| Year |
Citation |
Score |
| 2023 |
Clardy SM, Uttard A, Du B, Catcott KC, Lancaster KL, Ditty E, Sadowsky J, Zurita J, Malli N, Qin L, Bradley SP, Avocetien K, Carter T, Kim D, Nazzaro M, ... ... Pillow TH, et al. Site-specific Dolasynthen antibody-drug conjugates exhibit consistent pharmacokinetic profiles across a wide range of drug to antibody ratios. Molecular Cancer Therapeutics. PMID 37774393 DOI: 10.1158/1535-7163.MCT-23-0262 |
0.364 |
|
| 2022 |
Pillow T. ortho-Quinone drugs go pro. Nature Chemistry. 14: 719-720. PMID 35778561 DOI: 10.1038/s41557-022-00993-2 |
0.36 |
|
| 2022 |
Zacharias N, Podust VN, Kajihara KK, Leipold D, Del Rosario G, Thayer D, Dong E, Paluch M, Fischer D, Zheng K, Lei C, He J, Ng C, Su D, Liu L, ... ... Pillow T, et al. A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides. Chemical Science. 13: 3147-3160. PMID 35414872 DOI: 10.1039/d1sc05243h |
0.394 |
|
| 2021 |
Vollmar BS, Frantz C, Schutten MM, Zhong F, Del Rosario G, Go MAT, Yu SF, Leipold DD, Kamath AV, Ng C, Xu K, Dela Cruz Chuh J, Kozak KR, Chen J, Xu Z, ... ... Pillow TH, et al. A Novel Calicheamicin Antibody-Drug Conjugate with Improved Properties. Molecular Cancer Therapeutics. PMID 33722856 DOI: 10.1158/1535-7163.MCT-20-0035 |
0.353 |
|
| 2021 |
Dragovich PS, Pillow TH, Blake RA, Sadowsky JD, Adaligil E, Adhikari P, Chen J, Corr N, Dela Cruz-Chuh J, Del Rosario G, Fullerton A, Hartman SJ, Jiang F, Kaufman S, Kleinheinz T, et al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. Journal of Medicinal Chemistry. PMID 33596073 DOI: 10.1021/acs.jmedchem.0c01846 |
0.336 |
|
| 2021 |
Dragovich PS, Pillow TH, Blake RA, Sadowsky JD, Adaligil E, Adhikari P, Bhakta S, Blaquiere N, Chen J, Dela Cruz-Chuh J, Gascoigne KE, Hartman SJ, He M, Kaufman S, Kleinheinz T, et al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties. Journal of Medicinal Chemistry. PMID 33596065 DOI: 10.1021/acs.jmedchem.0c01845 |
0.327 |
|
| 2021 |
Dela Cruz Chuh J, Go M, Chen Y, Guo J, Rafidi H, Mandikian D, Sun Y, Lin Z, Schneider K, Zhang P, Vij R, Sharpnack D, Chan P, de la Cruz C, Sadowsky J, ... ... Pillow TH, et al. Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response. Mabs. 13: 1862452. PMID 33382956 DOI: 10.1080/19420862.2020.1862452 |
0.361 |
|
| 2020 |
Staben LR, Chen J, Cruz-Chuh JD, Del Rosario G, Go MA, Guo J, Khojasteh SC, Kozak KR, Li G, Ng C, Lewis Phillips G, Pillow TH, Rowntree RK, Wai J, Wei B, et al. Systematic Variation of Pyrrolobenzodiazepine (PBD)-dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. Journal of Medicinal Chemistry. PMID 32787101 DOI: 10.1021/Acs.Jmedchem.0C00691 |
0.463 |
|
| 2020 |
Fourie-O'Donohue A, Chu PY, Dela Cruz Chuh J, Tchelepi R, Tsai SP, Tran JC, Sawyer WS, Su D, Ng C, Xu K, Yu SF, Pillow TH, Sadowsky J, Dragovich PS, Liu Y, et al. Improved translation of stability for conjugated antibodies using an in vitro whole blood assay. Mabs. 12: 1715705. PMID 31997712 DOI: 10.1080/19420862.2020.1715705 |
0.449 |
|
| 2020 |
