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Philip A. Beachy - Publications

Biochemistry Stanford University, Palo Alto, CA 
Hedgehog proteins and other extracellular signals in morphogenesis

123 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, ... ... Beachy PA, et al. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science (New York, N.Y.). 376: eabl4896. PMID 35549404 DOI: 10.1126/science.abl4896  0.737
2021 Wang Q, Asarnow DE, Ding K, Mann RK, Hatakeyama J, Zhang Y, Ma Y, Cheng Y, Beachy PA. Dispatched uses Na flux to power release of lipid-modified Hedgehog. Nature. PMID 34707294 DOI: 10.1038/s41586-021-03996-0  0.436
2020 Zhang Y, Lu WJ, Bulkley DP, Liang J, Ralko A, Han S, Roberts KJ, Li A, Cho W, Cheng Y, Manglik A, Beachy PA. Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit. Proceedings of the National Academy of Sciences of the United States of America. PMID 33139559 DOI: 10.1073/pnas.2011560117  0.691
2019 Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A. Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature. PMID 31263273 DOI: 10.2210/Pdb6O3C/Pdb  0.42
2018 Zhang Y, Bulkley DP, Xin Y, Roberts KJ, Asarnow DE, Sharma A, Myers BR, Cho W, Cheng Y, Beachy PA. Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched. Cell. PMID 30415841 DOI: 10.1016/J.Cell.2018.10.026  0.374
2018 Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, ... ... Beachy PA, et al. Cilia-Associated Oxysterols Activate Smoothened. Molecular Cell. 72: 316-327.e5. PMID 30340023 DOI: 10.1016/J.Molcel.2018.08.034  0.387
2018 Beachy P, Cai S, Ma Y, Hatakeyama J, Zhao C, Stoffels M, Verhaegh W, Stolpe Avd, Pegram M. Abstract P5-03-11: Targeted disruption of transcriptional effector GLI2 attenuates breast tumor growth and metastasis Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P5-03-11  0.399
2018 Kiss B, Kershner A, Lu W, Beachy P. MP81-10 MOLECULAR CHARACTERIZATION OF THE MURINE URINARY BLADDER USING SINGLE CELL RNA SEQUENCING Journal of Urology. 199. DOI: 10.1016/J.Juro.2018.02.2718  0.67
2017 Lu WJ, Mann RK, Nguyen A, Bi T, Silverstein M, Tang JY, Chen X, Beachy PA. Neuronal delivery of Hedgehog directs spatial patterning of taste organ regeneration. Proceedings of the National Academy of Sciences of the United States of America. PMID 29279401 DOI: 10.1073/Pnas.1719109115  0.692
2017 Myers BR, Neahring L, Zhang Y, Roberts KJ, Beachy PA. Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium. Proceedings of the National Academy of Sciences of the United States of America. PMID 29229834 DOI: 10.1073/Pnas.1717891115  0.399
2017 Hsia EYC, Zhang Y, Tran HS, Lim A, Chou YH, Lan G, Beachy PA, Zheng X. Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs. Nature Communications. 8: 1275. PMID 29097673 DOI: 10.1038/S41467-017-01364-Z  0.438
2017 Roberts KJ, Kershner AM, Beachy PA. The Stromal Niche for Epithelial Stem Cells: A Template for Regeneration and a Brake on Malignancy. Cancer Cell. 32: 404-410. PMID 29017054 DOI: 10.1016/J.Ccell.2017.08.007  0.358
2017 Zhao C, Cai S, Shin K, Lim A, Kalisky T, Lu WJ, Clarke MF, Beachy PA. Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells. Science (New York, N.Y.). PMID 28280246 DOI: 10.1126/Science.Aal3485  0.715
2017 Tevlin R, Seo EY, Marecic O, McArdle A, Tong X, Zimdahl B, Malkovskiy A, Sinha R, Gulati G, Li X, Wearda T, Morganti R, Lopez M, Ransom RC, Duldulao CR, ... ... Beachy PA, et al. Pharmacological rescue of diabetic skeletal stem cell niches. Science Translational Medicine. 9. PMID 28077677 DOI: 10.1126/Scitranslmed.Aag2809  0.303
