| Year |
Citation |
Score |
| 2014 |
Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proceedings of the National Academy of Sciences of the United States of America. 111: 18590-5. PMID 25518860 DOI: 10.1073/Pnas.1415365112 |
0.523 |
|
| 2013 |
Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL, Wells JA, Mapp AK. Ordering a dynamic protein via a small-molecule stabilizer. Journal of the American Chemical Society. 135: 3363-6. PMID 23384013 DOI: 10.1021/Ja3122334 |
0.687 |
|
| 2011 |
Sadowsky JD, Burlingame MA, Wolan DW, McClendon CL, Jacobson MP, Wells JA. Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proceedings of the National Academy of Sciences of the United States of America. 108: 6056-61. PMID 21430264 DOI: 10.1073/Pnas.1102376108 |
0.364 |
|
| 2010 |
Wells JA, Wolan D, Zorn J, Datta D, Gray D, Sadowsky J. Abstract SY11-03: Turning enzymes on with small molecules Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Sy11-03 |
0.305 |
|
| 2009 |
Lee EF, Sadowsky JD, Smith BJ, Czabotar PE, Peterson-Kaufman KJ, Colman PM, Gellman SH, Fairlie WD. High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angewandte Chemie (International Ed. in English). 48: 4318-22. PMID 19229915 DOI: 10.1002/Anie.200805761 |
0.694 |
|
| 2008 |
Boersma MD, Sadowsky JD, Tomita YA, Gellman SH. Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domain. Protein Science : a Publication of the Protein Society. 17: 1232-40. PMID 18467496 DOI: 10.1110/Ps.032896.107 |
0.716 |
|
| 2008 |
Peterson KJ, Sadowsky JD, Scheef EA, Pal S, Kourentzi KD, Willson RC, Bresnick EH, Sheibani N, Gellman SH. A fluorescence polarization assay for identifying ligands that bind to vascular endothelial growth factor Analytical Biochemistry. 378: 8-14. PMID 18413228 DOI: 10.1016/J.Ab.2008.03.043 |
0.522 |
|
| 2008 |
Murray JK, Sadowsky JD, Scalf M, Smith LM, Tomita Y, Gellman SH. Exploration of structure--activity relationships among foldamer ligands for a specific protein binding site via parallel and split-and-mix library synthesis. Journal of Combinatorial Chemistry. 10: 204-15. PMID 18275161 DOI: 10.1021/Cc700153Z |
0.754 |
|
| 2007 |
Tang L, Hopper ED, Tong Y, Sadowsky JD, Peterson KJ, Gellman SH, Fitzgerald MC. H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding. Analytical Chemistry. 79: 5869-77. PMID 17580981 DOI: 10.1021/Ac0700777 |
0.566 |
|
| 2007 |
Sadowsky JD, Murray JK, Tomita Y, Gellman SH. Exploration of backbone space in foldamers containing alpha- and beta-amino acid residues: developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-xL. Chembiochem : a European Journal of Chemical Biology. 8: 903-16. PMID 17503422 DOI: 10.1002/Cbic.200600546 |
0.757 |
|
| 2007 |
Sadowsky JD, Fairlie WD, Hadley EB, Lee HS, Umezawa N, Nikolovska-Coleska Z, Wang S, Huang DC, Tomita Y, Gellman SH. (alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions. Journal of the American Chemical Society. 129: 139-54. PMID 17199293 DOI: 10.1021/Ja0662523 |
0.73 |
|
| 2005 |
Murray JK, Farooqi B, Sadowsky JD, Scalf M, Freund WA, Smith LM, Chen J, Gellman SH. Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation. Journal of the American Chemical Society. 127: 13271-80. PMID 16173757 DOI: 10.1021/Ja052733V |
0.704 |
|
| 2005 |
Sadowsky JD, Schmitt MA, Lee HS, Umezawa N, Wang S, Tomita Y, Gellman SH. Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition. Journal of the American Chemical Society. 127: 11966-8. PMID 16117535 DOI: 10.1021/Ja053678T |
0.764 |
|
| 2002 |
Jank MM, Sadowsky JD, Peikert C, Berger S. NMR studies on the solution structure of a deletion mutant of the transcarboxylase biotin carrier subunit. International Journal of Biological Macromolecules. 30: 233-42. PMID 12297230 DOI: 10.1016/S0141-8130(02)00033-8 |
