Xianhai Huang, Ph.D. - Publications

2000 University of Illinois at Chicago, Chicago, IL, United States 
diastereoselective free radical chemistry, acyl radical chemistry, enantioselective synthesis of á-disubstituted amino acids, and carbohydrate chemistry

27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Xiao D, Palani A, Huang X, Sofolarides M, Zhou W, Chen X, Aslanian R, Guo Z, Fossetta J, Tian F, Trivedi P, Spacciapoli P, Whitehurst CE, Lundell D. Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 3262-6. PMID 23602398 DOI: 10.1016/j.bmcl.2013.03.109  0.96
2012 Huang X, Zhou W, Liu X, Li H, Sun G, Mandal M, Vicarel M, Zhu X, Bennett C, McCraken T, Pissarnitski D, Zhao Z, Cole D, Gallo G, Zhu Z, et al. Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease. Acs Medicinal Chemistry Letters. 3: 931-5. PMID 24900409 DOI: 10.1021/ml300209g  0.96
2012 Palani A, Rao AU, Chen X, Huang X, Su J, Tang H, Huang Y, Qin J, Xiao D, Degrado S, Sofolarides M, Zhu X, Liu Z, McKittrick B, Zhou W, et al. Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. Acs Medicinal Chemistry Letters. 3: 63-8. PMID 24900372 DOI: 10.1021/ml200243g  0.96
2012 Huang X, Su J, Rao AU, Tang H, Zhou W, Zhu X, Chen X, Liu Z, Huang Y, Degrado S, Xiao D, Qin J, Aslanian R, McKittrick BA, Greenfeder S, et al. SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist. Bioorganic & Medicinal Chemistry Letters. 22: 854-8. PMID 22209457 DOI: 10.1016/j.bmcl.2011.12.041  0.96
2012 Rao AU, Xiao D, Huang X, Zhou W, Fossetta J, Lundell D, Tian F, Trivedi P, Aslanian R, Palani A. Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1068-72. PMID 22182499 DOI: 10.1016/j.bmcl.2011.11.113  0.96
2012 Huang X, Zhu X, Chen X, Zhou W, Xiao D, Degrado S, Aslanian R, Fossetta J, Lundell D, Tian F, Trivedi P, Palani A. A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 65-70. PMID 22169260 DOI: 10.1016/j.bmcl.2011.11.074  0.96
2012 Sun ZY, Asberom T, Bara T, Bennett C, Burnett D, Chu I, Clader J, Cohen-Williams M, Cole D, Czarniecki M, Durkin J, Gallo G, Greenlee W, Josien H, Huang X, et al. Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo. Journal of Medicinal Chemistry. 55: 489-502. PMID 22098494 DOI: 10.1021/jm201407j  0.96
2011 Qin J, Rao A, Chen X, Zhu X, Liu Z, Huang X, Degrado S, Huang Y, Xiao D, Aslanian R, Cheewatrakoolpong B, Zhang H, Greenfeder S, Farley C, Cook J, et al. Discovery of a potent nicotinic Acid receptor agonist for the treatment of dyslipidemia. Acs Medicinal Chemistry Letters. 2: 171-6. PMID 24900295 DOI: 10.1021/ml100251u  0.96
2011 Qin J, Dhondi P, Huang X, Mandal M, Zhao Z, Pissarnitski D, Zhou W, Aslanian R, Zhu Z, Greenlee W, Clader J, Zhang L, Cohen-Williams M, Jones N, Hyde L, et al. Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators. Bioorganic & Medicinal Chemistry Letters. 21: 664-9. PMID 21195610 DOI: 10.1016/j.bmcl.2010.12.012  0.96
2004 Huang X, Palani A, Xiao D, Aslanian R, Shih NY. Manipulation of N,O-nucleophilicity: efficient formation of 4-N-substituted 2,4-dihydro-3H-1,2,4-triazolin-3-ones. Organic Letters. 6: 4795-8. PMID 15575688 DOI: 10.1021/ol0478638  0.96
2004 Nicolaou KC, Snyder SA, Longbottom DA, Nalbandian AZ, Huang X. New uses for the Burgess reagent in chemical synthesis: methods for the facile and stereoselective formation of sulfamidates, glycosylamines, and sulfamides. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 5581-606. PMID 15470695 DOI: 10.1002/chem.200400503  0.96
2004 Nicolaou KC, Hao J, Reddy MV, Rao PB, Rassias G, Snyder SA, Huang X, Chen DY, Brenzovich WE, Giuseppone N, O'Brate A, Giannakakou P. Chemistry and biology of diazonamide A: second total synthesis and biological investigations. Journal of the American Chemical Society. 126: 12897-906. PMID 15469287 DOI: 10.1021/ja040093a  0.96
2004 Nicolaou KC, Chen DY, Huang X, Ling T, Bella M, Snyder SA. Chemistry and biology of diazonamide A: first total synthesis and confirmation of the true structure. Journal of the American Chemical Society. 126: 12888-96. PMID 15469286 DOI: 10.1021/ja040092i  0.96
2004 Nicolaou KC, Snyder SA, Giuseppone N, Huang X, Bella M, Reddy MV, Rao PB, Koumbis AE, O'Brate A, Giannakakou P. Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure. Journal of the American Chemical Society. 126: 10174-82. PMID 15303893 DOI: 10.1021/ja040091q  0.96
