John Albert Beutler, Ph.D. - Publications

Affiliations: 
1984- Molecular Targets Laboratory National Cancer Institute, Rockville, MD, United States 
Area:
natural products, cancer

116 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Senadeera SPD, Wang D, Kim CK, Smith EA, Durrant DE, Alexander PA, Wendt KL, Stephen AG, Morrison DK, Cichewicz RH, Henrich CJ, Beutler JA. Tolypocladamides A-G: Cytotoxic Peptaibols from . Journal of Natural Products. PMID 35696348 DOI: 10.1021/acs.jnatprod.2c00240  0.459
2021 Wang D, Jiang W, Kim CK, Bokesch HR, Woldemichael GM, Gryder BE, Shern JF, Khan J, O'Keefe BR, Beutler JA, Gustafson KR. Neopetrothiazide: An Intriguing Pentacyclic Thiazide Alkaloid from the Sponge sp. Organic Letters. PMID 33848174 DOI: 10.1021/acs.orglett.1c00743  0.613
2021 Cortelo PC, Demarque DP, Dusi RG, Albernaz LC, Braz-Filho R, Goncharova EI, Bokesch HR, Gustafson KR, Beutler JA, Espindola LS. A Molecular Networking Strategy: High-Throughput Screening and Chemical Analysis of Brazilian Cerrado Plant Extracts against Cancer Cells. Cells. 10. PMID 33804755 DOI: 10.3390/cells10030691  0.791
2020 Wu Z, Suppo JS, Tumova S, Strope J, Bravo F, Moy M, Weinstein ES, Peer CJ, Figg WD, Chain WJ, Echavarren AM, Beech DJ, Beutler JA. Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition. Acs Medicinal Chemistry Letters. 11: 1711-1716. PMID 32944138 DOI: 10.1021/Acsmedchemlett.0C00186  0.794
2020 Long SA, Huang S, Kambala A, Ren L, Wilson J, Goetz M, Hao X, Yang X, Goncharova EI, Jia L, LeBlanc A, Khanna C, Henrich CJ, Beutler JA. Identification of Potential Modulators of Osteosarcoma Metastasis by High Throughput Cellular Screening of Natural Products. Chemical Biology & Drug Design. PMID 32666679 DOI: 10.1111/Cbdd.13762  0.614
2019 Valdeira ASC, Darvishi E, Woldemichael GM, Beutler JA, Gustafson KR, Salvador JAR. Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation. Journal of Natural Products. PMID 31343174 DOI: 10.1021/Acs.Jnatprod.8B00864  0.397
2019 Tosun F, Beutler JA, Ransom TT, Miski M. Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of . Molecules (Basel, Switzerland). 24. PMID 30909537 DOI: 10.3390/Molecules24061153  0.449
2018 Espindola LS, Dusi RG, Demarque DP, Braz-Filho R, Yan P, Bokesch HR, Gustafson KR, Beutler JA. Cytotoxic Triterpenes from and Metabolite Profiling of Celastraceae Species. Molecules (Basel, Switzerland). 23. PMID 29925807 DOI: 10.3390/Molecules23061494  0.79
2017 Jia L, Lin H, Oppenheim J, Howard OMZ, Li J, Fan H, Zhao Z, Farrar W, Zhang Y, Colburn N, Young MR, Li W, Newman D, O'Keefe BR, Beutler J, et al. US National Cancer Institute-China Collaborative Studies on Chinese Medicine and Cancer. Journal of the National Cancer Institute. Monographs. 2017. PMID 29140488 DOI: 10.1093/Jncimonographs/Lgx007  0.58
2017 Hirsch DR, Schiavone DV, Berkowitz AJ, Morrison LA, Masaoka T, Wilson JA, Lomonosova E, Zhao H, Patel BS, Datla SH, Hoft SG, Majidi SJ, Pal RK, Gallicchio E, Tang L, ... ... Beutler JA, et al. Synthesis and biological assessment of 3,7-dihydroxytropolones. Organic & Biomolecular Chemistry. PMID 29098212 DOI: 10.1039/C7Ob02453C  0.337
2017 Stockdale DP, Beutler JA, Wiemer DF. Synthesis of amide isosteres of schweinfurthin-based stilbenes. Bioorganic & Medicinal Chemistry. PMID 28866376 DOI: 10.1016/J.Bmc.2017.08.016  0.338
2017 Elliott DC, Beutler JA, Parker KA. Importance of a 4-Alkyl Substituent for Activity in the Englerin Series. Acs Medicinal Chemistry Letters. 8: 746-750. PMID 28740610 DOI: 10.1021/Acsmedchemlett.7B00161  0.339
