Matthew G. LaPorte, Ph.D. - Publications

2000 Pennsylvania State University, State College, PA, United States 
Total Synthesis of Natural Products

23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 LaPorte MG, Wang Z, Colombo R, Garzan A, Peshkov VA, Liang M, Johnston PA, Schurdak ME, Sen M, Camarco DP, Hua Y, Pollock NI, Lazo JS, Grandis JR, Wipf P, et al. Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27381083 DOI: 10.1016/J.Bmcl.2016.06.017  0.4
2016 Deng Y, Haimowitz T, LaPorte MG, Rippin SR, Alexander MD, Kumar PT, Hendi MS, Lee YH, Condon SM. Electrophilic Oxidation and [1,2]-Rearrangement of the Biindole Core of Birinapant. Acs Medicinal Chemistry Letters. 7: 318-23. PMID 26985322 DOI: 10.1021/Acsmedchemlett.5B00461  0.4
2016 Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway Acs Medicinal Chemistry Letters. 7: 182-187. DOI: 10.1021/acsmedchemlett.5b00396  0.4
2016 Deng Y, Xie Q, LaPorte MG, Chasnoff ATA, Mortensen MA, Patra D, Putrelo SA, Antonovich RS, Cao H, Yan J, Cooper AJ, Rippin SR, Alexander MD, Kumar PT, Hendi MS, et al. Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate Organic Process Research and Development. 20: 242-252. DOI: 10.1021/Acs.Oprd.5B00390  0.4
2015 Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, Wilson GM, Resnick LO, LaPorte MG, Wipf P, Huryn DM, Grandis JR. HCS Campaign to Identify Selective Inhibitors of IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. Assay and Drug Development Technologies. 13: 356-76. PMID 26317883 DOI: 10.1089/Adt.2015.663  0.4
2015 Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, Laporte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97 Acs Medicinal Chemistry Letters. 6: 1225-1230. DOI: 10.1021/acsmedchemlett.5b00364  0.4
2014 LaPorte MG, da Paz Lima DJ, Zhang F, Sen M, Grandis JR, Camarco D, Hua Y, Johnston PA, Lazo JS, Resnick LO, Wipf P, Huryn DM. 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. Bioorganic & Medicinal Chemistry Letters. 24: 5081-5. PMID 25288188 DOI: 10.1016/J.Bmcl.2014.09.001  0.4
2014 Condon SM, Mitsuuchi Y, Deng Y, LaPorte MG, Rippin SR, Haimowitz T, Alexander MD, Kumar PT, Hendi MS, Lee YH, Benetatos CA, Yu G, Kapoor GS, Neiman E, Seipel ME, et al. Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies. Journal of Medicinal Chemistry. 57: 3666-77. PMID 24684347 DOI: 10.1021/Jm500176W  0.4
2014 Benetatos CA, Mitsuuchi Y, Burns JM, Neiman EM, Condon SM, Yu G, Seipel ME, Kapoor GS, Laporte MG, Rippin SR, Deng Y, Hendi MS, Tirunahari PK, Lee YH, Haimowitz T, et al. Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models. Molecular Cancer Therapeutics. 13: 867-79. PMID 24563541 DOI: 10.1158/1535-7163.Mct-13-0798  0.4
2014 Zhang H, Jeon KO, Hay EB, Geib SJ, Curran DP, LaPorte MG. Radical [3 + 2]-annulation of divinylcyclopropanes: rapid synthesis of complex meloscine analogs. Organic Letters. 16: 94-7. PMID 24313360 DOI: 10.1021/Ol403078E  0.4
2014 Colombo R, Jeon KO, Huryn DM, LaPorte MG, Wipf P. A new synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-c] pyrimidines by a retro-mannich cascade rearrangement Australian Journal of Chemistry. 67: 420-425. DOI: 10.1071/Ch13468  0.4
2013 Arnold DM, Laporte MG, Anderson SM, Wipf P. Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles. Tetrahedron. 69: 7719-7731. PMID 23976798 DOI: 10.1016/J.Tet.2013.04.127  0.4