0.343 |
|
| 2001 |
Blackwell HE, Sadowsky JD, Howard RJ, Sampson JN, Chao JA, Steinmetz WE, O'Leary DJ, Grubbs RH. Ring-closing metathesis of olefinic peptides: design, synthesis, and structural characterization of macrocyclic helical peptides. The Journal of Organic Chemistry. 66: 5291-302. PMID 11485448 DOI: 10.1021/Jo015533K |
0.446 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2017 |
Sadowsky JD, Pillow TH, Chen J, Fan F, He C, Wang Y, Yan G, Yao H, Xu Z, Martin S, Zhang D, Chu P, Cruz-Chuh JD, O'Donohue A, Li G, et al. Development of efficient chemistry to generate site-specific disulfide-linked protein- and peptide-payload conjugates: Application to THIOMAB™ antibody-drug conjugates. Bioconjugate Chemistry. PMID 28636382 DOI: 10.1021/Acs.Bioconjchem.7B00258 |
0.274 |
|
| 2001 |
Steinmetz WE, Sadowsky JD, Rice JS, Roberts JJ, Bui YK. Determination of the aqueous-phase structure of 6-O-methylerythromycin from NMR constraints Magnetic Resonance in Chemistry. 39: 163-172. DOI: 10.1002/Mrc.826 |
0.256 |
|
| 2019 |
Dragovich PS, Adhikari P, Blake RA, Blaquiere N, Chen J, Cheng YX, den Besten W, Han J, Hartman SJ, He J, He M, Rei Ingalla E, Kamath AV, Kleinheinz T, Lai T, ... ... Sadowsky JD, et al. Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα). Bioorganic & Medicinal Chemistry Letters. 126907. PMID 31902710 DOI: 10.1016/J.Bmcl.2019.126907 |
0.219 |
|
| 2018 |
Sadowsky J, Vance N, Zacharias N, Ultsch M, Li G, Fourie A, Liu P, Lafrance-Vanasse J, Ernst JA, Sandoval W, Kozak KR, Lewis-Phillips GD, Wang W. Development, optimization and structural characterization of an efficient peptide-based photoaffinity crosslinking reaction for generation of homogeneous conjugates from wild-type antibodies. Bioconjugate Chemistry. PMID 30566343 DOI: 10.1021/acs.bioconjchem.8b00809 |
0.211 |
|
| 2021 |
Dragovich PS, Pillow TH, Blake RA, Sadowsky JD, Adaligil E, Adhikari P, Chen J, Corr N, Dela Cruz-Chuh J, Del Rosario G, Fullerton A, Hartman SJ, Jiang F, Kaufman S, Kleinheinz T, et al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. Journal of Medicinal Chemistry. PMID 33596073 DOI: 10.1021/acs.jmedchem.0c01846 |
0.21 |
|
| 2019 |
Pillow TH, Adhikari P, Blake RA, Chen J, Del Rosario G, Deshmukh G, Figueroa I, Gascoigne KE, Kamath AV, Kaufman S, Kleinheinz T, Kozak KR, Latifi B, Leipold DD, Li CS, ... ... Sadowsky JD, et al. Antibody Conjugation of a Chimeric BET Degrader Enables In Vivo Activity. Chemmedchem. PMID 31674143 DOI: 10.1002/Cmdc.201900497 |
0.207 |
|
| 2000 |
Tung JC, Gonzales AJ, Sadowsky JD, O'Leary DJ. On the 1H NMR chemical shift assignments for ampicillin Magnetic Resonance in Chemistry. 38: 126-128. DOI: 10.1002/(Sici)1097-458X(200002)38:2<126::Aid-Mrc601>3.0.Co;2-W |
0.191 |
|
| 2019 |
Scales S, Tsai SP, Zacharias N, Cruz-Chuh JD, Bullen G, Velasquez E, Chang J, Bruguera E, Kozak KR, Sadowsky J. Development of a cysteine-conjugatable disulfide FRET probe: Influence of Charge on Linker Cleavage and Payload Trafficking for an anti-HER2 antibody conjugate. Bioconjugate Chemistry. PMID 31726009 DOI: 10.1021/acs.bioconjchem.9b00678 |
0.177 |
|
| 2019 |
Zhang D, Fourie-O'Donohue A, Dragovich PS, Pillow TH, Sadowsky JD, Kozak KR, Cass RT, Liu L, Deng Y, Liu Y, Hop CE, Khojasteh SC. Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody- drug conjugates. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31085544 DOI: 10.1124/Dmd.118.086132 |
0.173 |
|
| 2020 |
Nazarova L, Rafidi H, Mandikian D, Ferl GZ, Koerber JT, Davies CW, Ulufatu S, Ho J, Lau J, Yu SF, Ernst J, Sadowsky JD, Boswell CA. Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-Length Antibodies. Molecular Cancer Therapeutics. PMID 32024685 DOI: 10.1158/1535-7163.Mct-19-1015 |
