Michael B. Lazarus, Ph.D. - Publications

Affiliations: 
2010 Harvard University, Cambridge, MA, United States 
Area:
molecular mechanisms of various antibiotics

16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zeng Z, Xiang M, Guan H, Liu Y, Zhang H, Xia L, Zhan J, Hu Q. Early fibroproliferative signs on high-resolution CT are associated with mortality in COVID-19 pneumonia patients with ARDS: a retrospective study. Therapeutic Advances in Chronic Disease. 12: 2040622320982171. PMID 33613933 DOI: 10.1177/2040622320982171  0.36
2021 Baidin V, Owens TW, Lazarus MB, Kahne D. Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. Journal of the American Chemical Society. PMID 33411531 DOI: 10.1021/jacs.0c11113  0.44
2018 Martin SES, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, Boutz PL, Törk L, Moss FA, Thomas CJ, Gygi SP, Lazarus MB, Walker S. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. Journal of the American Chemical Society. PMID 30285435 DOI: 10.1021/jacs.8b07328  0.68
2017 May JM, Owens TW, Mandler MD, Simpson BW, Lazarus M, Sherman DJ, Davis RM, Okuda S, Massefski W, Ruiz N, Kahne D. The antibiotic novobiocin binds and activates the ATPase that powers lipopolysaccharide transport. Journal of the American Chemical Society. PMID 29135241 DOI: 10.1021/jacs.7b07736  0.44
2017 Lazarus MB, Levin RS, Shokat KM. Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response. Cellular Signalling. 29: 78-83. PMID 27760376 DOI: 10.1016/j.cellsig.2016.10.006  0.92
2016 Janetzko J, Trauger SA, Lazarus MB, Walker S. How the glycosyltransferase OGT catalyzes amide bond cleavage. Nature Chemical Biology. PMID 27618188 DOI: 10.1038/nchembio.2173  0.68
2015 Lazarus MB, Shokat KM. Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1. Bioorganic & Medicinal Chemistry. 23: 5483-8. PMID 26275681 DOI: 10.1016/j.bmc.2015.07.034  0.92
2015 Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. A small molecule that inhibits OGT activity in cells. Acs Chemical Biology. 10: 1392-7. PMID 25751766 DOI: 10.1021/acschembio.5b00004  0.56
2015 Lazarus MB, Novotny CJ, Shokat KM. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors. Acs Chemical Biology. 10: 257-61. PMID 25551253 DOI: 10.1021/cb500835z  0.92
2015 Lazarus MB, Novotny CJ, Shokat KM. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors Acs Chemical Biology. 10: 257-261. DOI: 10.1021/cb500835z  0.8
2014 Sherman DJ, Lazarus MB, Murphy L, Liu C, Walker S, Ruiz N, Kahne D. Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport. Proceedings of the National Academy of Sciences of the United States of America. 111: 4982-7. PMID 24639492 DOI: 10.1073/pnas.1323516111  0.68
2013 Lazarus MB, Jiang J, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science (New York, N.Y.). 342: 1235-9. PMID 24311690 DOI: 10.1126/science.1243990  0.68
2012 Lazarus MB, Jiang J, Gloster TM, Zandberg WF, Whitworth GE, Vocadlo DJ, Walker S. Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nature Chemical Biology. 8: 966-8. PMID 23103939 DOI: 10.1038/nchembio.1109  0.68
2012 Jiang J, Lazarus MB, Pasquina L, Sliz P, Walker S. A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Nature Chemical Biology. 8: 72-7. PMID 22082911 DOI: 10.1038/nchembio.711  0.56
2011 Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S. Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature. 469: 564-7. PMID 21240259 DOI: 10.1038/nature09638  0.56
2006 Tiyanont K, Doan T, Lazarus MB, Fang X, Rudner DZ, Walker S. Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 103: 11033-8. PMID 16832063 DOI: 10.1073/pnas.0600829103  0.68
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