 155-61. PMID 24981843 DOI: 10.1016/J.Ddtec.2005.05.002  0.337
2004 Wolkenberg SE, Wisnoski DD, Leister WH, Wang Y, Zhao Z, Lindsley CW. Efficient synthesis of imidazoles from aldehydes and 1,2-diketones using microwave irradiation. Organic Letters. 6: 1453-6. PMID 15101765 DOI: 10.1021/Ol049682B  0.468
2004 Zhao Z, Wisnoski DD, Wolkenberg SE, Leister WH, Wang Y, Lindsley CW. General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines Tetrahedron Letters. 45: 4873-4876. DOI: 10.1016/J.Tetlet.2004.04.144  0.393
2003 Parrish JP, Kastrinsky DB, Wolkenberg SE, Igarashi Y, Boger DL. DNA alkylation properties of yatakemycin. Journal of the American Chemical Society. 125: 10971-6. PMID 12952479 DOI: 10.1021/Ja035984H  0.715
2002 Wolkenberg SE, Boger DL. Total synthesis of anhydrolycorinone utilizing sequential intramolecular Diels-Alder reactions of a 1,3,4-oxadiazole. The Journal of Organic Chemistry. 67: 7361-4. PMID 12375965 DOI: 10.1021/Jo020437K  0.611
2002 Wilkie GD, Elliott GI, Blagg BS, Wolkenberg SE, Soenen DR, Miller MM, Pollack S, Boger DL. Intramolecular Diels-Alder and tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reactions of 1,3,4-oxadiazoles. Journal of the American Chemical Society. 124: 11292-4. PMID 12236743 DOI: 10.1021/Ja027533N  0.53
2002 Wolkenberg SE, Boger DL. Mechanisms of in situ activation for DNA-targeting antitumor agents. Chemical Reviews. 102: 2477-95. PMID 12105933 DOI: 10.1021/Cr010046Q  0.425
2001 Ellis DA, Wolkenberg SE, Boger DL. Metal cation complexation and activation of reversed CPyI analogues of CC-1065 and duocarmycin SA: partitioning the effects of binding and catalysis. Journal of the American Chemical Society. 123: 9299-306. PMID 11562212 DOI: 10.1021/Ja010769R  0.496
2000 Boger DL, Wolkenberg SE. Total synthesis of Amaryllidaceae alkaloids utilizing sequential intramolecular heterocyclic azadiene Diels-Alder reactions of an unsymmetrical 1,2,4,5-tetrazine. The Journal of Organic Chemistry. 65: 9120-4. PMID 11149859 DOI: 10.1021/Jo0012546  0.57
2000 Boger DL, Santillán A, Searcey M, Brunette SR, Wolkenberg SE, Hedrick MP, Jin Q. Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis. The Journal of Organic Chemistry. 65: 4101-11. PMID 10866627 DOI: 10.1021/Jo000297J  0.568
2000 Boger DL, Wolkenberg SE, Boyce CW. A new method of in situ activation for a novel class of DNA alkylating agents: Tunable metal cation complexation and activation [20] Journal of the American Chemical Society. 122: 6325-6326. DOI: 10.1021/Ja000653F  0.451
Low-probability matches (unlikely to be authored by this person)
2008 Zhao Z, Wolkenberg SE, Sanderson PE, Lu M, Munshi V, Moyer G, Feng M, Carella AV, Ecto LT, Gabryelski LJ, Lai MT, Prasad SG, Yan Y, McGaughey GB, Miller MD, et al. Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs). Bioorganic & Medicinal Chemistry Letters. 18: 554-9. PMID 18083561 DOI: 10.1016/J.Bmcl.2007.11.085  0.299
2017 Pero JE, Rossi MA, Lehman HDGF, Kelly MJ, Mulhearn JJ, Wolkenberg SE, Cato MJ, Clements MK, Daley CJ, Filzen T, Finger EN, Gregan Y, Henze DA, Jovanovska A, Klein R, et al. Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model. Bioorganic & Medicinal Chemistry Letters. PMID 28465103 DOI: 10.1016/J.Bmcl.2017.04.040  0.298
2001 Wolkenberg SE, Su AI. Combinatorial synthesis and discovery of an antibiotic compound: An experiment suitable for high school and undergraduate laboratories Journal of Chemical Education. 78: 784-785. DOI: 10.1021/Ed078P784  0.297
2011 Hamill TG, Eng W, Jennings A, Lewis R, Thomas S, Wood S, Street L, Wisnoski D, Wolkenberg S, Lindsley C, Sanabria-Bohórquez SM, Patel S, Riffel K, Ryan C, Cook J, et al. The synthesis and preclinical evaluation in rhesus monkey of [¹⁸F]MK-6577 and [¹¹C]CMPyPB glycine transporter 1 positron emission tomography radiotracers. Synapse (New York, N.Y.). 65: 261-70. PMID 20687108 DOI: 10.1002/Syn.20842  0.297
