Xuechen Li, Ph.D. - Publications

Affiliations: 
2007 Harvard University, Cambridge, MA, United States 
Area:
molecular mechanisms of various antibiotics

34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wang C, Yu Y, Su Z, Li X, Cao H. Metal-Free C-B Bond Cleavage: An Acid Catalyzed Three-Component Reaction Construction of Imidazole-Containing Triarylmethanes. Organic Letters. PMID 31184175 DOI: 10.1021/acs.orglett.9b00969  0.36
2018 Yang D, Yu Y, Wu Y, Feng H, Li X, Cao H. One-Pot Regiospecific Synthesis of Indolizines: A Solvent-Free, Metal-Free, Three-Component Reaction of 2-(Pyridin-2-yl)acetates, Ynals, and Alcohols or Thiols. Organic Letters. PMID 29613809 DOI: 10.1021/acs.orglett.8b00835  0.36
2017 Wang C, Lai J, Chen C, Li X, Cao H. A Ag-Catalyzed Tandem Three-Component Reaction towards the Synthesis of Multisubstituted Imidazoles. The Journal of Organic Chemistry. PMID 29161038 DOI: 10.1021/acs.joc.7b02612  0.36
2016 Jin K, Sam IH, Po KH, Lin D, Ghazvini Zadeh EH, Chen S, Yuan Y, Li X. Total synthesis of teixobactin. Nature Communications. 7: 12394. PMID 27484680 DOI: 10.1038/ncomms12394  0.36
2016 Lee CL, Liu H, Wong CT, Chow HY, Li X. Enabling N-to-C Ser/Thr Ligation for Convergent Protein Synthesis via Combining Chemical Ligation Approaches. Journal of the American Chemical Society. PMID 27479006 DOI: 10.1021/jacs.6b04238  0.36
2016 Tung CL, Wong CT, Fung EY, Li X. Traceless and Chemoselective Amine Bioconjugation via Phthalimidine Formation in Native Protein Modification. Organic Letters. PMID 27191384 DOI: 10.1021/acs.orglett.6b00983  0.36
2015 Lee CL, Lam HY, Li X. Serine/threonine ligation for natural cyclic peptide syntheses. Natural Product Reports. 32: 1274-9. PMID 26023909 DOI: 10.1039/c5np00001g  0.36
2015 Tung CL, Wong CT, Li X. Peptide 2-formylthiophenol esters do not proceed through a Ser/Thr ligation pathway, but participate in a peptide aminolysis to enable peptide condensation and cyclization. Organic & Biomolecular Chemistry. 13: 6922-6. PMID 26013965 DOI: 10.1039/c5ob00825e  0.36
2015 Lee JP, Liu C, Li T, Zhu G, Li X. Development of stapled helical peptides to perturb the Cdt1-Mcm6 interaction. Journal of Peptide Science : An Official Publication of the European Peptide Society. 21: 593-8. PMID 25921752 DOI: 10.1002/psc.2779  0.36
2014 Lam HY, Gaarden RI, Li X. A journey to the total synthesis of daptomycin. Chemical Record (New York, N.Y.). 14: 1086-99. PMID 25205345 DOI: 10.1002/tcr.201402049  0.36
2014 Tung CL, Lam HY, Xu J, Li X. A fluorogenic probe for recognizing 5-hydroxylysine inspired by serine/threonine ligation. Chemical Communications (Cambridge, England). 50: 5298-300. PMID 24192710 DOI: 10.1039/c3cc47465h  0.36
2013 Wong CT, Lam HY, Li X. Effective synthesis of kynurenine-containing peptides via on-resin ozonolysis of tryptophan residues: synthesis of cyclomontanin B. Organic & Biomolecular Chemistry. 11: 7616-20. PMID 24104948 DOI: 10.1039/c3ob41631c  0.36
2013 Xu C, Lam HY, Zhang Y, Li X. Convergent synthesis of MUC1 glycopeptides via serine ligation. Chemical Communications (Cambridge, England). 49: 6200-2. PMID 23732560 DOI: 10.1039/c3cc42573h  0.36
2013 Zhang Y, Xu C, Lam HY, Lee CL, Li X. Protein chemical synthesis by serine and threonine ligation. Proceedings of the National Academy of Sciences of the United States of America. 110: 6657-62. PMID 23569249 DOI: 10.1073/pnas.1221012110  0.36
2013 Lam HY, Zhang Y, Liu H, Xu J, Wong CT, Xu C, Li X. Total synthesis of daptomycin by cyclization via a chemoselective serine ligation. Journal of the American Chemical Society. 135: 6272-9. PMID 23560543 DOI: 10.1021/ja4012468  0.36
2012 Wilson RM, Stockdill JL, Wu X, Li X, Vadola PA, Park PK, Wang P, Danishefsky SJ. A fascinating journey into history: exploration of the world of isonitriles en route to complex amides. Angewandte Chemie (International Ed. in English). 51: 2834-48. PMID 22368033 DOI: 10.1002/anie.201106628  0.36
2011 Wang P, Li X, Zhu J, Chen J, Yuan Y, Wu X, Danishefsky SJ. Encouraging progress in the ω-aspartylation of complex oligosaccharides as a general route to β-N-linked glycopolypeptides. Journal of the American Chemical Society. 133: 1597-602. PMID 21207981 DOI: 10.1021/ja110115a  0.36