0.17 |
|
| 2021 |
Dragovich PS, Pillow TH, Blake RA, Sadowsky JD, Adaligil E, Adhikari P, Bhakta S, Blaquiere N, Chen J, Dela Cruz-Chuh J, Gascoigne KE, Hartman SJ, He M, Kaufman S, Kleinheinz T, et al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties. Journal of Medicinal Chemistry. PMID 33596065 DOI: 10.1021/acs.jmedchem.0c01845 |
0.162 |
|
| 2017 |
Pillow TH, Schutten M, Yu SF, Ohri R, Sadowsky J, Poon KA, Solis W, Zhong F, Del Rosario G, Go MA, Lau J, Yee S, He J, Liu L, Ng C, et al. Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers. Molecular Cancer Therapeutics. PMID 28223423 DOI: 10.1158/1535-7163.Mct-16-0641 |
0.161 |
|
| 2017 |
Caculitan NG, Dela Cruz Chuh J, Ma Y, Zhang D, Kozak KR, Liu Y, Pillow TH, Sadowsky J, Cheung TK, Phung Q, Haley B, Lee BC, Akita R, Sliwkowski MX, Polson AG. Cathepsin B is dispensable for cellular processing of cathepsin B-cleavable antibody-drug conjugates. Cancer Research. PMID 29046337 DOI: 10.1158/0008-5472.Can-17-2391 |
0.141 |
|
| 2017 |
Pillow TH, Sadowsky JD, Zhang D, Yu SF, Del Rosario G, Xu K, He J, Bhakta S, Ohri R, Kozak KR, Ha E, Junutula JR, Flygare JA. Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates. Chemical Science. 8: 366-370. PMID 28451181 DOI: 10.1039/C6Sc01831A |
0.13 |
|
| 2016 |
Zhang D, Pillow TH, Ma Y, Cruz-Chuh JD, Kozak KR, Sadowsky JD, Lewis Phillips GD, Guo J, Darwish M, Fan P, Chen J, He C, Wang T, Yao H, Xu Z, et al. Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates. Acs Medicinal Chemistry Letters. 7: 988-993. PMID 27882196 DOI: 10.1021/Acsmedchemlett.6B00233 |
0.12 |
|
| 2023 |
Clardy SM, Uttard A, Du B, Catcott KC, Lancaster KL, Ditty E, Sadowsky J, Zurita J, Malli N, Qin L, Bradley SP, Avocetien K, Carter T, Kim D, Nazzaro M, et al. Site-specific Dolasynthen antibody-drug conjugates exhibit consistent pharmacokinetic profiles across a wide range of drug to antibody ratios. Molecular Cancer Therapeutics. PMID 37774393 DOI: 10.1158/1535-7163.MCT-23-0262 |
0.119 |
|
| 2020 |
Fourie-O'Donohue A, Chu PY, Dela Cruz Chuh J, Tchelepi R, Tsai SP, Tran JC, Sawyer WS, Su D, Ng C, Xu K, Yu SF, Pillow TH, Sadowsky J, Dragovich PS, Liu Y, et al. Improved translation of stability for conjugated antibodies using an in vitro whole blood assay. Mabs. 12: 1715705. PMID 31997712 DOI: 10.1080/19420862.2020.1715705 |
0.115 |
|
| 2016 |
Zhang D, Yu SF, Ma Y, Xu K, Dragovich PS, Pillow TH, Liu L, Del Rosario G, He J, Pei Z, Sadowsky JD, Erickson HK, Hop CE, Khojasteh SC. The chemical structure and concentration of intratumor catabolites determine the efficacy of antibody drug conjugates. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27417182 DOI: 10.1124/Dmd.116.070631 |
0.113 |
|
| 2018 |
Zhang D, Le H, Cruz-Chuh JD, Bobba S, Guo J, Staben L, Zhang C, Ma Y, Kozak KR, Lewis-Phillips GD, Vollmar B, Sadowsky J, Vandlen R, Wei B, Su D, et al. Immolation of p-aminobenzyl ether linker and payload potency and stability determine the cell killing activity of antibody-drug conjugates with phenol-containing payloads. Bioconjugate Chemistry. PMID 29369629 DOI: 10.1021/Acs.Bioconjchem.7B00576 |
0.108 |
|
| 2018 |
Su D, Kozak K, Sadowsky J, Yu SF, Fourie-O'Donohue A, Nelson C, Vandlen R, Ohri R, Liu L, Ng C, He J, Davis H, Lau J, Del Rosario G, Cosino E, et al. Modulating ADC payload metabolism by conjugation site and linker modification. Bioconjugate Chemistry. PMID 29481745 DOI: 10.1021/Acs.Bioconjchem.7B00785 |
0.106 |
|
| 2020 |
