Jason E. Gestwicki, Ph.D. - Publications

Affiliations: 
2002 University of Wisconsin, Madison, Madison, WI 
Area:
Biomolecular recognition

99 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE. Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chemical Biology. PMID 27499529 DOI: 10.1016/j.chembiol.2016.04.014  1
2016 Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27450084 DOI: 10.1073/pnas.1603883113  1
2016 Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO. Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel. Cell Chemical Biology. 23: 561-6. PMID 27203376 DOI: 10.1016/j.chembiol.2016.04.008  1
2016 Martin MD, Baker JD, Suntharalingam A, Nordhues BA, Shelton LB, Zheng D, Sabbagh JJ, Haystead TA, Gestwicki JE, Dickey CA. Inhibition of Both Hsp70 Activity and Tau Aggregation In Vitro Best Predicts Tau Lowering Activity of Small Molecules. Acs Chemical Biology. PMID 27177119 DOI: 10.1021/acschembio.6b00223  1
2016 Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki JE, French SW. Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly. International Journal of Antimicrobial Agents. PMID 27013001 DOI: 10.1016/j.ijantimicag.2016.01.012  1
2015 Taguwa S, Maringer K, Li X, Bernal-Rubio D, Rauch JN, Gestwicki JE, Andino R, Fernandez-Sesma A, Frydman J. Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection. Cell. PMID 26582131 DOI: 10.1016/j.cell.2015.10.046  1
2015 Assimon VA, Southworth DR, Gestwicki JE. Specific binding of tetratricopeptide repeat (TPR) proteins to heat shock protein 70 (Hsp70) and heat shock protein 90 (Hsp90) is regulated by affinity and phosphorylation. Biochemistry. PMID 26565746 DOI: 10.1021/acs.biochem.5b00801  1
2015 Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE. Pharmacological chaperone for α-crystallin partially restores transparency in cataract models. Science (New York, N.Y.). 350: 674-7. PMID 26542570 DOI: 10.1126/science.aac9145  1
2015 Dunyak BM, Nakamura RL, Frankel AD, Gestwicki JE. Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of Two Intracellular Proteins. Acs Chemical Biology. PMID 26322864 DOI: 10.1021/acschembio.5b00426  1
2015 Guan S, Trnka MJ, Bushnell DA, Robinson PJ, Gestwicki JE, Burlingame AL. Deconvolution method for specific and nonspecific binding of ligand to multiprotein complex by native mass spectrometry. Analytical Chemistry. 87: 8541-6. PMID 26189511 DOI: 10.1021/acs.analchem.5b02258  1
2015 Fontaine SN, Martin MD, Akoury E, Assimon VA, Borysov S, Nordhues BA, Sabbagh JJ, Cockman M, Gestwicki JE, Zweckstetter M, Dickey CA. The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human Molecular Genetics. 24: 3971-81. PMID 25882706 DOI: 10.1093/hmg/ddv135  1
2015 Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM, Zuiderweg ER, Gestwicki JE, Dickey CA. Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement. The Journal of Biological Chemistry. 290: 13115-27. PMID 25864199 DOI: 10.1074/jbc.M115.637595  1
2015 Martin MD, Calcul L, Smith C, Jinwal UK, Fontaine SN, Darling A, Seeley K, Wojtas L, Narayan M, Gestwicki JE, Smith GR, Reitz AB, Baker BJ, Dickey CA. Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance. Acs Chemical Biology. 10: 1099-109. PMID 25588114 DOI: 10.1021/cb501013w  1
2015 Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the hsp70-bag3 protein-protein interaction as a potential therapeutic target in cancer. Molecular Cancer Therapeutics. 14: 642-8. PMID 25564440 DOI: 10.1158/1535-7163.MCT-14-0650  1
2015 Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annual Review of Pharmacology and Toxicology. 55: 353-71. PMID 25292434 DOI: 10.1146/annurev-pharmtox-010814-124332  1
