Jason E. Gestwicki, Ph.D. - Publications

Affiliations: 
2002 University of Wisconsin, Madison, Madison, WI 
Area:
Biomolecular recognition

185 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zhang JZ, Greenwood N, Hernandez J, Cuperus JT, Huang B, Ryder BD, Queitsch C, Gestwicki JE, Baker D. designed Hsp70 activator dissolves intracellular condensates. Biorxiv : the Preprint Server For Biology. PMID 37781598 DOI: 10.1101/2023.09.18.558356  0.312
2023 Elsasser S, Elia LP, Morimoto RI, Powers ET, Elsasser S, Finley D, Costa B, Budron M, Tokuno Z, Wang S, Iyer RG, Barth B, Mockler E, Elia LP, Finkbeiner S, ... Gestwicki JE, et al. A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway. Biorxiv : the Preprint Server For Biology. PMID 36993380 DOI: 10.1101/2023.03.22.533675  0.561
2022 Shao H, Taguwa S, Gilbert L, Shkedi A, Sannino S, Guerriero CJ, Gale-Day ZJ, Young ZT, Brodsky JL, Weissman J, Gestwicki JE, Frydman J. A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities. Cell Chemical Biology. PMID 35830852 DOI: 10.1016/j.chembiol.2022.06.006  0.584
2022 Johnson OT, Gestwicki JE. Multivalent protein-protein interactions are pivotal regulators of eukaryotic Hsp70 complexes. Cell Stress & Chaperones. PMID 35670950 DOI: 10.1007/s12192-022-01281-1  0.375
2022 Carrettiero DC, Almeida MC, Longhini AP, Rauch JN, Han D, Zhang X, Najafi S, Gestwicki JE, Kosik KS. Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate. Nature Communications. 13: 3074. PMID 35654899 DOI: 10.1038/s41467-022-30751-4  0.74
2022 Opoku-Nsiah KA, de la Pena AH, Williams SK, Chopra N, Sali A, Lander GC, Gestwicki JE. The YΦ motif defines the structure-activity relationships of human 20S proteasome activators. Nature Communications. 13: 1226. PMID 35264557 DOI: 10.1038/s41467-022-28864-x  0.749
2022 Johnson OT, Nadel CM, Carroll EC, Arhar T, Gestwicki JE. Two distinct classes of co-chaperones compete for the EEVD motif in heat shock protein 70 (Hsp70) to tune its chaperone activities. The Journal of Biological Chemistry. 101697. PMID 35148989 DOI: 10.1016/j.jbc.2022.101697  0.384
2021 Arhar T, Shkedi A, Nadel CM, Gestwicki JE. The interactions of molecular chaperones with client proteins: why are they so weak? The Journal of Biological Chemistry. 297: 101282. PMID 34624315 DOI: 10.1016/j.jbc.2021.101282  0.314
2021 Lee K, Thwin AC, Nadel CM, Tse E, Gates SN, Gestwicki JE, Southworth DR. The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state. Molecular Cell. PMID 34380015 DOI: 10.1016/j.molcel.2021.07.023  0.322
2021 Shao H, Li X, Hayashi S, Bertron JL, Schwarz DMC, Tang BC, Gestwicki JE. Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels. Bioorganic & Medicinal Chemistry Letters. 41: 128025. PMID 33839251 DOI: 10.1016/j.bmcl.2021.128025  0.311
2021 Tao J, Berthet A, Citron YR, Tsiolaki PL, Stanley R, Gestwicki JE, Agard DA, McConlogue L. Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism. The Journal of Biological Chemistry. 100613. PMID 33798554 DOI: 10.1016/j.jbc.2021.100613  0.351
2021 Makley LN, Johnson OT, Ghanakota P, Rauch JN, Osborn D, Wu TS, Cierpicki T, Carlson HA, Gestwicki JE. Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods. Bioorganic & Medicinal Chemistry. 34: 115990. PMID 33549906 DOI: 10.1016/j.bmc.2020.115990  0.721
2020 Nadel CM, Ran X, Gestwicki JE. Luminescence Complementation Assay for Measurement of Binding to Protein C-Termini in Live Cells. Analytical Biochemistry. 113947. PMID 32918866 DOI: 10.1016/J.Ab.2020.113947  0.432
2020 Shao H, Oltion K, Wu T, Gestwicki JE. Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein-protein interactions. Organic & Biomolecular Chemistry. PMID 32458889 DOI: 10.1039/D0Ob00928H  0.414
2020 Bengoechea R, Findlay AR, Bhadra AK, Shao H, Stein KC, Pittman SK, Daw J, Gestwicki JE, True HL, Weihl CC. Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy. The Journal of Clinical Investigation. PMID 32427588 DOI: 10.1172/Jci136167  0.395
2020 Wu PK, Hong SK, Chen W, Becker AE, Gundry RL, Lin CW, Shao H, Gestwicki JE, Park JI. Mortalin (HSPA9) facilitates -mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability. Science Signaling. 13. PMID 32156782 DOI: 10.1126/Scisignal.Aay1478  0.352
2020 Jackson JW, Rivera-Marquez G, Beebe K, Tran AD, Trepel JB, Gestwicki JE, Blagg BSJ, Ohkubo S, Neckers LM. Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function. Journal of Thrombosis and Haemostasis : Jth. PMID 32022992 DOI: 10.1111/Jth.14758  0.31
2020 Singh JK, Hutt DM, Tait B, Guy NC, Sivils JC, Ortiz NR, Payan AN, Komaragiri SK, Owens JJ, Culbertson D, Blair LJ, Dickey C, Kuo SY, Finley D, Dyson HJ, ... ... Gestwicki JE, et al. Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone. Cell Chemical Biology. PMID 32017918 DOI: 10.1016/J.Chembiol.2020.01.008  0.439
2020 Shao H, Gestwicki JE. Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98. Bioorganic & Medicinal Chemistry Letters. 126954. PMID 31952963 DOI: 10.1016/J.Bmcl.2020.126954  0.416
2019 Ravalin M, Basu K, Gestwicki JE, Craik CS. End-binding E3 ubiquitin ligases enable protease signaling. Acs Chemical Biology. PMID 31714737 DOI: 10.1021/Acschembio.9B00621  0.378
2019 Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pierattelli R, Felli IC, Brun-Heath I, ... ... Gestwicki JE, et al. Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. Nature Communications. 10: 4605. PMID 31591399 DOI: 10.1038/S41467-019-12578-8  0.713
