Izzat T. Raheem, Ph.D. - Publications

2008 Harvard University, Cambridge, MA, United States 
Mechanistic and synthetic chemistry

15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Raheem IT, Schreier JD, Fuerst J, Gantert L, Hostetler ED, Huszar S, Joshi A, Kandebo M, Kim SH, Li J, Ma B, McGaughey G, Sharma S, Shipe WD, Uslaner J, et al. Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorganic & Medicinal Chemistry Letters. PMID 26602277 DOI: 10.1016/j.bmcl.2015.11.013  1
2015 Hostetler ED, Fan H, Joshi AD, Zeng Z, Eng W, Gantert L, Holahan M, Meng X, Miller P, O'Malley S, Purcell M, Riffel K, Salinas C, Williams M, Ma B, ... ... Raheem IT, et al. Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 26596571 DOI: 10.1007/s11307-015-0910-0  1
2015 Raheem I, Walji A, Klein D, Sanders JM, Powell D, Abeywickrema P, Barbe G, Bennet A, Clas SD, Dubost D, Embrey M, Grobler J, Hafey M, Hartingh TJ, Hazuda DJ, et al. Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors. Journal of Medicinal Chemistry. PMID 26397965 DOI: 10.1021/acs.jmedchem.5b01037  1
2015 Cox CD, Hostetler ED, Flores BA, Evelhoch JL, Fan H, Gantert L, Holahan M, Eng W, Joshi A, McGaughey G, Meng X, Purcell M, Raheem IT, Riffel K, Yan Y, et al. Discovery of [(11)C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 26077491 DOI: 10.1016/j.bmcl.2015.05.080  1
2015 Raheem IT, Breslin MJ, Bruno J, Cabalu TD, Cooke A, Cox CD, Cui D, Garson S, Gotter AL, Fox SV, Harrell CM, Kuduk SD, Lemaire W, Prueksaritanont T, Renger JJ, et al. Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant. Bioorganic & Medicinal Chemistry Letters. 25: 444-50. PMID 25577040 DOI: 10.1016/j.bmcl.2014.12.056  1
2014 Nawrocki AR, Rodriguez CG, Toolan DM, Price O, Henry M, Forrest G, Szeto D, Keohane CA, Pan Y, Smith KM, Raheem IT, Cox CD, Hwa J, Renger JJ, Smith SM. Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance. Diabetes. 63: 300-11. PMID 24101672 DOI: 10.2337/db13-0247  1
2014 Peterson EA, Dillon B, Raheem I, Richardson P, Richter D, Schmidt R, Sneddon HF. Sustainable chromatography (an oxymoron?) Green Chemistry. 16: 4060-4075. DOI: 10.1039/c4gc00615a  1
2013 Bryan MC, Dillon B, Hamann LG, Hughes GJ, Kopach ME, Peterson EA, Pourashraf M, Raheem I, Richardson P, Richter D, Sneddon HF. Sustainable practices in medicinal chemistry: current state and future directions. Journal of Medicinal Chemistry. 56: 6007-21. PMID 23586692 DOI: 10.1021/jm400250p  1
2013 Smith SM, Uslaner JM, Cox CD, Huszar SL, Cannon CE, Vardigan JD, Eddins D, Toolan DM, Kandebo M, Yao L, Raheem IT, Schreier JD, Breslin MJ, Coleman PJ, Renger JJ. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey. Neuropharmacology. 64: 215-23. PMID 22750078 DOI: 10.1016/j.neuropharm.2012.06.013  1
2013 Bassan E, Ruck RT, Dienemann E, Emerson KM, Humphrey GR, Raheem IT, Tschaen DM, Vickery TP, Wood HB, Yasuda N. Merck's Reaction Review Policy: An Exercise in Process Safety Organic Process Research and Development. 17: 1611-1616. DOI: 10.1021/op4002033  0.4
2012 Raheem IT, Breslin MJ, Fandozzi C, Fuerst J, Hill N, Huszar S, Kandebo M, Kim SH, Ma B, McGaughey G, Renger JJ, Schreier JD, Sharma S, Smith S, Uslaner J, et al. Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorganic & Medicinal Chemistry Letters. 22: 5903-8. PMID 22892116 DOI: 10.1016/j.bmcl.2012.07.072  1
2008 Raheem IT, Thiara PS, Jacobsen EN. Regio- and enantioselective catalytic cyclization of pyrroles onto N-acyliminium ions. Organic Letters. 10: 1577-80. PMID 18341346 DOI: 10.1021/ol800256j  1
2007 Raheem IT, Thiara PS, Peterson EA, Jacobsen EN. Enantioselective Pictet-Spengler-type cyclizations of hydroxylactams: H-bond donor catalysis by anion binding. Journal of the American Chemical Society. 129: 13404-5. PMID 17941641 DOI: 10.1021/ja076179w  1
2005 Raheem IT, Jacobsen EN. Highly enantioselective aza-Baylis-Hillman reactions catalyzed by chiral thiourea derivatives Advanced Synthesis and Catalysis. 347: 1701-1708. DOI: 10.1002/adsc.200505230  1
2004 Raheem IT, Goodman SN, Jacobsen EN. Catalytic asymmetric total syntheses of quinine and quinidine. Journal of the American Chemical Society. 126: 706-7. PMID 14733531 DOI: 10.1021/ja039550y  1
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