Yinyan Tang, Ph.D. - Publications

2008 Stanford University, Palo Alto, CA 
Bioorganic and Biophysical Chemistry

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Harvey CJB, Tang M, Schlecht U, Horecka J, Fischer CR, Lin HC, Li J, Naughton B, Cherry J, Miranda M, Li YF, Chu AM, Hennessy JR, Vandova GA, Inglis D, ... Tang Y, et al. HEx: A heterologous expression platform for the discovery of fungal natural products. Science Advances. 4: eaar5459. PMID 29651464 DOI: 10.1126/sciadv.aar5459  1
2017 Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, ... ... Tang Y, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. PMID 29045385 DOI: 10.1038/nature24006  0.88
2016 Yamamoto T, Tsunematsu Y, Hara K, Suzuki T, Kishimoto S, Kawagishi H, Noguchi H, Hashimoto H, Tang Y, Hotta K, Watanabe K. Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis. Angewandte Chemie (International Ed. in English). PMID 27072782 DOI: 10.1002/anie.201600940  1
2016 Billingsley JM, DeNicola AB, Tang Y. Technology development for natural product biosynthesis in Saccharomyces cerevisiae. Current Opinion in Biotechnology. 42: 74-83. PMID 26994377 DOI: 10.1016/j.copbio.2016.02.033  1
2016 Lin HC, McMahon TC, Patel A, Corsello M, Simon A, Xu W, Zhao M, Houk KN, Garg NK, Tang Y. P450-Mediated Coupling of Indole Fragments to Forge Communesin and Unnatural Isomers. Journal of the American Chemical Society. PMID 26963294 DOI: 10.1021/jacs.6b01413  1
2016 Sato M, Winter JM, Kishimoto S, Noguchi H, Tang Y, Watanabe K. Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis. Organic Letters. PMID 26959241 DOI: 10.1021/acs.orglett.6b00380  1
2016 Bond C, Tang Y, Li L. Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases. Fungal Genetics and Biology : Fg & B. PMID 26850128 DOI: 10.1016/j.fgb.2016.01.005  1
2016 Tang Y, Dai F, Gu X, Wang Z, Zhang W. Secondary dislocation structures in a Ni-TiN system from the GMS and O-lattice theory Physica E: Low-Dimensional Systems and Nanostructures. 77: 97-101. DOI: 10.1016/j.physe.2015.11.007  0.68
2016 Xue Z, Tang Y, Duan X, Ye Y, Xie X, Zhou X. Ionic polymer-metal composite actuators obtained from sulfonated poly(ether ether sulfone) ion-exchange membranes Composites Part a: Applied Science and Manufacturing. 81: 13-21. DOI: 10.1016/j.compositesa.2015.11.007  0.4
2015 Noey EL, Tibrewal N, Jiménez-Osés G, Osuna S, Park J, Bond CM, Cascio D, Liang J, Zhang X, Huisman GW, Tang Y, Houk KN. Origins of stereoselectivity in evolved ketoreductases. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644568 DOI: 10.1073/pnas.1507910112  1
2015 Lv P, Xiao Y, Liu B, Wang Y, Zhang X, Sun H, Li F, Yao L, Zhang W, Liu L, Gao X, Wu M, Tang Y, Chen Q, Gong Q, et al. Dose-dependent effects of isoflurane on regional activity and neural network function: A resting-state fMRI study of 14 rhesus monkeys: An observational study. Neuroscience Letters. PMID 26633103 DOI: 10.1016/j.neulet.2015.11.037  0.68
2015 Cacho RA, Thuss J, Xu W, Sanichar R, Gao Z, Nguyen A, Vederas JC, Tang Y. Understanding Programming of Fungal Iterative Polyketide Synthases: the Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase. Journal of the American Chemical Society. PMID 26630357 DOI: 10.1021/jacs.5b11814  1