2019 Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M. Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. The Journal of Biological Chemistry. PMID 31578281 DOI: 10.1074/Jbc.Ra119.009432  0.368
2019 Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, ... Gestwicki JE, et al. Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis. Neuron. PMID 31542321 DOI: 10.1016/J.Neuron.2019.08.008  0.493
2019 Wang C, Scott SM, Sun S, Zhao P, Hutt DM, Shao H, Gestwicki JE, Balch WE. Individualized Management of Genetic Diversity in Niemann-Pick C1 through Modulation of the Hsp70 Chaperone System. Human Molecular Genetics. PMID 31509197 DOI: 10.1093/Hmg/Ddz215  0.375
2019 Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pieratelli R, Felli IC, Brun-Heath I, ... ... Gestwicki JE, et al. Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. Nature Communications. 10: 3562. PMID 31395886 DOI: 10.1038/S41467-019-11594-Y  0.745
2019 Molnar KS, Dunyak BM, Su B, Izrayelit Y, McGlasson-Naumann B, Hamilton PD, Qian M, Covey DF, Gestwicki JE, Makley LN, Andley UP. Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts. Investigative Ophthalmology & Visual Science. 60: 3320-3331. PMID 31369034 DOI: 10.1167/Iovs.18-25647  0.314
2019 Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE. Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nature Chemical Biology. 15: 786-794. PMID 31320752 DOI: 10.1038/S41589-019-0322-6  0.79
2019 Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S. A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis. Cell Host & Microbe. PMID 30827827 DOI: 10.1016/J.Chom.2019.01.006  0.433
2019 Taguwa S, Yeh MT, Rainbolt TK, Nayak A, Shao H, Gestwicki JE, Andino R, Frydman J. Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease. Cell Reports. 26: 906-920.e3. PMID 30673613 DOI: 10.1016/J.Celrep.2018.12.095  0.576
2018 Meister-Broekema M, Freilich R, Jagadeesan C, Rauch JN, Bengoechea R, Motley WW, Kuiper EFE, Minoia M, Furtado GV, van Waarde MAWH, Bird SJ, Rebelo A, Zuchner S, Pytel P, Scherer SS, ... ... Gestwicki JE, et al. Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks. Nature Communications. 9: 5342. PMID 30559338 DOI: 10.1038/S41467-018-07718-5  0.746
2018 Pabon NA, Xia Y, Estabrooks SK, Ye Z, Herbrand AK, Süß E, Biondi RM, Assimon VA, Gestwicki JE, Brodsky JL, Camacho CJ, Bar-Joseph Z. Predicting protein targets for drug-like compounds using transcriptomics. Plos Computational Biology. 14: e1006651. PMID 30532261 DOI: 10.1371/Journal.Pcbi.1006651  0.332
2018 Zaiter S, Huo Y, Tiew FY, Gestwicki JE, McAlpine SR. Designing de novo small molecules that control Heat shock protein 70 (Hsp70) and Heat shock organizing protein (HOP) within the chaperone protein-folding machinery. Journal of Medicinal Chemistry. PMID 30507174 DOI: 10.1021/Acs.Jmedchem.8B01436  0.444
2018 Kampinga HH, Andreasson C, Barducci A, Cheetham ME, Cyr D, Emanuelsson C, Genevaux P, Gestwicki JE, Goloubinoff P, Huerta-Cepas J, Kirstein J, Liberek K, Mayer MP, Nagata K, Nillegoda NB, et al. Function, evolution, and structure of J-domain proteins. Cell Stress & Chaperones. PMID 30478692 DOI: 10.1007/S12192-018-0948-4  0.397
2018 Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE. Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau. Nature Communications. 9: 4563. PMID 30385828 DOI: 10.1038/S41467-018-07012-4  0.448
2018 Rinaldi S, Assimon VA, Young ZT, Morra G, Shao H, Taylor IR, Gestwicki JE, Colombo G. A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions. Acs Chemical Biology. PMID 30372610 DOI: 10.1021/Acschembio.8B00712  0.465
2018 Opoku-Nsiah KA, Gestwicki JE. Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration. Translational Research : the Journal of Laboratory and Clinical Medicine. 198: 48-57. PMID 30244692 DOI: 10.1016/J.Trsl.2018.05.002  0.79
2018 Gestwicki JE, Shao H. Inhibitors and chemical probes for molecular chaperone networks. The Journal of Biological Chemistry. PMID 30213856 DOI: 10.1074/Jbc.Tm118.002813  0.447
2018 Polson ES, Kuchler VB, Abbosh C, Ross EM, Mathew RK, Beard HA, da Silva B, Holding AN, Ballereau S, Chuntharpursat-Bon E, Williams J, Griffiths HBS, Shao H, Patel A, Davies AJ, ... ... Gestwicki JE, et al. KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice. Science Translational Medicine. 10. PMID 30111643 DOI: 10.1126/Scitranslmed.Aar2718  0.305
2018 Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers LM, Gestwicki JE. Exploration of Benzothiazole-Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). Journal of Medicinal Chemistry. PMID 29953808 DOI: 10.1021/Acs.Jmedchem.8B00583  0.434
2018 Ran X, Gestwicki JE. Inhibitors of protein-protein interactions (PPIs): an analysis of scaffold choices and buried surface area. Current Opinion in Chemical Biology. 44: 75-86. PMID 29908451 DOI: 10.1016/J.Cbpa.2018.06.004  0.366
2018 Glazier AA, Hafeez N, Mellacheruvu D, Basrur V, Nesvizhskii AI, Lee LM, Shao H, Tang V, Yob JM, Gestwicki JE, Helms AS, Day SM. HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C. Jci Insight. 3. PMID 29875314 DOI: 10.1172/Jci.Insight.99319  0.399
2018 Taylor IR, Ahmad A, Wu T, Nordhues BA, Bhullar A, Gestwicki JE, Zuiderweg ERP. The disorderly conduct of Hsc70 and its interaction with the Alzheimer's related Tau protein. The Journal of Biological Chemistry. PMID 29764935 DOI: 10.1074/Jbc.Ra118.002234  0.412
2018 Moses MA, Kim YS, Rivera-Marquez GM, Oshima N, Watson MJ, Beebe K, Wells C, Lee S, Zuehlke AD, Shao H, Bingman WE, Kumar V, Malhotra S, Weigel NL, Gestwicki JE, et al. Targeting the Hsp40/Hsp70 chaperone axis as a novel strategy to treat castration-resistant prostate cancer. Cancer Research. PMID 29764864 DOI: 10.1158/0008-5472.Can-17-3728  0.427
