| Year |
Citation |
Score |
| 2013 |
Arnold U, Huck BR, Gellman SH, Raines RT. Protein prosthesis: β-peptides as reverse-turn surrogates. Protein Science : a Publication of the Protein Society. 22: 274-9. PMID 23238807 DOI: 10.1002/Pro.2208 |
0.59 |
|
| 2005 |
Huck BR, Gellman SH. Synthesis of 2,2-disubstituted pyrrolidine-4-carboxylic acid derivatives and their incorporation into beta-peptide oligomers. The Journal of Organic Chemistry. 70: 3353-62. PMID 15844969 DOI: 10.1021/Jo048639Z |
0.679 |
|
| 2003 |
Huck BR, Fisk JD, Guzei IA, Carlson HA, Gellman SH. Secondary structural preferences of 2,2-disubstituted pyrrolidine-4-carboxylic acid oligomers: beta-peptide foldamers that cannot form internal hydrogen bonds. Journal of the American Chemical Society. 125: 9035-7. PMID 15369358 DOI: 10.1021/Ja034561C |
0.682 |
|
| 2002 |
Lai JR, Huck BR, Weisblum B, Gellman SH. Design of non-cysteine-containing antimicrobial beta-hairpins: structure-activity relationship studies with linear protegrin-1 analogues. Biochemistry. 41: 12835-42. PMID 12379126 DOI: 10.1021/Bi026127D |
0.673 |
|
| 2002 |
Arnold U, Hinderaker MP, Nilsson BL, Huck BR, Gellman SH, Raines RT. Protein prosthesis: a semisynthetic enzyme with a beta-peptide reverse turn. Journal of the American Chemical Society. 124: 8522-3. PMID 12121081 DOI: 10.1021/Ja026114N |
0.61 |
|
| 2001 |
Chung YJ, Huck BR, Christianson LA, Stanger HE, Krauthäuser S, Powell DR, Gellman SH. Stereochemical Control of Hairpin Formation in β-Peptides Containing Dinipecotic Acid Reverse Turn Segments [J. Am. Chem. Soc.2000,122, 3995−4004]. Journal of the American Chemical Society. 123: 5851-5851. DOI: 10.1021/Ja0151549 |
0.569 |
|
| 2000 |
Huck BR, Fisk JD, Gellman SH. Promotion of sheet formation in alpha-peptide strands by a beta-peptide reverse turn. Organic Letters. 2: 2607-10. PMID 10990408 DOI: 10.1021/Ol006120T |
0.703 |
|
| 2000 |
Chung YJ, Huck BR, Christianson LA, Stanger HE, Krauthäuser S, Powell DR, Gellman SH. Stereochemical control of hairpin formation in β-peptides containing dinipecotic acid reverse turn segments Journal of the American Chemical Society. 122: 3995-4004. DOI: 10.1021/Ja993416P |
0.601 |
|
| 1999 |
Huck BR, Langenhan JM, Gellman SH. Non-hydrogen-bonded secondary structure in beta-peptides: evidence from circular dichroism of (S)-pyrrolidine-3-carboxylic acid oligomers and (S)-nipecotic acid oligomers. Organic Letters. 1: 1717-20. PMID 10836030 DOI: 10.1021/Ol9909482 |
0.633 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2004 |
Tumey LN, Huck B, Gleason E, Wang J, Silver D, Brunden K, Boozer S, Rundlett S, Sherf B, Murphy S, Bailey A, Dent T, Leventhal C, Harrington J, Bennani YL. The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 14: 4915-8. PMID 15341951 DOI: 10.1016/j.bmcl.2004.07.028 |
0.12 |
|
| 2021 |
DeSelm L, Huck B, Lan R, Neagu C, Potnick J, Xiao Y, Chen X, Jones R, Richardson TE, Heasley BH, Haxell T, Moore J, Tian H, Georgi K, Rohdich F, et al. Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers. Journal of Medicinal Chemistry. PMID 34596404 DOI: 10.1021/acs.jmedchem.1c01087 |
0.076 |
|
| 2005 |
Tumey LN, Bom D, Huck B, Gleason E, Wang J, Silver D, Brunden K, Boozer S, Rundlett S, Sherf B, Murphy S, Dent T, Leventhal C, Bailey A, Harrington J, et al. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 277-81. PMID 15603939 DOI: 10.1016/j.bmcl.2004.10.086 |
0.068 |
|
| 2023 |
Guler S, DiPoto MC, Crespo A, Caldwell R, Doerfel B, Grossmann N, Ho K, Huck B, Jones CC, Lan R, Musil D, Potnick J, Schilke H, Sherer B, Simon S, et al. Selective Wee1 Inhibitors Led to Antitumor Activity and Correlated with Myelosuppression. Acs Medicinal Chemistry Letters. 14: 566-576. PMID 37197456 DOI: 10.1021/acsmedchemlett.2c00481 |
