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Kamil Paruch, Ph.D. - Publications

Affiliations: 
2000 Columbia University, New York, NY 
Area:
organic chemistry
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Němec V, Hylsová M, Maier L, Flegel J, Sievers S, Ziegler S, Schroeder M, Berger BT, Chaikuad A, Valčíková B, Uldrijan S, Drápela S, Souček K, Waldmann H, Knapp S, ... Paruch K, et al. Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angewandte Chemie (International Ed. in English). PMID 30569600 DOI: 10.1002/anie.201810312  0.324
2018 Havel S, Khirsariya P, Akavaram N, Paruch K, Carbain BJ. Preparation of 3,4-substituted-5-aminopyrazoles and 4-substituted-2-aminothiazoles. The Journal of Organic Chemistry. PMID 30458618 DOI: 10.1021/Acs.Joc.8B02655  0.379
2017 Hylse O, Maier L, Kučera R, Perečko T, Svobodová A, Kubala L, Paruch K, Svenda J. A concise synthesis of forskolin. Angewandte Chemie (International Ed. in English). PMID 28782270 DOI: 10.1002/Anie.201706809  0.39
2017 Samadder P, Suchanková T, Hylse O, Khirsariya P, Nikulenkov F, Drápela S, Straková N, Vaňhara P, Vašíčková K, Kolářová H, Binó L, Bittová M, Ovesná P, Kollar P, Fedr R, ... ... Paruch K, et al. Synthesis and profiling of a novel potent selective inhibitor of CHK1 kinase possessing unusual N-trifluoromethylpyrazole pharmacophore resistant to metabolic N-dealkylation. Molecular Cancer Therapeutics. PMID 28619751 DOI: 10.1158/1535-7163.Mct-17-0018  0.321
2017 Maier L, Khirsariya P, Hylse O, Adla SK, Černová L, Poljak M, Krajčovičová S, Weis E, Drápela S, Souček K, Paruch K. Diastereoselective Flexible Synthesis of Carbocyclic C-nucleosides. The Journal of Organic Chemistry. PMID 28267331 DOI: 10.1021/Acs.Joc.6B02594  0.381
2017 Hobza P, Nekardová M, Vymětalová L, Khirsariya P, Kováčová S, Jorda R, Kryštof V, Fanfrlík J, Paruch K, Hylsová M. Structural basis of interaction of CDK2 with roscovitine and its analogs possessing bioisosteric central heterocycles. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. PMID 28128514 DOI: 10.1002/Cphc.201601319  0.327
2016 Hylsová M, Carbain B, Fanfrlík J, Musilová L, Haldar S, Köprülüoğlu C, Ajani H, Brahmkshatriya PS, Jorda R, Kryštof V, Hobza P, Echalier A, Paruch K, Lepšík M. Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines. European Journal of Medicinal Chemistry. 126: 1118-1128. PMID 28039837 DOI: 10.1016/J.Ejmech.2016.12.023  0.304
2015 Kováčová S, Adla SK, Maier L, Babiak M, Mizushina Y, Paruch K. Synthesis of carbocyclic analogs of dehydroaltenusin: Identification of a stable inhibitor of calf DNA polymerase α Tetrahedron. 71: 7575-7582. DOI: 10.1016/J.Tet.2015.08.005  0.353
2014 Maier L, Hylse O, Nečas M, Trbušek M, Ytre-Arne M, Dalhus B, Bjorås M, Paruch K. New carbocyclic nucleosides: Synthesis of carbocyclic pseudoisocytidine and its analogs Tetrahedron Letters. 55: 3713-3716. DOI: 10.1016/J.Tetlet.2014.05.030  0.412
2014 Labroli MA, Dwyer MP, Shen R, Popovici-Muller J, Pu Q, Richard J, Rosner K, Paruch K, Guzi TJ. Syntheses of 5′-amino-2′,5′-dideoxy-2′,2′- difluorocytidine derivatives as novel anticancer nucleoside analogs Tetrahedron Letters. 55: 598-602. DOI: 10.1016/J.Tetlet.2013.11.018  0.384
2013 Dwyer MP, Keertikar K, Paruch K, Alvarez C, Labroli M, Poker C, Fischmann TO, Mayer-Ezell R, Bond R, Wang Y, Azevedo R, Guzi TJ. Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach. Bioorganic & Medicinal Chemistry Letters. 23: 6178-82. PMID 24091081 DOI: 10.1016/J.Bmcl.2013.08.110  0.351
2013 Brahmkshatriya PS, Dobeš P, Fanfrlik J, Rezáç J, Paruch K, Bronowska A, Lepšík M, Hobza P. Quantum mechanical scoring: structural and energetic insights into cyclin-dependent kinase 2 inhibition by pyrazolo[1,5-a]pyrimidines. Current Computer-Aided Drug Design. 9: 118-29. PMID 23157414 DOI: 10.2174/1573409911309010011  0.306
2012 Jorda R, Paruch K, Krystof V. Cyclin-dependent kinase inhibitors inspired by roscovitine: purine bioisosteres. Current Pharmaceutical Design. 18: 2974-80. PMID 22571665 DOI: 10.2174/138161212800672804  0.339
2011 Guzi TJ, Paruch K, Dwyer MP, Labroli M, Shanahan F, Davis N, Taricani L, Wiswell D, Seghezzi W, Penaflor E, Bhagwat B, Wang W, Gu D, Hsieh Y, Lee S, et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Molecular Cancer Therapeutics. 10: 591-602. PMID 21321066 DOI: 10.1158/1535-7163.Mct-10-0928  0.304
