Sean F. Brady, Ph.D. - Publications

Affiliations: 
2007- Rockefeller University, New York, NY, United States 
Area:
natural products

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Libis V, Antonovsky N, Zhang M, Shang Z, Montiel D, Maniko J, Ternei MA, Calle PY, Lemetre C, Owen JG, Brady SF. Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences. Nature Communications. 10: 3848. PMID 31451725 DOI: 10.1038/s41467-019-11658-z  0.76
2019 Wu C, Shang Z, Lemetre C, Ternei MA, Brady SF. Cadasides, calcium-dependent acidic lipopeptides from the soil metagenome that are active against multidrug resistant bacteria. Journal of the American Chemical Society. PMID 30735616 DOI: 10.1021/jacs.8b12087  0.76
2018 Kim SH, Lu W, Ahmadi MK, Montiel D, Ternei MA, Brady SF. Atolypenes, Tricyclic Bacterial Sesterterpenes Discovered Using a Multiplexed In Vitro Cas9-TAR Gene Cluster Refactoring Approach. Acs Synthetic Biology. PMID 30575381 DOI: 10.1021/acssynbio.8b00361  0.76
2018 Peek J, Lilic M, Montiel D, Milshteyn A, Woodworth I, Biggins JB, Ternei MA, Calle PY, Danziger M, Warrier T, Saito K, Braffman N, Fay A, Glickman MS, Darst SA, ... ... Brady SF, et al. Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nature Communications. 9: 4147. PMID 30297823 DOI: 10.1038/s41467-018-06587-2  0.92
2018 Hover BM, Kim SH, Katz M, Charlop-Powers Z, Owen JG, Ternei MA, Maniko J, Estrela AB, Molina H, Park S, Perlin DS, Brady SF. Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens. Nature Microbiology. PMID 29434326 DOI: 10.1038/s41564-018-0110-1  0.76
2018 Vila-Farres X, Chu J, Ternei MA, Lemetre C, Park S, Perlin DS, Brady SF. An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds. Msphere. 3. PMID 29404414 DOI: 10.1128/mSphere.00528-17  0.76
2017 Bitok JK, Lemetre C, Ternei MA, Brady SF. Identification of biosynthetic gene clusters from metagenomic libraries using PPTase complementation in a Streptomyces host. Fems Microbiology Letters. 364. PMID 28817927 DOI: 10.1093/femsle/fnx155  0.76
2017 Vila-Farres X, Chu J, Inoyama D, Ternei MA, Lemetre C, Cohen LJ, Cho W, Reddy BV, Zebroski HA, Freundlich JS, Perlin DS, Brady SF. Antimicrobials inspired by nonribosomal peptide synthetase gene clusters. Journal of the American Chemical Society. PMID 28055186 DOI: 10.1021/jacs.6b11861  0.76
2016 Charlop-Powers Z, Pregitzer CC, Lemetre C, Ternei MA, Maniko J, Hover BM, Calle PY, McGuire KL, Garbarino J, Forgione HM, Charlop-Powers S, Brady SF. Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911822 DOI: 10.1073/pnas.1615581113  0.76
2016 Iqbal HA, Low-Beinart L, Obiajulu JU, Brady SF. Natural Product Discovery through Improved Functional Metagenomics in Streptomyces. Journal of the American Chemical Society. PMID 27447056 DOI: 10.1021/jacs.6b02921  0.92
2016 Kang HS, Charlop-Powers Z, Brady SF. Multiplexed CRISPR/Cas9 and TAR-mediated promoter engineering of natural product biosynthetic gene clusters in yeast. Acs Synthetic Biology. PMID 27197732 DOI: 10.1021/acssynbio.6b00080  0.92
2015 Katz M, Hover BM, Brady SF. Culture-independent discovery of natural products from soil metagenomes. Journal of Industrial Microbiology & Biotechnology. PMID 26586404 DOI: 10.1007/s10295-015-1706-6  0.92
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Brady SF, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/nchembio.1890  0.92