0.065 |
|
| 2023 |
Toure M, Johnson T, Li B, Schmidt R, Ma H, Neagu C, Lopez AU, Wang Y, Guler S, Xiao Y, Henkes R, Ho K, Zhang S, Chu CL, Gundra UM, ... ... Huck B, et al. Discovery of quinazoline HPK1 inhibitors with high cellular potency. Bioorganic & Medicinal Chemistry. 92: 117423. PMID 37531921 DOI: 10.1016/j.bmc.2023.117423 |
0.063 |
|
| 2020 |
Kötzner L, Huck B, Garg S, Urbahns K. Small molecules-Giant leaps for immuno-oncology. Progress in Medicinal Chemistry. 59: 1-62. PMID 32362326 DOI: 10.1016/bs.pmch.2019.11.001 |
0.06 |
|
| 2013 |
Karra S, Xiao Y, Chen X, Liu-Bujalski L, Huck B, Sutton A, Goutopoulos A, Askew B, Josephson K, Jiang X, Shutes A, Shankar V, Noonan T, Garcia-Berrios G, Dong R, et al. SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 3081-7. PMID 23570792 DOI: 10.1016/j.bmcl.2013.03.008 |
0.056 |
|
| 2006 |
Huck BR, Llamas L, Robarge MJ, Dent TC, Song J, Hodnick WF, Crumrine C, Stricker-Krongrad A, Harrington J, Brunden KR, Bennani YL. The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist. Bioorganic & Medicinal Chemistry Letters. 16: 4130-4. PMID 16750364 DOI: 10.1016/j.bmcl.2006.04.070 |
0.047 |
|
| 2019 |
Caldwell R, Qiu H, Askew BC, Bender AT, Brugger N, Camps M, Dhanabal M, Dutt V, Eichhorn T, Gardberg AS, Goutopoulos A, Grenningloh R, Head J, Healey B, Hodous BL, ... Huck BR, et al. Discovery of Evobrutinib: An Oral, Potent and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases. Journal of Medicinal Chemistry. PMID 31368705 DOI: 10.1021/Acs.Jmedchem.9B00794 |
0.044 |
|
| 2022 |
Xiao Y, Huck BR, Lan R, DeSelm L, Chen X, Qiu H, Neagu C, Johnson T, Mochalkin I, Gardberg A, Jiang X, Tian H, Dutt V, Santos D, Head J, et al. Corrigendum to "Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors" [Bioorgan. Med. Chem. Lett. 50 (2021) 128352]. Bioorganic & Medicinal Chemistry Letters. 128758. PMID 35484006 DOI: 10.1016/j.bmcl.2022.128758 |
0.042 |
|
| 2017 |
Urbahns K, Huck BR, Kötzner L. Small Molecules Drive Big Improvements in Immuno-oncology Therapies. Angewandte Chemie (International Ed. in English). PMID 28971564 DOI: 10.1002/anie.201707816 |
0.04 |
|
| 2006 |
Huck BR, Llamas L, Robarge MJ, Dent TC, Song J, Hodnick WF, Crumrine C, Stricker-Krongrad A, Harrington J, Brunden KR, Bennani YL. The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonists. Bioorganic & Medicinal Chemistry Letters. 16: 2891-4. PMID 16546379 DOI: 10.1016/j.bmcl.2006.03.007 |
0.038 |
|
| 2022 |
Offringa R, Kötzner L, Huck B, Urbahns K. The expanding role for small molecules in immuno-oncology. Nature Reviews. Drug Discovery. PMID 35982333 DOI: 10.1038/s41573-022-00538-9 |
0.036 |
|
| 2023 |
Hartung IV, Huck BR, Crespo A. Rules were made to be broken. Nature Reviews. Chemistry. 7: 3-4. PMID 37117823 DOI: 10.1038/s41570-022-00451-0 |
0.035 |
|
| 2016 |
Machl A, Wilker EW, Tian H, Liu X, Schroeder P, Clark A, Huck BR. M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. American Journal of Cancer Research. 6: 806-18. PMID 27186432 |
0.029 |
|
| 2021 |
Xiao Y, Huck BR, Lan R, DeSelm L, Chen X, Qiu H, Neagu C, Johnson T, Mochalkin I, Gardberg A, Jiang X, Tian H, Dutt V, Santos D, Head J, et al. Discovery of 4-Aminopyrimidine Analogs as highly Potent Dual P70S6K/Akt Inhibitors. Bioorganic & Medicinal Chemistry Letters. 128352. PMID 34481987 DOI: 10.1016/j.bmcl.2021.128352 |
0.026 |
|
| 2017 |
Huck BR, Mochalkin I. Recent progress towards clinically relevant ATP-competitive Akt inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28506751 DOI: 10.1016/j.bmcl.2017.04.090 |
0.017 |
|
| Hide low-probability matches. |