2017 Cho N, Ransom TT, Sigmund J, Tran T, Cichewicz RH, Goetz M, Beutler JA. Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species. Journal of Natural Products. PMID 28654255 DOI: 10.1021/Acs.Jnatprod.7B00170  0.747
2017 Wu Z, Zhao S, Fash DM, Li Z, Chain WJ, Beutler JA. Englerins: A Comprehensive Review. Journal of Natural Products. PMID 28170253 DOI: 10.1021/Acs.Jnatprod.6B01167  0.729
2016 Murelli RP, D'Erasmo MP, Hirsch DR, Meck C, Masaoka T, Wilson JA, Zhang B, Pal RK, Gallicchio E, Beutler JA, Le Grice SF. Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity. Medchemcomm. 7: 1783-1788. PMID 28093576 DOI: 10.1039/C6Md00238B  0.342
2016 Cho N, Kim HW, Kim TB, Ransom TT, Beutler JA, Sung SH. Preparative Purification of Anti-Proliferative Diarylheptanoids from Betula platyphylla by High-Speed Counter-Current Chromatography. Molecules (Basel, Switzerland). 21. PMID 27240338 DOI: 10.3390/Molecules21060700  0.755
2016 Fash DM, Peer CJ, Li Z, Talisman IJ, Hayavi S, Sulzmaier FJ, Ramos JW, Sourbier C, Neckers L, Figg WD, Beutler JA, Chain WJ. Synthesis of a stable and orally bioavailable englerin analogue. Bioorganic & Medicinal Chemistry Letters. PMID 27107948 DOI: 10.1016/J.Bmcl.2016.04.016  0.743
2016 Cho N, Moon EH, Kim HW, Hong J, Beutler JA, Sung SH. Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus. Molecules (Basel, Switzerland). 21. PMID 27070561 DOI: 10.3390/Molecules21040459  0.764
2016 López-Suárez L, Riesgo L, Bravo F, Ransom TT, Beutler JA, Echavarren AM. Synthesis and Biological Evaluation of New (-)-Englerin Analogues. Chemmedchem. PMID 27005578 DOI: 10.1002/Cmdc.201600040  0.552
2016 Masaoka T, Zhao H, Hirsch DR, D'Erasmo MP, Meck C, Varnado B, Gupta A, Meyers MJ, Baines J, Beutler JA, Murelli RP, Tang L, Le Grice SF. Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors. Biochemistry. PMID 26829613 DOI: 10.1021/Acs.Biochem.5B01254  0.306
2016 Espindola L, Dusi R, Gustafson K, McMahon J, Beutler J. High throughput screening to investigate Brazilian Cerrado biome plant extract bank chemical diversity Planta Medica. 81: S1-S381. DOI: 10.1055/S-0036-1596238  0.761
2015 Qin T, Iwata T, Ransom TT, Beutler JA, Porco JA. Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of "Shapeshifting" Properties. Journal of the American Chemical Society. PMID 26544765 DOI: 10.1021/Jacs.5B09825  0.594
2015 da Cunha MG, Rosalen PL, Franchin M, de Alencar SM, Ikegaki M, Ransom T, Beutler JA. Antiproliferative Constituents of Geopropolis from the Bee Melipona scutellaris. Planta Medica. PMID 26544117 DOI: 10.1055/S-0035-1558142  0.416
2015 Sourbier C, Scroggins BT, Mannes PZ, Liao PJ, Siems K, Wolf D, Beutler JA, Linehan WM, Neckers L. Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent. Oncotarget. 6: 29963-74. PMID 26298773 DOI: 10.18632/Oncotarget.4676  0.346
2015 Ma J, Pawar RS, Grundel E, Mazzola EP, Ridge CD, Masaoka T, Le Grice SF, Wilson J, Beutler JA, Krynitsky AJ. Sesquiterpenoid tropolone glycosides from Liriosma ovata. Journal of Natural Products. 78: 315-9. PMID 25587934 DOI: 10.1021/Np5006696  0.371
2015 Huynh N, Beutler JA, Shulkes A, Baldwin GS, He H. Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway. Biochimica Et Biophysica Acta. 1853: 157-65. PMID 25409929 DOI: 10.1016/J.Bbamcr.2014.10.013  0.324
2015 Espindola L, Wilson B, Beutler J, Gustafson K, O'Keefe B. Brazilian cerrado biome plant extract bank screening in inflammatory disease and cancer enzymes Planta Medica. 81. DOI: 10.1055/S-0035-1556521  0.776
2014 Sunassee SN, Ransom T, Henrich CJ, Beutler JA, Covell DG, McMahon JB, Gustafson KR. Steroidal alkaloids from the marine sponge Corticium niger that inhibit growth of human colon carcinoma cells. Journal of Natural Products. 77: 2475-80. PMID 25338277 DOI: 10.1021/Np500556T  0.454