Adhikari P, Zacharias N, Ohri R, Sadowsky J. Site-Specific Conjugation to Cys-Engineered THIOMAB™ Antibodies. Methods in Molecular Biology (Clifton, N.J.). 2078: 51-69. PMID 31643049 DOI: 10.1007/978-1-4939-9929-3_4 |
0.104 |
|
| 2022 |
Zacharias N, Podust VN, Kajihara KK, Leipold D, Del Rosario G, Thayer D, Dong E, Paluch M, Fischer D, Zheng K, Lei C, He J, Ng C, Su D, Liu L, ... ... Sadowsky J, et al. A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides. Chemical Science. 13: 3147-3160. PMID 35414872 DOI: 10.1039/d1sc05243h |
0.098 |
|
| 2024 |
Lewis GD, Li G, Guo J, Yu SF, Fields CT, Lee G, Zhang D, Dragovich PS, Pillow T, Wei B, Sadowsky J, Leipold D, Wilson T, Kamath A, Mamounas M, et al. The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results. Nature Communications. 15: 466. PMID 38212321 DOI: 10.1038/s41467-023-44533-z |
0.083 |
|
| 2021 |
Dela Cruz Chuh J, Go M, Chen Y, Guo J, Rafidi H, Mandikian D, Sun Y, Lin Z, Schneider K, Zhang P, Vij R, Sharpnack D, Chan P, de la Cruz C, Sadowsky J, et al. Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response. Mabs. 13: 1862452. PMID 33382956 DOI: 10.1080/19420862.2020.1862452 |
0.081 |
|
| 2018 |
Mandikian D, Rafidi H, Adhikari P, Venkatraman P, Nazarova L, Fung G, Figueroa I, Ferl GZ, Ulufatu S, Ho J, McCaughey C, Lau J, Yu SF, Prabhu S, Sadowsky J, et al. Site-specific conjugation allows modulation of click reaction stoichiometry for pretargeted SPECT imaging. Mabs. PMID 30199303 DOI: 10.1080/19420862.2018.1521132 |
0.08 |
|
| 2022 |
Krishnamurty AT, Shyer JA, Thai M, Gandham V, Buechler MB, Yang YA, Pradhan RN, Wang AW, Sanchez PL, Qu Y, Breart B, Chalouni C, Dunlap D, Ziai J, Elstrott J, ... ... Sadowsky J, et al. LRRC15 myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Nature. PMID 36171287 DOI: 10.1038/s41586-022-05272-1 |
0.079 |
|
| 2020 |
Pillow TH, Adhikari P, Blake RA, Chen J, Del Rosario G, Deshmukh G, Figueroa I, Gascoigne KE, Kamath AV, Kaufman S, Kleinheinz T, Kozak KR, Latifi B, Leipold DD, Sing Li C, ... ... Sadowsky JD, et al. Front Cover: Antibody Conjugation of a Chimeric BET Degrader Enables
in vivo
Activity (ChemMedChem 1/2020) Chemmedchem. 15: 1-1. DOI: 10.1002/Cmdc.201900683 |
0.071 |
|
| 2018 |
Zhang D, Yu SF, Khojasteh SC, Ma Y, Pillow TH, Sadowsky JD, Su D, Kozak KR, Xu K, Polson AG, Dragovich P, Hop CE. Intratumoral Payload Concentration Correlates with the Activity of Antibody- Drug Conjugates. Molecular Cancer Therapeutics. PMID 29348271 DOI: 10.1158/1535-7163.Mct-17-0697 |
0.067 |
|
| 2019 |
Zhang D, Dragovich PS, Yu SF, Ma Y, Pillow TH, Sadowsky JD, Su D, Wang W, Polson A, Khojasteh SC, Hop CE. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31358513 DOI: 10.1124/Dmd.119.087023 |
0.057 |
|
| 2019 |
Zhang D, Ma Y, Yu S, Pillow TH, Sadowsky JD, Su D, Polson AG, Dragovich PS, Hop CE, Khojasteh SC. Intra-tissue catabolite characterization is a missing link in discovery of ADCs Drug Metabolism and Pharmacokinetics. 34: S9. DOI: 10.1016/J.Dmpk.2018.09.043 |
0.049 |
|
| 2018 |
Zheng B, Yu SF, Del Rosario G, Leong SR, Lee GY, Vij R, Chiu CPC, Liang WC, Wu Y, Chalouni C, Sadowsky J, Clark VM, Hendricks A, Poon KA, Chu YW, et al. An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29959143 DOI: 10.1158/1078-0432.Ccr-18-0333 |
0.037 |
|
| 2020 |
Yu SF, Lee DW, Zheng B, Del Rosario G, Leipold D, Booler H, Zhong F, Carrasco-Triguero M, Hong K, Yan P, Rowntree RK, Schutten MM, Pillow T, Sadowsky JD, Dragovich PS, et al. An anti-CD22-seco-CBI-Dimer ADC for the treatment of non-Hodgkin lymphoma that provides a longer duration of response than auristatin ADCs in preclinical models. Molecular Cancer Therapeutics. PMID 33273056 DOI: 10.1158/1535-7163.MCT-20-0046 |
0.031 |
|
| Hide low-probability matches. |