2015 Assimon VA, Shao H, Garneau-Tsodikova S, Gestwicki JE. Concise synthesis of spergualin-inspired molecules with broad-spectrum antibiotic activity Medchemcomm. 6: 912-918. DOI: 10.1039/c4md00572d  1
2014 Jaeger AM, Makley LN, Gestwicki JE, Thiele DJ. Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity. The Journal of Biological Chemistry. 289: 30459-69. PMID 25204655 DOI: 10.1074/jbc.M114.591578  1
2014 Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. Journal of Neuroinflammation. 11: 152. PMID 25183004 DOI: 10.1186/s12974-014-0152-0  1
2014 Ung PM, Dunbar JB, Gestwicki JE, Carlson HA. An allosteric modulator of HIV-1 protease shows equipotent inhibition of wild-type and drug-resistant proteases. Journal of Medicinal Chemistry. 57: 6468-78. PMID 25062388 DOI: 10.1021/jm5008352  1
2014 Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, et al. Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Research. 74: 4731-40. PMID 24994713 DOI: 10.1158/0008-5472.CAN-14-0747  1
2014 Pratt WB, Morishima Y, Gestwicki JE, Lieberman AP, Osawa Y. A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases. Experimental Biology and Medicine (Maywood, N.J.). 239: 1405-13. PMID 24990484 DOI: 10.1177/1535370214539444  1
2014 Walter GM, Raveh A, Mok SA, McQuade TJ, Arevang CJ, Schultz PJ, Smith MC, Asare S, Cruz PG, Wisen S, Matainaho T, Sherman DH, Gestwicki JE. High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity. Chemical Biology & Drug Design. 83: 440-9. PMID 24636344 DOI: 10.1111/cbdd.12259  1
2014 Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D. The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain. The Journal of Biological Chemistry. 289: 2908-17. PMID 24327656 DOI: 10.1074/jbc.M113.519421  1
2013 Ung PM, Thompson AD, Chang L, Gestwicki JE, Carlson HA. Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaK. Plos Computational Biology. 9: e1003279. PMID 24277995 DOI: 10.1371/journal.pcbi.1003279  1
2013 Rauch JN, Nie J, Buchholz TJ, Gestwicki JE, Kennedy RT. Development of a capillary electrophoresis platform for identifying inhibitors of protein-protein interactions. Analytical Chemistry. 85: 9824-31. PMID 24060167 DOI: 10.1021/ac4023082  1
2013 Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER. The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry. 52: 5354-64. PMID 23865999 DOI: 10.1021/bi4009209  1
2013 Cesa LC, Patury S, Komiyama T, Ahmad A, Zuiderweg ER, Gestwicki JE. Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes. Acs Chemical Biology. 8: 1988-97. PMID 23819499 DOI: 10.1021/cb400356m  1
2013 Dunbar JB, Smith RD, Damm-Ganamet KL, Ahmed A, Esposito EX, Delproposto J, Chinnaswamy K, Kang YN, Kubish G, Gestwicki JE, Stuckey JA, Carlson HA. CSAR data set release 2012: ligands, affinities, complexes, and docking decoys. Journal of Chemical Information and Modeling. 53: 1842-52. PMID 23617227 DOI: 10.1021/ci4000486  1
2013 Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, ... ... Gestwicki JE, et al. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological Psychiatry. 74: 367-74. PMID 23607970 DOI: 10.1016/j.biopsych.2013.02.027  1
2013 Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. Acs Chemical Neuroscience. 4: 930-9. PMID 23472668 DOI: 10.1021/cn300210g  1
2013 Jinwal UK, Akoury E, Abisambra JF, O'Leary JC, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, ... ... Gestwicki JE, et al. Imbalance of Hsp70 family variants fosters tau accumulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1450-9. PMID 23271055 DOI: 10.1096/fj.12-220889  1
2013 Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nature Chemical Biology. 9: 112-8. PMID 23222885 DOI: 10.1038/nchembio.1140  1
2013 Assimon VA, Gillies AT, Rauch JN, Gestwicki JE. Hsp70 protein complexes as drug targets. Current Pharmaceutical Design. 19: 404-17. PMID 22920901  1