2014 Kodet JG, Beutler JA, Wiemer DF. Synthesis and structure activity relationships of schweinfurthin indoles. Bioorganic & Medicinal Chemistry. 22: 2542-52. PMID 24656801 DOI: 10.1016/J.Bmc.2014.02.043  0.406
2014 Lockett S, Verma C, Brafman A, Gudla P, Nandy K, Mimaki Y, Fuchs PL, Jaja J, Reilly KM, Beutler J, Turbyville TJ. Quantitative analysis of F-actin redistribution in astrocytoma cells treated with candidate pharmaceuticals. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 85: 512-21. PMID 24515854 DOI: 10.1002/Cyto.A.22442  0.701
2014 Yeo D, Huynh N, Beutler JA, Christophi C, Shulkes A, Baldwin GS, Nikfarjam M, He H. Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases. Cancer Letters. 346: 264-72. PMID 24491405 DOI: 10.1016/J.Canlet.2014.01.001  0.358
2014 Devkota KP, Wilson JA, Henrich CJ, McMahon JB, Reilly KM, Beutler JA. Compounds from Simarouba berteroana which inhibit proliferation of NF1-defective cancer cells. Phytochemistry Letters. 7: 42-45. PMID 24443661 DOI: 10.1016/J.Phytol.2013.09.007  0.676
2014 Sourbier C, Scroggins B, Mannes PZ, Beutler JA, Linehan WM, Neckers L. Abstract 3202: Deciphering the targets and mechanism of action of the natural product Tonantzitlolone in clear cell renal cell carcinomas Cancer Research. 74: 3202-3202. DOI: 10.1158/1538-7445.Am2014-3202  0.372
2013 Dossou KS, Devkota KP, Morton C, Egan JM, Lu G, Beutler JA, Moaddel R. Identification of CB1/CB2 ligands from Zanthoxylum bungeanum. Journal of Natural Products. 76: 2060-4. PMID 24175626 DOI: 10.1021/Np400478C  0.65
2013 Winter DK, Endoma-Arias MA, Hudlicky T, Beutler JA, Porco JA. Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a tetrahydroxanthone analogue. The Journal of Organic Chemistry. 78: 7617-26. PMID 23834060 DOI: 10.1021/Jo401169Z  0.514
2013 Masaoka T, Chung S, Caboni P, Rausch JW, Wilson JA, Taskent-Sezgin H, Beutler JA, Tocco G, Le Grice SF. Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. Journal of Medicinal Chemistry. 56: 5436-45. PMID 23631411 DOI: 10.1021/Jm400405Z  0.312
2013 Devkota KP, Covell D, Ransom T, McMahon JB, Beutler JA. Growth inhibition of human colon carcinoma cells by sesquiterpenoids and tetralones of Zygogynum calothyrsum. Journal of Natural Products. 76: 710-4. PMID 23517126 DOI: 10.1021/Np400042Q  0.631
2013 Dossou KS, Devkota KP, Kavanagh PV, Beutler JA, Egan JM, Moaddel R. Development and preliminary validation of a plate-based CB1/CB2 receptor functional assay. Analytical Biochemistry. 437: 138-43. PMID 23481912 DOI: 10.1016/J.Ab.2013.02.025  0.62
2013 Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee MJ, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L. Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality. Cancer Cell. 23: 228-37. PMID 23352416 DOI: 10.1016/J.Ccr.2012.12.007  0.654
2013 Devkota KP, Wilson J, Henrich CJ, McMahon JB, Reilly KM, Beutler JA. Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth. Journal of Natural Products. 76: 59-63. PMID 23268719 DOI: 10.1021/Np300696G  0.662
2013 Turbyville T, Brafman A, Chen D, Romanchuck K, Beutler J, Reilly K, Lockett S. Abstract 3429: Coordination of cell cycle repression and reduced cytoskeletal tension by the small molecule natural product, Schweinfurthin A. Cancer Research. 73: 3429-3429. DOI: 10.1158/1538-7445.Am2013-3429  0.719
2012 Dong S, Qin T, Hamel E, Beutler JA, Porco JA. Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation. Journal of the American Chemical Society. 134: 19782-7. PMID 23110297 DOI: 10.1021/Ja3084708  0.566