2016 Lee JJ, Rothenberg ME, Seeley ES, Zimdahl B, Kawano S, Lu WJ, Shin K, Sakata-Kato T, Chen JK, Diehn M, Clarke MF, Beachy PA. Control of inflammation by stromal Hedgehog pathway activation restrains colitis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27815529 DOI: 10.1073/Pnas.1616447113  0.748
2016 Raleigh D, Sever N, Sigg MA, Garcia-Gonzalo FR, Choksi PK, Hines KM, Choksi SP, Krup AL, McDonald JG, Xu L, Beachy PA, Reiter JF. Hsd11β2 Is Enriched in Medulloblastoma and Generates Ciliary Oxysterols to Stimulate Hedgehog Signaling. International Journal of Radiation Oncology, Biology, Physics. 96: E573-E574. PMID 27675052 DOI: 10.1016/J.Ijrobp.2016.06.2064  0.315
2016 Jeong Y, Hoang NT, Lovejoy A, Stehr H, Newman AM, Gentles AJ, Kong W, Truong D, Martin S, Chaudhuri A, Heiser D, Zhou L, Say C, Carter JN, Hiniker SM, ... ... Beachy P, et al. Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance. Cancer Discovery. PMID 27663899 DOI: 10.1158/2159-8290.Cd-16-0127  0.302
2016 Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon RE, ... ... Beachy PA, et al. Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell. 166: 451-467. PMID 27419872 DOI: 10.1016/J.Cell.2016.06.011  0.759
2016 Sever N, Mann RK, Xu L, Snell WJ, Hernandez-Lara CI, Porter NA, Beachy PA. Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols. Proceedings of the National Academy of Sciences of the United States of America. PMID 27162362 DOI: 10.1073/Pnas.1604984113  0.342
2016 Willsey HR, Zheng X, Carlos Pastor-Pareja J, Willsey AJ, Beachy PA, Xu T. Localized JNK signaling regulates organ size during development. Elife. 5. PMID 26974344 DOI: 10.7554/eLife.11491  0.363
2016 Willsey HR, Zheng X, Pastor-Pareja JC, Willsey AJ, Beachy PA, Xu T. Author response: Localized JNK signaling regulates organ size during development Elife. DOI: 10.7554/Elife.11491.021  0.325
2016 Fry M, Teng C, Lee A, Sun W, Parekh M, Rajadas J, Beachy P, Epstein E, Tang J. LB783 Topical Itraconazole inhibits the Hedgehog signaling pathway and reduces tumor development and size in murine models Journal of Investigative Dermatology. 136: B6. DOI: 10.1016/J.Jid.2016.05.033  0.326
2015 Oh S, Kato M, Zhang C, Guo Y, Beachy PA. A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response. Plos One. 10: e0135804. PMID 26271100 DOI: 10.1371/Journal.Pone.0135804  0.597
2015 Kim J, C Hsia EY, Brigui A, Plessis A, Beachy PA, Zheng X. The role of ciliary trafficking in Hedgehog receptor signaling. Science Signaling. 8: ra55. PMID 26038600 DOI: 10.1126/Scisignal.Aaa5622  0.419
2015 Chong YC, Mann RK, Zhao C, Kato M, Beachy PA. Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5. Genes & Development. 29: 262-76. PMID 25644602 DOI: 10.1101/gad.252676.114  0.44
2014 Lim A, Shin K, Zhao C, Kawano S, Beachy PA. Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate. Nature Cell Biology. 16: 1135-45. PMID 25362352 DOI: 10.1038/Ncb3057  0.335
2014 Shin K, Lim A, Zhao C, Sahoo D, Pan Y, Spiekerkoetter E, Liao JC, Beachy PA. Hedgehog signaling restrains bladder cancer progression by eliciting stromal production of urothelial differentiation factors. Cancer Cell. 26: 521-33. PMID 25314078 DOI: 10.1016/J.Ccell.2014.09.001  0.356
2014 Kim J, Hsia EY, Kim J, Sever N, Beachy PA, Zheng X. Simultaneous measurement of smoothened entry into and exit from the primary cilium. Plos One. 9: e104070. PMID 25119726 DOI: 10.1371/Journal.Pone.0104070  0.385