2009 Wu X, Li X, Danishefsky SJ. Thio-mediated two-component coupling reaction of carboxylic acids and isonitriles under mild conditions. Tetrahedron Letters. 50: 1523-1525. PMID 20161329 DOI: 10.1016/j.tetlet.2009.01.046  0.36
2009 Yuan Y, Zhu J, Li X, Wu X, Danishefsky SJ. Preparation and reactions of N-thioformyl peptides from amino thioacids and isonitriles. Tetrahedron Letters. 50: 2329-2333. PMID 20161291 DOI: 10.1016/j.tetlet.2009.02.205  0.36
2009 Wu X, Yuan Y, Li X, Danishefsky SJ. Thio-mediated synthesis of derivatized N-linked glycopeptides using isonitrile chemistry. Tetrahedron Letters. 50: 4666-4669. PMID 20161157 DOI: 10.1016/j.tetlet.2009.06.005  0.36
2009 Rao Y, Li X, Nagorny P, Hayashida J, Danishefsky SJ. A Simple Method for the Conversion of Carboxylic Acids into Thioacids with Lawesson's Reagent. Tetrahedron Letters. 50: 6684-6686. PMID 20160926 DOI: 10.1016/j.tetlet.2009.09.080  0.36
2009 Rao Y, Li X, Danishefsky SJ. Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds. Journal of the American Chemical Society. 131: 12924-6. PMID 19697932 DOI: 10.1021/ja906005j  0.36
2009 Nagorny P, Fasching B, Li X, Chen G, Aussedat B, Danishefsky SJ. Toward fully synthetic homogeneous beta-human follicle-stimulating hormone (beta-hFSH) with a biantennary N-linked dodecasaccharide. synthesis of beta-hFSH with chitobiose units at the natural linkage sites. Journal of the American Chemical Society. 131: 5792-9. PMID 19341309 DOI: 10.1021/ja809554x  0.36
2008 Li X, Danishefsky SJ. Noncatalytic reaction of isonitriles and carboxylic acids en route to amide-type linkages. Nature Protocols. 3: 1666-70. PMID 18833204 DOI: 10.1038/nprot.2008.153  0.36
2008 Li X, Yuan Y, Kan C, Danishefsky SJ. Addressing mechanistic issues in the coupling of isonitriles and carboxylic acids: potential routes to peptidic constructs. Journal of the American Chemical Society. 130: 13225-7. PMID 18783225 DOI: 10.1021/ja804709s  0.36
2008 Li X, Yuan Y, Berkowitz WF, Todaro LJ, Danishefsky SJ. On the two-component microwave-mediated reaction of isonitriles with carboxylic acids: regarding alleged formimidate carboxylate mixed anhydrides. Journal of the American Chemical Society. 130: 13222-4. PMID 18783224 DOI: 10.1021/ja8047078  0.36
2008 Jones GO, Li X, Hayden AE, Houk KN, Danishefsky SJ. The coupling of isonitriles and carboxylic acids occurring by sequential concerted rearrangement mechanisms. Organic Letters. 10: 4093-6. PMID 18707109 DOI: 10.1021/ol8016287  0.36
2008 Li X, Danishefsky SJ. New chemistry with old functional groups: on the reaction of isonitriles with carboxylic acids--a route to various amide types. Journal of the American Chemical Society. 130: 5446-8. PMID 18370392 DOI: 10.1021/ja800612r  0.36
2006 Taylor JG, Li X, Oberthür M, Zhu W, Kahne DE. The total synthesis of moenomycin A. Journal of the American Chemical Society. 128: 15084-5. PMID 17117848 DOI: 10.1021/ja065907x  0.36
2006 Gennadios HA, Whittington DA, Li X, Fierke CA, Christianson DW. Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase. Biochemistry. 45: 7940-8. PMID 16800620 DOI: 10.1021/bi060823m  0.36
2005 Coggins BE, McClerren AL, Jiang L, Li X, Rudolph J, Hindsgaul O, Raetz CR, Zhou P. Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design. Biochemistry. 44: 1114-26. PMID 15667205 DOI: 10.1021/bi047820z  0.36
2004 Coggins BE, Li X, Hindsgaul O, Raetz CR, Zhou P. Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514. Journal of Biomolecular Nmr. 28: 201-2. PMID 14755169 DOI: 10.1023/B:JNMR.0000013817.29493.87  0.36
2003 Coggins BE, Li X, McClerren AL, Hindsgaul O, Raetz CR, Zhou P. Structure of the LpxC deacetylase with a bound substrate-analog inhibitor. Nature Structural Biology. 10: 645-51. PMID 12833153 DOI: 10.1038/nsb948  0.36
2003 Li X, Uchiyama T, Raetz CR, Hindsgaul O. Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis. Organic Letters. 5: 539-41. PMID 12583763 DOI: 10.1021/ol027458l  0.36
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