2012 Diyabalanage T, Ratnayake R, Bokesch HR, Ransom TT, Henrich CJ, Beutler JA, McMahon JB, Gustafson KR. Flabelliferins A and B, sesterterpenoids from the South Pacific sponge Carteriospongia flabellifera. Journal of Natural Products. 75: 1490-4. PMID 22834941 DOI: 10.1021/Np3003518  0.682
2012 Akee RK, Ransom T, Ratnayake R, McMahon JB, Beutler JA. Chlorinated englerins with selective inhibition of renal cancer cell growth. Journal of Natural Products. 75: 459-63. PMID 22280462 DOI: 10.1021/Np200905U  0.724
2012 Devkota K, Covell D, Ransom T, McMahon J, Beutler J. Growth inhibition of human colon carcinoma cells by diterpenes and tetralones of Zygogynum calothyrsum Planta Medica. 78. DOI: 10.1055/S-0032-1320929  0.61
2012 Devkota K, McMahon J, Beutler J. Phytochemical Investigation of Zanthoxylum armatum in NF1-Dependent Tumors Planta Medica. 78. DOI: 10.1055/S-0032-1307607  0.584
2011 Topczewski JJ, Callahan MP, Kodet JG, Inbarasu JD, Mente NR, Beutler JA, Wiemer DF. Relevance of the C-5 position to schweinfurthin induced cytotoxicity. Bioorganic & Medicinal Chemistry. 19: 7570-81. PMID 22055715 DOI: 10.1016/J.Bmc.2011.10.034  0.372
2011 Dong S, Cahill KJ, Kang MI, Colburn NH, Henrich CJ, Wilson JA, Beutler JA, Johnson RP, Porco JA. Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers. The Journal of Organic Chemistry. 76: 8944-54. PMID 21942286 DOI: 10.1021/Jo201658Y  0.523
2011 Zhao LX, Huang SX, Tang SK, Jiang CL, Duan Y, Beutler JA, Henrich CJ, McMahon JB, Schmid T, Blees JS, Colburn NH, Rajski SR, Shen B. Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600. Journal of Natural Products. 74: 1990-5. PMID 21870828 DOI: 10.1021/Np200603G  0.419
2011 Popplewell WL, Ratnayake R, Wilson JA, Beutler JA, Colburn NH, Henrich CJ, McMahon JB, McKee TC. Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula. Journal of Natural Products. 74: 1686-91. PMID 21806011 DOI: 10.1021/Np2005083  0.658
2011 Diyabalanage T, Ratnayake R, Wilson JA, Henrich CJ, Beutler JA, Colburn NH, McMahon JB, Gustafson KR. Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii. Bioorganic & Medicinal Chemistry Letters. 21: 4397-9. PMID 21733691 DOI: 10.1016/J.Bmcl.2011.06.044  0.729
2011 Tai BH, Nhut ND, Nhiem NX, Quang TH, Thanh Ngan NT, Thuy Luyen BT, Huong TT, Wilson J, Beutler JA, Ban NK, Cuong NM, Kim YH. An evaluation of the RNase H inhibitory effects of Vietnamese medicinal plant extracts and natural compounds. Pharmaceutical Biology. 49: 1046-51. PMID 21595586 DOI: 10.3109/13880209.2011.563316  0.408
2011 Chung S, Himmel DM, Jiang JK, Wojtak K, Bauman JD, Rausch JW, Wilson JA, Beutler JA, Thomas CJ, Arnold E, Le Grice SF. Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. Journal of Medicinal Chemistry. 54: 4462-73. PMID 21568335 DOI: 10.1021/Jm2000757  0.324
2011 Kim JA, Yang SY, Wamiru A, McMahon JB, Le Grice SF, Beutler JA, Kim YH. New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H. Bioorganic & Medicinal Chemistry Letters. 21: 2840-4. PMID 21489793 DOI: 10.1016/J.Bmcl.2011.03.091  0.448
2011 Sloman DL, Mitasev B, Scully SS, Beutler JA, Porco JA. Synthesis and biological evaluation of ABCD ring fragments of the kibdelones. Angewandte Chemie (International Ed. in English). 50: 2511-5. PMID 21370327 DOI: 10.1002/Anie.201007613  0.615
2011 Devkota KP, Ratnayake R, Colburn NH, Wilson JA, Henrich CJ, McMahon JB, Beutler JA. Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius. Journal of Natural Products. 74: 374-7. PMID 21306129 DOI: 10.1021/Np100736Y  0.768
2011 Best AM, Chang J, Dull AB, Beutler JA, Martinez ED. Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay. Journal of Biomedicine & Biotechnology. 2011: 868095. PMID 21234371 DOI: 10.1155/2011/868095  0.355