2014 Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, ... ... Beachy PA, et al. Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 111: E3091-100. PMID 25024225 DOI: 10.1073/Pnas.1411679111  0.563
2014 Shin K, Lim A, Odegaard JI, Honeycutt JD, Kawano S, Hsieh MH, Beachy PA. Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma. Nature Cell Biology. 16: 469-78. PMID 24747439 DOI: 10.1038/Ncb2956  0.313
2014 McClary AC, Sweeney RT, Biscocho J, Myers BR, Neahring L, Kwei KA, Qu K, Gong X, Ng T, Jones CD, Varma S, Odegaard JI, Rubin B, Troxell ML, Pelham RJ, ... ... Beachy PA, et al. Abstract 3436: Ameloblastoma driver mutations revealed by next-generation sequencing of formalin-fixed paraffin-embedded specimens Cancer Research. 74: 3436-3436. DOI: 10.1158/1538-7445.Am2014-3436  0.31
2013 Myers BR, Sever N, Chong YC, Kim J, Belani JD, Rychnovsky S, Bazan JF, Beachy PA. Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Developmental Cell. 26: 346-57. PMID 23954590 DOI: 10.1016/J.Devcel.2013.07.015  0.39
2013 Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, ... ... Beachy PA, et al. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. The Journal of Clinical Investigation. 123: 3600-13. PMID 23867624 DOI: 10.1172/Jci65592  0.335
2013 Kim J, Aftab BT, Tang JY, Kim D, Lee AH, Rezaee M, Kim J, Chen B, King EM, Borodovsky A, Riggins GJ, Epstein EH, Beachy PA, Rudin CM. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell. 23: 23-34. PMID 23291299 DOI: 10.1016/J.Ccr.2012.11.017  0.344
2013 Aftab BT, Kim J, Tang JY, King EM, Kim D, Kim J, Epstein EH, Beachy PA, Rudin CM. Abstract 5644: Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to vismodegib. Cancer Research. 73: 5644-5644. DOI: 10.1158/1538-7445.Am2013-5644  0.339
2012 Creanga A, Glenn TD, Mann RK, Saunders AM, Talbot WS, Beachy PA. Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes & Development. 26: 1312-25. PMID 22677548 DOI: 10.1101/Gad.191866.112  0.761
2012 Rothenberg ME, Nusse Y, Kalisky T, Lee JJ, Dalerba P, Scheeren F, Lobo N, Kulkarni S, Sim S, Qian D, Beachy PA, Pasricha PJ, Quake SR, Clarke MF. Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology. 142: 1195-1205.e6. PMID 22333952 DOI: 10.1053/J.Gastro.2012.02.006  0.36
2012 Kim D, Kim J, Spaunhurst K, Montoya J, Chandra K, Khodosh R, Fu T, Epstein EH, Molgo M, Beachy P, Tang JY. Abstract LB-223: An open-label, exploratory phase II study of oral itraconazole for the treatment of basal cell carcinoma Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-223  0.302
2012 Zaghloul M, Ahmed S, Eldebaway E, Mousa A, Amin A, Elkhateeb N, Sabry M, Ogiwara H, Morota N, Sufit A, Donson A, Birks D, Patel P, Foreman N, Handler M, ... ... Beachy P, et al. DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) Neuro-Oncology. 14: i26-i32. DOI: 10.1093/Neuonc/Nos098  0.49
2012 Rothenberg ME, Nusse Y, Kalisky T, Lee J, Dalerba PD, Czechowicz A, Scheeren F, Kulkarni S, Lobo NA, Sim S, Beachy P, Pasricha PJ, Quake S, Clarke MF. 906 CKit/CD117 Identifies a Colonic Paneth-Like Cell That Contributes to the Stem Cell Niche and Regulates Crypt Homeostasis Gastroenterology. 142: S-159. DOI: 10.1016/S0016-5085(12)60601-5  0.31
2011 Kim MS, Saunders AM, Hamaoka BY, Beachy PA, Leahy DJ. Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: 13112-7. PMID 21828006 DOI: 10.1073/Pnas.1109877108  0.383