2015 Zhang W, Qu X, Chen B, Snyder M, Wang M, Li B, Tang Y, Chen H, Zhu W, Zhan L, Yin N, Li D, Li X, Liu Y, Zhang JJ, et al. Critical Roles of STAT3 in β-Adrenergic Functions in the Heart. Circulation. PMID 26628621 DOI: 10.1161/CIRCULATIONAHA.115.017472  0.68
2015 Wang Y, Chen CL, Pan QZ, Wu YY, Zhao JJ, Jiang SS, Chao J, Zhang XF, Zhang HX, Zhou ZQ, Tang Y, Huang XQ, Zhang JH, Xia JC. Decreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma. Oncotarget. PMID 26575170 DOI: 10.18632/oncotarget.6319  1
2015 Zhang H, Zhang Z, Yin X, Zhan J, Zhao Z, Tang Y, Liu C, Liu S, Zhong S. Early development of the fetal central sulcus on 7.0T magnetic resonance imaging. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. PMID 26562179 DOI: 10.1016/j.ijdevneu.2015.10.006  0.64
2015 Shi ZH, Li NG, Wang ZJ, Tang YP, Dong ZX, Zhang W, Zhang PX, Gu T, Wu WY, Yang JP, Duan JA. Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. European Journal of Medicinal Chemistry. 106: 95-105. PMID 26523667 DOI: 10.1016/j.ejmech.2015.10.039  0.68
2015 Jiang SS, Tang Y, Zhang YJ, Weng DS, Zhou ZG, Pan K, Pan QZ, Wang QJ, Liu Q, He J, Zhao JJ, Li J, Chen MS, Chang AE, Li Q, et al. A phase I clinical trial utilizing autologous tumor-infiltrating lymphocytes in patients with primary hepatocellular carcinoma. Oncotarget. PMID 26515587 DOI: 10.18632/oncotarget.5463  1
2015 Tang MC, Lin HC, Li D, Zou Y, Li J, Xu W, Cacho RA, Hillenmeyer ME, Garg NK, Tang Y. Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast. Journal of the American Chemical Society. PMID 26469304 DOI: 10.1021/jacs.5b06108  1
2015 Chen H, Dou Y, Tang Y, Zhang Z, Zheng X, Niu X, Yang J, Yu X, Diao Y. Isolation and Genomic Characterization of a Duck-Origin GPV-Related Parvovirus from Cherry Valley Ducklings in China. Plos One. 10: e0140284. PMID 26465143 DOI: 10.1371/journal.pone.0140284  1
2015 Shi ZH, Li NG, Shi QP, Zhang W, Dong ZX, Tang YP, Zhang PX, Gu T, Wu WY, Fang F, Xin-Xue, Li HM, Yang JP, Duan JA. Synthesis of scutellarein derivatives to increase biological activity and water solubility. Bioorganic & Medicinal Chemistry. PMID 26455656 DOI: 10.1016/j.bmc.2015.09.047  0.68
2015 Sato M, Yagishita F, Mino T, Uchiyama N, Patel A, Chooi YH, Goda Y, Xu W, Noguchi H, Yamamoto T, Hotta K, Houk KN, Tang Y, Watanabe K. Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition. Chembiochem : a European Journal of Chemical Biology. PMID 26360642 DOI: 10.1002/cbic.201500386  1
2015 Soliman S, Tang Y. Natural and engineered production of taxadiene with taxadiene synthase. Biotechnology and Bioengineering. 112: 229-35. PMID 25257933 DOI: 10.1002/bit.25468  1
2014 Winter JM, Tang Y. Natural products: Getting a handle on peptides. Nature Chemistry. 6: 1037-8. PMID 25411879 DOI: 10.1038/nchem.2117  1
2014 Zhao M, Liu Y, Hsieh RS, Wang N, Tai W, Joo KI, Wang P, Gu Z, Tang Y. Clickable protein nanocapsules for targeted delivery of recombinant p53 protein. Journal of the American Chemical Society. 136: 15319-25. PMID 25289975 DOI: 10.1021/ja508083g  1
2014 Arkin MR, Tang Y, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. Chemistry & Biology. 21: 1102-14. PMID 25237857 DOI: 10.1016/j.chembiol.2014.09.001  0.88