2011 Sourbier C, Ratnayake R, Scroggins B, Lee M, Lee S, Trepel J, Beutler J, Neckers L, Linehan WM. Abstract 959: Targeting renal cell carcinoma with englerin A Cancer Research. 71: 959-959. DOI: 10.1158/1538-7445.Am2011-959  0.7
2010 Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O'Keefe BR, Bermingham A, Beutler JA, Liu S, Zhuang X, Le Grice SF. Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Antimicrobial Agents and Chemotherapy. 54: 3913-21. PMID 20547794 DOI: 10.1128/Aac.00434-10  0.622
2010 Turbyville TJ, Gürsel DB, Tuskan RG, Walrath JC, Lipschultz CA, Lockett SJ, Wiemer DF, Beutler JA, Reilly KM. Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner. Molecular Cancer Therapeutics. 9: 1234-43. PMID 20442305 DOI: 10.1158/1535-7163.Mct-09-0834  0.707
2010 Ulrich NC, Kodet JG, Mente NR, Kuder CH, Beutler JA, Hohl RJ, Wiemer DF. Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure. Bioorganic & Medicinal Chemistry. 18: 1676-83. PMID 20116262 DOI: 10.1016/J.Bmc.2009.12.063  0.397
2010 Klausmeyer P, Van QN, Jato J, McCloud TG, Beutler JA. Schweinfurthins I and J from Macaranga schweinfurthii. Journal of Natural Products. 73: 479-81. PMID 20000454 DOI: 10.1021/Np9006348  0.351
2010 ERICKSON KL, BEUTLER JA, CARDELLINA JHI, BOYD MR. ChemInform Abstract: Salicylihalamides A (I) and B (II), Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp. Cheminform. 29: no-no. DOI: 10.1002/chin.199815264  0.549
2009 Cui C, JaJa J, Turbyville T, Beutler J, Gudla P, Nandy K, Lockett S. Quantifying the astrocytoma cell response to candidate pharmaceutical from F-ACTIN image analysis. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 5768-71. PMID 19963655 DOI: 10.1109/IEMBS.2009.5332528  0.67
2009 Beutler JA, Kang MI, Robert F, Clement JA, Pelletier J, Colburn NH, McKee TC, Goncharova E, McMahon JB, Henrich CJ. Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition. Journal of Natural Products. 72: 503-6. PMID 19199792 DOI: 10.1021/Np800732N  0.408
2009 Wrona IE, Lowe JT, Turbyville TJ, Johnson TR, Beignet J, Beutler JA, Panek JS. Synthesis of a 35-member stereoisomer library of bistramide A: evaluation of effects on actin state, cell cycle and tumor cell growth. The Journal of Organic Chemistry. 74: 1897-916. PMID 19191575 DOI: 10.1021/Jo802269Q  0.721
2009 Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA. Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor. Angewandte Chemie (International Ed. in English). 48: 1494-7. PMID 19140149 DOI: 10.1002/Anie.200805486  0.52
2009 Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA. Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri. Organic Letters. 11: 57-60. PMID 19061394 DOI: 10.1021/Ol802339W  0.716
2009 Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA. Synthesis of (+)-Chamaecypanone C Synfacts. 2009: 829-829. DOI: 10.1055/S-0029-1217508  0.494
2008 Weissman AM, Yang Y, Kitagaki J, Sasiela CA, Beutler JA, O'Keefe BR. Inhibiting Hdm2 and ubiquitin-activating enzyme: targeting the ubiquitin conjugating system in cancer. Ernst Schering Foundation Symposium Proceedings. 171-90. PMID 19202599  0.587
2008 Wendeler M, Lee HF, Bermingham A, Miller JT, Chertov O, Bona MK, Baichoo NS, Ehteshami M, Beutler J, O'Keefe BR, Götte M, Kvaratskhelia M, Le Grice S. Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. Acs Chemical Biology. 3: 635-44. PMID 18831589 DOI: 10.1021/Cb8001039  0.598
2008 Bokesch HR, Wamiru A, Le Grice SF, Beutler JA, McKee TC, McMahon JB. HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis. Journal of Natural Products. 71: 1634-6. PMID 18763827 DOI: 10.1021/Np8002518  0.373