2015 Cohen LJ, Kang HS, Chu J, Huang YH, Gordon EA, Reddy BV, Ternei MA, Craig JW, Brady SF. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proceedings of the National Academy of Sciences of the United States of America. 112: E4825-34. PMID 26283367 DOI: 10.1073/pnas.1508737112  0.92
2015 Montiel D, Kang HS, Chang FY, Charlop-Powers Z, Brady SF. Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters. Proceedings of the National Academy of Sciences of the United States of America. PMID 26150486 DOI: 10.1073/pnas.1507606112  0.92
2015 Charlop-Powers Z, Brady SF. phylogeo: an R package for geographic analysis and visualization of microbiome data. Bioinformatics (Oxford, England). PMID 25913208 DOI: 10.1093/bioinformatics/btv269  0.92
2015 Chang FY, Ternei MA, Calle PY, Brady SF. Targeted metagenomics: finding rare tryptophan dimer natural products in the environment. Journal of the American Chemical Society. 137: 6044-52. PMID 25872030 DOI: 10.1021/jacs.5b01968  0.92
2015 Owen JG, Charlop-Powers Z, Smith AG, Ternei MA, Calle PY, Reddy BV, Montiel D, Brady SF. Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 112: 4221-6. PMID 25831524 DOI: 10.1073/pnas.1501124112  0.92
2014 Kang HS, Brady SF. Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study. Journal of the American Chemical Society. 136: 18111-9. PMID 25521786 DOI: 10.1021/ja510606j  0.92
2014 Chang FY, Kawashima SA, Brady SF. Mutations in the proteolipid subunits of the vacuolar H+-ATPase provide resistance to indolotryptoline natural products. Biochemistry. 53: 7123-31. PMID 25319670 DOI: 10.1021/bi501078j  0.92
2014 Milshteyn A, Schneider JS, Brady SF. Mining the metabiome: identifying novel natural products from microbial communities. Chemistry & Biology. 21: 1211-23. PMID 25237864 DOI: 10.1016/j.chembiol.2014.08.006  0.92
2014 Charlop-Powers Z, Milshteyn A, Brady SF. Metagenomic small molecule discovery methods Current Opinion in Microbiology. 19: 70-75. PMID 25000402 DOI: 10.1016/j.mib.2014.05.021  0.92
2014 Biggins JB, Kang HS, Ternei MA, DeShazer D, Brady SF. The chemical arsenal of Burkholderia pseudomallei is essential for pathogenicity. Journal of the American Chemical Society. 136: 9484-90. PMID 24884988 DOI: 10.1021/ja504617n  0.92
2014 Kang HS, Brady SF. Arixanthomycins A-C: Phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols. Acs Chemical Biology. 9: 1267-72. PMID 24730509 DOI: 10.1021/cb500141b  0.44
2014 Iqbal HA, Craig JW, Brady SF. Antibacterial enzymes from the functional screening of metagenomic libraries hosted in Ralstonia metallidurans. Fems Microbiology Letters. 354: 19-26. PMID 24661178 DOI: 10.1111/1574-6968.12431  0.92
2014 Chang FY, Brady SF. Characterization of an environmental DNA-derived gene cluster that encodes the bisindolylmaleimide methylarcyriarubin. Chembiochem : a European Journal of Chemical Biology. 15: 815-21. PMID 24648189 DOI: 10.1002/cbic.201300756  0.92
2014 Charlop-Powers Z, Owen JG, Reddy BVB, Ternei MA, Brady SF. Chemical-biogeographic survey of secondary metabolism in soil Proceedings of the National Academy of Sciences of the United States of America. 111: 3757-3762. PMID 24550451 DOI: 10.1073/pnas.1318021111  0.92
2014 Biggins JB, Kang HS, Ternei MA, Deshazer D, Brady SF. The chemical arsenal of burkholderia pseudomallei is essential for pathogenicity Journal of the American Chemical Society. 136: 9484-9490. DOI: 10.1021/ja504617n  0.92