2014 Tsunematsu Y, Fukutomi M, Saruwatari T, Noguchi H, Hotta K, Tang Y, Watanabe K. Elucidation of pseurotin biosynthetic pathway points to trans-acting C-methyltransferase: generation of chemical diversity. Angewandte Chemie (International Ed. in English). 53: 8475-9. PMID 24939566 DOI: 10.1002/anie.201404804  1
2014 Zabala AO, Chooi YH, Choi MS, Lin HC, Tang Y. Fungal polyketide synthase product chain-length control by partnering thiohydrolase. Acs Chemical Biology. 9: 1576-86. PMID 24845309 DOI: 10.1021/cb500284t  1
2014 Hu Y, Dietrich D, Xu W, Patel A, Thuss JA, Wang J, Yin WB, Qiao K, Houk KN, Vederas JC, Tang Y. A carbonate-forming Baeyer-Villiger monooxygenase. Nature Chemical Biology. 10: 552-4. PMID 24838010 DOI: 10.1038/nchembio.1527  1
2014 Jiménez-Osés G, Osuna S, Gao X, Sawaya MR, Gilson L, Collier SJ, Huisman GW, Yeates TO, Tang Y, Houk KN. The role of distant mutations and allosteric regulation on LovD active site dynamics. Nature Chemical Biology. 10: 431-6. PMID 24727900 DOI: 10.1038/nchembio.1503  1
2014 Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area. Combinatorial Chemistry & High Throughput Screening. 17: 333-42. PMID 24661212 DOI: 10.2174/1386207317666140323133841  0.88
2014 Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y. Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway. Journal of the American Chemical Society. 136: 4426-36. PMID 24568283 DOI: 10.1021/ja500881e  1
2014 Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, et al. Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem. 9: 73-7, 2. PMID 24259468 DOI: 10.1002/cmdc.201300424  0.88
2013 Chooi YH, Hong YJ, Cacho RA, Tantillo DJ, Tang Y. A cytochrome P450 serves as an unexpected terpene cyclase during fungal meroterpenoid biosynthesis. Journal of the American Chemical Society. 135: 16805-8. PMID 24161266 DOI: 10.1021/ja408966t  1
2013 Dhingra S, Lind AL, Lin HC, Tang Y, Rokas A, Calvo AM. The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus. Plos One. 8: e77147. PMID 24116213 DOI: 10.1371/journal.pone.0077147  1
2013 Liu Y, Ding G, Li Y, Qu J, Ma S, Lv H, Liu Y, Wang W, Dai J, Tang Y, Yu S. Structures and absolute configurations of penicillactones A-C from an endophytic microorganism, Penicillium dangeardii Pitt. Organic Letters. 15: 5206-9. PMID 24093807 DOI: 10.1021/ol4023485  1
2013 Winter JM, Chiou G, Bothwell IR, Xu W, Garg NK, Luo M, Tang Y. Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain. Organic Letters. 15: 3774-7. PMID 23837609 DOI: 10.1021/ol401723h  1
2013 Walsh CT, Haynes SW, Ames BD, Gao X, Tang Y. Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. Acs Chemical Biology. 8: 1366-82. PMID 23659680 DOI: 10.1021/cb4001684  1
2013 Xu W, Chooi YH, Choi JW, Li S, Vederas JC, Da Silva NA, Tang Y. LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. Angewandte Chemie (International Ed. in English). 52: 6472-5. PMID 23653178 DOI: 10.1002/anie.201302406  1
2013 Chooi YH, Fang J, Liu H, Filler SG, Wang P, Tang Y. Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. Organic Letters. 15: 780-3. PMID 23368997 DOI: 10.1021/ol303435y  1
2013 Haynes SW, Gao X, Tang Y, Walsh CT. Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin. Acs Chemical Biology. 8: 741-8. PMID 23330675 DOI: 10.1021/cb3006787  1
