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Chaozhong Cai, Ph.D. - Publications

Affiliations: 
2001 University of Arizona, Tucson, AZ 
Area:
Organic Chemistry, Biochemistry, Chemical Biology and Medicinal Chemistry
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Zhang X, Cai C, Sui Z, Macielag M, Wang Y, Yan W, Suckow A, Hua H, Bell A, Haug P, Clapper W, Jenkinson C, Gunnet J, Leonard J, Murray WV. Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes. Acs Medicinal Chemistry Letters. 8: 947-952. PMID 28947942 DOI: 10.1021/Acsmedchemlett.7B00233  0.32
2017 Zhang X, Cai C, Winters M, Wells M, Wall M, Lanter J, Sui Z, Ma J, Novack A, Nashashibi I, Wang Y, Yan W, Suckow A, Hua H, Bell A, et al. Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists. Bioorganic & Medicinal Chemistry Letters. PMID 28642104 DOI: 10.1016/J.Bmcl.2017.06.028  0.436
2014 Teleha CA, Branum S, Zhang Y, Reuman ME, Van Der Steen L, Verbeek M, Fawzy N, Leo GC, Kang FA, Cai C, Kolpak M, Beauchamp DA, Wall MJ, Russell RK, Sui Z, et al. Lab-scale preparation of a novel carbocyclic chemokine receptor antagonist Organic Process Research and Development. 18: 1622-1629. DOI: 10.1021/Op500265Z  0.428
2013 Cai C, Kang FA, Hou C, O'Neill JC, Opas E, McKenney S, Johnson D, Sui Z. Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists. Bioorganic & Medicinal Chemistry Letters. 23: 351-4. PMID 23182090 DOI: 10.1016/J.Bmcl.2012.10.069  0.337
2013 Cai C, Kang F, Beauchamp DA, Sui Z, Russell RK, Teleha CA. Chiral aminocyclopentene-based cycloaddition strategies to bicyclic [3.3.0] rings Tetrahedron: Asymmetry. 24: 651-656. DOI: 10.1016/J.Tetasy.2013.04.014  0.374
2012 Breslin HJ, Diamond CJ, Kavash RW, Cai C, Dyatkin AB, Miskowski TA, Zhang SP, Wade PR, Hornby PJ, He W. Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d). Bioorganic & Medicinal Chemistry Letters. 22: 4869-72. PMID 22695132 DOI: 10.1016/J.Bmcl.2012.05.042  0.319
2011 Zhang X, Hufnagel H, Markotan T, Lanter J, Cai C, Hou C, Singer M, Opas E, McKenney S, Crysler C, Johnson D, Sui Z. Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists. Bioorganic & Medicinal Chemistry Letters. 21: 5577-82. PMID 21783361 DOI: 10.1016/J.Bmcl.2011.06.080  0.312
2010 Soloshonok VA, Cai C, Hruby VJ. ChemInform Abstract: (S)- or (R)-3-(E-Enoyl)-4-phenyl-1,3-oxazolidin-2-ones: Ideal Michael Acceptors to Afford a Virtually Complete Control of Simple and Face Diastereoselectivity in Addition Reactions with Glycine Derivatives. Cheminform. 31: no-no. DOI: 10.1002/chin.200027129  0.441
2010 Soloshonok VA, Cai C, Hruby VJ. ChemInform Abstract: Asymmetric Michael Addition Reactions of Chiral Ni(II)-Complex of Glycine with (N-trans-Enoyl)oxazolidines: Improved Reactivity and Stereochemical Outcome. Cheminform. 31: no-no. DOI: 10.1002/chin.200012189  0.425
2010 HAN Y, LIAO S, QIU W, CAI C, HRUBY VJ. ChemInform Abstract: Total Asymmetric Synthesis of Highly Constrained Amino Acids β- Isopropyl-2′,6′-dimethyl-tyrosines. Cheminform. 28: no-no. DOI: 10.1002/chin.199743204  0.446
2006 Breslin HJ, Cai C, Miskowski TA, Coutinho SV, Zhang SP, Hornby P, He W. Identification of potent phenyl imidazoles as opioid receptor agonists. Bioorganic & Medicinal Chemistry Letters. 16: 2505-8. PMID 16483774 DOI: 10.1016/J.Bmcl.2006.01.082  0.329