2014 Kang HS, Brady SF. Arixanthomycins A-C: Phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols Acs Chemical Biology. 9: 1267-1272. DOI: 10.1021/cb500141b  0.92
2013 Chang FY, Ternei MA, Calle PY, Brady SF. Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment. Journal of the American Chemical Society. 135: 17906-12. PMID 24171465 DOI: 10.1021/ja408683p  0.76
2013 Kang HS, Brady SF. Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes. Angewandte Chemie (International Ed. in English). 52: 11063-7. PMID 24038656 DOI: 10.1002/anie.201305109  0.92
2013 Engel K, Ashby D, Brady SF, Cowan DA, Doemer J, Edwards EA, Fiebig K, Martens EC, McCormac D, Mead DA, Miyazaki K, Moreno-Hagelsieb G, O'Gara F, Reid A, Rose DR, et al. Meeting report: 1st international functional metagenomics workshop may 7-8, 2012, st. Jacobs, ontario, Canada. Standards in Genomic Sciences. 8: 106-11. PMID 23961315 DOI: 10.4056/sigs.3406845  0.92
2013 Owen JG, Reddy BV, Ternei MA, Charlop-Powers Z, Calle PY, Kim JH, Brady SF. Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products. Proceedings of the National Academy of Sciences of the United States of America. 110: 11797-802. PMID 23824289 DOI: 10.1073/pnas.1222159110  0.92
2013 Qaisar U, Luo L, Haley CL, Brady SF, Carty NL, Colmer-Hamood JA, Hamood AN. The pvc operon regulates the expression of the Pseudomonas aeruginosa fimbrial chaperone/usher pathway (cup) genes. Plos One. 8: e62735. PMID 23646138 DOI: 10.1371/journal.pone.0062735  0.92
2013 Charlop-Powers Z, Banik JJ, Owen JG, Craig JW, Brady SF. Selective enrichment of environmental DNA libraries for genes encoding nonribosomal peptides and polyketides by phosphopantetheine transferase-dependent complementation of siderophore biosynthesis. Acs Chemical Biology. 8: 138-43. PMID 23072412 DOI: 10.1021/cb3004918  0.92
2012 Kallifidas D, Kang HS, Brady SF. Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters. Journal of the American Chemical Society. 134: 19552-5. PMID 23157252 DOI: 10.1021/ja3093828  0.44
2012 Biggins JB, Ternei MA, Brady SF. Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens. Journal of the American Chemical Society. 134: 13192-5. PMID 22765305 DOI: 10.1021/ja3052156  0.92
2012 Iqbal HA, Feng Z, Brady SF. Biocatalysts and small molecule products from metagenomic studies. Current Opinion in Chemical Biology. 16: 109-16. PMID 22455793 DOI: 10.1016/j.cbpa.2012.02.015  0.92
2012 Reddy BV, Kallifidas D, Kim JH, Charlop-Powers Z, Feng Z, Brady SF. Natural product biosynthetic gene diversity in geographically distinct soil microbiomes. Applied and Environmental Microbiology. 78: 3744-52. PMID 22427492 DOI: 10.1128/AEM.00102-12  0.92
2012 Feng Z, Chakraborty D, Dewell SB, Reddy BV, Brady SF. Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis. Journal of the American Chemical Society. 134: 2981-7. PMID 22224500 DOI: 10.1021/ja207662w  0.32
2011 Craig JW, Cherry MA, Brady SF. Long-chain N-acyl amino acid synthases are linked to the putative PEP-CTERM/exosortase protein-sorting system in Gram-negative bacteria. Journal of Bacteriology. 193: 5707-15. PMID 21840974 DOI: 10.1128/JB.05426-11  0.92
2011 Feng Z, Kallifidas D, Brady SF. Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites. Proceedings of the National Academy of Sciences of the United States of America. 108: 12629-34. PMID 21768346 DOI: 10.1073/pnas.1103921108  0.32
