Marc Antoniu Ilies - Publications

Affiliations: 
Temple University, Philadelphia, PA, United States 
Area:
medicinal chemistry, supramolecular chemistry, drug and gene delivery systems

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Mondal UK, Doroba K, Shabana AM, Adelberg R, Alam MR, Supuran CT, Ilies MA. PEG Linker Length Strongly Affects Tumor Cell Killing by PEGylated Carbonic Anhydrase Inhibitors in Hypoxic Carcinomas Expressing Carbonic Anhydrase IX. International Journal of Molecular Sciences. 22. PMID 33498779 DOI: 10.3390/ijms22031120  1
2020 Andring JT, Fouch M, Akocak S, Angeli A, Supuran CT, Ilies MA, McKenna R. Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone. Journal of Medicinal Chemistry. PMID 33085484 DOI: 10.1021/acs.jmedchem.0c01390  1
2020 Akocak S, Güzel-Akdemir Ö, Kishore Kumar Sanku R, Russom SS, Iorga BI, Supuran CT, Ilies MA. Pyridinium derivatives of 3-aminobenzenesulfonamide are nanomolar-potent inhibitors of tumor-expressed carbonic anhydrase isozymes CA IX and CA XII. Bioorganic Chemistry. 103: 104204. PMID 32891000 DOI: 10.1016/J.Bioorg.2020.104204  1
2019 Zamanova S, Shabana AM, Mondal UK, Ilies MA. Carbonic anhydrases as disease markers. Expert Opinion On Therapeutic Patents. PMID 31172829 DOI: 10.1080/13543776.2019.1629419  1
2019 Brailoiu E, Chakraborty S, Brailoiu GC, Zhao P, Barr JL, Ilies MA, Unterwald EM, Abood ME, Taylor CW. Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP-Evoked Ca Signals through Sigma-1 Receptors. Cell Reports. 26: 330-337.e4. PMID 30625315 DOI: 10.1016/J.Celrep.2018.12.051  1
2018 Shabana AM, Mondal UK, Alam MR, Spoon T, Ross CA, Madesh M, Supuran CT, Ilies MA. pH-Sensitive Multi-ligand Gold Nanoplatform Targeting Carbonic Anhydrase IX Enhances the Delivery of Doxorubicin to Hypoxic Tumor Spheroids and Overcomes the Hypoxia-Induced Chemoresistance. Acs Applied Materials & Interfaces. PMID 29733576 DOI: 10.1021/Acsami.8B05607  1
2018 Sanku RKK, John JS, Salkovitz M, Ilies MA, Walker EA. Potential learning and memory disruptors and enhancers in a simple, 1-day operant task in mice. Behavioural Pharmacology. PMID 29570113 DOI: 10.1097/Fbp.0000000000000400  1
2018 Bhatt A, Mondal UK, Supuran CT, Ilies MA, McKenna R. Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function. Molecular Neurobiology. PMID 29423818 DOI: 10.1007/S12035-017-0854-2  1
2017 Satyal U, Draghici B, Dragic LL, Zhang Q, Norris K, Madesh M, Brailoiu E, Ilies MA. Interfacially-engineered pyridinium pseudo-gemini surfactants as versatile and efficient supramolecular delivery systems for DNA, siRNA and mRNA. Acs Applied Materials & Interfaces. PMID 28809098 DOI: 10.1021/Acsami.7B07066  1
2016 Lu Z, Yang Y, Covington RA, Bi YV, Dürig T, Ilies M, Fassihi R. Supersaturated controlled release matrix using amorphous dispersions of glipizide. International Journal of Pharmaceutics. PMID 27492020 DOI: 10.1016/J.Ijpharm.2016.07.072  1
2016 Akocak S, Alam MR, Shabana AM, Sanku RK, Vullo D, Thompson H, Swenson ER, Supuran CT, Ilies MA. PEGylated bis-sulfonamide carbonic anhydrase inhibitors can efficiently control the growth of several carbonic anhydrase IX-expressing carcinomas. Journal of Medicinal Chemistry. PMID 27144971 DOI: 10.1021/Acs.Jmedchem.6B00492  1
