Ralph E. Kleiner, Ph.D. - Publications

Affiliations: 
2011 Harvard University, Cambridge, MA, United States 
Area:
The Chemistry of Molecular Evolution

13 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Aleem SU, Georghiou G, Kleiner RE, Guja KE, Craddock BP, Lyczek A, Chan AI, Garcia-Diaz M, Miller WT, Liu DR, Seeliger MA. Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles. Cell Chemical Biology. PMID 27593110 DOI: 10.1016/j.chembiol.2016.07.017  0.56
2016 Ti SC, Pamula MC, Howes SC, Duellberg C, Cade NI, Kleiner RE, Forth S, Surrey T, Nogales E, Kapoor TM. Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends. Developmental Cell. 37: 72-84. PMID 27046833 DOI: 10.1016/j.devcel.2016.03.003  0.56
2015 Kleiner RE, Verma P, Molloy KR, Chait BT, Kapoor TM. Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response. Nature Chemical Biology. 11: 807-14. PMID 26344695 DOI: 10.1038/nchembio.1908  0.56
2014 Maianti JP, McFedries A, Foda ZH, Kleiner RE, Du XQ, Leissring MA, Tang WJ, Charron MJ, Seeliger MA, Saghatelian A, Liu DR. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. 511: 94-8. PMID 24847884 DOI: 10.1038/nature13297  0.56
2013 Kleiner RE, Kapoor TM. Bumping up kinase activity with an ATP-derived neo-substrate. Cell. 154: 716-8. PMID 23953104 DOI: 10.1016/j.cell.2013.07.043  0.56
2013 Kleiner RE, Ti SC, Kapoor TM. Site-specific chemistry on the microtubule polymer. Journal of the American Chemical Society. 135: 12520-3. PMID 23930594 DOI: 10.1021/ja405199h  0.56
2012 Georghiou G, Kleiner RE, Pulkoski-Gross M, Liu DR, Seeliger MA. Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles. Nature Chemical Biology. 8: 366-74. PMID 22344177 DOI: 10.1038/nchembio.792  0.56
2011 Kleiner RE, Dumelin CE, Liu DR. Small-molecule discovery from DNA-encoded chemical libraries. Chemical Society Reviews. 40: 5707-17. PMID 21674077 DOI: 10.1039/c1cs15076f  0.56
2010 Kleiner RE, Dumelin CE, Tiu GC, Sakurai K, Liu DR. In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors. Journal of the American Chemical Society. 132: 11779-91. PMID 20681606 DOI: 10.1021/ja104903x  0.56
2010 Brudno Y, Birnbaum ME, Kleiner RE, Liu DR. An in vitro translation, selection and amplification system for peptide nucleic acids. Nature Chemical Biology. 6: 148-55. PMID 20081830 DOI: 10.1038/nchembio.280  0.56
2008 Kleiner RE, Brudno Y, Birnbaum ME, Liu DR. DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes. Journal of the American Chemical Society. 130: 4646-59. PMID 18341334 DOI: 10.1021/ja0753997  0.56
2005 Bradley LH, Kleiner RE, Wang AF, Hecht MH, Wood DW. An intein-based genetic selection allows the construction of a high-quality library of binary patterned de novo protein sequences. Protein Engineering, Design & Selection : Peds. 18: 201-7. PMID 15849217 DOI: 10.1093/protein/gzi020  0.56
2000 Kleiner RE. The new science of staffing Chemical Innovation. 30: 39-44.  0.4
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