2011 Labroli M, Paruch K, Dwyer MP, Alvarez C, Keertikar K, Poker C, Rossman R, Duca JS, Fischmann TO, Madison V, Parry D, Davis N, Seghezzi W, Wiswell D, Guzi TJ. Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 2. Bioorganic & Medicinal Chemistry Letters. 21: 471-4. PMID 21094607 DOI: 10.1016/J.Bmcl.2010.10.114  0.345
2010 Paruch K, Dwyer MP, Alvarez C, Brown C, Chan TY, Doll RJ, Keertikar K, Knutson C, McKittrick B, Rivera J, Rossman R, Tucker G, Fischmann T, Hruza A, Madison V, et al. Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases. Acs Medicinal Chemistry Letters. 1: 204-8. PMID 24900195 DOI: 10.1021/Ml100051D  0.305
2010 Parry D, Guzi T, Shanahan F, Davis N, Prabhavalkar D, Wiswell D, Seghezzi W, Paruch K, Dwyer MP, Doll R, Nomeir A, Windsor W, Fischmann T, Wang Y, Oft M, et al. Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. Molecular Cancer Therapeutics. 9: 2344-53. PMID 20663931 DOI: 10.1158/1535-7163.Mct-10-0324  0.311
2007 Paruch K, Dwyer MP, Alvarez C, Brown C, Chan TY, Doll RJ, Keertikar K, Knutson C, McKittrick B, Rivera J, Rossman R, Tucker G, Fischmann TO, Hruza A, Madison V, et al. Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2. Bioorganic & Medicinal Chemistry Letters. 17: 6220-3. PMID 17904841 DOI: 10.1016/J.Bmcl.2007.09.017  0.307
2007 Dwyer MP, Paruch K, Alvarez C, Doll RJ, Keertikar K, Duca J, Fischmann TO, Hruza A, Madison V, Lees E, Parry D, Seghezzi W, Sgambellone N, Shanahan F, Wiswell D, et al. Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 6216-9. PMID 17904366 DOI: 10.1016/J.Bmcl.2007.09.018  0.32
2003 Paruch K, Vyklický L, Wang DZ, Katz TJ, Incarvito C, Zakharov L, Rheingold AL. Functionalizations of [6]- and [7]helicenes at their most sterically hindered positions. The Journal of Organic Chemistry. 68: 8539-44. PMID 14575483 DOI: 10.1021/Jo035057T  0.634
2003 Paruch K, Vyklický L, Katz TJ. Helicenebisquinones: Synthesis of a [7]Helicenebisquinone Organic Syntheses. 80: 233-239. DOI: 10.1002/0471264180.Os080.28  0.528
2003 Paruch K, Vyklický L, Katz TJ. Preparation of 9,10‐Dimethoxyphenanthrene and 3,6‐Diacetyl‐9,10‐Dimethoxyphenanthrene Organic Syntheses. 80: 227-232. DOI: 10.1002/0471264180.Os080.27  0.515
2003 Paruch K, Vyklický L, Katz TJ. Preparation of 9,10-dimethoxyphenanthrene and 3,6-diacetyl-9,10- dimethoxyphenanthrene: (Phenanthrene, 9,10-dimethoxy- and ethanone, 1,1′-(9,10-dimethoxy-3,6-phenanthrenediyl)bis-) Organic Syntheses. 80: 227-232.  0.508
2003 Paruch K, Vyklický L, Katz TJ. Helicenebisquinones: Synthesis of a [7]helicenebisquinone (dinaphtho[2,1-c:1′,2′-g]phenanthrene-1,4,15,18-tetrone, 9,10-dimethoxy-6,13-bis[[tris(1-methylethyl)silyl]oxy]-) Organic Syntheses. 80: 233-238.  0.499
2000 Paruch K, Vyklický L, Katz TJ, Incarvito CD, Rheingold AL. Expeditious procedure to synthesize ethers and esters of tri- and Tetrahydroxy[6]helicenebisquinones from the dye-intermediates disodium 4-hydroxy- and 4,5-dihydroxynaphthalene-2,7-disulfonates. The Journal of Organic Chemistry. 65: 8774-82. PMID 11112603 DOI: 10.1021/Jo001356W  0.656
2000 Paruch K, Katz TJ, Incarvito C, Lam KC, Rhatigan B, Rheingold AL. First friedel-crafts diacylation of a phenanthrene as the basis for an efficient synthesis of nonracemic The Journal of Organic Chemistry. 65: 7602-8. PMID 11076621 DOI: 10.1021/Jo001055M  0.573
2000 Thongpanchang T, Paruch K, Katz TJ, Rheingold AL, Lam KC, Liable-Sands L. Why (1S)-Camphanates Are Excellent Resolving Agents for Helicen-1-ols and Why They Can Be Used to Analyze Absolute Configurations. The Journal of Organic Chemistry. 65: 1850-1856. PMID 10814159 DOI: 10.1021/Jo9919411  0.539
2000 Dreher SD, Paruch K, Katz TJ. Acidified alcohols as agents to introduce and exchange alkoxyls on the periphery of helicenes Journal of Organic Chemistry. 65: 806-814. DOI: 10.1021/Jo9914972  0.531
2000 Paruch K, Katz TJ, Incarvito C, Lam KC, Rhatigan B, Rheingold AL. First Friedel-Crafts diacylation of a phenanthrene as the basis for an efficient synthesis of nonracemic [7]helicenes Journal of Organic Chemistry. 65: 7602-7608. DOI: 10.1021/jo001055m  0.505
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