Guoxia Han, Ph.D. - Related publications

2000 University of Arizona, Tucson, AZ 
Organic Chemistry, Biochemistry, Chemical Biology and Medicinal Chemistry
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Dengler DG, Harikumar KG, Pollari S, Sun Q, Brown BT, Shinoki-Iwaya A, Ardecky R, Miller LJ, Sergienko EA. Discovery of small molecule positive allosteric modulators of the secretin receptor. Biochemical Pharmacology. 114451. PMID 33545115 DOI: 10.1016/j.bcp.2021.114451   
2021 Mannes M, Martin C, Triest S, Dimmito MP, Mollica A, Laeremans T, Menet CJ, Ballet S. Development of Generic G Protein Peptidomimetics Able to Stabilize Active State Gs Protein-Coupled Receptors for Application in Drug Discovery. Angewandte Chemie (International Ed. in English). PMID 33596327 DOI: 10.1002/anie.202100180   
2021 Shahraki A, Işbilir A, Dogan B, Lohse MJ, Durdagi S, Birgul-Iyison N. Structural and Functional Characterization of Allatostatin Receptor Type-C of , a Potential Target for Next-Generation Pest Control Agents. Journal of Chemical Information and Modeling. PMID 33476150 DOI: 10.1021/acs.jcim.0c00985   
2021 Noguchi T, Umezaki Y, Takano R, Fujimoto T, Domon Y, Kubota K, Ueda K, Kawase Y, Yabe K, Yokoyama M, Shimada K. A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity. Bioorganic & Medicinal Chemistry Letters. 36: 127790. PMID 33454387 DOI: 10.1016/j.bmcl.2021.127790   
2021 Burghi V, Echeverría EB, Zappia CD, Díaz Nebreda A, Ripoll S, Gómez N, Shayo C, Davio CA, Monczor F, Fernández NC. Biased agonism at histamine H receptor: desensitization, internalization and MAPK activation triggered by antihistamines. European Journal of Pharmacology. 173913. PMID 33508282 DOI: 10.1016/j.ejphar.2021.173913   
2021 Mi YN, Ping NN, Cao YX. Ligands and Signaling of Mas-Related G Protein-Coupled Receptor-X2 in Mast Cell Activation. Reviews of Physiology, Biochemistry and Pharmacology. PMID 33479839 DOI: 10.1007/112_2020_53   
2021 Bechthold E, Schreiber JA, Lehmkuhl K, Frehland B, Schepmann D, Bernal FA, Daniliuc C, Álvarez I, Garcia CV, Schmidt TJ, Seebohm G, Wünsch B. Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity. Journal of Medicinal Chemistry. PMID 33426889 DOI: 10.1021/acs.jmedchem.0c01912   
2021 Zirimwabagabo JO, Jailani ABA, Avgoustou P, Tozer MJ, Gibson KR, Glossop PA, Mills JEJ, Porter RA, Blaney P, Wang N, Skerry TM, Richards GO, Harrity JPA. Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure-Activity Relationships and Optimization. Journal of Medicinal Chemistry. PMID 33666424 DOI: 10.1021/acs.jmedchem.0c02191   
2021 Deganutti G, Barkan K, Preti B, Leuenberger M, Wall M, Frenguelli BG, Lochner M, Ladds G, Reynolds CA. Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor. Acs Pharmacology & Translational Science. 4: 314-326. PMID 33615181 DOI: 10.1021/acsptsci.0c00195   
2021 Ostergaard S, Wulff BS, Paulsson JF, Gerstenberg MK. The design of a GLP-1/PYY dual acting agonist. Angewandte Chemie (International Ed. in English). PMID 33448563 DOI: 10.1002/anie.202016464   
2021 Sereti E, Tsimplouli C, Kalaitsidou E, Sakellaridis N, Dimas K. Study of the Relationship between Sigma Receptor Expression Levels and Some Common Sigma Ligand Activity in Cancer Using Human Cancer Cell Lines of the NCI-60 Cell Line Panel. Biomedicines. 9. PMID 33466391 DOI: 10.3390/biomedicines9010038   