2018 Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, ... ... Gestwicki JE, et al. Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural & Molecular Biology. 25: 384-393. PMID 29728653 DOI: 10.1038/S41594-018-0057-1  0.792
2018 Ran X, Burchfiel ET, Dong B, Rettko NJ, Dunyak BM, Shao H, Thiele DJ, Gestwicki JE. Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1). Bioorganic & Medicinal Chemistry. PMID 29661622 DOI: 10.1016/J.Bmc.2018.04.018  0.425
2018 Freilich R, Arhar T, Abrams JL, Gestwicki JE. Protein-Protein Interactions in the Molecular Chaperone Network. Accounts of Chemical Research. PMID 29613769 DOI: 10.1021/Acs.Accounts.8B00036  0.463
2018 Ouimet CM, Dawod M, Grinias J, Assimon VA, Lodge J, Mapp AK, Gestwicki JE, Kennedy RT. Protein cross-linking capillary electrophoresis at increased throughput for a range of protein-protein interactions. The Analyst. PMID 29565056 DOI: 10.1039/C7An02098H  0.455
2018 Min SW, Sohn PD, Li Y, Devidze N, Johnson JR, Krogan NJ, Masliah E, Mok SA, Gestwicki JE, Gan L. SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29540553 DOI: 10.1523/Jneurosci.2369-17.2018  0.316
2018 Taylor IR, Dunyak BM, Komiyama T, Shao H, Ran X, Assimon VA, Kalyanaraman C, Rauch JN, Jacobson MP, Zuiderweg ERP, Gestwicki JE. High Throughput Screen for Inhibitors of Protein-Protein Interactions in a Reconstituted Heat Shock Protein 70 (Hsp70) Complex. The Journal of Biological Chemistry. PMID 29414793 DOI: 10.1074/Jbc.Ra117.001575  0.756
2018 Ferguson I, Lam C, Mariano MC, Wang D, Phojanakong P, Toumivaara S, Shao H, Hann BC, Gestwicki J, Wiita AP. Novel Allosteric Inhibitors of Heat Shock Protein 70 As Agents to Probe Protein Homeostasis and Overcome Proteasome Inhibitor Resistance in Multiple Myeloma Blood. 132: 3212-3212. DOI: 10.1182/Blood-2018-99-117401  0.414
2018 Moses MA, Rivera-Marquez G, Taylor I, Shao H, Gestwicki J, Trepel J, Neckers L. Abstract 2901: Identifying synthetic lethal interactions in castration-resistant prostate cancer using HSP40 and HSP70 inhibitors Cancer Research. 78: 2901-2901. DOI: 10.1158/1538-7445.Am2018-2901  0.42
2017 Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE. X-Linked Inhibitor of Apoptosis Protein (XIAP) is a Client of Heat Shock Protein 70 (Hsp70) and a Biomarker of its Inhibition. The Journal of Biological Chemistry. PMID 29255093 DOI: 10.1074/Jbc.Ra117.000634  0.436
2017 Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett C, Gestwicki JE. Heat Shock Protein 70 (Hsp70) Suppresses RIP1-dependent Apoptotic and Necroptotic Cascades. Molecular Cancer Research : McR. PMID 28970360 DOI: 10.1158/1541-7786.Mcr-17-0408  0.429
2017 Pricer R, Gestwicki JE, Mapp AK. From Fuzzy to Function: The New Frontier of Protein-Protein Interactions. Accounts of Chemical Research. 50: 584-589. PMID 28945413 DOI: 10.1021/Acs.Accounts.6B00565  0.417
2017 Zuiderweg ER, Hightower LE, Gestwicki JE. The remarkable multivalency of the Hsp70 chaperones. Cell Stress & Chaperones. PMID 28220454 DOI: 10.1007/S12192-017-0776-Y  0.448
2017 Young ZT, Mok SA, Gestwicki JE. Therapeutic Strategies for Restoring Tau Homeostasis. Cold Spring Harbor Perspectives in Medicine. PMID 28159830 DOI: 10.1101/Cshperspect.A024612  0.377
2017 Moses MA, Kim YS, Rivera-Marquez G, Watson MJ, Lee S, Kravats A, Wickner S, Gestwicki J, Trepel J, Neckers L. Abstract 1180: Targeting the HSP40/HSP70 chaperone axis as a novel strategy to treat castration-resistant prostate cancer Cancer Research. 77: 1180-1180. DOI: 10.1158/1538-7445.Am2017-1180  0.415
2016 Rauch JN, Olson SH, Gestwicki JE. Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules. Cold Spring Harbor Perspectives in Medicine. PMID 27940599 DOI: 10.1101/Cshperspect.A024034  0.707
2016 Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE. BAG3 is a modular, scaffolding protein that physically links heat shock protein 70 (Hsp70) to the small heat shock proteins. Journal of Molecular Biology. PMID 27884606 DOI: 10.1016/J.Jmb.2016.11.013  0.751
2016 Zuiderweg ER, Gestwicki JE. Backbone and methyl resonance assignments of the 42 kDa human Hsc70 nucleotide binding domain in the ADP state. Biomolecular Nmr Assignments. PMID 27699616 DOI: 10.1007/S12104-016-9711-X  0.407
2016 Costa MD, Ashraf NS, Fischer S, Yang Y, Schapka E, Joshi G, McQuade TJ, Dharia RM, Dulchavsky M, Ouyang M, Cook D, Sun D, Larsen MJ, Gestwicki JE, Todi SV, et al. Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3. Brain : a Journal of Neurology. PMID 27645800 DOI: 10.1093/Brain/Aww228  0.335
2016 Gabai VL, Yaglom J, Wang Y, Meng L, Shao H, Kim G, Colvin T, Gestwicki J, Sherman MY. Anti-cancer effects of targeting Hsp70 in tumor stromal cells. Cancer Research. PMID 27503927 DOI: 10.1158/0008-5472.Can-16-0800  0.307
2016 Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE. Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chemical Biology. PMID 27499529 DOI: 10.1016/J.Chembiol.2016.04.014  0.763
2016 Rauch JN, Zuiderweg ER, Gestwicki JE. Non-Canonical Interactions Between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-Associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release. The Journal of Biological Chemistry. PMID 27474739 DOI: 10.1074/Jbc.M116.742502  0.73
2016 Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27450084 DOI: 10.1073/Pnas.1603883113  0.413