2011 Shin K, Lee J, Guo N, Kim J, Lim A, Qu L, Mysorekar IU, Beachy PA. Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature. 472: 110-4. PMID 21389986 DOI: 10.1038/Nature09851  0.383
2011 Monje M, Mitra SS, Freret ME, Raveh TB, Kim J, Masek M, Attema JL, Li G, Haddix T, Edwards MS, Fisher PG, Weissman IL, Rowitch DH, Vogel H, Wong AJ, ... Beachy PA, et al. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proceedings of the National Academy of Sciences of the United States of America. 108: 4453-8. PMID 21368213 DOI: 10.1073/Pnas.1101657108  0.613
2011 Monje M, Beachy PA, Fisher PG. Hedgehogs, flies, Wnts and MYCs: the time has come for many things in medulloblastoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 1395-8. PMID 21357776 DOI: 10.1200/Jco.2010.34.0547  0.563
2011 Beachy PA. Abstract SY05-02: Hedgehog/wnt feedback supports regenerative proliferation of epithelial stem cells in bladder Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Sy05-02  0.39
2010 Chou YH, Zheng X, Beachy PA, Luo L. Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps. Cell. 142: 954-66. PMID 20850015 DOI: 10.1016/j.cell.2010.08.015  0.313
2010 Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C. Interactions between Hedgehog proteins and their binding partners come into view. Genes & Development. 24: 2001-12. PMID 20844013 DOI: 10.1101/Gad.1951710  0.405
2010 Kim J, Lee JJ, Kim J, Gardner D, Beachy PA. Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proceedings of the National Academy of Sciences of the United States of America. 107: 13432-7. PMID 20624968 DOI: 10.1073/Pnas.1006822107  0.376
2010 Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner D, Reya T, Liu JO, Epstein EH, Stevens DA, Beachy PA. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 17: 388-99. PMID 20385363 DOI: 10.1016/J.Ccr.2010.02.027  0.36
2010 Williams EH, Pappano WN, Saunders AM, Kim MS, Leahy DJ, Beachy PA. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proceedings of the National Academy of Sciences of the United States of America. 107: 5869-74. PMID 20231458 DOI: 10.1073/Pnas.1001777107  0.425
2010 Zheng X, Mann RK, Sever N, Beachy PA. Genetic and biochemical definition of the Hedgehog receptor. Genes & Development. 24: 57-71. PMID 20048000 DOI: 10.1101/gad.1870310  0.381
2010 Rothenberg ME, Dalerba PD, Nusse Y, Lee J, Lobo N, Kalisky T, Leyrat A, Quake S, Beachy P, Diehn M, Clarke MF. 788 Evidence for an Evolutionarily-Conserved Mechanism Regulating Stem and Progenitor Cell Numbers in the Regenerative Response to Ulcerative Colitis Gastroenterology. 138: S-111. DOI: 10.1016/S0016-5085(10)60509-4  0.33
2009 Kim J, Kato M, Beachy PA. Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proceedings of the National Academy of Sciences of the United States of America. 106: 21666-71. PMID 19996169 DOI: 10.1073/Pnas.0912180106  0.415
2009 Roessler E, Ma Y, Ouspenskaia MV, Lacbawan F, Bendavid C, Dubourg C, Beachy PA, Muenke M. Truncating loss-of-function mutations of DISP1 contribute to holoprosencephaly-like microform features in humans. Human Genetics. 125: 393-400. PMID 19184110 DOI: 10.1007/s00439-009-0628-7  0.497
2009 Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA, Reya T. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 458: 776-9. PMID 19169242 DOI: 10.1038/Nature07737  0.39
2008 McLellan JS, Zheng X, Hauk G, Ghirlando R, Beachy PA, Leahy DJ. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature. 455: 979-83. PMID 18794898 DOI: 10.1038/Nature07358  0.426