2006 Shipe WD, Yang F, Zhao Z, Wolkenberg SE, Nolt MB, Lindsley CW. Convenient and general microwave-assisted protocols for the expedient synthesis of heterocycles Heterocycles. 70: 655-689.  0.292
2015 Harrison ST, Poslusney MS, Mulhearn JJ, Zhao Z, Kett NR, Schubert JW, Melamed JY, Allison TJ, Patel SB, Sanders JM, Sharma S, Smith RF, Hall DL, Robinson RG, Sachs NA, ... ... Wolkenberg SE, et al. Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT). Acs Medicinal Chemistry Letters. 6: 318-23. PMID 25815153 DOI: 10.1021/Ml500502D  0.279
2006 Nolt MB, Smiley MA, Varga SL, McClain RT, Wolkenberg SE, Lindsley CW. Convenient Preparation of Substituted 5-Aminooxazoles via a Microwave-Assisted Cornforth Rearrangement. Cheminform. 37. DOI: 10.1002/chin.200632152  0.268
2011 Wolkenberg SE, Zhao Z, Thut C, Maxwell JW, McDonald TP, Kinose F, Reilly M, Lindsley CW, Hartman GD. Design, synthesis, and evaluation of novel 3,6-diaryl-4-aminoalkoxyquinolines as selective agonists of somatostatin receptor subtype 2. Journal of Medicinal Chemistry. 54: 2351-8. PMID 21395312 DOI: 10.1021/Jm101501B  0.266
2023 Liu W, Mulhearn J, Hao B, Cañellas S, Last S, Gómez JE, Jones A, De Vera A, Kumar K, Rodríguez R, Van Eynde L, Strambeanu II, Wolkenberg SE. Enabling Deoxygenative C(sp)-C(sp) Cross-Coupling for Parallel Medicinal Chemistry. Acs Medicinal Chemistry Letters. 14: 853-859. PMID 37312855 DOI: 10.1021/acsmedchemlett.3c00118  0.261
2012 Robinson RG, Smith SM, Wolkenberg SE, Kandebo M, Yao L, Gibson CR, Harrison ST, Polsky-Fisher S, Barrow JC, Manley PJ, Mulhearn JJ, Nanda KK, Schubert JW, Trotter BW, Zhao Z, et al. Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates. Acs Chemical Neuroscience. 3: 129-40. PMID 22860182 DOI: 10.1021/Cn200109W  0.256
2009 Wolkenberg SE, Zhao Z, Wisnoski DD, Leister WH, O'Brien J, Lemaire W, Williams DL, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Gibson C, Ma BK, et al. Discovery of GlyT1 inhibitors with improved pharmacokinetic properties. Bioorganic & Medicinal Chemistry Letters. 19: 1492-5. PMID 19181525 DOI: 10.1016/J.Bmcl.2009.01.015  0.246
2010 Wolkenberg SE, Sur C. Recent progress in the discovery of non-sarcosine based GlyT1 inhibitors. Current Topics in Medicinal Chemistry. 10: 170-86. PMID 20166956 DOI: 10.2174/156802610790410974  0.243
2017 Wolkenberg SE, Nolt MB, Bilodeau MT, Trotter BW, Manley PJ, Kett NR, Nanda KK, Wu Z, Cato MJ, Kane SA, Kiss L, Spencer RH, Wang J, Lynch JJ, Regan CP, et al. Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics. Bioorganic & Medicinal Chemistry Letters. PMID 28131713 DOI: 10.1016/J.Bmcl.2016.12.054  0.242
2010 Zhao Z, Wolkenberg SE, Sanderson PE, Lu M, Munshi V, Moyer G, Feng M, Carella AV, Ecto LT, Gabryelski LJ, Lai M, Prasad SG, Yan Y, McGaughey GB, Miller MD, et al. Corrigendum to “Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)” [Bioorg. Med. Chem. Lett. (2008) 554] Bioorganic & Medicinal Chemistry Letters. 20: 5360. DOI: 10.1016/J.Bmcl.2010.02.013  0.242
2006 Wolkenberg SE, Zhao Z, Kapitskaya M, Webber AL, Petrukhin K, Tang YS, Dean DC, Hartman GD, Lindsley CW. Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand. Bioorganic & Medicinal Chemistry Letters. 16: 5001-4. PMID 16879962 DOI: 10.1016/J.Bmcl.2006.07.056  0.241
2011 Wolkenberg SE, Zhao Z, Mulhearn JJ, Harrison ST, Sanders JM, Cato MJ, Jovanovska A, Panigel J, Cook SP, Henze DA, Kane SA, Hartman GD, Barrow JC. High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 2646-9. PMID 21257308 DOI: 10.1016/J.Bmcl.2010.12.115  0.237
2011 Harrison ST, Mulhearn J, Wolkenberg SE, Miller PJ, O'Malley SS, Zeng Z, Williams DL, Hostetler ED, Sanabria-Bohórquez S, Gammage L, Fan H, Sur C, Culberson JC, Hargreaves RJ, Cook JJ, et al. Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328. Acs Medicinal Chemistry Letters. 2: 498-502. PMID 24900338 DOI: 10.1021/Ml200018N  0.23
