Leslie A. Dakin, Ph.D. - Publications

Affiliations: 
2005 Boston University, Boston, MA, United States 
Area:
synthetic organic chemistry

24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Taylor AM, Côté A, Hewitt MC, Pastor R, Leblanc Y, Nasveschuk CG, Romero FA, Crawford TD, Cantone N, Jayaram H, Setser J, Murray J, Beresini MH, de Leon Boenig G, Chen Z, ... ... Dakin LA, et al. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Medicinal Chemistry Letters. 7: 531-536. PMID 27190605 DOI: 10.1021/acsmedchemlett.6b00075  0.92
2015 Gehling VS, Vaswani RG, Nasveschuk CG, Duplessis M, Iyer P, Balasubramanian S, Zhao F, Good AC, Campbell R, Lee C, Dakin LA, Cook AS, Gagnon A, Harmange JC, Audia JE, et al. Discovery, design, and synthesis of indole-based EZH2 inhibitors Bioorganic and Medicinal Chemistry Letters. 25: 3644-3649. DOI: 10.1016/j.bmcl.2015.06.056  0.92
2014 Bradley WD, Arora S, Busby J, Balasubramanian S, Gehling VS, Nasveschuk CG, Vaswani RG, Yuan CC, Hatton C, Zhao F, Williamson KE, Iyer P, Méndez J, Campbell R, Cantone N, ... ... Dakin LA, et al. EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation. Chemistry & Biology. 21: 1463-75. PMID 25457180 DOI: 10.1016/j.chembiol.2014.09.017  0.92
2014 Vaswani RG, Albrecht BK, Audia JE, Côté A, Dakin LA, Duplessis M, Gehling VS, Harmange JC, Hewitt MC, Leblanc Y, Nasveschuk CG, Taylor AM. A practical synthesis of indoles via a Pd-catalyzed C-N ring formation. Organic Letters. 16: 4114-7. PMID 25068576 DOI: 10.1021/ol5018118  0.92
2014 Keeton EK, McEachern K, Dillman KS, Palakurthi S, Cao Y, Grondine MR, Kaur S, Wang S, Chen Y, Wu A, Shen M, Gibbons FD, Lamb ML, Zheng X, Stone RM, ... ... Dakin LA, et al. AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood. 123: 905-13. PMID 24363397 DOI: 10.1182/blood-2013-04-495366  0.92
2013 Ward RA, Anderton MJ, Ashton S, Bethel PA, Box M, Butterworth S, Colclough N, Chorley CG, Chuaqui C, Cross DA, Dakin LA, Debreczeni JÉ, Eberlein C, Finlay MR, Hill GB, et al. Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR). Journal of Medicinal Chemistry. 56: 7025-48. PMID 23930994 DOI: 10.1021/jm400822z  0.92
2013 Scott DA, Dakin LA, Daly K, Del Valle DJ, Diebold RB, Drew L, Ezhuthachan J, Gero TW, Ogoe CA, Omer CA, Redmond SP, Repik G, Thakur K, Ye Q, Zheng X. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorganic & Medicinal Chemistry Letters. 23: 4591-6. PMID 23842474 DOI: 10.1016/j.bmcl.2013.06.031  0.92
2012 Dakin LA, Block MH, Chen H, Code E, Dowling JE, Feng X, Ferguson AD, Green I, Hird AW, Howard T, Keeton EK, Lamb ML, Lyne PD, Pollard H, Read J, et al. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorganic & Medicinal Chemistry Letters. 22: 4599-604. PMID 22727640 DOI: 10.1016/j.bmcl.2012.05.098  0.92
2012 Yang B, Hird AW, Russell DJ, Fauber BP, Dakin LA, Zheng X, Su Q, Godin R, Brassil P, Devereaux E, Janetka JW. Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO Bioorganic and Medicinal Chemistry Letters. 22: 4907-4911. PMID 22704236 DOI: 10.1016/j.bmcl.2012.04.104  0.92
2011 Scott DA, Dakin LA, Del Valle DJ, Diebold RB, Drew L, Gero TW, Ogoe CA, Omer CA, Repik G, Thakur K, Ye Q, Zheng X. 3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor. Bioorganic & Medicinal Chemistry Letters. 21: 1382-4. PMID 21295474 DOI: 10.1016/j.bmcl.2011.01.033  0.92