2005 Soloshonok VA, Cai C, Yamada T, Ueki H, Ohfune Y, Hruby VJ. Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity. Journal of the American Chemical Society. 127: 15296-303. PMID 16248672 DOI: 10.1021/Ja0535561  0.592
2005 Cai C, Breslin HJ, He W. A convenient, large-scale synthesis of 4′-carboxamido N-Boc-2′,6′-dimethyl-l-phenylalanines Tetrahedron. 61: 6836-6838. DOI: 10.1016/J.Tet.2005.04.065  0.351
2004 Soloshonok VA, Ueki H, Tiwari R, Cai C, Hruby VJ. Virtually complete control of simple and face diastereoselectivity in the Michael addition reactions between achiral equivalents of a nucleophilic glycine and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: practical method for preparation of beta-substituted pyroglutamic acids and prolines. The Journal of Organic Chemistry. 69: 4984-90. PMID 15255725 DOI: 10.1021/Jo0495438  0.603
2004 Cai M, Cai C, Mayorov AV, Xiong C, Cabello CM, Soloshonok VA, Swift JR, Trivedi D, Hruby VJ. Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity. The Journal of Peptide Research : Official Journal of the American Peptide Society. 63: 116-31. PMID 15009533 DOI: 10.1111/J.1399-3011.2003.00105.X  0.693
2004 Cai C, Yamada T, Tiwari R, Hruby VJ, Soloshonok VA. Application of (S)- and (R)-methyl pyroglutamates as inexpensive, yet highly efficient chiral auxiliaries in the asymmetric Michael addition reactions Tetrahedron Letters. 45: 6855-6858. DOI: 10.1016/J.Tetlet.2004.07.096  0.573
2003 Soloshonok VA, Ueki H, Jiang C, Cai C, Hruby VJ. A Convenient, Room-Temperature — Organic Base Protocol for Preparing Chiral 3-(Enoyl)-1,3-oxazolidin-2-ones. Cheminform. 34. DOI: 10.1002/1522-2675(200211)85:11<3616::Aid-Hlca3616>3.0.Co;2-O  0.503
2002 Wang W, Yang J, Ying J, Xiong C, Zhang J, Cai C, Hruby VJ. Stereoselective synthesis of dipeptide beta-turn mimetics: 7-benzyl and 8-phenyl substituted azabicyclo[4.3.0]nonane amino acid esters. The Journal of Organic Chemistry. 67: 6353-60. PMID 12201753 DOI: 10.1021/Jo0203591  0.719
2002 Xiong C, Wang W, Cai C, Hruby VJ. Regioselective and stereoselective nucleophilic ring opening reactions of a phenyl-substituted aziridine: enantioselective synthesis of beta-substituted tryptophan, cysteine, and serine derivatives. The Journal of Organic Chemistry. 67: 1399-402. PMID 11846696 DOI: 10.1021/Jo010860D  0.668
2002 Hruby VJ, Agnes RS, Cai C. Design of peptide agonists. Methods in Enzymology. 343: 73-91. PMID 11665596 DOI: 10.1016/S0076-6879(02)43128-X  0.682
2002 Soloshonok V, Ueki H, Jiang C, Cai C, Hruby V. A Convenient, Room-Temperature–Organic Base Protocol for Preparing Chiral 3-(Enoyl)-1,3-oxazolidin-2-ones Helvetica Chimica Acta. 85: 3616-3623. DOI: 10.1002/1522-2675(200211)85:11<3616::AID-HLCA3616>3.0.CO;2-O  0.396
2001 Cai C, Soloshonok VA, Hruby VJ. Michael addition reactions between chiral Ni(II) complex of glycine and 3-(trans-enoyl)oxazolidin-2-ones. A case of electron donor-acceptor attractive interaction-controlled face diastereoselectivity. The Journal of Organic Chemistry. 66: 1339-50. PMID 11312965 DOI: 10.1021/Jo0014865  0.559
2000 Soloshonok VA, Cai C, Hruby VJ, Van Meervelt L, Yamazaki T. Rational design of highly diastereoselective, organic base-catalyzed, room-temperature Michael addition reactions. The Journal of Organic Chemistry. 65: 6688-96. PMID 11052120 DOI: 10.1021/Jo0008791  0.566