Pillow TH, Adhikari P, Blake RA, Chen J, Del Rosario G, Deshmukh G, Figueroa I, Gascoigne KE, Kamath AV, Kaufman S, Kleinheinz T, Kozak KR, Latifi B, Leipold DD, Sing Li C, et al. Front Cover: Antibody Conjugation of a Chimeric BET Degrader Enables
in vivo
Activity (ChemMedChem 1/2020) Chemmedchem. 15: 1-1. DOI: 10.1002/Cmdc.201900683 |
0.361 |
|
| 2019 |
Dragovich PS, Adhikari P, Blake RA, Blaquiere N, Chen J, Cheng YX, den Besten W, Han J, Hartman SJ, He J, He M, Rei Ingalla E, Kamath AV, Kleinheinz T, Lai T, ... ... Pillow TH, et al. Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα). Bioorganic & Medicinal Chemistry Letters. 126907. PMID 31902710 DOI: 10.1016/J.Bmcl.2019.126907 |
0.415 |
|
| 2019 |
Pillow TH, Adhikari P, Blake RA, Chen J, Del Rosario G, Deshmukh G, Figueroa I, Gascoigne KE, Kamath AV, Kaufman S, Kleinheinz T, Kozak KR, Latifi B, Leipold DD, Li CS, et al. Antibody Conjugation of a Chimeric BET Degrader Enables In Vivo Activity. Chemmedchem. PMID 31674143 DOI: 10.1002/Cmdc.201900497 |
0.403 |
|
| 2019 |
Zhang D, Dragovich PS, Yu SF, Ma Y, Pillow TH, Sadowsky JD, Su D, Wang W, Polson A, Khojasteh SC, Hop CE. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31358513 DOI: 10.1124/Dmd.119.087023 |
0.383 |
|
| 2019 |
Zhang D, Fourie-O'Donohue A, Dragovich PS, Pillow TH, Sadowsky JD, Kozak KR, Cass RT, Liu L, Deng Y, Liu Y, Hop CE, Khojasteh SC. Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody- drug conjugates. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31085544 DOI: 10.1124/Dmd.118.086132 |
0.411 |
|
| 2019 |
Ma Y, Cruz-Chuh JD, Khojasteh SC, Dragovich PS, Pillow TH, Zhang D. Carfilzomib is not an appropriate payload of antibody-drug conjugates as rapid inactivation by lysosomal enzymes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31072822 DOI: 10.1124/Dmd.119.086595 |
0.442 |
|
| 2019 |
Su D, Chen J, Cosino E, Cruz-Chuh JD, Davis H, Del Rosario G, Figueroa I, Goon L, He J, Kamath A, Kaur S, Kozak K, Lau J, Lee D, Lee MV, ... ... Pillow T, et al. Antibody-drug Conjugates Derived From Cytotoxic seco-CBI-Dimer Payloads are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjugate Chemistry. PMID 30966735 DOI: 10.1021/Acs.Bioconjchem.9B00133 |
0.484 |
|
| 2018 |
Pei Z, Chen C, Chen J, Cruz-Chuh JD, Delarosa R, Deng Y, Fourie-O'Donohue A, Figueroa I, Guo J, Jin W, Khojasteh C, Kozak KR, Latifi B, Lee J, Li G, ... ... Pillow TH, et al. Exploration of Pyrrolobenzodiazepine(PBD)-dimers Containing Disulfide-based Prodrugs as Payloads for Antibody-Drug Conjugates. Molecular Pharmaceutics. PMID 30040421 DOI: 10.1021/Acs.Molpharmaceut.8B00431 |
0.455 |
|
| 2018 |
Zheng B, Yu SF, Del Rosario G, Leong SR, Lee GY, Vij R, Chiu CPC, Liang WC, Wu Y, Chalouni C, Sadowsky J, Clark VM, Hendricks A, Poon KA, Chu YW, ... Pillow TH, et al. An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29959143 DOI: 10.1158/1078-0432.Ccr-18-0333 |
0.396 |
|
| 2018 |
Dragovich P, Blake RA, Chen C, Chen J, Chuh J, den Besten W, Fan F, Fourie A, Hartman SJ, He C, He J, Rei Ingalla E, Kozak KR, Leong SR, Lu J, ... ... Pillow TH, et al. Conjugation of Indoles to Antibodies via a Novel Self-Immolating Linker. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29493023 DOI: 10.1002/Chem.201800859 |