2009 Scott DA, Bell KJ, Campbell CT, Cook DJ, Dakin LA, Del Valle DJ, Drew L, Gero TW, Hattersley MM, Omer CA, Tyurin B, Zheng X. 3-amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile. Bioorganic & Medicinal Chemistry Letters. 19: 701-5. PMID 19114305 DOI: 10.1016/j.bmcl.2008.12.044  0.92
2009 Lyne PD, Aquila B, Cook DJ, Dakin LA, Ezhuthachan J, Ioannidis S, Pontz T, Su M, Ye Q, Zheng X, Block MH, Cowen S, Deegan TL, Lee JW, Scott DA, et al. Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity. Bioorganic & Medicinal Chemistry Letters. 19: 1026-9. PMID 19097792 DOI: 10.1016/j.bmcl.2008.10.053  0.92
2008 Scott DA, Aquila BM, Bebernitz GA, Cook DJ, Dakin LA, Deegan TL, Hattersley MM, Ioannidis S, Lyne PD, Omer CA, Ye M, Zheng X. Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer. Bioorganic & Medicinal Chemistry Letters. 18: 4794-7. PMID 18694641 DOI: 10.1016/j.bmcl.2008.07.093  0.92
2007 Froimowitz M, Gu Y, Dakin LA, Nagafuji PM, Kelley CJ, Parrish D, Deschamps JR, Janowsky A. Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter. Journal of Medicinal Chemistry. 50: 219-32. PMID 17228864 DOI: 10.1021/jm0608614  0.92
2007 Su Q, Dakin LA, Panek JS. [4 + 2]-Annulations of chiral organosilanes: Application to the total synthesis of leucascandrolide A Journal of Organic Chemistry. 72: 2-24. PMID 17194076 DOI: 10.1021/jo0610412  0.92
2005 Froimowitz M, Gu Y, Dakin LA, Kelley CJ, Parrish D, Deschamps JR. Vinylogous amide analogs of methylphenidate. Bioorganic & Medicinal Chemistry Letters. 15: 3044-7. PMID 15908207 DOI: 10.1016/j.bmcl.2005.04.034  0.92
2003 Dakin LA, Panek JS. Enantioselective [4 + 2]-Annulation of Chiral Crotylsilanes: Application to the Synthesis of a C1-C22 Fragment of Leucascandrolide A Organic Letters. 5: 3995-3998. PMID 14535762 DOI: 10.1021/ol035581m  0.92
2003 Langille NF, Dakin LA, Panek JS. A mild, chemoselective protocol for the removal of thioketals and thioacetals mediated by Dess-Martin periodinane. Organic Letters. 5: 575-8. PMID 12583773 DOI: 10.1021/ol027518n  1
2003 Langille NF, Dakin LA, Panek JS. A mild, chemoselective protocol for the removal of thioketals and thioacetals mediated by Dess-Martin periodinane Organic Letters. 5: 575-578. DOI: 10.1021/ol027518n  0.92
2002 Dakin LA, Langille NF, Panek JS. Synthesis of the C1'-C11' oxazole-containing side chain of leucascandrolide A. Application of a Sonogashira cross-coupling. The Journal of Organic Chemistry. 67: 6812-5. PMID 12227815  1
2002 Langille NF, Dakin LA, Panek JS. Sonogashira coupling of functionalized trifloyl oxazoles and thiazoles with terminal alkynes: Synthesis of disubstituted heterocycles Organic Letters. 4: 2485-2488. PMID 12123357 DOI: 10.1021/ol026099r  0.92
2002 Dakin LA, Langille NF, Panek JS. Synthesis of the C1′-C11′ oxazole-containing side chain of leucascandrolide A. Application of a Sonogashira cross-coupling Journal of Organic Chemistry. 67: 6812-6815. DOI: 10.1021/jo0204000  0.92
1998 Dakin LA, Schaus SE, Jacobsen EN, Panek JS. Carbenoid insertions into the silicon-hydrogen bond catalyzed by chiral copper (I) Schiff base complexes Tetrahedron Letters. 39: 8947-8950.  0.92
1998 Dakin LA, Tu Y, Panek JS, Wang ZX, Shi Y, Frohn M, Zhang JR, Denmark SE, Forfaes DC, Hays DS, DePue J, Wilde RG, Wu Z, Crudden CM, Matsuhashi H. Recent advances in catalytic asymmetric epoxidation of trisubstituted and trans-olefins Chemtracts. 11: 531-536.  0.92
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