2016 Ouimet CM, Shao H, Rauch JN, Dawod M, Nordhues BA, Dickey CA, Gestwicki JE, Kennedy RT. Protein Cross-linking Capillary Electrophoresis (PXCE) for Protein-Protein Interaction Analysis. Analytical Chemistry. PMID 27434096 DOI: 10.1021/Acs.Analchem.6B02126  0.75
2016 Dunyak BM, Gestwicki JE. Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds. Journal of Medicinal Chemistry. PMID 27409354 DOI: 10.1021/Acs.Jmedchem.6B00411  0.395
2016 Morozova K, Clement CC, Kaushik S, Stiller B, Arias E, Ahmad A, Rauch JN, Chatterjee V, Melis C, Scharf B, Gestwicki JE, Cuervo AM, Zuiderweg ER, Santambrogio L. Hsc-70 Structural and Biological Interaction with Phosphatidylserine in Endosomal Microautophagy. The Journal of Biological Chemistry. PMID 27405763 DOI: 10.1074/Jbc.M116.736744  0.728
2016 Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO. Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel. Cell Chemical Biology. 23: 561-6. PMID 27203376 DOI: 10.1016/J.Chembiol.2016.04.008  0.397
2016 Martin MD, Baker JD, Suntharalingam A, Nordhues BA, Shelton LB, Zheng D, Sabbagh JJ, Haystead TA, Gestwicki JE, Dickey CA. Inhibition of Both Hsp70 Activity and Tau Aggregation In Vitro Best Predicts Tau Lowering Activity of Small Molecules. Acs Chemical Biology. PMID 27177119 DOI: 10.1021/Acschembio.6B00223  0.383
2016 Li X, Shao H, Taylor IR, Gestwicki JE. Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70). Current Topics in Medicinal Chemistry. PMID 27072701 DOI: 10.2174/1568026616666160413140911  0.474
2016 Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki JE, French SW. Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly. International Journal of Antimicrobial Agents. PMID 27013001 DOI: 10.1016/J.Ijantimicag.2016.01.012  0.414
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Gestwicki JE, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.311
2016 Gilbert LA, Horlbeck MA, Villalta J, Hao S, Gestwicki JE, Weissman JS. Abstract IA27: Retooling CRISPR to turn genes on and off Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-Ia27  0.341
2015 Taguwa S, Maringer K, Li X, Bernal-Rubio D, Rauch JN, Gestwicki JE, Andino R, Fernandez-Sesma A, Frydman J. Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection. Cell. PMID 26582131 DOI: 10.1016/J.Cell.2015.10.046  0.762
2015 Assimon VA, Southworth DR, Gestwicki JE. Specific binding of tetratricopeptide repeat (TPR) proteins to heat shock protein 70 (Hsp70) and heat shock protein 90 (Hsp90) is regulated by affinity and phosphorylation. Biochemistry. PMID 26565746 DOI: 10.1021/Acs.Biochem.5B00801  0.478
2015 Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE. Pharmacological chaperone for α-crystallin partially restores transparency in cataract models. Science (New York, N.Y.). 350: 674-7. PMID 26542570 DOI: 10.1126/Science.Aac9145  0.341
2015 Cesa LC, Mapp AK, Gestwicki JE. Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks. Frontiers in Bioengineering and Biotechnology. 3: 119. PMID 26380257 DOI: 10.3389/Fbioe.2015.00119  0.37
2015 Dunyak BM, Nakamura RL, Frankel AD, Gestwicki JE. Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of Two Intracellular Proteins. Acs Chemical Biology. PMID 26322864 DOI: 10.1021/Acschembio.5B00426  0.402
2015 Guan S, Trnka MJ, Bushnell DA, Robinson PJ, Gestwicki JE, Burlingame AL. Deconvolution method for specific and nonspecific binding of ligand to multiprotein complex by native mass spectrometry. Analytical Chemistry. 87: 8541-6. PMID 26189511 DOI: 10.1021/Acs.Analchem.5B02258  0.35
2015 Fontaine SN, Martin MD, Akoury E, Assimon VA, Borysov S, Nordhues BA, Sabbagh JJ, Cockman M, Gestwicki JE, Zweckstetter M, Dickey CA. The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human Molecular Genetics. 24: 3971-81. PMID 25882706 DOI: 10.1093/Hmg/Ddv135  0.37
2015 Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM, Zuiderweg ER, Gestwicki JE, Dickey CA. Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement. The Journal of Biological Chemistry. 290: 13115-27. PMID 25864199 DOI: 10.1074/Jbc.M115.637595  0.753
2015 Martin MD, Calcul L, Smith C, Jinwal UK, Fontaine SN, Darling A, Seeley K, Wojtas L, Narayan M, Gestwicki JE, Smith GR, Reitz AB, Baker BJ, Dickey CA. Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance. Acs Chemical Biology. 10: 1099-109. PMID 25588114 DOI: 10.1021/Cb501013W  0.327
2015 Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the hsp70-bag3 protein-protein interaction as a potential therapeutic target in cancer. Molecular Cancer Therapeutics. 14: 642-8. PMID 25564440 DOI: 10.1158/1535-7163.Mct-14-0650  0.752
2015 Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annual Review of Pharmacology and Toxicology. 55: 353-71. PMID 25292434 DOI: 10.1146/Annurev-Pharmtox-010814-124332  0.442
2015 Acosta-Alvear D, Kampmann M, Cho MY, Aftab BT, Li X, Gestwicki JE, Shuman MA, Weissman JS, Walter P. Abstract A2-57: Identification of genetic vulnerabilities within the proteostasis network of multiple myeloma Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A2-57  0.345
2014 Jaeger AM, Makley LN, Gestwicki JE, Thiele DJ. Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity. The Journal of Biological Chemistry. 289: 30459-69. PMID 25204655 DOI: 10.1074/Jbc.M114.591578  0.382
2014 Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. Journal of Neuroinflammation. 11: 152. PMID 25183004 DOI: 10.1186/S12974-014-0152-0  0.773
2014 Rauch JN, Gestwicki JE. Rehabilitating mutant GCase. Chemistry & Biology. 21: 919-20. PMID 25126987 DOI: 10.1016/J.Chembiol.2014.07.010  0.669