0.333 |
|
| 2018 |
Su D, Kozak K, Sadowsky J, Yu SF, Fourie-O'Donohue A, Nelson C, Vandlen R, Ohri R, Liu L, Ng C, He J, Davis H, Lau J, Del Rosario G, Cosino E, ... ... Pillow T, et al. Modulating ADC payload metabolism by conjugation site and linker modification. Bioconjugate Chemistry. PMID 29481745 DOI: 10.1021/Acs.Bioconjchem.7B00785 |
0.414 |
|
| 2018 |
Ohri R, Bhakta S, Fourie-O'Donohue A, Dela Cruz-Chuh J, Tsai SP, Cook R, Wei B, Ng C, Wong AW, Bos AB, Farahi F, Bhakta J, Pillow TH, Raab H, Vandlen R, et al. High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers. Bioconjugate Chemistry. PMID 29425028 DOI: 10.1021/Acs.Bioconjchem.7B00791 |
0.402 |
|
| 2018 |
Zhang D, Le H, Cruz-Chuh JD, Bobba S, Guo J, Staben L, Zhang C, Ma Y, Kozak KR, Lewis-Phillips GD, Vollmar B, Sadowsky J, Vandlen R, Wei B, Su D, ... ... Pillow TH, et al. Immolation of p-aminobenzyl ether linker and payload potency and stability determine the cell killing activity of antibody-drug conjugates with phenol-containing payloads. Bioconjugate Chemistry. PMID 29369629 DOI: 10.1021/Acs.Bioconjchem.7B00576 |
0.4 |
|
| 2018 |
Zhang D, Yu SF, Khojasteh SC, Ma Y, Pillow TH, Sadowsky JD, Su D, Kozak KR, Xu K, Polson AG, Dragovich P, Hop CE. Intratumoral Payload Concentration Correlates with the Activity of Antibody- Drug Conjugates. Molecular Cancer Therapeutics. PMID 29348271 DOI: 10.1158/1535-7163.Mct-17-0697 |
0.435 |
|
| 2017 |
Wei B, Gunzner-Toste J, Yao H, Wang T, Wang J, Xu Z, Chen J, Wai J, Nonomiya J, Tsai SP, Cruz-Chuh JD, Kozak KR, Liu Y, Yu SF, Lau J, ... ... Pillow TH, et al. Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. Journal of Medicinal Chemistry. PMID 29227683 DOI: 10.1021/Acs.Jmedchem.7B01430 |
0.431 |
|
| 2017 |
Gregson SJ, Masterson LA, Wei B, Pillow TH, Spencer SD, Kang GD, Yu SF, Raab H, Lau J, Li G, Lewis Phillips GD, Gunzner-Toste J, Safina BS, Ohri R, Darwish M, et al. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Non-Cleavable Drug-Linkers. Journal of Medicinal Chemistry. PMID 29112410 DOI: 10.1021/Acs.Jmedchem.7B00736 |
0.415 |
|
| 2017 |
Dragovich PS, Broccatelli F, Chen J, Fan P, Le H, Mao W, Pillow TH, Polson AG, Wai J, Xu Z, Yao H, Zhang D. Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs. Bioorganic & Medicinal Chemistry Letters. PMID 29079474 DOI: 10.1016/J.Bmcl.2017.10.023 |
0.301 |
|
| 2017 |
Staben LR, Yu SF, Chen J, Yan G, Xu Z, Del Rosario G, Lau JT, Liu L, Guo J, Zheng B, Cruz-Chuh JD, Lee BC, Ohri R, Cai W, Zhou H, ... ... Pillow TH, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. Acs Medicinal Chemistry Letters. 8: 1037-1041. PMID 29057047 DOI: 10.1021/Acsmedchemlett.7B00243 |
0.483 |
|
| 2017 |
Caculitan NG, Dela Cruz Chuh J, Ma Y, Zhang D, Kozak KR, Liu Y, Pillow TH, Sadowsky J, Cheung TK, Phung Q, Haley B, Lee BC, Akita R, Sliwkowski MX, Polson AG. Cathepsin B is dispensable for cellular processing of cathepsin B-cleavable antibody-drug conjugates. Cancer Research. PMID 29046337 DOI: 10.1158/0008-5472.Can-17-2391 |