2008 Sasiela CA, Stewart DH, Kitagaki J, Safiran YJ, Yang Y, Weissman AM, Oberoi P, Davydov IV, Goncharova E, Beutler JA, McMahon JB, O'Keefe BR. Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen. Journal of Biomolecular Screening. 13: 229-37. PMID 18270365 DOI: 10.1177/1087057108315038  0.645
2008 Marchand C, Beutler JA, Wamiru A, Budihas S, Möllmann U, Heinisch L, Mellors JW, Le Grice SF, Pommier Y. Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H. Antimicrobial Agents and Chemotherapy. 52: 361-4. PMID 17967911 DOI: 10.1128/Aac.00883-07  0.327
2007 Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, McMahon JB. An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis. Journal of Natural Products. 70: 1647-9. PMID 17935297 DOI: 10.1021/Np0702279  0.621
2007 Yang Y, Kitagaki J, Dai RM, Tsai YC, Lorick KL, Ludwig RL, Pierre SA, Jensen JP, Davydov IV, Oberoi P, Li CC, Kenten JH, Beutler JA, Vousden KH, Weissman AM. Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Research. 67: 9472-81. PMID 17909057 DOI: 10.1158/0008-5472.Can-07-0568  0.348
2007 Dat NT, Bae K, Wamiru A, McMahon JB, Le Grice SF, Bona M, Beutler JA, Kim YH. A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H. Journal of Natural Products. 70: 839-41. PMID 17397219 DOI: 10.1021/Np060359M  0.401
2006 Martinez ED, Dull AB, Beutler JA, Hager GL. High-content fluorescence-based screening for epigenetic modulators. Methods in Enzymology. 414: 21-36. PMID 17110184 DOI: 10.1016/S0076-6879(06)14002-1  0.359
2006 Kim YH, Park EJ, Park MH, Badarch U, Woldemichael GM, Beutler JA. Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2. Biological & Pharmaceutical Bulletin. 29: 2140-2. PMID 17015967 DOI: 10.1248/Bpb.29.2140  0.312
2006 Liang MC, Bardhan S, Pace EA, Rosman D, Beutler JA, Porco JA, Gilmore TD. Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity. Biochemical Pharmacology. 71: 634-45. PMID 16360644 DOI: 10.1016/J.Bcp.2005.11.013  0.576
2006 Neighbors JD, Salnikova MS, Beutler JA, Wiemer DF. Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity. Bioorganic & Medicinal Chemistry. 14: 1771-84. PMID 16290161 DOI: 10.1016/J.Bmc.2005.10.025  0.386
2005 Budihas SR, Gorshkova I, Gaidamakov S, Wamiru A, Bona MK, Parniak MA, Crouch RJ, McMahon JB, Beutler JA, Le Grice SF. Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. Nucleic Acids Research. 33: 1249-56. PMID 15741178 DOI: 10.1093/Nar/Gki268  0.316
2005 Neighbors JD, Beutler JA, Wiemer DF. Synthesis of nonracemic 3-deoxyschweinfurthin B. The Journal of Organic Chemistry. 70: 925-31. PMID 15675850 DOI: 10.1021/Jo048444R  0.319
2004 Chan KC, Budihas SR, Le Grice SF, Parniak MA, Crouch RJ, Gaidamakov SA, Isaaq HJ, Wamiru A, McMahon JB, Beutler JA. A capillary electrophoretic assay for ribonuclease H activity. Analytical Biochemistry. 331: 296-302. PMID 15265735 DOI: 10.1016/J.Ab.2004.05.017  0.336
2004 Bokesch HR, Charan RD, Meragelman KM, Beutler JA, Gardella R, O'Keefe BR, McKee TC, McMahon JB. Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea. Febs Letters. 567: 287-90. PMID 15178338 DOI: 10.1016/J.Febslet.2004.04.085  0.586
2003 Beutler JA, McKee TC. Novel marine and microbial natural product inhibitors of vacuolar ATPase. Current Medicinal Chemistry. 10: 787-96. PMID 12678782 DOI: 10.2174/0929867033457827  0.369
2002 Erickson KL, Gustafson KR, Pannell LK, Beutler JA, Boyd MR. New dimeric macrolide glycosides from the marine sponge Myriastra clavosa. Journal of Natural Products. 65: 1303-6. PMID 12350152 DOI: 10.1021/Np020193Z  0.633