2014 Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, et al. Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Research. 74: 4731-40. PMID 24994713 DOI: 10.1158/0008-5472.Can-14-0747  0.731
2014 Pratt WB, Morishima Y, Gestwicki JE, Lieberman AP, Osawa Y. A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases. Experimental Biology and Medicine (Maywood, N.J.). 239: 1405-13. PMID 24990484 DOI: 10.1177/1535370214539444  0.45
2014 Walter GM, Raveh A, Mok SA, McQuade TJ, Arevang CJ, Schultz PJ, Smith MC, Asare S, Cruz PG, Wisen S, Matainaho T, Sherman DH, Gestwicki JE. High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity. Chemical Biology & Drug Design. 83: 440-9. PMID 24636344 DOI: 10.1111/Cbdd.12259  0.378
2014 Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D. The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain. The Journal of Biological Chemistry. 289: 2908-17. PMID 24327656 DOI: 10.1074/Jbc.M113.519421  0.456
2014 Rauch JN, Gestwicki JE. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. The Journal of Biological Chemistry. 289: 1402-14. PMID 24318877 DOI: 10.1074/Jbc.M113.521997  0.765
2013 Li X, Srinivasan SR, Connarn J, Ahmad A, Young ZT, Kabza AM, Zuiderweg ER, Sun D, Gestwicki JE. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. Acs Medicinal Chemistry Letters. 4. PMID 24312699 DOI: 10.1021/Ml400204N  0.386
2013 Ung PM, Thompson AD, Chang L, Gestwicki JE, Carlson HA. Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaK. Plos Computational Biology. 9: e1003279. PMID 24277995 DOI: 10.1371/Journal.Pcbi.1003279  0.323
2013 Rauch JN, Nie J, Buchholz TJ, Gestwicki JE, Kennedy RT. Development of a capillary electrophoresis platform for identifying inhibitors of protein-protein interactions. Analytical Chemistry. 85: 9824-31. PMID 24060167 DOI: 10.1021/Ac4023082  0.732
2013 Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER. The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry. 52: 5354-64. PMID 23865999 DOI: 10.1021/Bi4009209  0.394
2013 Cesa LC, Patury S, Komiyama T, Ahmad A, Zuiderweg ER, Gestwicki JE. Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes. Acs Chemical Biology. 8: 1988-97. PMID 23819499 DOI: 10.1021/Cb400356M  0.415
2013 Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, ... ... Gestwicki JE, et al. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological Psychiatry. 74: 367-74. PMID 23607970 DOI: 10.1016/J.Biopsych.2013.02.027  0.349
2013 Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. Acs Chemical Neuroscience. 4: 930-9. PMID 23472668 DOI: 10.1021/Cn300210G  0.372
2013 Jinwal UK, Akoury E, Abisambra JF, O'Leary JC, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, ... ... Gestwicki JE, et al. Imbalance of Hsp70 family variants fosters tau accumulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1450-9. PMID 23271055 DOI: 10.1096/Fj.12-220889  0.43
2013 Makley LN, Gestwicki JE. Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions. Chemical Biology & Drug Design. 81: 22-32. PMID 23253128 DOI: 10.1111/Cbdd.12066  0.363
2013 Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nature Chemical Biology. 9: 112-8. PMID 23222885 DOI: 10.1038/Nchembio.1140  0.483
2013 Assimon VA, Gillies AT, Rauch JN, Gestwicki JE. Hsp70 protein complexes as drug targets. Current Pharmaceutical Design. 19: 404-17. PMID 22920901 DOI: 10.2174/138161213804143699  0.809
2013 Zuiderweg ER, Bertelsen EB, Rousaki A, Mayer MP, Gestwicki JE, Ahmad A. Allostery in the Hsp70 chaperone proteins. Topics in Current Chemistry. 328: 99-153. PMID 22576356 DOI: 10.1007/128_2012_323  0.462
2013 Kampmann M, Acosta-Alvear D, Cho M, Chen Y, Li X, Gilbert L, Aftab BT, Gestwicki J, Walter P, Weissman JS. Abstract PR07: Systematic genetic interaction maps reveal rewiring of the stress response network and resulting vulnerabilities in leukemia and multiple myeloma cells Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Pr07  0.341
2013 Acosta-Alvear D, Kampmann M, Bassik MC, Lee CP, Cho MY, Aftab BT, Li X, Gestwicki JE, Shuman MA, Weissman JS, Walter P. Abstract C01: Systematic blueprinting of genetic vulnerabilities using ultra-complex shRNA libraries identifies genes synergizing with proteasome inhibition or blockade of IRE1 in multiple myeloma cells Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-C01  0.373
2013 Gestwicki J. S3-02-03: Targeting protein-protein interactions in heat shock protein 70 (Hsp70) to treat neurodegenerative disease Alzheimer's & Dementia. 9: P512-P512. DOI: 10.1016/J.Jalz.2013.04.220  0.43
2013 Fontaine S, Jinwal U, Thompson A, Gestwicki J, Dickey C. O2-01-06: The nucleotide binding domain of heat shock cognate protein 70 (Hsc70) regulates tau clearance and stability Alzheimer's & Dementia. 9: P315-P315. DOI: 10.1016/J.Jalz.2013.04.140  0.39
2012 Miyata Y, Rauch JN, Jinwal UK, Thompson AD, Srinivasan S, Dickey CA, Gestwicki JE. Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chemistry & Biology. 19: 1391-9. PMID 23177194 DOI: 10.1016/J.Chembiol.2012.07.026  0.737
2012 Gillies AT, Taylor R, Gestwicki JE. Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones. Molecular Biosystems. 8: 2901-8. PMID 22851130 DOI: 10.1039/C2Mb25248A  0.812
2012 Smith MC, Gestwicki JE. Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity. Expert Reviews in Molecular Medicine. 14: e16. PMID 22831787 DOI: 10.1017/Erm.2012.10  0.404