2011 Hostetler ED, Sanabria-Bohórquez S, Fan H, Zeng Z, Gammage L, Miller P, O'Malley S, Connolly B, Mulhearn J, Harrison ST, Wolkenberg SE, Barrow JC, Williams DL, Hargreaves RJ, Sur C, et al. [18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey. Nuclear Medicine and Biology. 38: 1193-203. PMID 21741254 DOI: 10.1016/J.Nucmedbio.2011.04.004  0.228
2010 Sur C, Zeng Z, Hostetler E, Connolly BM, Miller PJ, O'Malley S, Chen T, Culberson C, Harrison S, Mulhearn J, Wolkenberg S, Barrow J, Sanabria S, Cook JJ, Hargreaves R, et al. In vitro Characterization of MK-3328: A Novel Fluorinated Positron Emission Tomography Tracer for Plaques Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.112  0.225
2006 Lindsley CW, Wolkenberg SE, Kinney GG. Progress in the preparation and testing of glycine transporter type-1 (GlyT1) inhibitors. Current Topics in Medicinal Chemistry. 6: 1883-96. PMID 17017963 DOI: 10.2174/156802606778249784  0.215
2006 Lindsley CW, Shipe WD, Wolkenberg SE, Theberge CR, Williams DL, Sur C, Kinney GG. Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia. Current Topics in Medicinal Chemistry. 6: 771-85. PMID 16719816 DOI: 10.2174/156802606777057599  0.21
2010 Hostetler E, Sanabria-Bohórquez S, Fan H, Zeng Z, Williams D, O'Malley S, Miller P, Chen T, Culberson C, Daneker L, Harrison S, Mulhearn J, Wolkenberg S, Barrow J, Hargreaves R, et al. [F-18]MK-3328: Evaluation of a novel PET tracer for amyloid plaque in rhesus monkey Neuroimage. 52: S154. DOI: 10.1016/J.Neuroimage.2010.04.126  0.202
2022 Hendrick CE, Jorgensen JR, Chaudhry C, Strambeanu II, Brazeau JF, Schiffer J, Shi Z, Venable JD, Wolkenberg SE. Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation. Acs Medicinal Chemistry Letters. 13: 1182-1190. PMID 35859867 DOI: 10.1021/acsmedchemlett.2c00124  0.189
2020 Liu J, Yu Y, Kelly J, Sha D, Alhassan AB, Yu W, Maletic MM, Duffy JL, Klein DJ, Holloway MK, Carroll S, Howell BJ, Barnard RJO, Wolkenberg S, Kozlowski JA. Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group. Acs Medicinal Chemistry Letters. 11: 2476-2483. PMID 33335670 DOI: 10.1021/acsmedchemlett.0c00462  0.184
2021 Reiher CA, Schuman DP, Simmons N, Wolkenberg SE. Trends in Hit-to-Lead Optimization Following DNA-Encoded Library Screens. Acs Medicinal Chemistry Letters. 12: 343-350. PMID 33738060 DOI: 10.1021/acsmedchemlett.0c00615  0.133
2005 Wolkenberg SE, Shipe WD, Lindsley CW, Guare JP, Pawluczyk JM. Applications of microwave-assisted organic synthesis on the multigram scale. Current Opinion in Drug Discovery & Development. 8: 701-8. PMID 16312146  0.129
2021 Beshore DC, Adam GC, Barnard RJO, Burlein C, Gallicchio SN, Holloway MK, Krosky D, Lemaire W, Myers RW, Patel S, Plotkin MA, Powell DA, Rada V, Cox CD, Coleman PJ, ... ... Wolkenberg SE, et al. Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction. Acs Medicinal Chemistry Letters. 12: 540-547. PMID 33854701 DOI: 10.1021/acsmedchemlett.1c00074  0.129
2021 Bukhtiyarova M, Cook EM, Hancock PJ, Hruza AW, Shaw AW, Adam GC, Barnard RJO, McKenna PM, Holloway MK, Bell IM, Carroll S, Cornella-Taracido I, Cox CD, Kutchukian PS, Powell DA, ... ... Wolkenberg S, et al. Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen. Acs Medicinal Chemistry Letters. 12: 99-106. PMID 33488970 DOI: 10.1021/acsmedchemlett.0c00551  0.112
2008 Garbaccio RM, Wolkenberg SE. ChemInform Abstract: 2-Aminoalkanoic Acid Esters (α-Amino Acid Esters) Cheminform. 39. DOI: 10.1002/chin.200849255  0.068
2008 Wolkenberg SE, Thut CJ. Recent progress in the discovery of selective, non-peptide ligands of somatostatin receptors. Current Opinion in Drug Discovery & Development. 11: 446-57. PMID 18600562  0.064
2005 Shipe WD, Wolkenberg SE, Williams DL, Lindsley CW. Recent advances in positive allosteric modulators of metabotropic glutamate receptors. Current Opinion in Drug Discovery & Development. 8: 449-57. PMID 16022181  0.039
2008 Wolkenberg SE, Garbaccio RM. ChemInform Abstract: 2-Aminoalkanoic Acids (α-Amino Acids) Cheminform. 39. DOI: 10.1002/chin.200846265  0.037
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