0.424 |
|
| 2017 |
Sadowsky JD, Pillow TH, Chen J, Fan F, He C, Wang Y, Yan G, Yao H, Xu Z, Martin S, Zhang D, Chu P, Cruz-Chuh JD, O'Donohue A, Li G, et al. Development of efficient chemistry to generate site-specific disulfide-linked protein- and peptide-payload conjugates: Application to THIOMAB™ antibody-drug conjugates. Bioconjugate Chemistry. PMID 28636382 DOI: 10.1021/Acs.Bioconjchem.7B00258 |
0.451 |
|
| 2017 |
Pillow TH, Sadowsky JD, Zhang D, Yu SF, Del Rosario G, Xu K, He J, Bhakta S, Ohri R, Kozak KR, Ha E, Junutula JR, Flygare JA. Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates. Chemical Science. 8: 366-370. PMID 28451181 DOI: 10.1039/C6Sc01831A |
0.371 |
|
| 2017 |
He J, Su D, Ng CK, Liu L, Yu SF, Pillow TH, Del Rosario G, Darwish M, Lee BC, Ohri R, Zhou H, Wang X, Lu J, Kaur S, Xu K. High-resolution accurate-mass mass spectrometry enables in-depth characterization of in vivo biotransformations for intact antibody-drug conjugates. Analytical Chemistry. PMID 28429938 DOI: 10.1021/Acs.Analchem.7B00408 |
0.403 |
|
| 2017 |
Pillow TH, Schutten M, Yu SF, Ohri R, Sadowsky J, Poon KA, Solis W, Zhong F, Del Rosario G, Go MA, Lau J, Yee S, He J, Liu L, Ng C, et al. Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers. Molecular Cancer Therapeutics. PMID 28223423 DOI: 10.1158/1535-7163.Mct-16-0641 |
0.469 |
|
| 2017 |
Pillow TH. Novel linkers and connections for antibody-drug conjugates to treat cancer and infectious disease. Pharmaceutical Patent Analyst. PMID 28155578 DOI: 10.4155/Ppa-2016-0032 |
0.501 |
|
| 2016 |
Zhang D, Pillow TH, Ma Y, Cruz-Chuh JD, Kozak KR, Sadowsky JD, Lewis Phillips GD, Guo J, Darwish M, Fan P, Chen J, He C, Wang T, Yao H, Xu Z, et al. Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates. Acs Medicinal Chemistry Letters. 7: 988-993. PMID 27882196 DOI: 10.1021/Acsmedchemlett.6B00233 |
0.453 |
|
| 2016 |
Staben LR, Koenig SG, Lehar SM, Vandlen R, Zhang D, Chuh J, Yu SF, Ng C, Guo J, Liu Y, Fourie-O'Donohue A, Go M, Linghu X, Segraves NL, Wang T, ... ... Pillow TH, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nature Chemistry. 8: 1112-1119. PMID 27874860 DOI: 10.1038/Nchem.2635 |
0.522 |
|
| 2016 |
Giddens AC, Lee HH, Lu GL, Miller CK, Guo J, Lewis Phillips GD, Pillow TH, Tercel M. Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: Synthesis, cytotoxicity, and potential as payloads for antibody-drug conjugates. Bioorganic & Medicinal Chemistry. PMID 27745990 DOI: 10.1016/J.Bmc.2016.09.068 |
0.396 |
|
| 2016 |
Ma Y, Khojasteh SC, Hop CE, Erickson HK, Polson A, Pillow TH, Yu SF, Wang H, Dragovich PS, Zhang D. Antibody drug conjugates differentiate uptake and DNA alkylation of pyrrolobenzodiazepines in tumors and organs of xenograft mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27683653 DOI: 10.1124/Dmd.116.073031 |
0.318 |
|
| 2016 |
Zhang D, Yu SF, Ma Y, Xu K, Dragovich PS, Pillow TH, Liu L, Del Rosario G, He J, Pei Z, Sadowsky JD, Erickson HK, Hop CE, Khojasteh SC. The chemical structure and concentration of intratumor catabolites determine the efficacy of antibody drug conjugates. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27417182 DOI: 10.1124/Dmd.116.070631 |
