Ryan A. Mehl, Ph.D. - Publications

Affiliations: 
2001 Cornell University, Ithaca, NY, United States 
Area:
Barton Professor of Chemistry

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yang B, Kwon K, Jana S, Kim S, Avila-Crump S, Tae G, Mehl RA, Kwon I. Temporal Control of Efficient Bioconjugation Using a Genetically Encoded Tetrazine-Mediated Inverse-Electron-Demand Diels-Alder Reaction. Bioconjugate Chemistry. PMID 33034448 DOI: 10.1021/acs.bioconjchem.0c00497  0.4
2020 Jang HS, Jana S, Blizzard RJ, Meeuwsen JC, Mehl RA. Access To Faster Eukaryotic Cell Labeling With Encoded Tetrazine Amino Acids. Journal of the American Chemical Society. PMID 32251579 DOI: 10.1021/Jacs.9B11520  0.4
2019 Bednar R, Golbek TW, Kean KM, Brown WJ, Jana S, Baio JE, Karplus PA, Mehl RA. Immobilization of Proteins with Controlled Load and Orientation. Acs Applied Materials & Interfaces. PMID 31525993 DOI: 10.1021/Acsami.9B12746  0.4
2018 Popchock AR, Jana S, Mehl RA, Qiu W. Engineering Heterodimeric Kinesins through Genetic Incorporation of Noncanonical Amino Acids. Acs Chemical Biology. PMID 29894152 DOI: 10.1021/Acschembio.8B00399  0.4
2017 Lambert WD, Scinto SL, Dmitrenko O, Boyd SJ, Magboo R, Mehl RA, Chin JW, Fox JM, Wallace S. Correction: Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling. Organic & Biomolecular Chemistry. PMID 28848969 DOI: 10.1039/C7Ob90144E  0.68
2017 Lambert WD, Scinto SL, Dmitrenko O, Boyd SJ, