Albert A. Bowers, Ph.D. - Publications

2007 University of Illinois at Chicago, Chicago, IL, United States 
radical chemistry

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Bogart JW, Kramer NJ, Turlik A, Bleich RM, Catlin DS, Schroeder FC, Nair SK, Williamson RT, Houk KN, Bowers AA. Interception of the "Bycroft-Gowland" intermediate in the enzymatic macrocyclization of thiopeptides. Journal of the American Chemical Society. PMID 32609512 DOI: 10.1021/jacs.0c05639  0.6
2020 Puhl AC, Bogart JW, Haberman VA, Larson JE, Godoy AS, Norris-Drouin JL, Cholensky SH, Leisner TM, Frye SV, Parise LV, Bowers AA, Pearce KH. Discovery and Characterization of Peptide Inhibitors for CIB1. Acs Chemical Biology. PMID 32383857 DOI: 10.1021/acschembio.0c00144  0.6
2020 Fleming SR, Himes PM, Ghodge SV, Goto Y, Suga H, Bowers AA. Exploring the Post-Translational Enzymology of PaaA by mRNA Display. Journal of the American Chemical Society. PMID 32109054 DOI: 10.1021/jacs.0c01576  0.56
2019 Bogart JW, Bowers AA. Dehydroamino acids: chemical multi-tools for late-stage diversification. Organic & Biomolecular Chemistry. PMID 30849157 DOI: 10.1039/c8ob03155j  0.6
2019 Farag S, Bleich RM, Shank EA, Isayev O, Bowers AA, Tropsha A. Inter-Modular Linkers play a crucial role in governing the biosynthesis of non-ribosomal peptides. Bioinformatics (Oxford, England). PMID 30785185 DOI: 10.1093/bioinformatics/btz127  0.52
2019 Bogart JW, Bowers AA. Thiopeptide Pyridine Synthase TbtD Catalyzes an Intermolecular Formal Aza-Diels-Alder Reaction. Journal of the American Chemical Society. PMID 30653303 DOI: 10.1021/jacs.8b11852  0.6
2019 Fleming SR, Bartges TE, Vinogradov AA, Kirkpatrick CL, Goto Y, Suga H, Hicks LM, Bowers AA. Flexizyme-enabled benchtop biosynthesis of thiopeptides. Journal of the American Chemical Society. PMID 30602112 DOI: 10.1021/jacs.8b11521  0.4
2019 Gutgsell AR, Ghodge SV, Bowers AA, Neher SB. Mapping the sites of the lipoprotein lipase (LPL)-angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition. The Journal of Biological Chemistry. 294: 2678-2689. PMID 30591589 DOI: 10.1074/jbc.RA118.005932  0.56
2017 Grubbs KJ, Bleich RM, Santa Maria KC, Allen SE, Farag S, Shank EA, Bowers AA. Large-Scale Bioinformatics Analysis of Bacillus Genomes Uncovers Conserved Roles of Natural Products in Bacterial Physiology. Msystems. 2. PMID 29152584 DOI: 10.1128/mSystems.00040-17  0.52
2017 Grove TL, Himes PM, Hwang S, Yumerefendi H, Bonanno JB, Kuhlman B, Almo SC, Bowers AA. Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides. Journal of the American Chemical Society. PMID 28704043 DOI: 10.1021/jacs.7b01283  0.4
2017 Gober JG, Ghodge SV, Bogart JW, Wever WJ, Watkins RR, Brustad EM, Bowers AA. P450-Mediated Non-natural Cyclopropanation of Dehydro-alanine-containing Thiopeptides. Acs Chemical Biology. PMID 28535034 DOI: 10.1021/acschembio.7b00358  1
2017 Lauinger L, Li J, Shostak A, Cemel IA, Ha N, Zhang Y, Merkl PE, Obermeyer S, Stankovic-Valentin N, Schafmeier T, Wever WJ, Bowers AA, Carter KP, Palmer AE, Tschochner H, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nature Chemical Biology. PMID 28459440 DOI: 10.1038/nchembio.2370  1
2016 Wever WJ, Bogart JW, Bowers AA. Identification of Pyridine Synthase Recognition Sequences Allows Modular Solid-Phase Route to Thiopeptide Variants. Journal of the American Chemical Society. PMID 27575591 DOI: 10.1021/jacs.6b05389  1
