Xiaoguang Lei, Ph.D. - Publications

Affiliations: 
2007 Boston University, Boston, MA, United States 
Area:
synthesis of complex natural products

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Gao L, Su C, Du X, Wang R, Chen S, Zhou Y, Liu C, Liu X, Tian R, Zhang L, Xie K, Chen S, Guo Q, Guo L, Hano Y, ... ... Lei X, et al. FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis. Nature Chemistry. PMID 32451436 DOI: 10.1038/S41557-020-0467-7  0.349
2020 Wang J, Hong B, Hu D, Kadonaga Y, Tang R, Lei X. Protecting-group-free syntheses of ent-kaurane diterpenoids: [3+2+1] cycloaddition/cycloalkenylation approach. Journal of the American Chemical Society. PMID 31968171 DOI: 10.1021/Jacs.9B13722  0.301
2020 Meesakul P, Jaidee W, Richardson C, Andersen RJ, Patrick BO, Willis AC, Muanprasat C, Wang J, Lei X, Hadsadee S, Jungsuttiwong S, Pyne SG, Laphookhieo S. Styryllactones from Goniothalamus tamirensis. Phytochemistry. 171: 112248. PMID 31918304 DOI: 10.1016/J.Phytochem.2019.112248  0.311
2019 Zhang J, Zhao T, Yang R, Siridechakorn I, Wang S, Guo Q, Bai Y, Shen HC, Lei X. synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by . Chemical Science. 10: 6635-6641. PMID 31367316 DOI: 10.1039/C9Sc01405E  0.373
2019 Shi Y, Xu Z, Tan R, Lei X. Divergent Total Synthesis of Chaetoglines C to F. The Journal of Organic Chemistry. PMID 31185713 DOI: 10.1021/Acs.Joc.9B01076  0.32
2019 Lei X, Wu J, Kadonaga Y, Hong B, Wang J. 13-step Enantioselective Total Synthesis of (+)-Jungermatrobrunin A. Angewandte Chemie (International Ed. in English). PMID 31056826 DOI: 10.1002/Anie.201903682  0.312
2019 Hong B, Liu W, Wang J, Wu J, Kadonaga Y, Cai P, Lou H, Yu Z, Li H, Lei X. Photoinduced Skeletal Rearrangements Reveal Radical-Mediated Synthesis of Terpenoids Chem. 5: 1671-1681. DOI: 10.1016/J.Chempr.2019.04.023  0.369
2018 Wang X, Du C, Hong B, Lei X. Total synthesis of (±)-antroquinonol. Organic & Biomolecular Chemistry. PMID 30418462 DOI: 10.1039/C8Ob02494D  0.324
2018 Ozaki T, Shinde SS, Gao L, Okuizumi R, Liu C, Ogasawara Y, Lei X, Dairi T, Minami A, Oikawa H. Enzymatic formation of a skipped methyl-substituted octaprenyl side chain of longestin (KS-505a): Involvement of homo-IPP as a common extender unit. Angewandte Chemie (International Ed. in English). PMID 29603559 DOI: 10.1002/Anie.201802116  0.304
2017 Li H, Lei X. Fawcettimine-Type Lycopodium Alkaloids as a Driving Force for Discoveries in Organic Synthesis. Chemical Record (New York, N.Y.). PMID 29251805 DOI: 10.1002/Tcr.201700047  0.304
2017 Narita K, Sato H, Minami A, Kudo K, Gao L, Liu C, Ozaki T, Kodama M, Lei X, Taniguchi T, Monde K, Yamazaki M, Uchiyama M, Oikawa H. Focused Genome Mining of Structurally Related Sesterterpenes: Enzymatic Formation of Enantiomeric and Diastereomeric Products. Organic Letters. 19: 6696-6699. PMID 29185768 DOI: 10.1021/Acs.Orglett.7B03418  0.329
2017 Lei X, Hong B, Hu D, Wu J, Zhang J, Li H. Divergent Total Syntheses of (-)-Huperzine Q, (+)-Lycopladine B, (+)-Lycopladine C and (-)-4-epi-Lycopladine D. Chemistry, An Asian Journal. PMID 28440575 DOI: 10.1002/Asia.201700364  0.331
2016 Ren Y, Su Y, Sun L, He S, Meng L, Liao D, Liu X, Ma Y, Liu C, Li S, Ruan H, Lei X, Wang X, Zhang Z. Discovery of a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) for the treatment of systemic inflammatory response syndrome. Journal of Medicinal Chemistry. PMID 27992216 DOI: 10.1021/Acs.Jmedchem.6B01196  0.314
2016 Li D, Li C, Li L, Chen S, Wang L, Li Q, Wang X, Lei X, Shen Z. Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis. Cell Chemical Biology. 23: 257-266. PMID 27028885 DOI: 10.1016/J.Chembiol.2015.08.018  0.338