2013 Xu W, Qiao K, Tang Y. Structural analysis of protein-protein interactions in type I polyketide synthases. Critical Reviews in Biochemistry and Molecular Biology. 48: 98-122. PMID 23249187 DOI: 10.3109/10409238.2012.745476  1
2012 Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, ... Tang Y, et al. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. Plos One. 7: e50864. PMID 23227217 DOI: 10.1371/journal.pone.0050864  0.88
2012 Winter JM, Sato M, Sugimoto S, Chiou G, Garg NK, Tang Y, Watanabe K. Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase. Journal of the American Chemical Society. 134: 17900-3. PMID 23072467 DOI: 10.1021/ja3090498  1
2012 Haynes SW, Gao X, Tang Y, Walsh CT. Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E. Journal of the American Chemical Society. 134: 17444-7. PMID 23030663 DOI: 10.1021/ja308371z  1
2012 Wang P, Kim W, Pickens LB, Gao X, Tang Y. Heterologous expression and manipulation of three tetracycline biosynthetic pathways. Angewandte Chemie (International Ed. in English). 51: 11136-40. PMID 23024027 DOI: 10.1002/anie.201205426  1
2012 Cacho RA, Jiang W, Chooi YH, Walsh CT, Tang Y. Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. Journal of the American Chemical Society. 134: 16781-90. PMID 22998630 DOI: 10.1021/ja307220z  1
2012 Zabala AO, Xu W, Chooi YH, Tang Y. Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation. Chemistry & Biology. 19: 1049-59. PMID 22921072 DOI: 10.1016/j.chembiol.2012.07.004  1
2012 Gao X, Haynes SW, Ames BD, Wang P, Vien LP, Walsh CT, Tang Y. Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nature Chemical Biology. 8: 823-30. PMID 22902615 DOI: 10.1038/nchembio.1047  1
2012 Ames BD, Nguyen C, Bruegger J, Smith P, Xu W, Ma S, Wong E, Wong S, Xie X, Li JW, Vederas JC, Tang Y, Tsai SC. Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 11144-9. PMID 22733743 DOI: 10.1073/pnas.1113029109  1
2012 Zhou H, Gao Z, Qiao K, Wang J, Vederas JC, Tang Y. A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nature Chemical Biology. 8: 331-3. PMID 22406519 DOI: 10.1038/nchembio.912  1
2012 Winter JM, Tang Y. Synthetic biological approaches to natural product biosynthesis Current Opinion in Biotechnology. 23: 736-743. PMID 22221832 DOI: 10.1016/j.copbio.2011.12.016  1
2012 Zabala AO, Cacho RA, Tang Y. Protein engineering towards natural product synthesis and diversification. Journal of Industrial Microbiology & Biotechnology. 39: 227-41. PMID 22006344 DOI: 10.1007/s10295-011-1044-2  1
2012 Smanski MJ, Qu XD, Liu W, Shen B, Tang Y, Yu Y, Deng ZX. Biosynthesis of Pharmaceutical Natural Products and Their Pathway Engineering Organic Chemistry - Breakthroughs and Perspectives. 125-180. DOI: 10.1002/9783527664801.ch4  1
2011 Pickens LB, Tang Y, Chooi YH. Metabolic engineering for the production of natural products. Annual Review of Chemical and Biomolecular Engineering. 2: 211-36. PMID 22432617 DOI: 10.1146/annurev-chembioeng-061010-114209  1
2011 Qiao K, Chooi YH, Tang Y. Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1. Metabolic Engineering. 13: 723-32. PMID 21983160 DOI: 10.1016/j.ymben.2011.09.008  1
2011 Pickens LB, Sawaya MR, Rasool H, Pashkov I, Yeates TO, Tang Y. Structural and biochemical characterization of the salicylyl-acyltranferase SsfX3 from a tetracycline biosynthetic pathway. The Journal of Biological Chemistry. 286: 41539-51. PMID 21965680 DOI: 10.1074/jbc.M111.299859  1
