Landon R. Whitby, Ph.D. - Publications

2011 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
synthetic organic chemistry

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Plewe MB, Whitby LR, Naik S, Brown ER, Sokolova NV, Gantla VR, York J, Nunberg JH, Zhang L, Kalveram B, Freiberg AN, Boger DL, Henkel G, McCormack K. SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors. Bioorganic & Medicinal Chemistry Letters. 126620. PMID 31537423 DOI: 10.1016/j.bmcl.2019.08.024  0.68
2017 Whitby LR, Obach RS, Simon GM, Hayward MM, Cravatt BF. Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites. Acs Chemical Biology. PMID 28636309 DOI: 10.1021/acschembio.7b00346  0.4
2016 Zaro BW, Whitby LR, Lum KM, Cravatt BF. Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible Inhibitors. Journal of the American Chemical Society. 138: 15841-15844. PMID 27960302 DOI: 10.1021/jacs.6b10589  0.4
2016 Shankar S, Whitby LR, Casquilho-Gray HE, York J, Boger DL, Nunberg JH. Small-molecule fusion inhibitors bind the pH-sensing SSP-GP2 subunit interface of the Lassa virus envelope glycoprotein. Journal of Virology. PMID 27194767 DOI: 10.1128/JVI.00597-16  0.68
2016 Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM, Huang H, Shi H, Choi JH, Wang KW, Moresco EM, Berger M, Zhan X, Zhang H, Boger DL, et al. TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831104 DOI: 10.1073/pnas.1525639113  0.68
2014 Lanning BR, Whitby LR, Dix MM, Douhan J, Gilbert AM, Hett EC, Johnson TO, Joslyn C, Kath JC, Niessen S, Roberts LR, Schnute ME, Wang C, Hulce JJ, Wei B, et al. A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors. Nature Chemical Biology. 10: 760-7. PMID 25038787 DOI: 10.1038/nchembio.1582  0.68
2014 Sanchez-Cespedes J, Moyer CL, Whitby LR, Boger DL, Nemerow GR. Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative. Antiviral Research. 108: 65-73. PMID 24907427 DOI: 10.1016/j.antiviral.2014.05.010  0.68
2013 Hsu KL, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). Journal of Medicinal Chemistry. 56: 8270-9. PMID 24152295 DOI: 10.1021/jm400899c  0.68
2013 Hsu KL, Tsuboi K, Whitby LR, Speers AE, Pugh H, Inloes J, Cravatt BF. Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis. Journal of Medicinal Chemistry. 56: 8257-69. PMID 24152245 DOI: 10.1021/jm400898x  0.68
2013 Gochin M, Whitby LR, Phillips AH, Boger DL. NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41. Journal of Computer-Aided Molecular Design. 27: 569-82. PMID 23893342 DOI: 10.1007/s10822-013-9662-6  0.68
2013 Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Bioorganic & Medicinal Chemistry Letters. 23: 839-43. PMID 23260346 DOI: 10.1016/j.bmcl.2012.11.061  0.68
2012 Whitby LR, Boger DL. Comprehensive peptidomimetic libraries targeting protein-protein interactions. Accounts of Chemical Research. 45: 1698-709. PMID 22799570 DOI: 10.1021/ar300025n  0.68
2012 Whitby LR, Boyle KE, Cai L, Yu X, Gochin M, Boger DL. Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library. Bioorganic & Medicinal Chemistry Letters. 22: 2861-5. PMID 22424973 DOI: 10.1016/j.bmcl.2012.02.062  0.68
2011 Whitby LR, Ando Y, Setola V, Vogt PK, Roth BL, Boger DL. Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions. Journal of the American Chemical Society. 133: 10184-94. PMID 21609016 DOI: 10.1021/ja201878v  0.68
2010 Ambrus G, Whitby LR, Singer EL, Trott O, Choi E, Olson AJ, Boger DL, Gerace L. Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport. Bioorganic & Medicinal Chemistry. 18: 7611-20. PMID 20869252 DOI: 10.1016/j.bmc.2010.08.038  0.68
2010 Chang MW, Giffin MJ, Muller R, Savage J, Lin YC, Hong S, Jin W, Whitby LR, Elder JH, Boger DL, Torbett BE. Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries. The Biochemical Journal. 429: 527-32. PMID 20507280 DOI: 10.1042/BJ20091645  0.68
2009 Shi J, Stover JS, Whitby LR, Vogt PK, Boger DL. Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation. Bioorganic & Medicinal Chemistry Letters. 19: 6038-41. PMID 19800226 DOI: 10.1016/j.bmcl.2009.09.044  0.68
2009 Whitby LR, Lee AM, Kunz S, Oldstone MB, Boger DL. Characterization of lassa virus cell entry inhibitors: determination of the active enantiomer by asymmetric synthesis. Bioorganic & Medicinal Chemistry Letters. 19: 3771-4. PMID 19428249 DOI: 10.1016/j.bmcl.2009.04.098  0.68
2009 Shaginian A, Whitby LR, Hong S, Hwang I, Farooqi B, Searcey M, Chen J, Vogt PK, Boger DL. Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions. Journal of the American Chemical Society. 131: 5564-72. PMID 19334711 DOI: 10.1021/ja810025g  0.68
2003 Jammi NV, Whitby LR, Beal PA. Small molecule inhibitors of the RNA-dependent protein kinase Biochemical and Biophysical Research Communications. 308: 50-57. PMID 12890478 DOI: 10.1016/S0006-291X(03)01318-4  0.68
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