Year |
Citation |
Score |
2017 |
Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, ... ... Tang Y, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. PMID 29045385 DOI: 10.1038/nature24006 |
0.88 |
|
2015 |
Noey EL, Tibrewal N, Jiménez-Osés G, Osuna S, Park J, Bond CM, Cascio D, Liang J, Zhang X, Huisman GW, Tang Y, Houk KN. Origins of stereoselectivity in evolved ketoreductases. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644568 DOI: 10.1073/pnas.1507910112 |
1 |
|
2015 |
Cacho RA, Thuss J, Xu W, Sanichar R, Gao Z, Nguyen A, Vederas JC, Tang Y. Understanding Programming of Fungal Iterative Polyketide Synthases: the Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase. Journal of the American Chemical Society. PMID 26630357 DOI: 10.1021/jacs.5b11814 |
1 |
|
2015 |
Tang MC, Lin HC, Li D, Zou Y, Li J, Xu W, Cacho RA, Hillenmeyer ME, Garg NK, Tang Y. Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast. Journal of the American Chemical Society. PMID 26469304 DOI: 10.1021/jacs.5b06108 |
1 |
|
2015 |
Chen H, Dou Y, Tang Y, Zhang Z, Zheng X, Niu X, Yang J, Yu X, Diao Y. Isolation and Genomic Characterization of a Duck-Origin GPV-Related Parvovirus from Cherry Valley Ducklings in China. Plos One. 10: e0140284. PMID 26465143 DOI: 10.1371/journal.pone.0140284 |
1 |
|
2014 |
Arkin MR, Tang Y, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. Chemistry & Biology. 21: 1102-14. PMID 25237857 DOI: 10.1016/j.chembiol.2014.09.001 |
0.88 |
|
2014 |
Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area. Combinatorial Chemistry & High Throughput Screening. 17: 333-42. PMID 24661212 DOI: 10.2174/1386207317666140323133841 |
0.88 |
|
2014 |
Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, et al. Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem. 9: 73-7, 2. PMID 24259468 DOI: 10.1002/cmdc.201300424 |
0.88 |
|
2012 |
Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, ... Tang Y, et al. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. Plos One. 7: e50864. PMID 23227217 DOI: 10.1371/journal.pone.0050864 |
0.88 |
|
2011 |
Tang Y, Wells JA, Arkin MR. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. The Journal of Biological Chemistry. 286: 34147-54. PMID 21828056 DOI: 10.1074/jbc.M111.247627 |
0.88 |
|
2008 |
Kapur S, Worthington A, Tang Y, Cane DE, Burkart MD, Khosla C. Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. Bioorganic & Medicinal Chemistry Letters. 18: 3034-8. PMID 18243693 DOI: 10.1016/j.bmcl.2008.01.073 |
0.64 |
|
2007 |
Tang Y, Chen AY, Kim CY, Cane DE, Khosla C. Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. Chemistry & Biology. 14: 931-43. PMID 17719492 DOI: 10.1016/j.chembiol.2007.07.012 |
0.64 |
|
2007 |
Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE. Structure and mechanism of the 6-deoxyerythronolide B synthase. Annual Review of Biochemistry. 76: 195-221. PMID 17328673 DOI: 10.1146/annurev.biochem.76.053105.093515 |
0.64 |
|
2006 |
Tang Y, Lee HY, Tang Y, Kim CY, Mathews I, Khosla C. Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). Biochemistry. 45: 14085-93. PMID 17115703 DOI: 10.1021/bi061187v |
0.64 |
|
2006 |
Tang Y, Kim CY, Mathews II, Cane DE, Khosla C. The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America. 103: 11124-9. PMID 16844787 DOI: 10.1073/pnas.0601924103 |
0.64 |
|
2006 |
Bethune MT, Strop P, Tang Y, Sollid LM, Khosla C. Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease. Chemistry & Biology. 13: 637-47. PMID 16793521 DOI: 10.1016/j.chembiol.2006.04.008 |
0.64 |
|
2005 |
Lee TS, Khosla C, Tang Y. Orthogonal protein interactions in spore pigment producing and antibiotic producing polyketide synthases. The Journal of Antibiotics. 58: 663-6. PMID 16392683 DOI: 10.1038/ja.2005.91 |
1 |
|
2005 |
Lee TS, Khosla C, Tang Y. Engineered biosynthesis of aklanonic acid analogues. Journal of the American Chemical Society. 127: 12254-62. PMID 16131203 DOI: 10.1021/ja051429z |
1 |
|
2005 |
Khosla C, Tang Y. Chemistry. A new route to designer antibiotics. Science (New York, N.Y.). 308: 367-8. PMID 15831747 DOI: 10.1126/science.1111415 |
1 |
|
2004 |
Kim CY, Alekseyev VY, Chen AY, Tang Y, Cane DE, Khosla C. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. Biochemistry. 43: 13892-8. PMID 15518537 DOI: 10.1021/bi048418n |
0.64 |
|
2004 |
Kumar P, Khosla C, Tang Y. Manipulation and analysis of polyketide synthases. Methods in Enzymology. 388: 269-93. PMID 15289078 DOI: 10.1016/S0076-6879(04)88023-6 |
1 |
|
2004 |
Tang Y, Koppisch AT, Khosla C. The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units. Biochemistry. 43: 9546-55. PMID 15260498 DOI: 10.1021/bi049157k |
1 |
|
2004 |
Tang Y, Lee TS, Khosla C. Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. Plos Biology. 2: E31. PMID 14966533 DOI: 10.1371/journal.pbio.0020031 |
1 |
|
2003 |
Tang Y, Tsai SC, Khosla C. Polyketide chain length control by chain length factor. Journal of the American Chemical Society. 125: 12708-9. PMID 14558809 DOI: 10.1021/ja0378759 |
1 |
|
2003 |
Tang Y, Lee TS, Kobayashi S, Khosla C. Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. Biochemistry. 42: 6588-95. PMID 12767243 DOI: 10.1021/bi0341962 |
1 |
|
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