2016 Ghodge SV, Biernat KA, Bassett SJ, Redinbo MR, Bowers AA. Post-Translational Claisen Condensation and Decarboxylation en Route to the Bicyclic Core of Pantocin A. Journal of the American Chemical Society. PMID 27088303 DOI: 10.1021/jacs.5b13529  1
2016 Himes PM, Allen SE, Hwang S, Bowers AA. Production of Sactipeptides in Escherichia coli: Probing the Substrate Promiscuity of Subtilosin A Biosynthesis. Acs Chemical Biology. PMID 27019323 DOI: 10.1021/acschembio.6b00042  1
2015 Allen SE, Dokholyan NV, Bowers AA. Dynamic docking of conformationally constrained macrocycles: methods and applications. Acs Chemical Biology. PMID 26575401 DOI: 10.1021/acschembio.5b00663  1
2015 Powers MJ, Sanabria-Valentín E, Bowers AA, Shank EA. Inhibition of Cell Differentiation in Bacillus subtilis by Pseudomonas protegens. Journal of Bacteriology. 197: 2129-38. PMID 25825426 DOI: 10.1128/JB.02535-14  1
2015 Wever WJ, Bogart JW, Baccile JA, Chan AN, Schroeder FC, Bowers AA. Chemoenzymatic synthesis of thiazolyl peptide natural products featuring an enzyme-catalyzed formal [4 + 2] cycloaddition. Journal of the American Chemical Society. 137: 3494-7. PMID 25742119 DOI: 10.1021/jacs.5b00940  1
2015 Dunn ZD, Wever WJ, Economou NJ, Bowers AA, Li B. Enzymatic basis of "hybridity" in thiomarinol biosynthesis. Angewandte Chemie (International Ed. in English). 54: 5137-41. PMID 25726835 DOI: 10.1002/anie.201411667  1
2015 Bleich R, Watrous JD, Dorrestein PC, Bowers AA, Shank EA. Thiopeptide antibiotics stimulate biofilm formation in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 112: 3086-91. PMID 25713360 DOI: 10.1073/pnas.1414272112  1
2015 Li B, Wever WJ, Walsh CT, Bowers AA. Correction: Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics. Natural Product Reports. 32: 348-9. PMID 25598489 DOI: 10.1039/c4np90047b  1
2014 Li B, Wever WJ, Walsh CT, Bowers AA. Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics. Natural Product Reports. 31: 905-23. PMID 24835149 DOI: 10.1039/c3np70106a  1
2013 Guerra-Bubb JM, Bowers AA, Smith WB, Paranal R, Estiu G, Wiest O, Bradner JE, Williams RM. Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs. Bioorganic & Medicinal Chemistry Letters. 23: 6025-8. PMID 24035339 DOI: 10.1016/j.bmcl.2013.06.012  1
2013 Du X, Wojtowicz D, Bowers AA, Levens D, Benham CJ, Przytycka TM. The genome-wide distribution of non-B DNA motifs is shaped by operon structure and suggests the transcriptional importance of non-B DNA structures in Escherichia coli. Nucleic Acids Research. 41: 5965-77. PMID 23620297 DOI: 10.1093/nar/gkt308  1
2013 Wever WJ, Cinelli MA, Bowers AA. Visible light mediated activation and O-glycosylation of thioglycosides. Organic Letters. 15: 30-3. PMID 23256636 DOI: 10.1021/ol302941q  1
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/c2np20085f  1
2012 Li B, Forseth RR, Bowers AA, Schroeder FC, Walsh CT. A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus. Chembiochem : a European Journal of Chemical Biology. 13: 2521-6. PMID 23097183 DOI: 10.1002/cbic.201200536  1
2012 Bowers AA, Acker MG, Young TS, Walsh CT. Generation of thiocillin ring size variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. Journal of the American Chemical Society. 134: 10313-6. PMID 22686940 DOI: 10.1021/ja302820x  1
2010 Bowers AA, Walsh CT, Acker MG. Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus. Journal of the American Chemical Society. 132: 12182-4. PMID 20707374 DOI: 10.1021/ja104524q  1