2012 Thompson AD, Scaglione KM, Prensner J, Gillies AT, Chinnaiyan A, Paulson HL, Jinwal UK, Dickey CA, Gestwicki JE. Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. Acs Chemical Biology. 7: 1677-86. PMID 22769591 DOI: 10.1021/Cb3002599  0.81
2012 Srinivasan SR, Gillies AT, Chang L, Thompson AD, Gestwicki JE. Molecular chaperones DnaK and DnaJ share predicted binding sites on most proteins in the E. coli proteome. Molecular Biosystems. 8: 2323-33. PMID 22732719 DOI: 10.1039/C2Mb25145K  0.796
2012 Thompson AD, Dugan A, Gestwicki JE, Mapp AK. Fine-tuning multiprotein complexes using small molecules. Acs Chemical Biology. 7: 1311-20. PMID 22725693 DOI: 10.1021/Cb300255P  0.372
2012 Chafekar SM, Wisén S, Thompson AD, Echeverria A, Walter GM, Evans CG, Makley LN, Gestwicki JE, Duennwald ML. Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation. Acs Chemical Biology. 7: 1556-64. PMID 22709427 DOI: 10.1021/Cb300166P  0.435
2012 Hammer ND, McGuffie BA, Zhou Y, Badtke MP, Reinke AA, Brännström K, Gestwicki JE, Olofsson A, Almqvist F, Chapman MR. The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation. Journal of Molecular Biology. 422: 376-89. PMID 22684146 DOI: 10.1016/J.Jmb.2012.05.043  0.306
2012 Jinwal UK, Abisambra JF, Zhang J, Dharia S, O'Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA. Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. The Journal of Biological Chemistry. 287: 24814-20. PMID 22674575 DOI: 10.1074/Jbc.M112.367268  0.459
2012 Gestwicki JE, Garza D. Protein quality control in neurodegenerative disease. Progress in Molecular Biology and Translational Science. 107: 327-53. PMID 22482455 DOI: 10.1016/B978-0-12-385883-2.00003-5  0.334
2012 Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy. 8: 609-22. PMID 22361619 DOI: 10.4161/Auto.19048  0.335
2012 Thompson AD, Bernard SM, Skiniotis G, Gestwicki JE. Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK). Cell Stress & Chaperones. 17: 313-27. PMID 22076723 DOI: 10.1007/S12192-011-0307-1  0.457
2011 Walter GM, Smith MC, Wisén S, Basrur V, Elenitoba-Johnson KS, Duennwald ML, Kumar A, Gestwicki JE. Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes. The Journal of Biological Chemistry. 286: 40486-93. PMID 21969373 DOI: 10.1074/Jbc.M111.284448  0.386
2011 Miyata Y, Koren J, Kiray J, Dickey CA, Gestwicki JE. Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies. Future Medicinal Chemistry. 3: 1523-37. PMID 21882945 DOI: 10.4155/Fmc.11.88  0.405
2011 Scaglione KM, Zavodszky E, Todi SV, Patury S, Xu P, Rodríguez-Lebrón E, Fischer S, Konen J, Djarmati A, Peng J, Gestwicki JE, Paulson HL. Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. Molecular Cell. 43: 599-612. PMID 21855799 DOI: 10.1016/J.Molcel.2011.05.036  0.353
2011 Morishima Y, Lau M, Peng HM, Miyata Y, Gestwicki JE, Pratt WB, Osawa Y. Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft. Biochemistry. 50: 7146-56. PMID 21755988 DOI: 10.1021/Bi200751T  0.363
2011 Rousaki A, Miyata Y, Jinwal UK, Dickey CA, Gestwicki JE, Zuiderweg ER. Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. Journal of Molecular Biology. 411: 614-32. PMID 21708173 DOI: 10.1016/J.Jmb.2011.06.003  0.448
2011 Chang L, Miyata Y, Ung PM, Bertelsen EB, McQuade TJ, Carlson HA, Zuiderweg ER, Gestwicki JE. Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism. Chemistry & Biology. 18: 210-21. PMID 21338918 DOI: 10.1016/J.Chembiol.2010.12.010  0.398
2011 Evans CG, Jinwal UK, Makley LN, Dickey CA, Gestwicki JE. Identification of dihydropyridines that reduce cellular tau levels. Chemical Communications (Cambridge, England). 47: 529-31. PMID 21082080 DOI: 10.1039/C0Cc02253E  0.316
2011 Koren J, Miyata Y, Kiray J, Guo J, Gestwicki J, Cheng JQ, Dickey C. Abstract 2094: Hsp70 inhibitors overcome tamoxifen resistance, in cell culture model Cancer Research. 71: 2094-2094. DOI: 10.1158/1538-7445.Am2011-2094  0.344
2010 Reinke AA, Ung PM, Quintero JJ, Carlson HA, Gestwicki JE. Chemical probes that selectively recognize the earliest Aβ oligomers in complex mixtures. Journal of the American Chemical Society. 132: 17655-7. PMID 21105683 DOI: 10.1021/Ja106291E  0.329
2010 Xu T, Johnson CA, Gestwicki JE, Kumar A. Conditionally controlling nuclear trafficking in yeast by chemical-induced protein dimerization. Nature Protocols. 5: 1831-43. PMID 21030958 DOI: 10.1038/Nprot.2010.141  0.348
2010 Miyata Y, Chang L, Bainor A, McQuade TJ, Walczak CP, Zhang Y, Larsen MJ, Kirchhoff P, Gestwicki JE. High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer. Journal of Biomolecular Screening. 15: 1211-9. PMID 20926844 DOI: 10.1177/1087057110380571  0.363
2010 Reinke AA, Abulwerdi GA, Gestwicki JE. Quantifying prefibrillar amyloids in vitro by using a "thioflavin-like" spectroscopic method. Chembiochem : a European Journal of Chemical Biology. 11: 1889-95. PMID 20677203 DOI: 10.1002/Cbic.201000358  0.318
2010 Wisén S, Bertelsen EB, Thompson AD, Patury S, Ung P, Chang L, Evans CG, Walter GM, Wipf P, Carlson HA, Brodsky JL, Zuiderweg ER, Gestwicki JE. Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. Acs Chemical Biology. 5: 611-22. PMID 20481474 DOI: 10.1021/Cb1000422  0.478
2010 Chang L, Thompson AD, Ung P, Carlson HA, Gestwicki JE. Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK). The Journal of Biological Chemistry. 285: 21282-91. PMID 20439464 DOI: 10.1074/Jbc.M110.124149  0.416
2010 Wang AM, Morishima Y, Clapp KM, Peng HM, Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. The Journal of Biological Chemistry. 285: 15714-23. PMID 20348093 DOI: 10.1074/Jbc.M109.098806  0.477