2016 Yang S, Liao D, Tian X, Lei X. Access to the 2H-Tetrahydro-4,6-dioxo-1,2-oxazine Ring System from Nitrone via a Tandem Nucleophilic Addition and Transesterification Reaction. Organic Letters. 18: 376-379. PMID 26849452 DOI: 10.1021/Acs.Orglett.5B03374  0.339
2016 Liu W, Li H, Cai PJ, Wang Z, Yu ZX, Lei X. Scalable Total Synthesis of rac-Jungermannenones B and C. Angewandte Chemie (International Ed. in English). PMID 26823176 DOI: 10.1002/Anie.201511659  0.361
2016 Dong T, Liu W, Shen Z, Li L, Chen S, Lei X. Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain. Scientific Reports. 6: 19231. PMID 26757824 DOI: 10.1038/Srep19231  0.362
2016 Gao L, Han J, Lei X. Enantioselective Total Syntheses of Kuwanon X, Kuwanon Y, and Kuwanol A. Organic Letters. PMID 26756182 DOI: 10.1021/Acs.Orglett.5B03285  0.32
2016 Lei XG, Zhu JH, Cheng WH, Bao Y, Ho YS, Reddi AR, Holmgren A, Arnér ES. Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications. Physiological Reviews. 96: 307-64. PMID 26681794 DOI: 10.1152/Physrev.00010.2014  0.394
2016 Hong B, Dong T, Lei X. Recent advances in target identification by natural product based chemical probes Science China Chemistry. 59: 1088-1092. DOI: 10.1007/S11426-016-0063-5  0.3
2015 Li X, Han J, Jones AX, Lei X. Chiral Boron Complex-Promoted Asymmetric Diels-Alder Cycloaddition and Its Application in Natural Product Synthesis. The Journal of Organic Chemistry. PMID 26693852 DOI: 10.1021/Acs.Joc.5B02248  0.37
2015 Abazov VM, Abbott B, Acharya BS, Adams M, Adams T, Agnew JP, Alexeev GD, Alkhazov G, Alton A, Askew A, Atkins S, Augsten K, Avila C, Badaud F, Bagby L, ... ... Lei X, et al. Inclusive Production of the X(4140) State in pp[over ¯] Collisions at D0. Physical Review Letters. 115: 232001. PMID 26684112 DOI: 10.1103/Physrevlett.115.232001  0.388
2015 Liao D, Yang S, Wang J, Zhang J, Hong B, Wu F, Lei X. Total Synthesis and Structural Reassignment of Aspergillomarasmine A. Angewandte Chemie (International Ed. in English). PMID 26592805 DOI: 10.1002/Anie.201509960  0.307
2015 Abazov VM, Abbott B, Acharya BS, Adams M, Adams T, Agnew JP, Alexeev GD, Alkhazov G, Alton A, Askew A, Atkins S, Augsten K, Avila C, Badaud F, Bagby L, ... ... Lei X, et al. Search for Violation of CPT and Lorentz Invariance in Bs(0) Meson Oscillations. Physical Review Letters. 115: 161601. PMID 26550864 DOI: 10.1103/Physrevlett.115.161601  0.371
2015 Aaltonen T, Abazov VM, Abbott B, Acharya BS, Adams M, Adams T, Agnew JP, Alexeev GD, Alkhazov G, Alton A, Amerio S, Amidei D, Anastassov A, Annovi A, Antos J, ... ... Lei X, et al. Tevatron Combination of Single-Top-Quark Cross Sections and Determination of the Magnitude of the Cabibbo-Kobayashi-Maskawa Matrix Element V_{tb}. Physical Review Letters. 115: 152003. PMID 26550718 DOI: 10.1103/Physrevlett.115.152003  0.361
2015 Aad G, Abbott B, Abdallah J, Abdinov O, Aben R, Abolins M, AbouZeid OS, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, Adelman J, ... Lei X, et al. ATLAS Run 1 searches for direct pair production of third-generation squarks at the Large Hadron Collider. The European Physical Journal. C, Particles and Fields. 75: 510. PMID 26549981 DOI: 10.1140/Epjc/S10052-015-3726-9  0.392
2015 Aad G, Abbott B, Abdallah J, Abdinov O, Aben R, Abolins M, AbouZeid OS, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, ... Lei X, et al. Search for metastable heavy charged particles with large ionisation energy loss in pp collisions at [Formula: see text] TeV using the ATLAS experiment. The European Physical Journal. C, Particles and Fields. 75: 407. PMID 26543401 DOI: 10.1140/Epjc/S10052-015-3609-0  0.363
2015 Li C, Jones AX, Lei X. Synthesis and mode of action of oligomeric sesquiterpene lactones. Natural Product Reports. PMID 26510522 DOI: 10.1039/C5Np00089K  0.381