2007 Gerdes JM, Liu Y, Zaghloul NA, Leitch CC, Lawson SS, Kato M, Beachy PA, Beales PL, DeMartino GN, Fisher S, Badano JL, Katsanis N. Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nature Genetics. 39: 1350-60. PMID 17906624 DOI: 10.1038/Ng.2007.12  0.368
2007 Peacock CD, Wang Q, Gesell GS, Corcoran-Schwartz IM, Jones E, Kim J, Devereux WL, Rhodes JT, Huff CA, Beachy PA, Watkins DN, Matsui W. Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America. 104: 4048-53. PMID 17360475 DOI: 10.1073/Pnas.0611682104  0.391
2007 Akiyama H, Stadler HS, Martin JF, Ishii TM, Beachy PA, Nakamura T, de Crombrugghe B. Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice. Matrix Biology : Journal of the International Society For Matrix Biology. 26: 224-33. PMID 17222543 DOI: 10.1016/J.Matbio.2006.12.002  0.365
2007 Dwyer JR, Sever N, Carlson M, Nelson SF, Beachy PA, Parhami F. Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. The Journal of Biological Chemistry. 282: 8959-68. PMID 17200122 DOI: 10.1074/jbc.M611741200  0.447
2006 McLellan JS, Yao S, Zheng X, Geisbrecht BV, Ghirlando R, Beachy PA, Leahy DJ. Structure of a heparin-dependent complex of Hedgehog and Ihog. Proceedings of the National Academy of Sciences of the United States of America. 103: 17208-13. PMID 17077139 DOI: 10.1073/Pnas.0606738103  0.631
2006 Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, et al. Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature Methods. 3: 777-9. PMID 16990807 DOI: 10.1038/Nmeth1006-777  0.418
2006 Ma Y, Creanga A, Lum L, Beachy PA. Prevalence of off-target effects in Drosophila RNA interference screens. Nature. 443: 359-63. PMID 16964239 DOI: 10.1038/Nature05179  0.68
2006 Dorner S, Lum L, Kim M, Paro R, Beachy PA, Green R. A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 11880-5. PMID 16882716 DOI: 10.1073/Pnas.0605210103  0.593
2006 Yao S, Lum L, Beachy P. The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell. 125: 343-57. PMID 16630821 DOI: 10.1016/J.Cell.2006.02.040  0.655
2006 Roper RJ, Baxter LL, Saran NG, Klinedinst DK, Beachy PA, Reeves RH. Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 1452-6. PMID 16432181 DOI: 10.1073/Pnas.0510750103  0.363
2006 Stultz BG, Jackson DG, Mortin MA, Yang X, Beachy PA, Hursh DA. Transcriptional activation by extradenticle in the Drosophila visceral mesoderm. Developmental Biology. 290: 482-94. PMID 16403493 DOI: 10.1016/j.ydbio.2005.11.041  0.4
2005 Maity T, Fuse N, Beachy PA. Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. Proceedings of the National Academy of Sciences of the United States of America. 102: 17026-31. PMID 16282375 DOI: 10.1073/pnas.0507848102  0.401
2004 Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (New York, N.Y.). 306: 2257-60. PMID 15618519 DOI: 10.1126/Science.1104135  0.509
2004 Zhang C, Williams EH, Guo Y, Lum L, Beachy PA. Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proceedings of the National Academy of Sciences of the United States of America. 101: 17900-7. PMID 15598741 DOI: 10.1073/pnas.0408093101  0.357
2004 Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature. 432: 324-31. PMID 15549094 DOI: 10.1038/nature03100  0.337
2004 Lum L, Beachy PA. The Hedgehog response network: sensors, switches, and routers. Science (New York, N.Y.). 304: 1755-9. PMID 15205520 DOI: 10.1126/science.1098020  0.405