2013 Deiss F, Mazzeo A, Hong E, Ingber DE, Derda R, Whitesides GM. Cells in gels in paper in a new device Assay and Drug Development Technologies. 11: 512-514. DOI: 10.1089/adt.2013.1109.lr  0.32
2012 Miyata Y, Rauch JN, Jinwal UK, Thompson AD, Srinivasan S, Dickey CA, Gestwicki JE. Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chemistry & Biology. 19: 1391-9. PMID 23177194 DOI: 10.1016/j.chembiol.2012.07.026  1
2012 Davis MJ, Gregorka B, Gestwicki JE, Swanson JA. Inducible renitence limits Listeria monocytogenes escape from vacuoles in macrophages. Journal of Immunology (Baltimore, Md. : 1950). 189: 4488-95. PMID 23002437 DOI: 10.4049/jimmunol.1103158  1
2012 Seguin SP, Ireland AW, Gupta T, Wright CM, Miyata Y, Wipf P, Pipas JM, Gestwicki JE, Brodsky JL. A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Research. 96: 70-81. PMID 22898086 DOI: 10.1016/j.antiviral.2012.07.012  1
2012 Gillies AT, Taylor R, Gestwicki JE. Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones. Molecular Biosystems. 8: 2901-8. PMID 22851130 DOI: 10.1039/c2mb25248a  1
2012 Thompson AD, Scaglione KM, Prensner J, Gillies AT, Chinnaiyan A, Paulson HL, Jinwal UK, Dickey CA, Gestwicki JE. Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. Acs Chemical Biology. 7: 1677-86. PMID 22769591 DOI: 10.1021/cb3002599  1
2012 Srinivasan SR, Gillies AT, Chang L, Thompson AD, Gestwicki JE. Molecular chaperones DnaK and DnaJ share predicted binding sites on most proteins in the E. coli proteome. Molecular Biosystems. 8: 2323-33. PMID 22732719 DOI: 10.1039/c2mb25145k  1
2012 Thompson AD, Dugan A, Gestwicki JE, Mapp AK. Fine-tuning multiprotein complexes using small molecules. Acs Chemical Biology. 7: 1311-20. PMID 22725693 DOI: 10.1021/cb300255p  1
2012 Chafekar SM, Wisén S, Thompson AD, Echeverria A, Walter GM, Evans CG, Makley LN, Gestwicki JE, Duennwald ML. Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation. Acs Chemical Biology. 7: 1556-64. PMID 22709427 DOI: 10.1021/cb300166p  1
2012 Jinwal UK, Abisambra JF, Zhang J, Dharia S, O'Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA. Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. The Journal of Biological Chemistry. 287: 24814-20. PMID 22674575 DOI: 10.1074/jbc.M112.367268  1
2012 Koren J, Miyata Y, Kiray J, O'Leary JC, Nguyen L, Guo J, Blair LJ, Li X, Li X, Jinwal UK, Cheng JQ, Gestwicki JE, Dickey CA. Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. Plos One. 7: e35566. PMID 22563386 DOI: 10.1371/journal.pone.0035566  1
2012 Gestwicki JE, Garza D. Protein quality control in neurodegenerative disease. Progress in Molecular Biology and Translational Science. 107: 327-53. PMID 22482455 DOI: 10.1016/B978-0-12-385883-2.00003-5  1
2012 Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy. 8: 609-22. PMID 22361619 DOI: 10.4161/auto.19048  1
2012 Thompson AD, Bernard SM, Skiniotis G, Gestwicki JE. Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK). Cell Stress & Chaperones. 17: 313-27. PMID 22076723 DOI: 10.1007/s12192-011-0307-1  1
2011 Walter GM, Smith MC, Wisén S, Basrur V, Elenitoba-Johnson KS, Duennwald ML, Kumar A, Gestwicki JE. Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes. The Journal of Biological Chemistry. 286: 40486-93. PMID 21969373 DOI: 10.1074/jbc.M111.284448  1
2011 Miyata Y, Koren J, Kiray J, Dickey CA, Gestwicki JE. Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies. Future Medicinal Chemistry. 3: 1523-37. PMID 21882945 DOI: 10.4155/fmc.11.88  1
2011 Scaglione KM, Zavodszky E, Todi SV, Patury S, Xu P, Rodríguez-Lebrón E, Fischer S, Konen J, Djarmati A, Peng J, Gestwicki JE, Paulson HL. Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. Molecular Cell. 43: 599-612. PMID 21855799 DOI: 10.1016/j.molcel.2011.05.036  1