2010 Evans CG, Chang L, Gestwicki JE. Heat shock protein 70 (hsp70) as an emerging drug target. Journal of Medicinal Chemistry. 53: 4585-602. PMID 20334364 DOI: 10.1021/Jm100054F  0.445
2010 Jinwal UK, O'Leary JC, Borysov SI, Jones JR, Li Q, Koren J, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA. Hsc70 rapidly engages tau after microtubule destabilization. The Journal of Biological Chemistry. 285: 16798-805. PMID 20308058 DOI: 10.1074/Jbc.M110.113753  0.348
2010 Gestwicki JE. Special series: Molecular chaperones in protein folding and disease. Biopolymers. 93: 209-10. PMID 20039372 DOI: 10.1002/Bip.21290  0.374
2010 Koren J, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA. Facilitating Akt clearance via manipulation of Hsp70 activity and levels. The Journal of Biological Chemistry. 285: 2498-505. PMID 19889640 DOI: 10.1074/Jbc.M109.057208  0.389
2009 Patury S, Miyata Y, Gestwicki JE. Pharmacological targeting of the Hsp70 chaperone. Current Topics in Medicinal Chemistry. 9: 1337-51. PMID 19860737 DOI: 10.2174/156802609789895674  0.461
2009 Jinwal UK, Miyata Y, Koren J, Jones JR, Trotter JH, Chang L, O'Leary J, Morgan D, Lee DC, Shults CL, Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE, Dickey CA. Chemical manipulation of hsp70 ATPase activity regulates tau stability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12079-88. PMID 19793966 DOI: 10.1523/Jneurosci.3345-09.2009  0.445
2009 Marinec PS, Evans CG, Gibbons GS, Tarnowski MA, Overbeek DL, Gestwicki JE. Synthesis of orthogonally reactive FK506 derivatives via olefin cross metathesis. Bioorganic & Medicinal Chemistry. 17: 5763-8. PMID 19643614 DOI: 10.1016/J.Bmc.2009.07.030  0.405
2009 Reinke AA, Seh HY, Gestwicki JE. A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. Bioorganic & Medicinal Chemistry Letters. 19: 4952-7. PMID 19640715 DOI: 10.1016/J.Bmcl.2009.07.082  0.309
2009 Bertelsen EB, Chang L, Gestwicki JE, Zuiderweg ER. Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proceedings of the National Academy of Sciences of the United States of America. 106: 8471-6. PMID 19439666 DOI: 10.1073/Pnas.0903503106  0.366
2009 Marinec PS, Chen L, Barr KJ, Mutz MW, Crabtree GR, Gestwicki JE. FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 1336-41. PMID 19164520 DOI: 10.1073/Pnas.0805375106  0.329
2009 Patury S, Geda P, Dobry CJ, Kumar A, Gestwicki JE. Conditional nuclear import and export of yeast proteins using a chemical inducer of dimerization. Cell Biochemistry and Biophysics. 53: 127-34. PMID 19159085 DOI: 10.1007/S12013-009-9044-9  0.383
2009 Dickey CA, Jinwal UK, Koren J, O'Leary J, Anderson L, Jones J, Shults C, Jin Y, Johnson A, Abisambra J, Morgan D, Lee DC, Chang L, Miyata Y, Thompson A, ... ... Gestwicki J, et al. P2-198: Chemical manipulation of Hsp70 activity regulates tau processing Alzheimer's & Dementia. 5: P319-P319. DOI: 10.1016/J.Jalz.2009.04.510  0.319
2008 Geda P, Patury S, Ma J, Bharucha N, Dobry CJ, Lawson SK, Gestwicki JE, Kumar A. A small molecule-directed approach to control protein localization and function. Yeast (Chichester, England). 25: 577-94. PMID 18668531 DOI: 10.1002/Yea.1610  0.399
2008 Marinec PS, Lancia JK, Gestwicki JE. Bifunctional molecules evade cytochrome P(450) metabolism by forming protective complexes with FK506-binding protein. Molecular Biosystems. 4: 571-8. PMID 18493655 DOI: 10.1039/B720011K  0.388
2008 Damm KL, Ung PM, Quintero JJ, Gestwicki JE, Carlson HA. A poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocket. Biopolymers. 89: 643-52. PMID 18381626 DOI: 10.1002/Bip.20993  0.351
2008 Wisén S, Gestwicki JE. Identification of small molecules that modify the protein folding activity of heat shock protein 70. Analytical Biochemistry. 374: 371-7. PMID 18191466 DOI: 10.1016/J.Ab.2007.12.009  0.431
2008 Wisén S, Androsavich J, Evans CG, Chang L, Gestwicki JE. Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase. Bioorganic & Medicinal Chemistry Letters. 18: 60-5. PMID 18060774 DOI: 10.1016/J.Bmcl.2007.11.027  0.388
2008 Chang L, Bertelsen EB, Wisén S, Larsen EM, Zuiderweg ER, Gestwicki JE. High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK. Analytical Biochemistry. 372: 167-76. PMID 17904512 DOI: 10.1016/J.Ab.2007.08.020  0.44
2007 Gestwicki JE, Marinec PS. Chemical control over protein-protein interactions: beyond inhibitors. Combinatorial Chemistry & High Throughput Screening. 10: 667-75. PMID 18045079 DOI: 10.2174/138620707782507296  0.443
2007 Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS. Derrubone, an inhibitor of the Hsp90 protein folding machinery. Journal of Natural Products. 70: 2014-8. PMID 18020309 DOI: 10.1021/Np070190S  0.388
2007 Reinke AA, Gestwicki JE. Structure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: influence of linker length and flexibility. Chemical Biology & Drug Design. 70: 206-15. PMID 17718715 DOI: 10.1111/J.1747-0285.2007.00557.X  0.304
2007 Stankunas K, Bayle JH, Havranek JJ, Wandless TJ, Baker D, Crabtree GR, Gestwicki JE. Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. Chembiochem : a European Journal of Chemical Biology. 8: 1162-9. PMID 17525916 DOI: 10.1002/Cbic.200700087  0.383
2006 Gestwicki JE. Reclamation of proteins from the cellular scrap heap. Acs Chemical Biology. 1: 201-3. PMID 17163671 DOI: 10.1021/Cb6001784  0.396
2006 Evans CG, Wisén S, Gestwicki JE. Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro. The Journal of Biological Chemistry. 281: 33182-91. PMID 16973602 DOI: 10.1074/Jbc.M606192200  0.383
