| Year |
Citation |
Score |
| 2022 |
Leandro J, Khamrui S, Suebsuwong C, Chen PJ, Secor C, Dodatko T, Yu C, Sanchez R, DeVita RJ, Houten SM, Lazarus MB. Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1. Open Biology. 12: 220179. PMID 36128717 DOI: 10.1098/rsob.220179 |
0.3 |
|
| 2021 |
Baidin V, Owens TW, Lazarus MB, Kahne D. Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. Journal of the American Chemical Society. PMID 33411531 DOI: 10.1021/jacs.0c11113 |
0.533 |
|
| 2020 |
Leandro J, Khamrui S, Wang H, Suebsuwong C, Nemeria NS, Huynh K, Moustakim M, Secor C, Wang M, Dodatko T, Stauffer B, Wilson CG, Yu C, Arkin MR, Jordan F, ... ... Lazarus MB, et al. Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex. Acs Chemical Biology. PMID 32633484 DOI: 10.1021/Acschembio.0C00114 |
0.401 |
|
| 2020 |
Kumar K, Wang P, Wilson J, Zlatanic V, Berrouet C, Khamrui S, Secor C, Swartz E, Lazarus MB, Sanchez R, Stewart AF, Garcia-Ocana A, DeVita RJ. Synthesis and Biological Validation of a Harmine-based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor. Journal of Medicinal Chemistry. PMID 32003560 DOI: 10.1021/Acs.Jmedchem.9B01379 |
0.423 |
|
| 2019 |
Khamrui S, Ung PMU, Secor C, Schlessinger A, Lazarus MB. High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4. Journal of the American Chemical Society. PMID 31841327 DOI: 10.2210/Pdb6U5L/Pdb |
0.441 |
|
| 2018 |
Martin SES, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, Boutz PL, Törk L, Moss FA, Thomas CJ, Gygi SP, Lazarus MB, Walker S. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. Journal of the American Chemical Society. PMID 30285435 DOI: 10.1021/Jacs.8B07328 |
0.752 |
|
| 2017 |
May JM, Owens TW, Mandler MD, Simpson BW, Lazarus M, Sherman DJ, Davis RM, Okuda S, Massefski W, Ruiz N, Kahne D. The antibiotic novobiocin binds and activates the ATPase that powers lipopolysaccharide transport. Journal of the American Chemical Society. PMID 29135241 DOI: 10.1021/Jacs.7B07736 |
0.693 |
|
| 2017 |
Lazarus MB, Levin RS, Shokat KM. Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response. Cellular Signalling. 29: 78-83. PMID 27760376 DOI: 10.1016/J.Cellsig.2016.10.006 |
0.703 |
|
| 2016 |
Janetzko J, Trauger SA, Lazarus MB, Walker S. How the glycosyltransferase OGT catalyzes amide bond cleavage. Nature Chemical Biology. PMID 27618188 DOI: 10.1038/Nchembio.2173 |
0.728 |
|
| 2015 |
Lazarus MB, Shokat KM. Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1. Bioorganic & Medicinal Chemistry. 23: 5483-8. PMID 26275681 DOI: 10.1016/J.Bmc.2015.07.034 |
0.595 |
|
| 2015 |
Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. A small molecule that inhibits OGT activity in cells. Acs Chemical Biology. 10: 1392-7. PMID 25751766 DOI: 10.1021/Acschembio.5B00004 |
0.74 |
|
| 2015 |
Lazarus MB, Novotny CJ, Shokat KM. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors. Acs Chemical Biology. 10: 257-61. PMID 25551253 DOI: 10.1021/Cb500835Z |
0.683 |
|
| 2015 |
Lazarus MB, Novotny CJ, Shokat KM. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors Acs Chemical Biology. 10: 257-261. DOI: 10.1021/cb500835z |
0.517 |
|
| 2014 |
Sherman DJ, Lazarus MB, Murphy L, Liu C, Walker S, Ruiz N, Kahne D. Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport. Proceedings of the National Academy of Sciences of the United States of America. 111: 4982-7. PMID 24639492 DOI: 10.1073/Pnas.1323516111 |
0.576 |
|
| 2013 |
Lazarus MB, Jiang J, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science (New York, N.Y.). 342: 1235-9. PMID 24311690 DOI: 10.1126/Science.1243990 |
0.725 |
|
| 2012 |
Lazarus MB, Jiang J, Gloster TM, Zandberg WF, Whitworth GE, Vocadlo DJ, Walker S. Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nature Chemical Biology. 8: 966-8. PMID 23103939 DOI: 10.1038/Nchembio.1109 |
0.447 |
|
| 2012 |
Jiang J, Lazarus MB, Pasquina L, Sliz P, Walker S. A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Nature Chemical Biology. 8: 72-7. PMID 22082911 DOI: 10.1038/Nchembio.711 |
0.512 |
|
| 2011 |
Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S. Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature. 469: 564-7. PMID 21240259 DOI: 10.1038/Nature09638 |
0.494 |
|
| 2011 |
Lynch TP, Jackson SR, Shahriari KS, Ferrer CM, Lazarus M, Walker S, Vosseller K, Reginato MJ. Abstract 1267: Metabolic sensor O-GlcNAc Transferase is a novel regulator of prostate cancer invasion and angiogenesis via regulation of FoxM1 Cancer Research. 71: 1267-1267. DOI: 10.1158/1538-7445.Am2011-1267 |
0.355 |
|
| 2006 |
Tiyanont K, Doan T, Lazarus MB, Fang X, Rudner DZ, Walker S. Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 103: 11033-8. PMID 16832063 DOI: 10.1073/Pnas.0600829103 |
0.3 |
|
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