2011 Morishima Y, Lau M, Peng HM, Miyata Y, Gestwicki JE, Pratt WB, Osawa Y. Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft. Biochemistry. 50: 7146-56. PMID 21755988 DOI: 10.1021/bi200751t  1
2011 Rousaki A, Miyata Y, Jinwal UK, Dickey CA, Gestwicki JE, Zuiderweg ER. Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. Journal of Molecular Biology. 411: 614-32. PMID 21708173 DOI: 10.1016/j.jmb.2011.06.003  1
2011 Evans CG, Smith MC, Carolan JP, Gestwicki JE. Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction. Bioorganic & Medicinal Chemistry Letters. 21: 2587-90. PMID 21420295 DOI: 10.1016/j.bmcl.2011.02.079  1
2011 Chang L, Miyata Y, Ung PM, Bertelsen EB, McQuade TJ, Carlson HA, Zuiderweg ER, Gestwicki JE. Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism. Chemistry & Biology. 18: 210-21. PMID 21338918 DOI: 10.1016/j.chembiol.2010.12.010  1
2011 Evans CG, Jinwal UK, Makley LN, Dickey CA, Gestwicki JE. Identification of dihydropyridines that reduce cellular tau levels. Chemical Communications (Cambridge, England). 47: 529-31. PMID 21082080 DOI: 10.1039/c0cc02253e  1
2011 Bainor A, Chang L, McQuade TJ, Webb B, Gestwicki JE. Bicinchoninic acid (BCA) assay in low volume. Analytical Biochemistry. 410: 310-2. PMID 21078286 DOI: 10.1016/j.ab.2010.11.015  1
2010 Reinke AA, Ung PM, Quintero JJ, Carlson HA, Gestwicki JE. Chemical probes that selectively recognize the earliest Aβ oligomers in complex mixtures. Journal of the American Chemical Society. 132: 17655-7. PMID 21105683 DOI: 10.1021/ja106291e  1
2010 O'Leary JC, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, et al. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular Neurodegeneration. 5: 45. PMID 21040568 DOI: 10.1186/1750-1326-5-45  1
2010 Miyata Y, Chang L, Bainor A, McQuade TJ, Walczak CP, Zhang Y, Larsen MJ, Kirchhoff P, Gestwicki JE. High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer. Journal of Biomolecular Screening. 15: 1211-9. PMID 20926844 DOI: 10.1177/1087057110380571  1
2010 Wisén S, Bertelsen EB, Thompson AD, Patury S, Ung P, Chang L, Evans CG, Walter GM, Wipf P, Carlson HA, Brodsky JL, Zuiderweg ER, Gestwicki JE. Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. Acs Chemical Biology. 5: 611-22. PMID 20481474 DOI: 10.1021/cb1000422  1
2010 Chang L, Thompson AD, Ung P, Carlson HA, Gestwicki JE. Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK). The Journal of Biological Chemistry. 285: 21282-91. PMID 20439464 DOI: 10.1074/jbc.M110.124149  1
2010 Wang AM, Morishima Y, Clapp KM, Peng HM, Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. The Journal of Biological Chemistry. 285: 15714-23. PMID 20348093 DOI: 10.1074/jbc.M109.098806  1
2010 Evans CG, Chang L, Gestwicki JE. Heat shock protein 70 (hsp70) as an emerging drug target. Journal of Medicinal Chemistry. 53: 4585-602. PMID 20334364 DOI: 10.1021/jm100054f  1
2010 Jinwal UK, O'Leary JC, Borysov SI, Jones JR, Li Q, Koren J, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA. Hsc70 rapidly engages tau after microtubule destabilization. The Journal of Biological Chemistry. 285: 16798-805. PMID 20308058 DOI: 10.1074/jbc.M110.113753  1
2010 Koren J, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA. Facilitating Akt clearance via manipulation of Hsp70 activity and levels. The Journal of Biological Chemistry. 285: 2498-505. PMID 19889640 DOI: 10.1074/jbc.M109.057208  1
2009 Jinwal UK, Miyata Y, Koren J, Jones JR, Trotter JH, Chang L, O'Leary J, Morgan D, Lee DC, Shults CL, Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE, Dickey CA. Chemical manipulation of hsp70 ATPase activity regulates tau stability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12079-88. PMID 19793966 DOI: 10.1523/JNEUROSCI.3345-09.2009  1