2002 Beutler JA, McMahon JB, Johnson TR, O'Keefe BR, Buzzell RA, Robbins D, Gardella R, Wilson J, Boyd MR. High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41. Journal of Biomolecular Screening. 7: 105-10. PMID 12006108 DOI: 10.1177/108705710200700202  0.601
2001 Kuroda M, Mimaki Y, Yokosuka A, Sashida Y, Beutler JA. Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae. Journal of Natural Products. 64: 88-91. PMID 11170674 DOI: 10.1021/Np0003084  0.395
2000 Davies-Coleman MT, Gustafson KR, Cantrell CL, Beutler JA, Pannell LK, Boyd MR. Stolonic acids A and B, new cytotoxic cyclic peroxides from an Indian Ocean ascidian Stolonica species. Journal of Natural Products. 63: 1411-3. PMID 11076564 DOI: 10.1021/Np000158X  0.356
2000 Keskin O, Bahar I, Jernigan RL, Beutler JA, Shoemaker RH, Sausville EA, Covell DG. Characterization of anticancer agents by their growth inhibitory activity and relationships to mechanism of action and structure. Anti-Cancer Drug Design. 15: 79-98. PMID 10901296 DOI: 10.5072/Zenodo.19292  0.404
2000 McMahon JB, Beutler JA, O'Keefe BR, Goodrum CB, Myers MA, Boyd MR. Development of a cyanovirin-N-HIV-1 gp120 binding assay for high throughput screening of natural product extracts by time-resolved fluorescence. Journal of Biomolecular Screening. 5: 169-76. PMID 10894760 DOI: 10.1177/108705710000500309  0.602
2000 Beutler JA, McCall KL, Herbert K, Herald DL, Pettit GR, Johnson T, Shoemaker RH, Boyd MR. Novel cytotoxic diterpenes from Casearia arborea. Journal of Natural Products. 63: 657-61. PMID 10843580 DOI: 10.1021/Np990553R  0.31
1998 Beutler JA, Shoemaker RH, Johnson T, Boyd MR. Cytotoxic geranyl stilbenes from Macaranga schweinfurthii. Journal of Natural Products. 61: 1509-12. PMID 9868152 DOI: 10.1021/Np980208M  0.388
1998 O'Keefe BR, Erim T, Beutler JA, Cardellina JH, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC, Johnson DG, Buckheit RW, Halliday S, Boyd MR. Isolation and characterization of adociavirin, a novel HIV-inhibitory protein from the sponge Adocia sp. Febs Letters. 431: 85-90. PMID 9684871 DOI: 10.1016/S0014-5793(98)00736-4  0.595
1998 Beutler JA, Hamel E, Vlietinck AJ, Haemers A, Rajan P, Roitman JN, Cardellina JH, Boyd MR. Structure-activity requirements for flavone cytotoxicity and binding to tubulin. Journal of Medicinal Chemistry. 41: 2333-8. PMID 9632366 DOI: 10.1021/Jm970842H  0.405
1997 Erickson KL, Beutler JA, Cardellina II JH, Boyd MR. Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp. The Journal of Organic Chemistry. 62: 8188-8192. PMID 11671930 DOI: 10.1021/Jo971556G  0.652
1997 O'Keefe BR, Beutler JA, Cardellina JH, Prather TR, Shoemaker RH, Sowder RC, Henderson LE, Pannell LK, Boyd MR. Isolation of a novel Kunitz family protease inhibitor in association with Tethya hemolysin from the sponge Tethya ingalli. Journal of Natural Products. 60: 1094-9. PMID 9392878 DOI: 10.1021/Np970242L  0.629
1997 Beutler JA, Kashman Y, Pannell LK, Cardellina JH, Alexander MR, Balaschak MS, Prather TR, Shoemaker RH, Boyd MR. Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum. Bioorganic & Medicinal Chemistry. 5: 1509-17. PMID 9313857 DOI: 10.1016/S0968-0896(97)00098-9  0.418
1997 O'Keefe BR, Beutler JA, Cardellina JH, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC, Henderson LE, Pannell LK, Pomponi SA, Boyd MR. Isolation and characterization of niphatevirin, a human-immunodeficiency-virus-inhibitory glycoprotein from the marine sponge Niphates erecta. European Journal of Biochemistry / Febs. 245: 47-53. PMID 9128723 DOI: 10.1111/J.1432-1033.1997.T01-1-00047.X  0.602
1997 Mimaki Y, Kuroda M, Kameyama A, Sashida Y, Hirano T, Oka K, Maekawa R, Wada T, Sugita K, Beutler JA. Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbs Bioorganic and Medicinal Chemistry Letters. 7: 633-636. DOI: 10.1016/S0960-894X(97)00071-1  0.376