2006 Kiessling LL, Gestwicki JE, Strong LE. Synthetic multivalent ligands as probes of signal transduction. Angewandte Chemie (International Ed. in English). 45: 2348-68. PMID 16557636 DOI: 10.1002/Anie.200502794  0.703
2006 Bayle JH, Grimley JS, Stankunas K, Gestwicki JE, Wandless TJ, Crabtree GR. Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chemistry & Biology. 13: 99-107. PMID 16426976 DOI: 10.1016/J.Chembiol.2005.10.017  0.442
2006 Geda P, Bharucha N, Dobry CJ, Gestwicki JE, Kumar A. Small molecule-directed protein mislocalization Developmental Biology. 295: 423. DOI: 10.1016/J.Ydbio.2006.04.302  0.334
2006 Kiessling LL, Gestwicki JE, Strong LE. Synthetische multivalente Liganden als Sonden für die Signaltransduktion Angewandte Chemie. 118: 2408-2429. DOI: 10.1002/Ange.200502794  0.64
2005 Bose M, Gestwicki JE, Devasthali V, Crabtree GR, Graef IA. 'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation. Biochemical Society Transactions. 33: 543-7. PMID 16042540 DOI: 10.1042/Bst0330543  0.434
2004 Gestwicki JE, Crabtree GR, Graef IA. Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science (New York, N.Y.). 306: 865-9. PMID 15514157 DOI: 10.1126/Science.1101262  0.379
2003 Stankunas K, Bayle JH, Gestwicki JE, Lin YM, Wandless TJ, Crabtree GR. Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Molecular Cell. 12: 1615-24. PMID 14690613 DOI: 10.1016/S1097-2765(03)00491-X  0.387
2003 Gestwicki JE, Cairo CW, Borrok MJ, Kiessling LL. Visualization and characterization of receptor clusters by transmission electron microscopy. Methods in Enzymology. 362: 301-12. PMID 12968372 DOI: 10.1016/S0076-6879(03)01021-8  0.773
2002 Gestwicki JE, Cairo CW, Strong LE, Oetjen KA, Kiessling LL. Influencing receptor-ligand binding mechanisms with multivalent ligand architecture. Journal of the American Chemical Society. 124: 14922-33. PMID 12475334 DOI: 10.1021/Ja027184X  0.78
2002 Lamanna AC, Gestwicki JE, Strong LE, Borchardt SL, Owen RM, Kiessling LL. Conserved amplification of chemotactic responses through chemoreceptor interactions. Journal of Bacteriology. 184: 4981-7. PMID 12193613 DOI: 10.1128/Jb.184.18.4981-4987.2002  0.762
2002 Owen RM, Gestwicki JE, Young T, Kiessling LL. Synthesis and applications of end-labeled neoglycopolymers. Organic Letters. 4: 2293-6. PMID 12098230 DOI: 10.1021/Ol0259239  0.749
2002 Gestwicki JE, Cairo CW, Mann DA, Owen RM, Kiessling LL. Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy. Analytical Biochemistry. 305: 149-55. PMID 12054443 DOI: 10.1006/Abio.2002.5652  0.785
2002 Gestwicki JE, Strong LE, Cairo CW, Boehm FJ, Kiessling LL. Cell aggregation by scaffolded receptor clusters. Chemistry & Biology. 9: 163-9. PMID 11880031 DOI: 10.1016/S1074-5521(02)00102-3  0.785
2002 Cairo CW, Gestwicki JE, Kanai M, Kiessling LL. Control of multivalent interactions by binding epitope density. Journal of the American Chemical Society. 124: 1615-9. PMID 11853434 DOI: 10.1021/Ja016727K  0.702
2002 Gestwicki JE, Kiessling LL. Inter-receptor communication through arrays of bacterial chemoreceptors. Nature. 415: 81-4. PMID 11780121 DOI: 10.1038/415081A  0.536
2002 Gestwicki JE, Hsieh HV, Pitner JB. Using receptor conformational change to detect low molecular weight analytes by surface plasmon resonance. Analytical Chemistry. 73: 5732-7. PMID 11774914 DOI: 10.1021/Ac0105888  0.343
2001 Gestwicki JE, Strong LE, Borchardt SL, Cairo CW, Schnoes AM, Kiessling LL. Designed potent multivalent chemoattractants for Escherichia coli. Bioorganic & Medicinal Chemistry. 9: 2387-93. PMID 11553480 DOI: 10.1016/S0968-0896(01)00162-6  0.798
2000 Gestwicki JE, Strong LE, Kiessling LL. Visualization of Single Multivalent Receptor-Ligand Complexes by Transmission Electron Microscopy The authors thank Colleen Lavin (UW Madison, Microscopy Resource) and Kim Dickson for experimental support. This work was supported in part by the NIH (GM 55984). J.E.G. acknowledges the NIH Biotechnology Training Grant for support (T32GM08349). L.E.S. was supported by an NIH predoctoral fellowship (GM 18750). Angewandte Chemie (International Ed. in English). 39: 4567-4570. PMID 11169672 DOI: 10.1002/1521-3773(20001215)39:24<4567::Aid-Anie4567>3.0.Co;2-F  0.67
2000 Kiessling LL, Gestwicki JE, Strong LE. Synthetic multivalent ligands in the exploration of cell-surface interactions. Current Opinion in Chemical Biology. 4: 696-703. PMID 11102876 DOI: 10.1016/S1367-5931(00)00153-8  0.719
2000 Gestwicki JE, Lamanna AC, Harshey RM, McCarter LL, Kiessling LL, Adler J. Evolutionary conservation of methyl-accepting chemotaxis protein location in Bacteria and Archaea. Journal of Bacteriology. 182: 6499-502. PMID 11053396 DOI: 10.1128/Jb.182.22.6499-6502.2000  0.77
2000 Gestwicki JE, Strong LE, Kiessling LL. Tuning chemotactic responses with synthetic multivalent ligands. Chemistry & Biology. 7: 583-91. PMID 11048949 DOI: 10.1016/S1074-5521(00)00002-8  0.699
2000 Maki N, Gestwicki JE, Lake EM, Kiessling LL, Adler J. Motility and chemotaxis of filamentous cells of Escherichia coli. Journal of Bacteriology. 182: 4337-42. PMID 10894745 DOI: 10.1128/Jb.182.15.4337-4342.2000  0.484
2000 Gordon EJ, Gestwicki JE, Strong LE, Kiessling LL. Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions. Chemistry & Biology. 7: 9-16. PMID 10662681 DOI: 10.1016/S1074-5521(00)00060-0  0.715
2000 Kiessling LL, Strong LE, Gestwicki JE. Chapter 29. Principles for multivalent ligand design Annual Reports in Medicinal Chemistry. 35: 321-330. DOI: 10.1016/S0065-7743(00)35030-8  0.708
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