2011 Ames BD, Haynes SW, Gao X, Evans BS, Kelleher NL, Tang Y, Walsh CT. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 50: 8756-69. PMID 21899262 DOI: 10.1021/bi201302w  1
2011 Li Y, Chooi YH, Sheng Y, Valentine JS, Tang Y. Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. Journal of the American Chemical Society. 133: 15773-85. PMID 21866960 DOI: 10.1021/ja206906d  1
2011 Tang Y, Wells JA, Arkin MR. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. The Journal of Biological Chemistry. 286: 34147-54. PMID 21828056 DOI: 10.1074/jbc.M111.247627  0.88
2011 Haynes SW, Ames BD, Gao X, Tang Y, Walsh CT. Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. Biochemistry. 50: 5668-79. PMID 21591693 DOI: 10.1021/bi2004922  1
2011 Joo KI, Fang Y, Liu Y, Xiao L, Gu Z, Tai A, Lee CL, Tang Y, Wang P. Enhanced real-time monitoring of adeno-associated virus trafficking by virus-quantum dot conjugates. Acs Nano. 5: 3523-35. PMID 21473596 DOI: 10.1021/nn102651p  1
2011 Qiao K, Zhou H, Xu W, Zhang W, Garg N, Tang Y. A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines. Organic Letters. 13: 1758-61. PMID 21384820 DOI: 10.1021/ol200288w  1
2011 Gao X, Chooi YH, Ames BD, Wang P, Walsh CT, Tang Y. Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. Journal of the American Chemical Society. 133: 2729-41. PMID 21299212 DOI: 10.1021/ja1101085  1
2011 Meehan MJ, Xie X, Zhao X, Xu W, Tang Y, Dorrestein PC. FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF. Biochemistry. 50: 287-99. PMID 21069965 DOI: 10.1021/bi1014776  1
2010 Zhou H, Qiao K, Gao Z, Vederas JC, Tang Y. Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. The Journal of Biological Chemistry. 285: 41412-21. PMID 20961859 DOI: 10.1074/jbc.M110.183574  1
2010 Xu W, Cai X, Jung ME, Tang Y. Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae. Journal of the American Chemical Society. 132: 13604-7. PMID 20828130 DOI: 10.1021/ja107084d  1
2010 Pickens LB, Tang Y. Oxytetracycline biosynthesis. The Journal of Biological Chemistry. 285: 27509-15. PMID 20522541 DOI: 10.1074/jbc.R110.130419  1
2010 Zhou H, Qiao K, Gao Z, Meehan MJ, Li JW, Zhao X, Dorrestein PC, Vederas JC, Tang Y. Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. Journal of the American Chemical Society. 132: 4530-1. PMID 20222707 DOI: 10.1021/ja100060k  1
2009 Pickens LB, Kim W, Wang P, Zhou H, Watanabe K, Gomi S, Tang Y. Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575. Journal of the American Chemical Society. 131: 17677-89. PMID 19908837 DOI: 10.1021/ja907852c  1
2009 Gao X, Xie X, Pashkov I, Sawaya MR, Laidman J, Zhang W, Cacho R, Yeates TO, Tang Y. Directed evolution and structural characterization of a simvastatin synthase. Chemistry & Biology. 16: 1064-74. PMID 19875080 DOI: 10.1016/j.chembiol.2009.09.017  1
2009 Tang Y, Wang P, Van Deventer JA, Link AJ, Tirrell DA. Introduction of an aliphatic ketone into recombinant proteins in a bacterial strain that overexpresses an editing-impaired leucyl-tRNA synthetase. Chembiochem : a European Journal of Chemical Biology. 10: 2188-90. PMID 19670197 DOI: 10.1002/cbic.200900407  1
2009 Wang M, Zhou H, Wirz M, Tang Y, Boddy CN. A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading. Biochemistry. 48: 6288-90. PMID 19530704 DOI: 10.1021/bi9009049  1