2004 Mann RK, Beachy PA. Novel lipid modifications of secreted protein signals. Annual Review of Biochemistry. 73: 891-923. PMID 15189162 DOI: 10.1146/annurev.biochem.73.011303.073933  0.404
2003 Lum L, Zhang C, Oh S, Mann RK, von Kessler DP, Taipale J, Weis-Garcia F, Gong R, Wang B, Beachy PA. Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Molecular Cell. 12: 1261-74. PMID 14636583 DOI: 10.1016/S1097-2765(03)00426-X  0.595
2003 Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, Beachy PA. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 425: 846-51. PMID 14520411 DOI: 10.1038/nature01972  0.361
2003 Lum L, Yao S, Mozer B, Rovescalli A, Von Kessler D, Nirenberg M, Beachy PA. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science (New York, N.Y.). 299: 2039-45. PMID 12663920 DOI: 10.1126/Science.1081403  0.639
2003 Cooper MK, Wassif CA, Krakowiak PA, Taipale J, Gong R, Kelley RI, Porter FD, Beachy PA. A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nature Genetics. 33: 508-13. PMID 12652302 DOI: 10.1038/ng1134  0.396
2003 Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature. 422: 313-7. PMID 12629553 DOI: 10.1038/Nature01493  0.409
2002 Chen JK, Taipale J, Cooper MK, Beachy PA. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes & Development. 16: 2743-8. PMID 12414725 DOI: 10.1101/Gad.1025302  0.56
2002 Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Small molecule modulation of Smoothened activity. Proceedings of the National Academy of Sciences of the United States of America. 99: 14071-6. PMID 12391318 DOI: 10.1073/Pnas.182542899  0.57
2002 Ma Y, Erkner A, Gong R, Yao S, Taipale J, Basler K, Beachy PA. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell. 111: 63-75. PMID 12372301 DOI: 10.1016/S0092-8674(02)00977-7  0.701
2002 Gallego MI, Beachy PA, Hennighausen L, Robinson GW. Differential requirements for shh in mammary tissue and hair follicle morphogenesis. Developmental Biology. 249: 131-9. PMID 12217324 DOI: 10.1006/dbio.2002.0761  0.345
2002 Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (New York, N.Y.). 297: 1559-61. PMID 12202832 DOI: 10.1126/Science.1073733  0.527
2002 Taipale J, Cooper MK, Maiti T, Beachy PA. Patched acts catalytically to suppress the activity of Smoothened. Nature. 418: 892-7. PMID 12192414 DOI: 10.1038/nature00989  0.306
2001 Chamoun Z, Mann RK, Nellen D, von Kessler DP, Bellotto M, Beachy PA, Basler K. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science (New York, N.Y.). 293: 2080-4. PMID 11486055 DOI: 10.1126/science.1064437  0.458
2001 Chiang C, Litingtung Y, Harris MP, Simandl BK, Li Y, Beachy PA, Fallon JF. Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Developmental Biology. 236: 421-35. PMID 11476582 DOI: 10.1006/Dbio.2001.0346  0.343
2001 Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature. 411: 349-54. PMID 11357142 DOI: 10.1038/35077219  0.422
2001 Muñoz-Sanjuán I, Cooper MK, Beachy PA, Fallon JF, Nathans J. Expression and regulation of chicken fibroblast growth factor homologous factor (FHF)-4 during craniofacial morphogenesis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 220: 238-45. PMID 11241832 DOI: 10.1002/1097-0177(20010301)220:3<238::Aid-Dvdy1104>3.0.Co;2-T  0.538
2000 Mann RK, Beachy PA. Cholesterol modification of proteins. Biochimica Et Biophysica Acta. 1529: 188-202. PMID 11111088 DOI: 10.1016/S1388-1981(00)00148-7  0.322
2000 Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature. 406: 1005-9. PMID 10984056 DOI: 10.1038/35023008  0.542
