Year |
Citation |
Score |
2017 |
Davoren JE, Garnsey M, Pettersen B, Brodney MA, Edgerton JR, Fortin JP, Grimwood S, Harris AR, Jenkinson S, Kenakin TP, Lazzaro JT, Lee CW, Lotarski SM, Nottebaum L, O'Neil SV, et al. Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity. Journal of Medicinal Chemistry. PMID 28598634 DOI: 10.1021/Acs.Jmedchem.7B00597 |
0.353 |
|
2016 |
Popiolek M, Nguyen DP, Reinhart V, Edgerton JR, Harms J, Lotarski SM, Steyn SJ, Davoren JE, Grimwood S. Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M1 Receptor Activation. Biochemistry. PMID 27958713 DOI: 10.1021/Acs.Biochem.6B00688 |
0.325 |
|
2016 |
Davoren JE, Lee CW, Garnsey M, Brodney MA, Cordes J, Dlugolenski K, Edgerton JR, Harris AR, Helal CJ, Jenkinson S, Kauffman GW, Kenakin T, Lazzaro JT, Lotarski SM, Mao Y, et al. Discovery of the potent and selective M1 PAM-agonist N-[(3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of efficacy and cholinergic side effects. Journal of Medicinal Chemistry. PMID 27275946 DOI: 10.1021/Acs.Jmedchem.6B00544 |
0.338 |
|
2015 |
Davoren JE, O'Neil SV, Anderson DP, Brodney MA, Chenard L, Dlugolenski K, Edgerton JR, Green M, Garnsey M, Grimwood S, Harris AR, Kauffman GW, LaChapelle E, Lazzaro JT, Lee CW, et al. Design and optimization of selective azaindole amide M1 positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. PMID 26631313 DOI: 10.1016/J.Bmcl.2015.11.053 |
0.347 |
|
2011 |
Wang Z, Chi Y, Harris AR, Gray D, Davoren JE. Scalable synthesis of 4-substituted 5-bromo-6-methylpyrimidines Synthesis. 1529-1531. DOI: 10.1055/S-0030-1259976 |
0.332 |
|
2011 |
Harris AR, Nason DM, Collantes EM, Xu W, Chi Y, Wang Z, Zhang B, Zhang Q, Gray DL, Davoren JE. Synthesis of 5-bromo-6-methyl imidazopyrazine, 5-bromo and 5-chloro-6-methyl imidazopyridine using electron density surface maps to guide synthetic strategy Tetrahedron. 67: 9063-9066. DOI: 10.1016/J.Tet.2011.08.090 |
0.302 |
|
2010 |
Davoren JE, Gray DL, Harris AR, Nason DM, Xu W. Remarkable [3+2] Annulations of Electron-Rich Olefins with Unstabilized Azomethine Ylides Synlett. 2490-2492. DOI: 10.1055/S-0030-1258026 |
0.314 |
|
2008 |
Davoren JE, Harcken C, Martin SF. Studies toward the enantioselective syntheses of oxylipins: total synthesis and structure revision of solandelactone E. The Journal of Organic Chemistry. 73: 391-402. PMID 18088137 DOI: 10.1021/Jo701739V |
0.46 |
|
2007 |
Davoren JE, Martin SF. Enantioselective synthesis and structure revision of solandelactone E. Journal of the American Chemical Society. 129: 510-1. PMID 17227012 DOI: 10.1021/Ja068270Q |
0.457 |
|
2001 |
Liras S, Davoren JE, Bordner J. An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine. Organic Letters. 3: 703-6. PMID 11259041 DOI: 10.1021/Ol0070482 |
0.368 |
|
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