2009 Zhan J, Qiao K, Tang Y. Investigation of tailoring modifications in pradimicin biosynthesis. Chembiochem : a European Journal of Chemical Biology. 10: 1447-52. PMID 19431159 DOI: 10.1002/cbic.200900082  1
2009 Pickens LB, Tang Y. Decoding and engineering tetracycline biosynthesis. Metabolic Engineering. 11: 69-75. PMID 19007902 DOI: 10.1016/j.ymben.2008.10.001  1
2009 Xie X, Pashkov I, Gao X, Guerrero JL, Yeates TO, Tang Y. Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity. Biotechnology and Bioengineering. 102: 20-8. PMID 18988191 DOI: 10.1002/bit.22028  1
2008 Zhou H, Xie X, Tang Y. Engineering natural products using combinatorial biosynthesis and biocatalysis. Current Opinion in Biotechnology. 19: 590-6. PMID 18992814 DOI: 10.1016/j.copbio.2008.10.012  1
2008 Zhan J, Watanabe K, Tang Y. Synergistic actions of a monooxygenase and cyclases in aromatic polyketide biosynthesis. Chembiochem : a European Journal of Chemical Biology. 9: 1710-5. PMID 18604835 DOI: 10.1002/cbic.200800178  0.68
2008 Zhou H, Zhan J, Watanabe K, Xie X, Tang Y. A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proceedings of the National Academy of Sciences of the United States of America. 105: 6249-54. PMID 18427109 DOI: 10.1073/pnas.0800657105  1
2008 Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J. Identifying the minimal enzymes required for anhydrotetracycline biosynthesis. Journal of the American Chemical Society. 130: 6068-9. PMID 18422316 DOI: 10.1021/ja800951e  1
2008 Kapur S, Worthington A, Tang Y, Cane DE, Burkart MD, Khosla C. Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. Bioorganic & Medicinal Chemistry Letters. 18: 3034-8. PMID 18243693 DOI: 10.1016/j.bmcl.2008.01.073  0.64
2007 Tang Y, Chen AY, Kim CY, Cane DE, Khosla C. Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. Chemistry & Biology. 14: 931-43. PMID 17719492 DOI: 10.1016/j.chembiol.2007.07.012  0.64
2007 Xie X, Wong WW, Tang Y. Improving simvastatin bioconversion in Escherichia coli by deletion of bioH. Metabolic Engineering. 9: 379-86. PMID 17625941 DOI: 10.1016/j.ymben.2007.05.006  1
2007 Zhang W, Wilke BI, Zhan J, Watanabe K, Boddy CN, Tang Y. A new mechanism for benzopyrone formation in aromatic polyketide biosynthesis. Journal of the American Chemical Society. 129: 9304-5. PMID 17625867 DOI: 10.1021/ja0736919  1
2007 Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE. Structure and mechanism of the 6-deoxyerythronolide B synthase. Annual Review of Biochemistry. 76: 195-221. PMID 17328673 DOI: 10.1146/annurev.biochem.76.053105.093515  0.64
2007 Xie X, Tang Y. Efficient synthesis of simvastatin by use of whole-cell biocatalysis. Applied and Environmental Microbiology. 73: 2054-60. PMID 17277201 DOI: 10.1128/AEM.02820-06  1
2006 Tang Y, Lee HY, Tang Y, Kim CY, Mathews I, Khosla C. Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). Biochemistry. 45: 14085-93. PMID 17115703 DOI: 10.1021/bi061187v  0.64
2006 Xie X, Watanabe K, Wojcicki WA, Wang CC, Tang Y. Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chemistry & Biology. 13: 1161-9. PMID 17113998 DOI: 10.1016/j.chembiol.2006.09.008  1