2009 Marinec PS, Evans CG, Gibbons GS, Tarnowski MA, Overbeek DL, Gestwicki JE. Synthesis of orthogonally reactive FK506 derivatives via olefin cross metathesis. Bioorganic & Medicinal Chemistry. 17: 5763-8. PMID 19643614 DOI: 10.1016/j.bmc.2009.07.030  1
2009 Reinke AA, Seh HY, Gestwicki JE. A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. Bioorganic & Medicinal Chemistry Letters. 19: 4952-7. PMID 19640715 DOI: 10.1016/j.bmcl.2009.07.082  1
2009 Evans CG, Gestwicki JE. Enantioselective organocatalytic Hantzsch synthesis of polyhydroquinolines. Organic Letters. 11: 2957-9. PMID 19527003 DOI: 10.1021/ol901114f  1
2009 Marinec PS, Chen L, Barr KJ, Mutz MW, Crabtree GR, Gestwicki JE. FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 1336-41. PMID 19164520 DOI: 10.1073/pnas.0805375106  1
2009 Lexa KW, Damm KL, Quintero JJ, Gestwicki JE, Carlson HA. Clarifying allosteric control of flap conformations in the 1TW7 crystal structure of HIV-1 protease. Proteins. 74: 872-80. PMID 18704936 DOI: 10.1002/prot.22195  1
2008 Geda P, Patury S, Ma J, Bharucha N, Dobry CJ, Lawson SK, Gestwicki JE, Kumar A. A small molecule-directed approach to control protein localization and function. Yeast (Chichester, England). 25: 577-94. PMID 18668531 DOI: 10.1002/yea.1610  1
2008 Marinec PS, Lancia JK, Gestwicki JE. Bifunctional molecules evade cytochrome P(450) metabolism by forming protective complexes with FK506-binding protein. Molecular Biosystems. 4: 571-8. PMID 18493655 DOI: 10.1039/b720011k  1
2008 Damm KL, Ung PM, Quintero JJ, Gestwicki JE, Carlson HA. A poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocket. Biopolymers. 89: 643-52. PMID 18381626 DOI: 10.1002/bip.20993  1
2008 Wisén S, Androsavich J, Evans CG, Chang L, Gestwicki JE. Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase. Bioorganic & Medicinal Chemistry Letters. 18: 60-5. PMID 18060774 DOI: 10.1016/j.bmcl.2007.11.027  1
2007 Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS. Derrubone, an inhibitor of the Hsp90 protein folding machinery. Journal of Natural Products. 70: 2014-8. PMID 18020309 DOI: 10.1021/np070190s  1
2007 Stankunas K, Bayle JH, Havranek JJ, Wandless TJ, Baker D, Crabtree GR, Gestwicki JE. Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. Chembiochem : a European Journal of Chemical Biology. 8: 1162-9. PMID 17525916 DOI: 10.1002/cbic.200700087  1
2006 Evans CG, Wisén S, Gestwicki JE. Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro. The Journal of Biological Chemistry. 281: 33182-91. PMID 16973602 DOI: 10.1074/jbc.M606192200  1
2006 Kiessling LL, Gestwicki JE, Strong LE. Synthetic multivalent ligands as probes of signal transduction. Angewandte Chemie (International Ed. in English). 45: 2348-68. PMID 16557636 DOI: 10.1002/anie.200502794  1
2006 Bayle JH, Grimley JS, Stankunas K, Gestwicki JE, Wandless TJ, Crabtree GR. Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chemistry & Biology. 13: 99-107. PMID 16426976 DOI: 10.1016/j.chembiol.2005.10.017  1
2005 Bose M, Gestwicki JE, Devasthali V, Crabtree GR, Graef IA. 'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation. Biochemical Society Transactions. 33: 543-7. PMID 16042540 DOI: 10.1042/BST0330543  1
2004 Gestwicki JE, Crabtree GR, Graef IA. Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science (New York, N.Y.). 306: 865-9. PMID 15514157 DOI: 10.1126/science.1101262  1
2004 Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, Graef IA, Crabtree GR. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell. 118: 649-63. PMID 15339668 DOI: 10.1016/j.cell.2004.08.010  1