2015 Kizewski A, Ilies MA. Efficient and synergetic DNA delivery with pyridinium amphiphiles-gold nanoparticle composite systems having different packing parameters. Chemical Communications (Cambridge, England). PMID 26553432 DOI: 10.1039/C5Cc05760D  1
2015 Draghici B, Ilies MA. Synthetic nucleic acid delivery systems: present and perspectives. Journal of Medicinal Chemistry. 58: 4091-130. PMID 25658858 DOI: 10.1021/Jm500330K  1
2015 Sharma VD, Akocak S, Ilies MA, Fassihi R. Solid-state interactions at the core-coat interface: physicochemical characterization of enteric-coated omeprazole pellets without a protective sub-coat. Aaps Pharmscitech. 16: 934-43. PMID 25595125 DOI: 10.1208/S12249-014-0263-Z  1
2014 Draghici B, Vullo D, Akocak S, Walker EA, Supuran CT, Ilies MA. Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect. Chemical Communications (Cambridge, England). 50: 5980-3. PMID 24763985 DOI: 10.1039/C4Cc02346C  1
2014 Sharma VD, Lees J, Hoffman NE, Brailoiu E, Madesh M, Wunder SL, Ilies MA. Modulation of pyridinium cationic lipid-DNA complex properties by pyridinium gemini surfactants and its impact on lipoplex transfection properties. Molecular Pharmaceutics. 11: 545-59. PMID 24377350 DOI: 10.1021/Mp4005035  1
2014 Ilies MA. New synthetic strategies for the management of Chagas disease (American trypanosomiasis). Journal of Medicinal Chemistry. 57: 296-7. PMID 24369927 DOI: 10.1021/Jm4019405  0.01
2014 Sharma VD, Ilies MA. Heterocyclic cationic gemini surfactants: a comparative overview of their synthesis, self-assembling, physicochemical, and biological properties. Medicinal Research Reviews. 34: 1-44. PMID 22907528 DOI: 10.1002/Med.21272  1
2013 Savarala S, Brailoiu E, Wunder SL, Ilies MA. Tuning the self-assembling of pyridinium cationic lipids for efficient gene delivery into neuronal cells. Biomacromolecules. 14: 2750-64. PMID 23834644 DOI: 10.1021/Bm400591D  1
2013 Sharma VD, Aifuwa EO, Heiney PA, Ilies MA. Interfacial engineering of pyridinium gemini surfactants for the generation of synthetic transfection systems. Biomaterials. 34: 6906-21. PMID 23768782 DOI: 10.1016/J.Biomaterials.2013.05.029  1
2013 Zhu X, Sharma VD, Fryd M, Ilies MA, Wayland BB. Enzyme and acid catalyzed degradation of PEG45-b-PBO 0,6,9-b-PCL60 micelles: Increased hydrolytic stability by engineering the hydrophilic-hydrophobic interface Polymer (United Kingdom). 54: 2879-2886. DOI: 10.1016/J.Polymer.2013.03.055  1
2012 Tangeysh B, Fryd M, Ilies MA, Wayland BB. Palladium metal nanoparticle size control through ion paired structures of [PdCl4]2- with protonated PDMAEMA. Chemical Communications (Cambridge, England). 48: 8955-7. PMID 22842614 DOI: 10.1039/C2Cc34401G  1
2012 Zhu X, Fryd M, Tran BD, Ilies MA, Wayland BB. Modifying the hydrophilic-hydrophobic interface of PEG-b-PCL to increase micelle stability: Preparation of PEG-b-PBO-b-PCL triblock copolymers, micelle formation, and hydrolysis kinetics Macromolecules. 45: 660-665. DOI: 10.1021/Ma202530V  1
2011 Shuvaev VV, Ilies MA, Simone E, Zaitsev S, Kim Y, Cai S, Mahmud A, Dziubla T, Muro S, Discher DE, Muzykantov VR. Endothelial targeting of antibody-decorated polymeric filomicelles. Acs Nano. 5: 6991-9. PMID 21838300 DOI: 10.1021/Nn2015453  1