2015 Hong B, Li C, Wang Z, Chen J, Li H, Lei X. Enantioselective Total Synthesis of (-)-Incarviatone A. Journal of the American Chemical Society. 137: 11946-9. PMID 26371964 DOI: 10.1021/Jacs.5B08551  0.359
2015 Qin XY, Chen BY, Fu JJ, Shan L, Lei XG, Zhang WD. Synthesis, cytotoxicity and inhibition of NO production of ivangustin enantiomer analogues. European Journal of Medicinal Chemistry. 102: 256-265. PMID 26280922 DOI: 10.1016/J.Ejmech.2015.07.051  0.334
2015 Dong T, Li C, Wang X, Dian L, Zhang X, Li L, Chen S, Cao R, Li L, Huang N, He S, Lei X. Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine. Nature Communications. 6: 6522. PMID 25813672 DOI: 10.1038/Ncomms7522  0.729
2015 Liu W, Li X, Chen J, Li T, Dong M, Lei X. Site-selective and metal-free aliphatic C-H oxidation enabled synthesis of [5,24,25-D3]-(25S)-Δ(7)-dafachronic acid. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 5345-9. PMID 25704922 DOI: 10.1002/Chem.201500324  0.321
2015 Hong B, Li H, Wu J, Zhang J, Lei X. Total syntheses of (-)-huperzine Q and (+)-lycopladines B and C. Angewandte Chemie (International Ed. in English). 54: 1011-5. PMID 25358669 DOI: 10.1002/Anie.201409503  0.368
2015 Han J, Jones AX, Lei X. Recent Advances in the Total Synthesis of Prenylflavonoid and Related Diels–Alder Natural Products Synthesis. 47: 1519-1533. DOI: 10.1055/S-0034-1378696  0.342
2014 Zhang J, Chen J, Zhang X, Lei X. Total syntheses of menisporphine and daurioxoisoporphine C enabled by photoredox-catalyzed direct C-H arylation of isoquinoline with aryldiazonium salt. The Journal of Organic Chemistry. 79: 10682-8. PMID 25313860 DOI: 10.1021/Jo5020432  0.361
2014 Li C, Dong T, Li Q, Lei X. Probing the anticancer mechanism of (-)-ainsliatrimer A through diverted total synthesis and bioorthogonal ligation. Angewandte Chemie (International Ed. in English). 53: 12111-5. PMID 25223829 DOI: 10.1002/Anie.201407225  0.363
2014 Zhang J, Wu J, Hong B, Ai W, Wang X, Li H, Lei X. Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group pairing pattern. Nature Communications. 5: 4614. PMID 25082077 DOI: 10.1038/Ncomms5614  0.343
2014 Han J, Li X, Guan Y, Zhao W, Wulff WD, Lei X. Enantioselective biomimetic total syntheses of kuwanons I and J and brosimones A and B. Angewandte Chemie (International Ed. in English). 53: 9257-61. PMID 25044511 DOI: 10.1002/Anie.201404499  0.379
2014 Li C, Lei X. Strategies toward the biomimetic syntheses of oligomeric sesquiterpenoids. The Journal of Organic Chemistry. 79: 3289-95. PMID 24620778 DOI: 10.1021/Jo5002092  0.342
2014 Liao D, Sun L, Liu W, He S, Wang X, Lei X. Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein Medchemcomm. 5: 333-337. DOI: 10.1039/C3Md00278K  0.303
2013 Wang G, Wang X, Yu H, Wei S, Williams N, Holmes DL, Halfmann R, Naidoo J, Wang L, Li L, Chen S, Harran P, Lei X. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells Nature Chemical Biology. 9: 84-89. PMID 23292651 DOI: 10.1038/Nchembio.1153  0.311
2013 Li H, Wang X, Hong B, Lei X. Collective synthesis of Lycopodium alkaloids and tautomer locking strategy for the total synthesis of (-)-lycojapodine A. The Journal of Organic Chemistry. 78: 800-21. PMID 22973823 DOI: 10.1021/Jo3017555  0.368
2013 Wang X, Li H, Lei X. Challenges and Strategies to the Total Syntheses of Fawcettimine-Type and Serratinine-Type Lycopodium Alkaloids Synlett. 24: 1032-1043. DOI: 10.1055/S-0032-1316912  0.307
2013 Li C, Dong T, Dian L, Zhang W, Lei X. Biomimetic syntheses and structural elucidation of the apoptosis-inducing sesquiterpenoid trimers: (−)-ainsliatrimers A and B Chemical Science. 4: 1163. DOI: 10.1039/C2Sc22023G  0.74