2003 Stankunas K, Bayle JH, Gestwicki JE, Lin YM, Wandless TJ, Crabtree GR. Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Molecular Cell. 12: 1615-24. PMID 14690613 DOI: 10.1016/S1097-2765(03)00491-X  1
2003 Gestwicki JE, Cairo CW, Borrok MJ, Kiessling LL. Visualization and characterization of receptor clusters by transmission electron microscopy. Methods in Enzymology. 362: 301-12. PMID 12968372 DOI: 10.1016/S0076-6879(03)01021-8  1
2002 Gestwicki JE, Cairo CW, Strong LE, Oetjen KA, Kiessling LL. Influencing receptor-ligand binding mechanisms with multivalent ligand architecture. Journal of the American Chemical Society. 124: 14922-33. PMID 12475334  1
2002 Lamanna AC, Gestwicki JE, Strong LE, Borchardt SL, Owen RM, Kiessling LL. Conserved amplification of chemotactic responses through chemoreceptor interactions. Journal of Bacteriology. 184: 4981-7. PMID 12193613  1
2002 Owen RM, Gestwicki JE, Young T, Kiessling LL. Synthesis and applications of end-labeled neoglycopolymers. Organic Letters. 4: 2293-6. PMID 12098230  1
2002 Gestwicki JE, Cairo CW, Mann DA, Owen RM, Kiessling LL. Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy. Analytical Biochemistry. 305: 149-55. PMID 12054443 DOI: 10.1006/abio.2002.5652  1
2002 Gestwicki JE, Strong LE, Cairo CW, Boehm FJ, Kiessling LL. Cell aggregation by scaffolded receptor clusters. Chemistry & Biology. 9: 163-9. PMID 11880031  1
2002 Cairo CW, Gestwicki JE, Kanai M, Kiessling LL. Control of multivalent interactions by binding epitope density. Journal of the American Chemical Society. 124: 1615-9. PMID 11853434  1
2002 Gestwicki JE, Kiessling LL. Inter-receptor communication through arrays of bacterial chemoreceptors. Nature. 415: 81-4. PMID 11780121 DOI: 10.1038/415081a  1
2001 Gestwicki JE, Strong LE, Borchardt SL, Cairo CW, Schnoes AM, Kiessling LL. Designed potent multivalent chemoattractants for Escherichia coli. Bioorganic & Medicinal Chemistry. 9: 2387-93. PMID 11553480 DOI: 10.1016/S0968-0896(01)00162-6  1
2000 Gestwicki JE, Strong LE, Kiessling LL. Visualization of Single Multivalent Receptor-Ligand Complexes by Transmission Electron Microscopy The authors thank Colleen Lavin (UW Madison, Microscopy Resource) and Kim Dickson for experimental support. This work was supported in part by the NIH (GM 55984). J.E.G. acknowledges the NIH Biotechnology Training Grant for support (T32GM08349). L.E.S. was supported by an NIH predoctoral fellowship (GM 18750). Angewandte Chemie (International Ed. in English). 39: 4567-4570. PMID 11169672 DOI: 10.1002/1521-3773(20001215)39:24<4567::AID-ANIE4567>3.0.CO;2-F  1
2000 Kiessling LL, Gestwicki JE, Strong LE. Synthetic multivalent ligands in the exploration of cell-surface interactions. Current Opinion in Chemical Biology. 4: 696-703. PMID 11102876 DOI: 10.1016/S1367-5931(00)00153-8  1
2000 Gestwicki JE, Lamanna AC, Harshey RM, McCarter LL, Kiessling LL, Adler J. Evolutionary conservation of methyl-accepting chemotaxis protein location in Bacteria and Archaea. Journal of Bacteriology. 182: 6499-502. PMID 11053396 DOI: 10.1128/JB.182.22.6499-6502.2000  1
2000 Gestwicki JE, Strong LE, Kiessling LL. Tuning chemotactic responses with synthetic multivalent ligands. Chemistry & Biology. 7: 583-91. PMID 11048949 DOI: 10.1016/S1074-5521(00)00002-8  1
2000 Maki N, Gestwicki JE, Lake EM, Kiessling LL, Adler J. Motility and chemotaxis of filamentous cells of Escherichia coli. Journal of Bacteriology. 182: 4337-42. PMID 10894745 DOI: 10.1128/JB.182.15.4337-4342.2000  1
2000 Gordon EJ, Gestwicki JE, Strong LE, Kiessling LL. Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions. Chemistry & Biology. 7: 9-16. PMID 10662681 DOI: 10.1016/S1074-5521(00)00060-0  1
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