2011 Biggins JB, Gleber CD, Brady SF. Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis. Organic Letters. 13: 1536-9. PMID 21348454 DOI: 10.1021/ol200225v  0.92
2011 Biggins JB, Liu X, Feng Z, Brady SF. Metabolites from the induced expression of cryptic single operons found in the genome of Burkholderia pseudomallei. Journal of the American Chemical Society. 133: 1638-41. PMID 21247113 DOI: 10.1021/ja1087369  0.92
2010 Bick MJ, Banik JJ, Darst SA, Brady SF. The 2.7 Å resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallographica. Section D, Biological Crystallography. 66: 1278-86. PMID 21123867 DOI: 10.1107/S0907444910036681  0.92
2010 Feng Z, Kim JH, Brady SF. Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster. Journal of the American Chemical Society. 132: 11902-3. PMID 20690632 DOI: 10.1021/ja104550p  0.32
2010 Kim JH, Feng Z, Bauer JD, Kallifidas D, Calle PY, Brady SF. Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR. Biopolymers. 93: 833-44. PMID 20577994 DOI: 10.1002/bip.21450  0.32
2010 Bauer JD, King RW, Brady SF. Utahmycins a and B, azaquinones produced by an environmental DNA clone. Journal of Natural Products. 73: 976-9. PMID 20387794 DOI: 10.1021/np900786s  0.92
2010 Bick MJ, Banik JJ, Darst SA, Brady SF. Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone. Biochemistry. 49: 4159-68. PMID 20361791 DOI: 10.1021/bi100150v  0.92
2010 Kim JH, Simmons TL, Brady SF. Unlocking environmental DNA derived gene clusters using a metagenomics approach Comprehensive Natural Products Ii: Chemistry and Biology. 2: 455-474.  0.92
2009 King RW, Bauer JD, Brady SF. An environmental DNA-derived type II polyketide biosynthetic pathway encodes the biosynthesis of the pentacyclic polyketide erdacin. Angewandte Chemie (International Ed. in English). 48: 6257-61. PMID 19621341 DOI: 10.1002/anie.200901209  0.92
2007 Clardy J, Brady SF. Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium. Journal of Bacteriology. 189: 6487-9. PMID 17586635 DOI: 10.1128/JB.00457-07  0.36
2006 Maloney KN, Hao W, Xu J, Gibbons J, Hucul J, Roll D, Brady SF, Schroeder FC, Clardy J. Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus. Organic Letters. 8: 4067-70. PMID 16928075 DOI: 10.1021/ol061556f  0.92
2005 Brady SF, Clardy J. Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom. Angewandte Chemie (International Ed. in English). 44: 7045-8. PMID 16217820 DOI: 10.1002/anie.200501942  0.36
2005 Brady SF, Clardy J. Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA. Angewandte Chemie (International Ed. in English). 44: 7063-5. PMID 16206308 DOI: 10.1002/anie.200501941  0.36
2005 Brady SF, Clardy J. N-acyl derivatives of arginine and tryptophan isolated from environmental DNA expressed in Escherichia coli. Organic Letters. 7: 3613-6. PMID 16092832 DOI: 10.1021/ol0509585  0.36
2005 Weibel DB, Lee A, Mayer M, Brady SF, Bruzewicz D, Yang J, Diluzio WR, Clardy J, Whitesides GM. Bacterial printing press that regenerates its ink: contact-printing bacteria using hydrogel stamps. Langmuir : the Acs Journal of Surfaces and Colloids. 21: 6436-42. PMID 15982051 DOI: 10.1021/la047173c  0.92
2004 Brady SF, Chao CJ, Clardy J. Long-chain N-acyltyrosine synthases from environmental DNA. Applied and Environmental Microbiology. 70: 6865-70. PMID 15528554 DOI: 10.1128/AEM.70.11.6865-6870.2004  0.36
2004 Brady SF, Clardy J. Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water. Journal of Natural Products. 67: 1283-6. PMID 15332842 DOI: 10.1021/np0499766  0.36