2021 Iyer MR, Kunos G. Therapeutic approaches targeting the neurotensin receptors. Expert Opinion On Therapeutic Patents. 1-26. PMID 33393392 DOI: 10.1080/13543776.2021.1866539   
2021 Koretz KS, McGraw CE, Stradley S, Elbaradei A, Malmstadt N, Robinson AS. Characterization of binding kinetics of AR to Gα protein by surface plasmon resonance. Biophysical Journal. PMID 33675761 DOI: 10.1016/j.bpj.2021.02.032   
2021 Tang T, Hartig C, Chen Q, Zhao W, Kaiser A, Zhang X, Zhang H, Qu H, Yi C, Ma L, Han S, Zhao Q, Beck-Sickinger AG, Wu B. Structural basis for ligand recognition of the neuropeptide Y Y receptor. Nature Communications. 12: 737. PMID 33531491 DOI: 10.1038/s41467-021-21030-9   
2021 Milliken BT, Elfers C, Chepurny OG, Chichura KS, Sweet IR, Borner T, Hayes MR, De Jonghe BC, Holz GG, Roth CL, Doyle RP. Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis. Journal of Medicinal Chemistry. PMID 33449689 DOI: 10.1021/acs.jmedchem.0c01783   
2021 Streffer J, Treyer V, Buck A, Ametamey SM, Blagoev M, Maguire RP, Gautier A, Auberson YP, Schmidt ME, Vranesic IT, Gomez-Mancilla B, Gasparini F. Regional brain mGlu5 receptor occupancy following single oral doses of mavoglurant as measured by [C]-ABP688 PET imaging in healthy volunteers. Neuroimage. 117785. PMID 33545349 DOI: 10.1016/j.neuroimage.2021.117785   
2021 Uddin MZ, Paul A, Rakib A, Sami SA, Mahmud S, Rana MS, Hossain S, Tareq AM, Dutta M, Emran TB, Simal-Gandara J. Chemical Profiles and Pharmacological Properties with in Silico Studies on Wedd. Molecules (Basel, Switzerland). 26. PMID 33557235 DOI: 10.3390/molecules26040809   
2021 Rhodes J, Yang H, Moussu S, Boutrot F, Santiago J, Zipfel C. Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2. Nature Communications. 12: 705. PMID 33514716 DOI: 10.1038/s41467-021-20932-y   
2021 Abid MSR, Mousavi S, Checco JW. Identifying Receptors for Neuropeptides and Peptide Hormones: Challenges and Recent Progress. Acs Chemical Biology. PMID 33539706 DOI: 10.1021/acschembio.0c00950   
2021 Johnstone EKM, See HB, Abhayawardana RS, Song A, Rosengren KJ, Hill SJ, Pfleger KDG. Investigation of Receptor Heteromers Using NanoBRET Ligand Binding. International Journal of Molecular Sciences. 22. PMID 33499147 DOI: 10.3390/ijms22031082   
2021 Wei L, Hou T, Li J, Zhang X, Zhou H, Wang Z, Cheng J, Xiang K, Wang J, Zhao Y, Liang X. Structure-Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle. Journal of Medicinal Chemistry. PMID 33630609 DOI: 10.1021/acs.jmedchem.0c01624   
2021 Schüß C, Vu O, Schubert M, Du Y, Mishra NM, Tough IR, Stichel J, Weaver CD, Emmitte KA, Cox HM, Meiler J, Beck-Sickinger AG. Highly Selective Y Receptor Antagonist Binds in an Allosteric Binding Pocket. Journal of Medicinal Chemistry. PMID 33595306 DOI: 10.1021/acs.jmedchem.0c02000   
2021 Elek M, Djokovic N, Frank A, Oljacic S, Zivkovic A, Nikolic K, Stark H. Synthesis, in silico, and in vitro studies of novel dopamine D and D receptor ligands. Archiv Der Pharmazie. e2000486. PMID 33615541 DOI: 10.1002/ardp.202000486   
2021 Kennedy C. That was then, this is now: the development of our knowledge and understanding of P2 receptor subtypes. Purinergic Signalling. PMID 33527235 DOI: 10.1007/s11302-021-09763-0   