2011 Savarala S, Monson F, Ilies MA, Wunder SL. Supported lipid bilayer nanosystems: stabilization by undulatory-protrusion forces and destabilization by lipid bridging. Langmuir : the Acs Journal of Surfaces and Colloids. 27: 5850-61. PMID 21500811 DOI: 10.1021/La200636K  1
2011 Savarala S, Ahmed S, Ilies MA, Wunder SL. Stabilization of soft lipid colloids: competing effects of nanoparticle decoration and supported lipid bilayer formation. Acs Nano. 5: 2619-28. PMID 21381770 DOI: 10.1021/Nn1025884  1
2011 Dave K, Scozzafava A, Vullo D, Supuran CT, Ilies MA. Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII. Organic & Biomolecular Chemistry. 9: 2790-800. PMID 21369613 DOI: 10.1039/C0Ob00703J  1
2011 Ghidu VP, Ilies MA, Cullen T, Pollet R, Abou-Gharbia M. A new and efficient synthetic route for the anxiolytic agent CL285032. Bioorganic & Medicinal Chemistry Letters. 21: 259-61. PMID 21095124 DOI: 10.1016/J.Bmcl.2010.11.017  1
2011 Dave K, Ilies MA, Scozzafava A, Temperini C, Vullo D, Supuran CT. An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II. Bioorganic & Medicinal Chemistry Letters. 21: 2764-8. PMID 21036610 DOI: 10.1016/J.Bmcl.2010.10.045  1
2011 Ilies MA, Sommers TV, He LC, Kizewski A, Sharma VD. Pyridinium amphiphiles in gene delivery-present and perspectives Acs Symposium Series. 1070: 23-38. DOI: 10.1021/bk-2011-1070.ch002  1
2010 Savarala S, Ahmed S, Ilies MA, Wunder SL. Formation and colloidal stability of DMPC supported lipid bilayers on SiO2 nanobeads. Langmuir : the Acs Journal of Surfaces and Colloids. 26: 12081-8. PMID 20527833 DOI: 10.1021/La101304V  1
2010 Balaban AT, Ilies MA, Eichhöfer A, Balaban TS. Molecular and crystal structure of a self-assembling pyridinium cationic lipid Journal of Molecular Structure. 984: 228-231. DOI: 10.1016/J.Molstruc.2010.09.032  1
2009 Ilies MA. Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase Inhibitors Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications. 439-472. DOI: 10.1002/9780470508169.ch21  0.01
2006 Ilies MA, Seitz WA, Johnson BH, Ezell EL, Miller AL, Thompson EB, Balaban AT. Lipophilic pyrylium salts in the synthesis of efficient pyridinium-based cationic lipids, gemini surfactants, and lipophilic oligomers for gene delivery. Journal of Medicinal Chemistry. 49: 3872-87. PMID 16789743 DOI: 10.1021/Jm0601755  1
2006 Percec V, Peterca M, Sienkowska MJ, Ilies MA, Aqad E, Smidrkal J, Heiney PA. Synthesis and retrostructural analysis of libraries of AB3 and constitutional isomeric AB2 phenylpropyl ether-based supramolecular dendrimers. Journal of the American Chemical Society. 128: 3324-34. PMID 16522114 DOI: 10.1021/Ja060062A  1
2005 Ilies MA, Johnson BH, Makori F, Miller A, Seitz WA, Thompson EB, Balaban AT. Pyridinium cationic lipids in gene delivery: an in vitro and in vivo comparison of transfection efficiency versus a tetraalkylammonium congener. Archives of Biochemistry and Biophysics. 435: 217-26. PMID 15680924 DOI: 10.1016/J.Abb.2004.12.010  1
2005 Ilies MA, Johnson BH, Seitz WA, Ezell EL, Miller A, Thompson EB, Balaban AT. 588. Structure-Activity Relationships in Two Series of Pyridinium Gemini Surfactants for Gene Delivery Molecular Therapy. 11: 227. DOI: 10.1016/J.Ymthe.2005.07.128  1
2004 Ilies MA, Seitz WA, Ghiviriga I, Johnson BH, Miller A, Thompson EB, Balaban AT. Pyridinium cationic lipids in gene delivery: a structure-activity correlation study. Journal of Medicinal Chemistry. 47: 3744-54. PMID 15239653 DOI: 10.1021/Jm0499763  1