2003 Brady SF, Clardy J. Synthesis of long-chain fatty acid enol esters isolated from an environmental DNA clone. Organic Letters. 5: 121-4. PMID 12529120 DOI: 10.1021/ol0267681  0.36
2002 Gillespie DE, Brady SF, Bettermann AD, Cianciotto NP, Liles MR, Rondon MR, Clardy J, Goodman RM, Handelsman J. Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA. Applied and Environmental Microbiology. 68: 4301-6. PMID 12200279 DOI: 10.1128/AEM.68.9.4301-4306.2002  0.92
2002 Brady SF, Chao CJ, Clardy J. New natural product families from an environmental DNA (eDNA) gene cluster. Journal of the American Chemical Society. 124: 9968-9. PMID 12188643 DOI: 10.1021/ja0268985  0.36
2001 Brady SF, Bondi SM, Clardy J. The guanacastepenes: a highly diverse family of secondary metabolites produced by an endophytic fungus. Journal of the American Chemical Society. 123: 9900-1. PMID 11583556 DOI: 10.1021/ja016176y  0.92
2001 Brady SF, Chao CJ, Handelsman J, Clardy J. Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA. Organic Letters. 3: 1981-4. PMID 11418029 DOI: 10.1021/ol015949k  0.36
2000 Brady SF, Singh MP, Janso JE, Clardy J. Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus. Organic Letters. 2: 4047-9. PMID 11112640  0.36
2000 Brady SF, Wagenaar MM, Singh MP, Janso JE, Clardy J. The cytosporones, new octaketide antibiotics isolated from an endophytic fungus. Organic Letters. 2: 4043-6. PMID 11112639  0.36
2000 Brady SF, Clardy J. CR377, a new pentaketide antifungal agent isolated from an endophytic fungus. Journal of Natural Products. 63: 1447-8. PMID 11076576 DOI: 10.1021/np990568p  0.36
2000 Rondon MR, August PR, Bettermann AD, Brady SF, Grossman TH, Liles MR, Loiacono KA, Lynch BA, MacNeil IA, Minor C, Tiong CL, Gilman M, Osburne MS, Clardy J, Handelsman J, et al. Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms. Applied and Environmental Microbiology. 66: 2541-7. PMID 10831436 DOI: 10.1128/AEM.66.6.2541-2547.2000  0.92
2000 Singh MP, Janso JE, Luckman SW, Brady SF, Clardy J, Greenstein M, Maiese WM. Biological activity of guanacastepene, a novel diterpenoid antibiotic produced by an unidentified fungus CR115. The Journal of Antibiotics. 53: 256-61. PMID 10819296  0.36
2000 Brady SF, Singh MP, Janso JE, Clardy J. Guanacastepene, a fungal-derived diterpene antibiotic with a new carbon skeleton Journal of the American Chemical Society. 122: 2116-2117. DOI: 10.1021/ja993835m  0.36
2000 Brady SF, Clardy J. Long-chain N-acyl amino acid antibiotics isolated from heterologously expressed environmental DNA [20] Journal of the American Chemical Society. 122: 12903-12904. DOI: 10.1021/ja002990u  0.36
1999 Stohl EA, Brady SF, Clardy J, Handelsman J. ZmaR, a novel and widespread antibiotic resistance determinant that acetylates zwittermicin A. Journal of Bacteriology. 181: 5455-60. PMID 10464220  0.36
1999 Brady SF, Wright SA, Lee JC, Sutton AE, Zumoff CH, Wodzinski RS, Beer SV, Clardy J. Pantocin B, an antibiotic from Erwinia herbicola discovered by heterologus expression of cloned genes [10] Journal of the American Chemical Society. 121: 11912-11913. DOI: 10.1021/ja992790m  0.92
1998 Handelsman J, Rondon MR, Brady SF, Clardy J, Goodman RM. Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products. Chemistry & Biology. 5: R245-9. PMID 9818143  0.92
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