2013 LaPorte MG, Tsegay S, Hong KB, Lu C, Fang C, Wang L, Xie XQ, Floreancig PE. Construction of a spirooxindole amide library through nitrile hydrozirconation-acylation-cyclization cascade. Acs Combinatorial Science. 15: 344-9. PMID 23731121 DOI: 10.1021/Co4000387  0.4
2013 LaPorte M, Hong KB, Xu J, Wipf P. 5-Hydroxyindoles by intramolecular alkynol-furan diels-alder cycloaddition. The Journal of Organic Chemistry. 78: 167-74. PMID 23136970 DOI: 10.1021/Jo3022605  0.4
2011 Jackson RW, LaPorte MG, Herbertz T, Draper TL, Gaboury JA, Rippin SR, Patel R, Chunduru SK, Benetatos CA, Young DC, Burns CJ, Condon SM. The discovery and structure-activity relationships of pyrano[3,4-b]indole-based inhibitors of hepatitis C virus NS5B polymerase. Bioorganic & Medicinal Chemistry Letters. 21: 3227-31. PMID 21550237 DOI: 10.1016/j.bmcl.2011.04.052  0.4
2011 Zaware N, Laporte MG, Farid R, Liu L, Wipf P, Floreancig PE. Diversity-oriented synthesis of a library of substituted tetrahydropyrones using oxidative carbon-hydrogen bond activation and click chemistry. Molecules (Basel, Switzerland). 16: 3648-62. PMID 21540794 DOI: 10.3390/Molecules16053648  0.4
2011 Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, Nghiem P, Quade B, Seguin SP, Wipf P. Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. Proceedings of the National Academy of Sciences of the United States of America. 108: 6757-62. PMID 21502524 DOI: 10.1073/Pnas.1015251108  0.4
2010 LaPorte MG, Draper TL, Miller LE, Blackledge CW, Leister LK, Amparo E, Hussey AR, Young DC, Chunduru SK, Benetatos CA, Rhodes G, Gopalsamy A, Herbertz T, Burns CJ, Condon SM. The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase. Bioorganic & Medicinal Chemistry Letters. 20: 2968-73. PMID 20347591 DOI: 10.1016/j.bmcl.2010.03.002  0.4
2008 Laporte MG, Jackson RW, Draper TL, Gaboury JA, Galie K, Herbertz T, Hussey AR, Rippin SR, Benetatos CA, Chunduru SK, Christensen JS, Coburn GA, Rizzo CJ, Rhodes G, O'Connell J, et al. The discovery of pyrano[3,4-b]indole-based allosteric inhibitors of HCV NS5B polymerase with in vivo activity. Chemmedchem. 3: 1508-15. PMID 18729128 DOI: 10.1002/cmdc.200800168  0.4
2006 Laporte MG, Lessen TA, Leister L, Cebzanov D, Amparo E, Faust C, Ortlip D, Bailey TR, Nitz TJ, Chunduru SK, Young DC, Burns CJ. Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase. Bioorganic & Medicinal Chemistry Letters. 16: 100-3. PMID 16260131 DOI: 10.1016/j.bmcl.2005.09.047  0.4
2000 Han G, LaPorte MG, Folmer JJ, Werner KM, Weinreb SM. Total syntheses of the Securinega alkaloids (+)-14,15-dihydronorsecurinine, (-)-norsecurinine, and phyllanthine. The Journal of Organic Chemistry. 65: 6293-306. PMID 11052071 DOI: 10.1021/Jo000260Z  0.4
2000 Han G, LaPorte MG, Folmer JJ, Werner KM, Weinreb SM. A New Enantioselective Approach to Total Synthesis of the Securinega Alkaloids: Application to (-)-Norsecurinine and Phyllanthine. Angewandte Chemie (International Ed. in English). 39: 237-240. PMID 10649387 DOI: 10.1002/(Sici)1521-3773(20000103)39:1<237::Aid-Anie237>3.0.Co;2-B  0.4
1996 Han G, LaPorte MG, McIntosh MC, Weinreb SM, Parvez M. Exploratory synthetic studies of the α-methoxylation of amides via cuprous ion-promoted decomposition of o-diazobenzamides Journal of Organic Chemistry. 61: 9483-9493. DOI: 10.1021/Jo961529A  0.4
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