1996 Beutler JA, Alvarado-Lindner AB, McCloud TG. Further studies on phorbol ester bioactivity in the Euphorbiaceae Annals of the Missouri Botanical Garden. 83: 530-533. DOI: 10.2307/2399992  0.304
1995 Erickson KL, Beutler JA, Gray GN, Cardellina JH, Boyd MR. Majapolene A, a cytotoxic peroxide, and related sesquiterpenes from the red alga Laurencia majuscula. Journal of Natural Products. 58: 1848-60. PMID 8691206 DOI: 10.1021/Np50126A007  0.662
1995 Erickson KL, Beutler JA, Cardellina JH, McMahon JB, Newman DJ, Boyd MR. A novel phorbol ester from Excoecaria agallocha. Journal of Natural Products. 58: 769-72. PMID 7623051 DOI: 10.1021/Np50119A020  0.623
1995 Beutler JA, Kashman Y, Tischler M, Cardellina JH, Gray GN, Currens MJ, Wall ME, Wani MC, Boyd MR. A reinvestigation of Maprounea triterpenes. Journal of Natural Products. 58: 1039-46. PMID 7561897 DOI: 10.1021/Np50121A008  0.376
1995 Erickson KL, Beutler JA, Cardellina JH, Boyd MR. Rottnestol, a new hemiketal from the sponge Haliclona sp. Tetrahedron. 51: 11953-11958. DOI: 10.1016/0040-4020(95)00761-V  0.606
1993 Beutler JA, Cardellina JH, Gray GN, Prather TR, Shoemaker RH, Boyd MR, Lin CM, Hamel E, Cragg GM. Two new cytotoxic chalcones from Calythropsis aurea. Journal of Natural Products. 56: 1718-22. PMID 8277311 DOI: 10.1021/Np50100A009  0.428
1993 Cardellina JH, Munro MH, Fuller RW, Manfredi KP, McKee TC, Tischler M, Bokesch HR, Gustafson KR, Beutler JA, Boyd MR. A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts. Journal of Natural Products. 56: 1123-9. PMID 8104236 DOI: 10.1021/Np50097A016  0.794
1993 Beutler JA, McKee TC, Fuller RW, Tischler M, Cardellina JH, Snader KM, McCloud TG, Boyd MR. Frequent occurrence of HIV-inhibitory sulphated polysaccharides in marine invertebrates Antiviral Chemistry and Chemotherapy. 4: 167-172. DOI: 10.1177/095632029300400306  0.377
1993 Beutler JA, Cardellina JH, Lin CM, Hamel E, Cragg GM, Boyd MR. Centaureidin, a cytotoxic flavone from Polymnia fruticosa, inhibits tubulin polymerization Bioorganic and Medicinal Chemistry Letters. 3: 581-584. DOI: 10.1016/S0960-894X(01)81233-6  0.42
1992 Beutler JA, Cardellina JH, McMahon JB, Boyd MR, Cragg GM. Anti-HIV and cytotoxic alkaloids from Buchenavia capitata. Journal of Natural Products. 55: 207-13. PMID 1624941 DOI: 10.1021/Np50080A008  0.389
1991 Schaufelberger DE, Chmurny GN, Beutler JA, Koleck MP, Alvarado AB, Schaufelberger BW, Muschik GM. Revised structure of bryostatin 3 and isolation of the bryostatin 3 26-ketone from Bugula neritina J Org Chem. 56: 2895-2900. DOI: 10.1021/Jo00008A054  0.327
1990 Beutler JA, Chmurny GN, Clark P, Metral CJ, Roman J, Forenza S. Two novel phenolics from Actinomadura verrucosospora. The Journal of Antibiotics. 43: 107-9. PMID 2307621 DOI: 10.7164/Antibiotics.43.107  0.335
1990 Schaufelberger DE, Alvarado AB, Andrews P, Beutler JA. Detection and quantitation of bryostatin 1 and 2 in Bugula neritina by combined high-performance liquid chromatography and 3H-phorbol dibutyrate displacemement J Liq Chromatogr. 13: 583-598. DOI: 10.1080/01483919008051807  0.302
1988 Beutler JA, Hilton BD, Clark P, Tempesta MS, Corley DG. Absolute and relative configuration of erythroskyrin. Journal of Natural Products. 51: 562-6. PMID 3404152 DOI: 10.1021/Np50057A018  0.319
1985 Beutler JA, Karbon EW, Brubaker AN, Malik R, Curtis DR, Enna SJ. Securinine alkaloids: a new class of GABA receptor antagonist. Brain Research. 330: 135-40. PMID 2985189 DOI: 10.1016/0006-8993(85)90014-9  0.467
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