2012 Li C, Dian L, Zhang W, Lei X. Biomimetic syntheses of (-)-gochnatiolides A-C and (-)-ainsliadimer B. Journal of the American Chemical Society. 134: 12414-7. PMID 22799742 DOI: 10.1021/Ja305464S  0.737
2012 Lei X, Li H. Selective alkene metathesis in the total synthesis of complex natural product. Topics in Current Chemistry. 327: 163-96. PMID 22527405 DOI: 10.1007/128_2012_318  0.341
2012 Li H, Wang X, Lei X. Total syntheses of Lycopodium alkaloids (+)-fawcettimine, (+)-fawcettidine, and (-)-8-deoxyserratinine. Angewandte Chemie (International Ed. in English). 51: 491-5. PMID 22109940 DOI: 10.1002/Anie.201106753  0.316
2012 Liao D, Li H, Lei X. Efficient generation of ortho-quinone methide: application to the biomimetic syntheses of (±)-schefflone and tocopherol trimers. Organic Letters. 14: 18-21. PMID 22047096 DOI: 10.1021/Ol202641Y  0.332
2011 Chou TC, Dong H, Zhang X, Lei X, Hartung J, Zhang Y, Lee JH, Wilson RM, Danishefsky SJ. Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol. Proceedings of the National Academy of Sciences of the United States of America. 108: 14336-41. PMID 21844359 DOI: 10.1073/Pnas.1111332108  0.307
2011 Li C, Tu S, Wen S, Li S, Chang J, Shao F, Lei X. Total synthesis of the G2/M DNA damage checkpoint inhibitor psilostachyin C. The Journal of Organic Chemistry. 76: 3566-70. PMID 21417227 DOI: 10.1021/Jo2001275  0.321
2010 Gong YN, Wang X, Wang J, Yang Z, Li S, Yang J, Liu L, Lei X, Shao F. Chemical probing reveals insights into the signaling mechanism of inflammasome activation. Cell Research. 20: 1289-305. PMID 20856264 DOI: 10.1038/Cr.2010.135  0.327
2010 Li C, Yu X, Lei X. A biomimetic total synthesis of (+)-ainsliadimer A. Organic Letters. 12: 4284-7. PMID 20812751 DOI: 10.1021/Ol101705J  0.328
2008 Lei X, Danishefsky SJ. Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition. Advanced Synthesis & Catalysis. 350: 1677-1681. PMID 21442009 DOI: 10.1002/Adsc.200800187  0.329
2008 Lei X, Dai M, Hua Z, Danishefsky SJ. Biomimetic total synthesis of tricycloillicinone and mechanistic studies toward the rearrangement of prenyl phenyl ethers. Tetrahedron Letters. 49: 6383-6385. PMID 19890380 DOI: 10.1016/J.Tetlet.2008.07.184  0.338
2007 Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA, Schreiber SL, Chung RT. Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrobial Agents and Chemotherapy. 51: 3756-9. PMID 17682098 DOI: 10.1128/Aac.00233-07  0.662
2006 Lei X, Porco JA. Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1. Journal of the American Chemical Society. 128: 14790-1. PMID 17105273 DOI: 10.1021/Ja066621V  0.562
2006 Porco JA, Su S, Lei X, Bardhan S, Rychnovsky SD. Total synthesis and structure assignment of (+)-hexacyclinol. Angewandte Chemie (International Ed. in English). 45: 5790-2. PMID 16871643 DOI: 10.1002/Anie.200602854  0.713
2005 Lei X, Zaarur N, Sherman MY, Porco JA. Stereocontrolled synthesis of a complex library via elaboration of angular epoxyquinol scaffolds. The Journal of Organic Chemistry. 70: 6474-83. PMID 16050712 DOI: 10.1021/Jo050956Y  0.569
2005 Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Organic Letters. 7: 2751-4. PMID 15957938 DOI: 10.1021/Ol051023R  0.643
2004 Lei X, Porco JA. Synthesis of a polymer-supported anthracene and its application as a dienophile scavenger. Organic Letters. 6: 795-8. PMID 14986977 DOI: 10.1021/Ol036502+  0.507
2003 Lei X, Johnson RP, Porco JA. Total synthesis of the ubiquitin-activating enzyme inhibitor (+)-panepophenanthrin. Angewandte Chemie (International Ed. in English). 42: 3913-7. PMID 12949867 DOI: 10.1002/Anie.200351862  0.534
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