2004 Nicolaou KC, Snyder SA, Huang X, Simonsen KB, Koumbis AE, Bigot A. Studies toward diazonamide A: initial synthetic forays directed toward the originally proposed structure. Journal of the American Chemical Society. 126: 10162-73. PMID 15303892 DOI: 10.1021/ja040090y  0.96
2003 Crich D, Ranganathan K, Neelamkavil S, Huang X. Tandem polar/radical crossover sequences for the formation of fused and bridged bicyclic nitrogen heterocycles involving radical ionic chain reactions, and alkene radical cation intermediates, performed under reducing conditions: scope and limitations. Journal of the American Chemical Society. 125: 7942-7. PMID 12823015 DOI: 10.1021/ja035639s  0.96
2003 Nicolaou KC, Bheema Rao P, Hao J, Reddy MV, Rassias G, Huang X, Chen DY, Snyder SA. The second total synthesis of diazonamide A. Angewandte Chemie (International Ed. in English). 42: 1753-8. PMID 12707898 DOI: 10.1002/anie.200351112  0.96
2002 Nicolaou KC, Huang X, Snyder SA, Bheema Rao P, Bella M, Reddy MV. A novel regio- and stereoselective synthesis of sulfamidates from 1,2-diols using Burgess and related reagents: a facile entry into beta-amino alcohols. Angewandte Chemie (International Ed. in English). 41: 834-8. PMID 12491352 DOI: 10.1002/1521-3773(20020301)41:5<834::AID-ANIE834>3.0.CO;2-V  0.96
2002 Nicolaou KC, Longbottom DA, Snyder SA, Nalbanadian AZ, Huang X. A new method for the synthesis of nonsymmetrical sulfamides using burgess-type reagents. Angewandte Chemie (International Ed. in English). 41: 3866-70. PMID 12386873 DOI: 10.1002/1521-3773(20021018)41:20<3866::AID-ANIE3866>3.0.CO;2-T  0.96
2002 Nicolaou KC, Bella M, Chen DY, Huang X, Ling T, Snyder SA. Total synthesis of diazonamide A. Angewandte Chemie (International Ed. in English). 41: 3495-9. PMID 12298077 DOI: 10.1002/1521-3773(20020916)41:18<3495::AID-ANIE3495>3.0.CO;2-7  0.96
2001 Nicolaou KC, Huang X, Giuseppone N, Bheema Rao P, Bella M, Reddy MV, Snyder SA. Construction of the Complete Aromatic Core of Diazonamide A by a Novel Hetero Pinacol Macrocyclization Cascade Reaction We thank Drs. D. H. Huang and G. Suizdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), American Biosciences, a predoctoral fellowship from the National Science Foundation (S.A.S.), a postdoctoral fellowship from the Association pour la Recherche sur le Cancer (N.G.), and grants from Abbott, Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 4705-4709. PMID 12404390 DOI: 10.1002/1521-3773(20011217)40:24<4705::AID-ANIE4705>3.0.CO;2-D  0.96
2001 Bales BC, Horner JH, Huang X, Newcomb M, Crich D, Greenberg MM. Product studies and laser flash photolysis on alkyl radicals containing two different beta-leaving groups are consonant with the formation of an olefin cation radical. Journal of the American Chemical Society. 123: 3623-9. PMID 11457093 DOI: 10.1021/ja0042938  0.96
2001 Newcomb M, Miranda N, Sannigrahi M, Huang X, Crich D. Direct measurement of enol ether radical cation reaction kinetics. Journal of the American Chemical Society. 123: 6445-6. PMID 11427083 DOI: 10.1021/ja015602c  0.96
2001 Crich D, Ranganathan K, Huang X. Generation and reaction of alkene radical cations under nonoxidizing conditions: synthesis of the pyrrolizidine nucleus. Organic Letters. 3: 1917-9. PMID 11405744 DOI: 10.1021/ol015965h  0.96
2000 Crich D, Huang X, Newcomb M. Inter- and intramolecular pathways for the formation of tetrahydrofurans from beta-(Phosphatoxy)alkyl radicals. Evidence for a dissociative mechanism The Journal of Organic Chemistry. 65: 523-9. PMID 10813967  0.96
1999 Crich D, Huang X, Beckwith AL. Free-Radical Ring Contraction of Six-, Seven-, and Eight-Membered Lactones by a 1,2-Shift Mechanism. A Kinetic and (17)O NMR Spectroscopic Study. The Journal of Organic Chemistry. 64: 1762-1764. PMID 11674254  0.96
1999 Whitted PO, Horner JH, Newcomb M, Huang X, Crich D. Heterolytic cleavage of a beta-phosphatoxyalkyl radical resulting in phosphate migration or radical cation formation as a function of solvent polarity. Organic Letters. 1: 153-6. PMID 10822551  0.96
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