Rebecca T. Ruck, Ph.D. - Publications

Affiliations: 
2003 Harvard University, Cambridge, MA, United States 
Area:
Mechanistic and synthetic chemistry

22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Metsänen TT, Lexa KW, Santiago CB, Chung CK, Xu Y, Liu Z, Humphrey GR, Ruck RT, Sherer EC, Sigman MS. Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir). Chemical Science. 9: 6922-6927. PMID 30210766 DOI: 10.1039/c8sc02089b  0.32
2017 Xu F, Zhong YL, Li H, Qi J, Desmond R, Song ZJ, Park J, Wang T, Truppo M, Humphrey GR, Ruck RT. Asymmetric Synthesis of Functionalized trans-Cyclopropoxy Building Block for Grazoprevir. Organic Letters. PMID 29052413 DOI: 10.1021/acs.orglett.7b02867  0.32
2017 Chung CK, Liu Z, Lexa K, Andreani T, Xu Y, Ji Y, DiRocco DA, Humphrey GR, Ruck RT. Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-containing Antiviral, Letermovir. Journal of the American Chemical Society. PMID 28737937 DOI: 10.1021/jacs.7b05806  0.32
2017 Ji Y, Li H, Hyde AM, Chen Q, Belyk KM, Lexa KW, Yin J, Sherer EC, Williamson RT, Brunskill A, Ren S, Campeau LC, Davies IW, Ruck RT. A rational pre-catalyst design for bis-phosphine mono-oxide palladium catalyzed reactions. Chemical Science. 8: 2841-2851. PMID 28553522 DOI: 10.1039/c6sc05472b  0.32
2017 McCabe Dunn JM, Reibarkh M, Sherer EC, Orr RK, Ruck RT, Simmons B, Bellomo A. The protecting-group free selective 3'-functionalization of nucleosides. Chemical Science. 8: 2804-2810. PMID 28553517 DOI: 10.1039/c6sc05081f  0.32
2017 DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW. A multifunctional catalyst that stereoselectively assembles prodrugs. Science (New York, N.Y.). 356: 426-430. PMID 28450641 DOI: 10.1126/science.aam7936  0.32
2016 Chung CK, Cleator E, Dumas AM, Hicks JD, Humphrey GR, Maligres PE, Nolting AF, Rivera N, Ruck RT, Shevlin M. A Synthesis of a Spirocyclic Macrocyclic Protease Inhibitor for the Treatment of Hepatitis C. Organic Letters. PMID 26950496 DOI: 10.1021/acs.orglett.6b00331  1
2016 Neelamkavil SF, Agrawal S, Bara T, Bennett C, Bhat S, Biswas D, Brockunier L, Buist N, Burnette D, Cartwright M, Chackalamannil S, Chase R, Chelliah M, Chen A, Clasby M, ... ... Ruck RT, et al. Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor. Acs Medicinal Chemistry Letters. 7: 111-6. PMID 26819676 DOI: 10.1021/acsmedchemlett.5b00425  1
2016 Christensen M, Nolting A, Shevlin M, Weisel M, Maligres PE, Lee J, Orr RK, Plummer CW, Tudge MT, Campeau LC, Ruck RT. Enantioselective Synthesis of α-Methyl-β-Cyclopropyldihydrocinnamates. The Journal of Organic Chemistry. PMID 26743694 DOI: 10.1021/acs.joc.5b02296  1
2013 Bassan E, Ruck RT, Dienemann E, Emerson KM, Humphrey GR, Raheem IT, Tschaen DM, Vickery TP, Wood HB, Yasuda N. Merck's Reaction Review Policy: An Exercise in Process Safety Organic Process Research and Development. 17: 1611-1616. DOI: 10.1021/op4002033  0.32
2012 He S, Ye Z, Truong Q, Shah S, Du W, Guo L, Dobbelaar PH, Lai Z, Liu J, Jian T, Qi H, Bakshi RK, Hong Q, Dellureficio J, Pasternak A, ... ... Ruck RT, et al. The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes. Acs Medicinal Chemistry Letters. 3: 484-9. PMID 24900499 DOI: 10.1021/ml300063m  1
2012 Bellomo A, Celebi-Olcum N, Bu X, Rivera N, Ruck RT, Welch CJ, Houk KN, Dreher SD. Rapid catalyst identification for the synthesis of the pyrimidinone core of HIV integrase inhibitors. Angewandte Chemie (International Ed. in English). 51: 6912-5. PMID 22689502 DOI: 10.1002/anie.201201720  1
2012 Ruck RT, Huffman MA, Stewart GW, Cleator E, Kandur WV, Kim MM, Zhao D. Route development and multikilogram GMP delivery of a somatostatin receptor antagonist Organic Process Research and Development. 16: 1329-1337. DOI: 10.1021/op300128c  1
2011 Mangion IK, Ruck RT, Rivera N, Huffman MA, Shevlin M. A concise synthesis of a β-lactamase inhibitor. Organic Letters. 13: 5480-3. PMID 21916523 DOI: 10.1021/ol202195n  1
2008 Ruck RT, Huffman MA, Kim MM, Shevlin M, Kandur WV, Davies IW. Palladium-catalyzed tandem Heck reaction/C-H functionalization--preparation of spiro-indane-oxindoles. Angewandte Chemie (International Ed. in English). 47: 4711-4. PMID 18491340 DOI: 10.1002/anie.200800549  1
2008 Kim MM, Ruck RT, Zhao D, Huffman MA. Green iodination of pyrazoles with iodine/hydrogen peroxide in water Tetrahedron Letters. 49: 4026-4028. DOI: 10.1016/j.tetlet.2008.04.082  1
2005 Blum SA, Rivera VA, Ruck RT, Michael FE, Bergman RG. Synthetic and Mechanistic Studies of Strained Heterocycle Opening Reactions Mediated by Zirconium(IV) Imido Complexes. Organometallics. 24: 1647-1659. PMID 16508693 DOI: 10.1021/om049105r  1
2004 Ruck RT, Bergman RG. Reactions of Imines with Azazirconacyclobutenes and Generation of Electron-Deficient Imidozirconocene Complexes. Organometallics. 23: 2231-2233. PMID 16508694 DOI: 10.1021/om0497994  1
2004 Ruck RT, Bergman RG. Zirconium-mediated conversion of amides to nitriles: a surprising additive effect. Angewandte Chemie (International Ed. in English). 43: 5375-7. PMID 15468091 DOI: 10.1002/anie.200461064  1
2004 Ruck RT, Zuckerman RL, Krska SW, Bergman RG. Carboamination: additions of imine C=N bonds across alkynes catalyzed by imidozirconium complexes. Angewandte Chemie (International Ed. in English). 43: 5372-4. PMID 15468090 DOI: 10.1002/anie.200461063  1
2003 Ruck RT, Jacobsen EN. Asymmetric hetero-ene reactions of trimethylsilyl enol ethers catalyzed by tridentate Schiff base chromium(III) complexes. Angewandte Chemie (International Ed. in English). 42: 4771-4. PMID 14562344 DOI: 10.1002/anie.200351591  1
2002 Ruck RT, Jacobsen EN. Asymmetric catalysis of hetero-ene reactions with tridentate Schiff base chromium(III) complexes. Journal of the American Chemical Society. 124: 2882-3. PMID 11902873 DOI: 10.1021/ja025588j  1
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