2004 Ilies MA, Masereel B, Rolin S, Scozzafava A, Câmpeanu G, Cîmpeanu V, Supuran CT. Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity. Bioorganic & Medicinal Chemistry. 12: 2717-26. PMID 15110853 DOI: 10.1016/J.Bmc.2004.03.008  1
2004 Ilies MA, Johnson BH, Seitz WA, Ezell EL, Miller A, Thompson EB, Balaban AT. 477. New pyridinium cationic lipids for gene delivery synthesized via pyrylium salts Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.374  1
2003 Ilies MA, Vullo D, Pastorek J, Scozzafava A, Ilies M, Caproiu MT, Pastorekova S, Supuran CT. Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives. Journal of Medicinal Chemistry. 46: 2187-96. PMID 12747790 DOI: 10.1021/Jm021123S  1
2003 Ilies M, Banciu MD, Scozzafava A, Ilies MA, Caproiu MT, Supuran CT. Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties. Bioorganic & Medicinal Chemistry. 11: 2227-39. PMID 12713832 DOI: 10.1016/S0968-0896(03)00113-5  1
2003 Ilies MA, Seitz WA, Caproiu MT, Wentz M, Garfield RE, Balaban AT. Pyridinium‐Based Cationic Lipids as Gene‐Transfer Agents European Journal of Organic Chemistry. 2003: 2645-2655. DOI: 10.1002/Ejoc.200300106  1
2003 Ilies MA, Seitz WA, Caproiu MT, Wentz M, Garfield RE, Balaban AT. Pyridinium-based cationic lipids as gene-transfer agents European Journal of Organic Chemistry. 2645-2655.  1
2002 Ilies MA, Seitz WA, Balaban AT. Cationic lipids in gene delivery: principles, vector design and therapeutical applications. Current Pharmaceutical Design. 8: 2441-73. PMID 12369942 DOI: 10.2174/1381612023392748  1
2002 Ilies M, Banciu MD, Ilies MA, Scozzafava A, Caproiu MT, Supuran CT. Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties. Journal of Medicinal Chemistry. 45: 504-10. PMID 11784154 DOI: 10.1021/Jm011031N  1
2002 Ilies MA, Scozzafava A, Supuran CT. Therapeutic applications of serine protease inhibitors Expert Opinion On Therapeutic Patents. 12: 1181-1214. DOI: 10.1517/13543776.12.8.1181  1
2001 Casini A, Mincione F, Ilies MA, Menabuoni L, Scozzafava A, Supuran CT. Carbonic anhydrase inhibitors: synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties. Journal of Enzyme Inhibition. 16: 113-23. PMID 11342280 DOI: 10.1080/14756360109162361  1
2001 Ilies MA, Balaban AT. Recent developments in cationic lipid-mediated gene delivery and gene therapy Expert Opinion On Therapeutic Patents. 11: 1729-1752. DOI: 10.1517/13543776.11.11.1729  1
2000 Ilies MA, Supuran CT, Scozzafava A. Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances. Metal-Based Drugs. 7: 57-62. PMID 18475926 DOI: 10.1155/Mbd.2000.57  1
2000 Casini A, Scozzafava A, Mincione F, Menabuoni L, Ilies MA, Supuran CT. Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. Journal of Medicinal Chemistry. 43: 4884-92. PMID 11123998 DOI: 10.1021/Jm001051+  1
2000 Supuran CT, Scozzafava A, Ilies MA, Briganti F. Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating 2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) versus the cytosolic (CA I and CA II) isozymes. Journal of Enzyme Inhibition. 15: 381-401. PMID 10995069 DOI: 10.1080/14756360009040695  1
2000 Supuran CT, Briganti F, Scozzafava A, Ilies MA. Protease inhibitors: Part 4. Synthesis of weakly basic thrombin inhibitors incorporating pyridinium-sulfanilylaminoguanidine moieties. Journal of Enzyme Inhibition. 15: 335-56. PMID 10995066 DOI: 10.1080/14756360009040692  1