2010 Walsh CT, Acker MG, Bowers AA. Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins. The Journal of Biological Chemistry. 285: 27525-31. PMID 20522549 DOI: 10.1074/jbc.R110.135970  1
2010 Bowers AA, Acker MG, Koglin A, Walsh CT. Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants. Journal of the American Chemical Society. 132: 7519-27. PMID 20455532 DOI: 10.1021/ja102339q  1
2009 Acker MG, Bowers AA, Walsh CT. Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. Journal of the American Chemical Society. 131: 17563-5. PMID 19911780 DOI: 10.1021/ja908777t  1
2009 Newkirk TL, Bowers AA, Williams RM. Discovery, biological activity, synthesis and potential therapeutic utility of naturally occurring histone deacetylase inhibitors. Natural Product Reports. 26: 1293-320. PMID 19779641 DOI: 10.1039/b817886k  1
2009 Crich D, Sasaki K, Rahaman MY, Bowers AA. One-pot syntheses of dissymmetric diamides based on the chemistry of cyclic monothioanhydrides. Scope and limitations and application to the synthesis of glycodipeptides Journal of Organic Chemistry. 74: 3886-3893. PMID 19385609 DOI: 10.1021/jo900532e  1
2009 Bowers AA, West N, Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O, Bradner JE, Williams RM. Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold. Organic Letters. 11: 1301-4. PMID 19239241 DOI: 10.1021/ol900078k  1
2009 Bowers AA, Greshock TJ, West N, Estiu G, Schreiber SL, Wiest O, Williams RM, Bradner JE. Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole. Journal of the American Chemical Society. 131: 2900-5. PMID 19193120 DOI: 10.1021/ja807772w  1
2007 Crich D, Bowers AA. Cyclic thioanhydrides: Linchpins for multicomponent coupling reactions based on the reaction of thioacids with electron-deficient sulfonamides and azides Organic Letters. 9: 5323-5325. PMID 17979281 DOI: 10.1021/ol702570x  1
2007 Crich D, Grant D, Bowers AA. Heterobivalent library expansion by "living radical" processes: thiocarbonyl addition/elimination, and nitroxide-based reactions with fluorous deconvolution. Journal of the American Chemical Society. 129: 12106-7. PMID 17880090 DOI: 10.1021/ja0756321  1
2007 Nokami T, Shibuya A, Tsuyama H, Suga S, Bowers AA, Crich D, Yoshida JI. Electrochemical generation of glycosyl triflate pools Journal of the American Chemical Society. 129: 10922-10928. PMID 17696345 DOI: 10.1021/ja072440x  1
2007 Crich D, Pedersen CM, Bowers AA, Wink DJ. On the use of 3,5-O-benzylidene and 3,5-O-(di-tert-butylsilylene)-2-O-benzylarabinothiofuranosides and their sulfoxides as glycosyl donors for the synthesis of beta-arabinofuranosides: importance of the activation method. The Journal of Organic Chemistry. 72: 1553-65. PMID 17286432 DOI: 10.1021/jo061440x  1
2006 Crich D, Bowers AA. Synthesis of a beta-(1-->3)-D-rhamnotetraose by a one-pot, multiple radical fragmentation. Organic Letters. 8: 4327-30. PMID 16956218 DOI: 10.1021/ol061706m  1
2006 Crich D, Bowers AA. 4,6-O-[1-cyano-2-(2-iodophenyl)ethylidene] acetals. improved second-generation acetals for the stereoselective formation of beta-D-mannopyranosides and regioselective reductive radical fragmentation to beta-D-rhamnopyranosides. scope and limitations. The Journal of Organic Chemistry. 71: 3452-63. PMID 16626126 DOI: 10.1021/jo0526688  1
2006 Crich D, Yao Q, Bowers AA. On the regioselectivity of the Hanessian-Hullar reaction in 4,6-O-benzylidene protected galactopyranosides. Carbohydrate Research. 341: 1748-52. PMID 16530738 DOI: 10.1016/j.carres.2006.02.024  1
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