2000 Muenke M, Beachy PA. Genetics of ventral forebrain development and holoprosencephaly. Current Opinion in Genetics & Development. 10: 262-9. PMID 10826992 DOI: 10.1016/S0959-437X(00)00084-8  0.329
2000 Wang B, Fallon JF, Beachy PA. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell. 100: 423-34. PMID 10693759 DOI: 10.1016/S0092-8674(00)80678-9  0.417
1999 Fuse N, Maiti T, Wang B, Porter JA, Hall TM, Leahy DJ, Beachy PA. Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proceedings of the National Academy of Sciences of the United States of America. 96: 10992-9. PMID 10500113 DOI: 10.1073/Pnas.96.20.10992  0.389
1999 Chen CH, von Kessler DP, Park W, Wang B, Ma Y, Beachy PA. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell. 98: 305-16. PMID 10458606 DOI: 10.1016/S0092-8674(00)81960-1  0.634
1999 Chiang C, Swan RZ, Grachtchouk M, Bolinger M, Litingtung Y, Robertson EK, Cooper MK, Gaffield W, Westphal H, Beachy PA, Dlugosz AA. Essential role for Sonic hedgehog during hair follicle morphogenesis. Developmental Biology. 205: 1-9. PMID 9882493 DOI: 10.1006/Dbio.1998.9103  0.331
1998 Cooper MK, Porter JA, Young KE, Beachy PA. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science (New York, N.Y.). 280: 1603-7. PMID 9616123 DOI: 10.1126/science.280.5369.1603  0.386
1997 Beachy PA, Cooper MK, Young KE, von Kessler DP, Park WJ, Hall TM, Leahy DJ, Porter JA. Multiple roles of cholesterol in hedgehog protein biogenesis and signaling. Cold Spring Harbor Symposia On Quantitative Biology. 62: 191-204. PMID 9598352 DOI: 10.1101/Sqb.1997.062.01.025  0.357
1997 Krishnan V, Pereira FA, Qiu Y, Chen CH, Beachy PA, Tsai SY, Tsai MJ. Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science (New York, N.Y.). 278: 1947-50. PMID 9395397 DOI: 10.1126/Science.278.5345.1947  0.603
1997 Hall TM, Porter JA, Young KE, Koonin EV, Beachy PA, Leahy DJ. Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins. Cell. 91: 85-97. PMID 9335337 DOI: 10.1016/S0092-8674(01)80011-8  0.317
1996 Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 383: 407-13. PMID 8837770 DOI: 10.1038/383407A0  0.345
1996 Porter JA, Young KE, Beachy PA. Cholesterol modification of hedgehog signaling proteins in animal development. Science (New York, N.Y.). 274: 255-9. PMID 8824192 DOI: 10.1126/science.274.5285.255  0.387
1996 Porter JA, Ekker SC, Park WJ, von Kessler DP, Young KE, Chen CH, Ma Y, Woods AS, Cotter RJ, Koonin EV, Beachy PA. Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell. 86: 21-34. PMID 8689684 DOI: 10.1016/S0092-8674(00)80074-4  0.677
1995 Porter JA, von Kessler DP, Ekker SC, Young KE, Lee JJ, Moses K, Beachy PA. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature. 374: 363-6. PMID 7885476 DOI: 10.1038/374363A0  0.379
1995 Sun B, Hursh DA, Jackson D, Beachy PA. Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm. The Embo Journal. 14: 520-35. PMID 7859741 DOI: 10.1002/J.1460-2075.1995.Tb07028.X  0.381
1995 Fan CM, Porter JA, Chiang C, Chang DT, Beachy PA, Tessier-Lavigne M. Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell. 81: 457-65. PMID 7736597 DOI: 10.1016/0092-8674(95)90398-4  0.398
1995 Hynes M, Porter JA, Chiang C, Chang D, Tessier-Lavigne M, Beachy PA, Rosenthal A. Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron. 15: 35-44. PMID 7619528 DOI: 10.1016/0896-6273(95)90062-4  0.351
1995 Ekker SC, Ungar AR, Greenstein P, von Kessler DP, Porter JA, Moon RT, Beachy PA. Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Current Biology : Cb. 5: 944-55. PMID 7583153 DOI: 10.1016/S0960-9822(95)00185-0  0.375