2006 Tang Y, Kim CY, Mathews II, Cane DE, Khosla C. The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America. 103: 11124-9. PMID 16844787 DOI: 10.1073/pnas.0601924103  0.64
2006 Bethune MT, Strop P, Tang Y, Sollid LM, Khosla C. Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease. Chemistry & Biology. 13: 637-47. PMID 16793521 DOI: 10.1016/j.chembiol.2006.04.008  0.64
2005 Lee TS, Khosla C, Tang Y. Orthogonal protein interactions in spore pigment producing and antibiotic producing polyketide synthases. The Journal of Antibiotics. 58: 663-6. PMID 16392683 DOI: 10.1038/ja.2005.91  1
2005 Lee TS, Khosla C, Tang Y. Engineered biosynthesis of aklanonic acid analogues. Journal of the American Chemical Society. 127: 12254-62. PMID 16131203 DOI: 10.1021/ja051429z  1
2005 Khosla C, Tang Y. Chemistry. A new route to designer antibiotics. Science (New York, N.Y.). 308: 367-8. PMID 15831747 DOI: 10.1126/science.1111415  1
2004 Kim CY, Alekseyev VY, Chen AY, Tang Y, Cane DE, Khosla C. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. Biochemistry. 43: 13892-8. PMID 15518537 DOI: 10.1021/bi048418n  0.64
2004 Kumar P, Khosla C, Tang Y. Manipulation and analysis of polyketide synthases. Methods in Enzymology. 388: 269-93. PMID 15289078 DOI: 10.1016/S0076-6879(04)88023-6  1
2004 Tang Y, Koppisch AT, Khosla C. The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units. Biochemistry. 43: 9546-55. PMID 15260498 DOI: 10.1021/bi049157k  1
2004 Tang Y, Lee TS, Khosla C. Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. Plos Biology. 2: E31. PMID 14966533 DOI: 10.1371/journal.pbio.0020031  1
2004 Tang Y, Lee TS, Lee HY, Khosla C. Exploring the biosynthetic potential of bimodular aromatic polyketide synthases Tetrahedron. 60: 7659-7671. DOI: 10.1016/j.tet.2004.05.118  1
2003 Tang Y, Tsai SC, Khosla C. Polyketide chain length control by chain length factor. Journal of the American Chemical Society. 125: 12708-9. PMID 14558809 DOI: 10.1021/ja0378759  1
2003 Cirino PC, Tang Y, Takahashi K, Tirrell DA, Arnold FH. Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity. Biotechnology and Bioengineering. 83: 729-34. PMID 12889037 DOI: 10.1002/bit.10718  1
2003 Wang P, Tang Y, Tirrell DA. Incorporation of trifluoroisoleucine into proteins in vivo. Journal of the American Chemical Society. 125: 6900-6. PMID 12783542 DOI: 10.1021/ja0298287  1
2003 Tang Y, Lee TS, Kobayashi S, Khosla C. Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. Biochemistry. 42: 6588-95. PMID 12767243 DOI: 10.1021/bi0341962  1
2002 Tang Y, Tirrell DA. Attenuation of the editing activity of the Escherichia coli leucyl-tRNA synthetase allows incorporation of novel amino acids into proteins in vivo. Biochemistry. 41: 10635-45. PMID 12186549 DOI: 10.1021/bi026130x  1
2001 Tang Y, Ghirlanda G, Petka WA, Nakajima T, DeGrado WF, Tirrell DA. Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability This work was supported by a grant from the U.S. Army Research Office. Y. Tang is supported by a Whitaker Graduate Research Fellowship. We thank Dr. Gary Hathaway for performing matrix-assisted laser desorption/ionization analyses. Angewandte Chemie (International Ed. in English). 40: 1494-1496. PMID 11317312 DOI: 10.1002/1521-3773(20010417)40:8<1494::AID-ANIE1494>3.0.CO;2-X  1
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