0.506 |
|
| 2016 |
Phillips GDL, Li G, Guo J, Lau J, Yu S, Pillow T, Lee B, Sadowsky J, Schutten M, Fields C, Sliwkowski MX. Abstract 1207: Preclinical development of 2nd generation HER2-directed antibody-drug conjugates Cancer Research. 76: 1207-1207. DOI: 10.1158/1538-7445.Am2016-1207 |
0.444 |
|
| 2015 |
Lehar SM, Pillow T, Xu M, Staben L, Kajihara KK, Vandlen R, DePalatis L, Raab H, Hazenbos WL, Hiroshi Morisaki J, Kim J, Park S, Darwish M, Lee BC, Hernandez H, et al. Novel antibody-antibiotic conjugate eliminates intracellular S. aureus. Nature. PMID 26536114 DOI: 10.1038/Nature16057 |
0.309 |
|
| 2015 |
Verma VA, Pillow TH, DePalatis L, Li G, Phillips GL, Polson AG, Raab HE, Spencer S, Zheng B. The cryptophycins as potent payloads for antibody drug conjugates. Bioorganic & Medicinal Chemistry Letters. 25: 864-8. PMID 25613677 DOI: 10.1016/J.Bmcl.2014.12.070 |
0.5 |
|
| 2014 |
Pillow TH, Tien J, Parsons-Reponte KL, Bhakta S, Li H, Staben LR, Li G, Chuh J, Fourie-O'Donohue A, Darwish M, Yip V, Liu L, Leipold DD, Su D, Wu E, et al. Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering. Journal of Medicinal Chemistry. 57: 7890-9. PMID 25191794 DOI: 10.1021/Jm500552C |
0.469 |
|
| 2013 |
Flygare JA, Pillow TH, Aristoff P. Antibody-drug conjugates for the treatment of cancer. Chemical Biology & Drug Design. 81: 113-21. PMID 23253133 DOI: 10.1111/Cbdd.12085 |
0.513 |
|
| 2012 |
Wender PA, Galliher WC, Bhat NM, Pillow TH, Bieber MM, Teng NN. Taxol-oligoarginine conjugates overcome drug resistance in-vitro in human ovarian carcinoma. Gynecologic Oncology. 126: 118-23. PMID 22484398 DOI: 10.1016/J.Ygyno.2012.03.049 |
0.615 |
|
| 2008 |
Dubikovskaya EA, Thorne SH, Pillow TH, Contag CH, Wender PA. Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters. Proceedings of the National Academy of Sciences of the United States of America. 105: 12128-33. PMID 18713866 DOI: 10.1073/Pnas.0805374105 |
0.56 |
|
| 2008 |
Wender PA, Galliher WC, Goun EA, Jones LR, Pillow TH. The design of guanidinium-rich transporters and their internalization mechanisms. Advanced Drug Delivery Reviews. 60: 452-72. PMID 18164781 DOI: 10.1016/J.Addr.2007.10.016 |
0.716 |
|
| 2008 |
Wender PA, Verma VA, Paxton TJ, Pillow TH. Function-oriented synthesis, step economy, and drug design. Accounts of Chemical Research. 41: 40-9. PMID 18159936 DOI: 10.1021/Ar700155P |
0.583 |
|
| 2007 |
Wender PA, Goun EA, Jones LR, Pillow TH, Rothbard JB, Shinde R, Contag CH. Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 10340-5. PMID 17563383 DOI: 10.1073/Pnas.0703919104 |
0.724 |
|
| 2006 |
Goun EA, Pillow TH, Jones LR, Rothbard JB, Wender PA. Molecular transporters: synthesis of oligoguanidinium transporters and their application to drug delivery and real-time imaging. Chembiochem : a European Journal of Chemical Biology. 7: 1497-515. PMID 16972294 DOI: 10.1002/Cbic.200600171 |
0.708 |
|
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