2021 Hu ZH, Zhao TS, Liu HY, Lin QX, Tu GG, Yang BW. Synthesis and receptor dependent 4D-QSAR studies of 4,5-dihydro-1,3,4-oxadiazole derivatives targeting cannabinoid receptor. Sar and Qsar in Environmental Research. 1-16. PMID 33618568 DOI: 10.1080/1062936X.2021.1879256   
2021 Yeliseev A, Iyer MR, Joseph TT, Coffey NJ, Cinar R, Zoubak L, Kunos G, Gawrisch K. Cholesterol as a modulator of cannabinoid receptor CB signaling. Scientific Reports. 11: 3706. PMID 33580091 DOI: 10.1038/s41598-021-83245-6   
2021 Ericson MD, Shaikh R, Larson CM, Freeman KT, Haskell-Luevano C. Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist. Acs Medicinal Chemistry Letters. 12: 115-120. PMID 33488972 DOI: 10.1021/acsmedchemlett.0c00561   
2021 Ofori E, Onyameh EK, Gonela UM, Voshavar C, Bricker B, Swanson TL, Eshleman AJ, Schmachtenberg JL, Bloom SH, Janowsky AJ, Ablordeppey SY. New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263. European Journal of Medicinal Chemistry. 214: 113243. PMID 33582388 DOI: 10.1016/j.ejmech.2021.113243   
2021 Pratt WE, Vaca-Tricerri R, Blanchard AC, Hopkins TR, Ilesanmi AO, Pierce-Messick Z, Rosner IA, Ying R. Selective serotonin receptor stimulation of the ventral tegmentum differentially affects appetitive motivation for sugar on a progressive ratio schedule of reinforcement. Behavioural Brain Research. 113139. PMID 33497748 DOI: 10.1016/j.bbr.2021.113139   
2021 Huang B, Gunta R, Wang H, Li M, Cao D, Mendez RE, Gillespie JC, Chen C, Huang LM, Liu-Chen LY, Selley DE, Zhang Y. Verifying the role of 3-hydroxy of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(4'-pyridyl) carboxamido]morphinan derivatives via their binding affinity and selectivity profiles on opioid receptors. Bioorganic Chemistry. 109: 104702. PMID 33631465 DOI: 10.1016/j.bioorg.2021.104702   
2021 Li Y, Lin W, Wright WC, Chai SC, Wu J, Chen T. Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70. Journal of Medicinal Chemistry. PMID 33497575 DOI: 10.1021/acs.jmedchem.0c02201   
2021 Arsova A, Møller TC, Hellyer SD, Vedel L, Foster SR, Hansen JL, Bräuner-Osborne H, Gregory KJ. Positive allosteric modulators of metabotropic glutamate receptor 5 as tool compounds to study signaling bias. Molecular Pharmacology. PMID 33602724 DOI: 10.1124/molpharm.120.000185   
2021 Witkin JM, Cerne R, Newman AH, Izenwasser S, Smith JL, Tortella FC. N-Substituted-3-alkoxy-derivatives of dextromethorphan are functional NMDA receptor antagonists in vivo:Evidence from an NMDA-induced seizure model in rats. Pharmacology, Biochemistry, and Behavior. 173154. PMID 33609599 DOI: 10.1016/j.pbb.2021.173154   
2021 Gregory KJ, Goudet C. International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors. Pharmacological Reviews. 73: 521-569. PMID 33361406 DOI: 10.1124/pr.119.019133   
2021 Batra S, Yadav VD, Kumar L, Kumari P, Kumar S, Singh M, Siddiqi MI, Yadav PN. Synthesis and Assessment of fused β-carboline derivatives as Kappa Opioid Receptor agonist. Chemmedchem. PMID 33599108 DOI: 10.1002/cmdc.202100029   
2021 Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O, Chapman TM. Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation. European Journal of Medicinal Chemistry. 214: 113194. PMID 33548634 DOI: 10.1016/j.ejmech.2021.113194   
2021 Milligan G, Barki N, Tobin AB. Chemogenetic Approaches to Explore the Functions of Free Fatty Acid Receptor 2. Trends in Pharmacological Sciences. PMID 33495026 DOI: 10.1016/   