2000 Scozzafava A, Ilies MA, Manole G, Supuran CT. Protease inhibitors. Part 12. Synthesis of potent matrix metalloproteinase and bacterial collagenase inhibitors incorporating sulfonylated N-4-nitrobenzyl-beta-alanine hydroxamate moieties. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 11: 69-79. PMID 10913755 DOI: 10.1016/S0928-0987(00)00089-0  1
2000 Fenesan I, Popescu R, Scozzafava A, Crucin V, Mateiciuc E, Bauer R, Ilies MA, Supuran CT. Carbonic anhydrase inhibitors; phosphoryl-sulfonamides--a new class of high affinity inhibitors of isozymes I and II. Journal of Enzyme Inhibition. 15: 297-310. PMID 10811034 DOI: 10.3109/14756360009040690  1
2000 Scozzafava A, Briganti F, Ilies MA, Supuran CT. Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes. Journal of Medicinal Chemistry. 43: 292-300. PMID 10649985 DOI: 10.1021/Jm990479+  1
1998 Supuran CT, Scozzafava A, Briganti F, Ilies MA, Jitianu A. Carbonic Anhydrase Inhibitors. Part 55 Metal Complexes of 1,3,4-Thiadiazole-2-Sulfonamide Derivatives: In Vitro Inhibition Studies With Carbonic Anhydrase Isozymes I, II and IV. Metal-Based Drugs. 5: 103-14. PMID 18475829 DOI: 10.1155/Mbd.1998.103  1
1998 Supuran CT, Mincione F, Scozzafava A, Briganti F, Mincione G, Ilies MA. Carbonic anhydrase inhibitors - Part 52. Metal complexes of heterocyclic sulfonamides: A new class of strong topical intraocular pressure-lowering agents in rabbits European Journal of Medicinal Chemistry. 33: 247-254. DOI: 10.1016/S0223-5234(98)80059-7  1
1998 Supuran CT, Ilies MA, Scozzafava A. Carbonic anhydrase inhibitors - Part 29: Interaction of isozymes I, II and IV with benzolamide-like derivatives European Journal of Medicinal Chemistry. 33: 739-751. DOI: 10.1016/S0223-5234(98)80042-1  1
1998 Supuran CT, Scozzafava A, Jurca BC, Ilies MA. Carbonic anhydrase inhibitors - Part 49: Synthesis of substituted ureido and thioureido derivatives of aromatic/heterocyclic sulfonamides with increased affinities for isozyme I European Journal of Medicinal Chemistry. 33: 83-93. DOI: 10.1016/S0223-5234(98)80033-0  1
1998 Supuran CT, Scozzafava A, Ilies MA, Iorga B, Cristea T, Briganti F, Chiraleu F, Banciu MD. Carbonic anhydrase inhibitors - Part 53. Synthesis of substituted-pyridinium derivatives of aromatic sulfonamides: The first non-polymeric membrane-impermeable inhibitors with selectivity for isozyme IV European Journal of Medicinal Chemistry. 33: 577-594. DOI: 10.1016/S0223-5234(98)80017-2  1
1997 Jitianu A, Ilies MA, Briganti F, Scozzafava A, Supuran CT. Complexes with biologically active ligands: Part 9. Metal complexes of 5-benzoylamino- and 5-(3-nitrobenzoyl-amino)-1,3,4-thiadiazole-2-sulfonamide as carbonic anhydrase inhibitors Metal-Based Drugs. 4: 1-7. DOI: 10.1155/MBD.1997.1  1
1997 Ilies MA, Banciu MD, Ilies M, Chiraleu F, Briganti F, Scozzafava A, Supuran CT. Carbonic anhydrase activators. Part 17. Synthesis and activation study of a series of 1-1,2,4-triazole-(1H)-3-yl)-2,4,6-trisubstituted-pyridinium salts against isozymes I, II and IV European Journal of Medicinal Chemistry. 32: 911-918. DOI: 10.1016/S0223-5234(97)82777-8  1
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