2000 Soloshonok VA, Cai C, Hruby VJ. A Practical Asymmetric Synthesis of Enantiomerically Pure 3-Substituted Pyroglutamic Acids and Related Compounds This work was supported by grants from the U.S. Public Health Service (Grant DK 17420) and the National Institute of Drug Abuse (DA 06284 and DA 04248). The views expressed are those of the authors and not necessarily those of the USPHS. Angewandte Chemie (International Ed. in English). 39: 2172-2175. PMID 10941052 DOI: 10.1002/1521-3773(20000616)39:12<2172::Aid-Anie2172>3.0.Co;2-0  0.454
2000 Soloshonok VA, Cai C, Hruby VJ. (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: ideal Michael acceptors to afford a virtually complete control of simple and face diastereoselectivity in addition reactions with glycine derivatives. Organic Letters. 2: 747-50. PMID 10754676 DOI: 10.1021/Ol990402F  0.525
2000 Soloshonok VA, Cai C, Hruby VJ. Toward design of a practical methodology for stereocontrolled synthesis of χ-constrained pyroglutamic acids and related compounds. Virtually complete control of simple diastereoselectivity in the Michael addition reactions of glycine Ni(II) complexes with N-(enoyl)oxazolidinones Tetrahedron Letters. 41: 135-139. DOI: 10.1016/S0040-4039(99)02018-3  0.573
2000 Soloshonok* VA, Cai C, Hruby VJ. A unique case of face diastereoselectivity in the Michael addition reactions between Ni(II)-complexes of glycine and chiral 3-(E-enoyl)-1,3-oxazolidin-2-ones Tetrahedron Letters. 41: 9645-9649. DOI: 10.1016/S0040-4039(00)01737-8  0.494
2000 Qiu W, Soloshonok VA, Cai C, Tang X, Hruby VJ. Convenient, Large-Scale Asymmetric Synthesis of Enantiomerically Pure trans-Cinnamylglycine and -α-Alanine Tetrahedron. 56: 2577-2582. DOI: 10.1016/S0040-4020(00)00176-9  0.611
2000 Soloshonok VA, Cai C, Hruby VJ. ChemInform Abstract: A Practical Asymmetric Synthesis of Enantiomerically Pure 3-Substituted Pyroglutamic Acids and Related Compounds. Cheminform. 31: no-no. DOI: 10.1002/chin.200040108  0.477
1999 Soloshonok VA, Cai C, Hruby VJ. Asymmetric Michael addition reactions of chiral Ni(II)-complex of glycine with (N-trans-enoyl)oxazolidines: Improved reactivity and stereochemical outcome Tetrahedron Asymmetry. 10: 4265-4269. DOI: 10.1016/S0957-4166(99)00483-8  0.556
1999 Soloshonok VA, Cai C, Hruby VJ, Van Meervelt L, Mischenko N. Stereochemically defined C-substituted glutamic acids and their derivatives. 1. An efficient asymmetric synthesis of (2S,3S)-3-methyl- and -3-trifluoromethylpyroglutamic acids Tetrahedron. 55: 12031-12044. DOI: 10.1016/S0040-4020(99)00711-5  0.572
1999 Soloshonok VA, Cai C, Hruby VJ, Van Meervelt L. Asymmetric synthesis of novel highly sterically constrained (2S,3S)-3-methyl-3-trifluoromethyl- and (2S,3S,4R)-3-trifluoromethyl-4-methylpyroglutamic acids Tetrahedron. 55: 12045-12058. DOI: 10.1016/S0040-4020(99)00710-3  0.55
1997 Han Y, Liao S, Qiu W, Cai C, Hruby VJ. Total asymmetric synthesis of highly constrained amino acids β-isopropyl-2′,6′-dimethyl-tyrosines Tetrahedron Letters. 38: 5135-5138. DOI: 10.1016/S0040-4039(97)01094-0  0.601
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