2021 Xu X, Cai X, Liu X, Guo SW. Possible involvement of neuropeptide and neurotransmitter receptors in Adenomyosis. Reproductive Biology and Endocrinology : Rb&E. 19: 25. PMID 33602248 DOI: 10.1186/s12958-021-00711-6   
2021 Khan AA, Baildya N, Dutta T, Ghosh NN. Inhibitory efficiency of potential drugs against SARS-CoV-2 by blocking human angiotensin converting enzyme-2: Virtual screening and molecular dynamics study. Microbial Pathogenesis. 104762. PMID 33524563 DOI: 10.1016/j.micpath.2021.104762   
2021 Yu J, Zhu H, Lape R, Greiner T, Du J, Lü W, Sivilotti L, Gouaux E. Mechanism of gating and partial agonist action in the glycine receptor. Cell. PMID 33567265 DOI: 10.1016/j.cell.2021.01.026   
2021 Kline JM, Heusinkveld LE, Taranto E, Martin CB, Tomasi AG, Hsu IJ, Cho K, Khillan JS, Murphy PM, Pontejo SM. Structural and functional analysis of Ccr1l1, a Rodentia-restricted eosinophil-selective chemokine receptor homologue. The Journal of Biological Chemistry. 100373. PMID 33548230 DOI: 10.1016/j.jbc.2021.100373   
2021 Kline JM, Heusinkveld LE, Taranto E, Martin CB, Tomasi AG, Hsu IJ, Cho K, Khillan JS, Murphy PM, Pontejo SM. Structural and functional analysis of Ccr1l1, a Rodentia-restricted eosinophil-selective chemokine receptor homologue. The Journal of Biological Chemistry. 100373. PMID 33548230 DOI: 10.1016/j.jbc.2021.100373   
2021 Zvi Y, Ugur E, Batko B, Gill J, Roth M, Gorlick R, Hall D, Tingling J, Barkauskas DA, Zhang J, Yang R, Hoang BH, Geller DS. Prognostic and Therapeutic Utility of Variably Expressed Cell Surface Receptors in Osteosarcoma. Sarcoma. 2021: 8324348. PMID 33603563 DOI: 10.1155/2021/8324348   
2021 Kimani FW, Ajit J, Galluppi A, Manna S, Howitz WJ, Tang S, Esser-Kahn AP. Receptor-Ligand Kinetics Influence the Mechanism of Action of Covalently Linked TLR Ligands. Acs Chemical Biology. PMID 33523635 DOI: 10.1021/acschembio.0c00924   
2021 Slosky LM, Caron MG, Barak LS. Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery. Trends in Pharmacological Sciences. PMID 33581873 DOI: 10.1016/   
2021 Song S, Kong X, Borlongan C, Sava V, Sanchez-Ramos J. Granulocyte Colony-Stimulating Factor Enhances Brain Repair Following Traumatic Brain Injury Without Requiring Activation of Cannabinoid Receptors. Cannabis and Cannabinoid Research. 6: 48-57. PMID 33614952 DOI: 10.1089/can.2019.0090   
2021 van Waarde A, Marcolini S, de Deyn PP, Dierckx RAJO. PET Agents in Dementia: An Overview. Seminars in Nuclear Medicine. PMID 33500121 DOI: 10.1053/j.semnuclmed.2020.12.008   
2021 Fischer A, Frehner G, Lill MA, Smieško M. Conformational Changes of Thyroid Receptors in Response to Antagonists. Journal of Chemical Information and Modeling. PMID 33449688 DOI: 10.1021/acs.jcim.0c01403   
2021 Ericson MD, Haslach EM, Schnell SM, Freeman KT, Xiang ZM, Portillo FP, Speth R, Litherland SA, Haskell-Luevano C. Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R. Acs Chemical Neuroscience. 12: 542-556. PMID 33470098 DOI: 10.1021/acschemneuro.0c00755   
2021 Zlotos DP, Abdelmalek CM, Botros LS, Banoub MM, Mandour YM, Breitinger U, El Nady A, Breitinger HG, Sotriffer C, Villmann C, Jensen AA, Holzgrabe U. C-2-Linked Dimeric Strychnine Analogues as Bivalent Ligands Targeting Glycine Receptors. Journal of Natural Products. PMID 33596384 DOI: 10.1021/acs.jnatprod.0c01030