1995 López-Martínez A, Chang DT, Chiang C, Porter JA, Ros MA, Simandl BK, Beachy PA, Fallon JF. Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage. Current Biology : Cb. 5: 791-6. PMID 7583126 DOI: 10.1016/S0960-9822(95)00156-4  0.358
1995 Hall TM, Porter JA, Beachy PA, Leahy DJ. A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature. 378: 212-6. PMID 7477329 DOI: 10.1038/378212A0  0.408
1994 Lee JJ, Ekker SC, von Kessler DP, Porter JA, Sun BI, Beachy PA. Autoproteolysis in hedgehog protein biogenesis. Science (New York, N.Y.). 266: 1528-37. PMID 7985023 DOI: 10.1126/Science.7985023  0.416
1994 Ekker SC, Jackson DG, von Kessler DP, Sun BI, Young KE, Beachy PA. The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. The Embo Journal. 13: 3551-60. PMID 7914870 DOI: 10.1002/J.1460-2075.1994.Tb06662.X  0.328
1994 Chiang C, Beachy PA. Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila. Mechanisms of Development. 47: 225-39. PMID 7848870 DOI: 10.1016/0925-4773(94)90041-8  0.353
1993 Ma C, Zhou Y, Beachy PA, Moses K. The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell. 75: 927-38. PMID 8252628 DOI: 10.1016/0092-8674(93)90536-Y  0.334
1993 Beachy PA, Varkey J, Young KE, von Kessler DP, Sun BI, Ekker SC. Cooperative binding of an Ultrabithorax homeodomain protein to nearby and distant DNA sites. Molecular and Cellular Biology. 13: 6941-56. PMID 8105373 DOI: 10.1128/Mcb.13.11.6941  0.332
1992 Lee JJ, von Kessler DP, Parks S, Beachy PA. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell. 71: 33-50. PMID 1394430 DOI: 10.1016/0092-8674(92)90264-D  0.363
1992 Ekker SC, von Kessler DP, Beachy PA. Differential DNA sequence recognition is a determinant of specificity in homeotic gene action. The Embo Journal. 11: 4059-72. PMID 1356765 DOI: 10.1002/J.1460-2075.1992.Tb05499.X  0.355
1991 Ekker SC, Young KE, von Kessler DP, Beachy PA. Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila. The Embo Journal. 10: 1179-86. PMID 1673656 DOI: 10.1002/J.1460-2075.1991.Tb08058.X  0.307
1990 Beachy PA. A molecular view of the Ultrabithorax homeotic gene of Drosophila. Trends in Genetics : Tig. 6: 46-51. PMID 1970912 DOI: 10.1016/0168-9525(90)90073-F  0.331
1989 Kornfeld K, Saint RB, Beachy PA, Harte PJ, Peattie DA, Hogness DS. Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila. Genes & Development. 3: 243-58. PMID 2565858 DOI: 10.1101/Gad.3.2.243  0.768
1988 Beachy PA, Krasnow MA, Gavis ER, Hogness DS. An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters. Cell. 55: 1069-81. PMID 2904838 DOI: 10.1016/0092-8674(88)90251-6  0.723
1985 Hogness DS, Lipshitz HD, Beachy PA, Peattie DA, Saint RB, Goldschmidt-Clermont M, Harte PJ, Gavis ER, Helfand SL. Regulation and products of the Ubx domain of the bithorax complex. Cold Spring Harbor Symposia On Quantitative Biology. 50: 181-94. PMID 3938361 DOI: 10.1101/Sqb.1985.050.01.024  0.729
1985 Beachy PA, Helfand SL, Hogness DS. Segmental distribution of bithorax complex proteins during Drosophila development. Nature. 313: 545-51. PMID 3918274 DOI: 10.1038/313545a0  0.722
1983 Bender W, Akam M, Karch F, Beachy PA, Peifer M, Spierer P, Lewis EB, Hogness DS. Molecular Genetics of the Bithorax Complex in Drosophila melanogaster. Science (New York, N.Y.). 221: 23-9. PMID 17737996 DOI: 10.1126/science.221.4605.23  0.744
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