Year |
Citation |
Score |
2021 |
Vemulapalli V, Chylek LA, Erickson A, Pfeiffer A, Gabriel KH, LaRochelle J, Subramanian K, Cao R, Stegmaier K, Mohseni M, LaMarche MJ, Acker MG, Sorger PK, Gygi SP, Blacklow SC. Time resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling. Elife. 10. PMID 33755016 DOI: 10.7554/eLife.64251 |
0.601 |
|
2019 |
Steinauer A, LaRochelle JR, Knox SL, Wissner RF, Berry S, Schepartz A. HOPS-dependent endosomal fusion required for efficient cytosolic delivery of therapeutic peptides and small proteins. Proceedings of the National Academy of Sciences of the United States of America. 116: 512-521. PMID 30610181 DOI: 10.1073/Pnas.1812044116 |
0.685 |
|
2018 |
LaRochelle JR, Fodor M, Vemulapalli V, Mohseni M, Wang P, Stams T, LaMarche MJ, Chopra R, Acker MG, Blacklow SC. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nature Communications. 9: 4508. PMID 30375388 DOI: 10.1038/s41467-018-06823-9 |
0.57 |
|
2018 |
Fodor M, Price E, Wang P, Lu H, Argintaru A, Chen Z, Glick M, Hao HX, Kato M, Koenig R, LaRochelle JR, Liu G, McNeill E, Majumdar D, Nishiguchi GA, et al. Dual Allosteric Inhibition of SHP2 Phosphatase. Acs Chemical Biology. PMID 29304282 DOI: 10.1021/Acschembio.7B00980 |
0.609 |
|
2017 |
Quach K, LaRochelle J, Li XH, Rhoades E, Schepartz A. Unique arginine array improves cytosolic localization of hydrocarbon-stapled peptides. Bioorganic & Medicinal Chemistry. PMID 29150077 DOI: 10.1016/J.Bmc.2017.11.008 |
0.623 |
|
2017 |
LaRochelle JR, Fodor M, Ellegast JM, Liu X, Vemulapalli V, Mohseni M, Stams T, Buhrlage SJ, Stegmaier K, LaMarche MJ, Acker MG, Blacklow SC. Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorganic & Medicinal Chemistry. PMID 29089257 DOI: 10.1016/J.Bmc.2017.10.025 |
0.634 |
|
2017 |
Acker MG, Chen YP, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, LaRochelle JR, Antonakos B, Chen CH, Chen Z, Cooke VG, Dobson JR, Deng Z, Feng F, Firestone B, et al. Abstract 2084: Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers Cancer Research. 77: 2084-2084. DOI: 10.1158/1538-7445.Am2017-2084 |
0.582 |
|
2016 |
LaRochelle JR, Fodor M, Xu X, Durzynska I, Fan L, Stams T, Chan H, LaMarche MJ, Chopra R, Wang P, Fortin PD, Acker MG, Blacklow SC. Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry. PMID 27030275 DOI: 10.1021/Acs.Biochem.5B01287 |
0.559 |
|
2015 |
Li M, Tao Y, Shu Y, LaRochelle JR, Steinauer A, Thompson D, Schepartz A, Chen ZY, Liu DR. Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo. Journal of the American Chemical Society. PMID 26465072 DOI: 10.1021/Jacs.5B05694 |
0.671 |
|
2015 |
LaRochelle JR, Cobb GB, Steinauer A, Rhoades E, Schepartz A. Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides. Journal of the American Chemical Society. 137: 2536-41. PMID 25679876 DOI: 10.1021/Ja510391N |
0.613 |
|
2014 |
Qian Z, LaRochelle JR, Jiang B, Lian W, Hard RL, Selner NG, Luechapanichkul R, Barrios AM, Pei D. Early endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery. Biochemistry. 53: 4034-46. PMID 24896852 DOI: 10.1021/Bi5004102 |
0.44 |
|
2013 |
Holub JM, Larochelle JR, Appelbaum JS, Schepartz A. Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics. Biochemistry. 52: 9036-46. PMID 24256505 DOI: 10.1021/Bi401069G |
0.695 |
|
2012 |
Appelbaum JS, LaRochelle JR, Smith BA, Balkin DM, Holub JM, Schepartz A. Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm. Chemistry & Biology. 19: 819-30. PMID 22840770 DOI: 10.1016/J.Chembiol.2012.05.022 |
0.658 |
|
2009 |
Sheftic SR, Croke RL, LaRochelle JR, Alexandrescu AT. Electrostatic contributions to the stabilities of native proteins and amyloid complexes. Methods in Enzymology. 466: 233-58. PMID 21609864 DOI: 10.1016/S0076-6879(09)66010-9 |
0.404 |
|
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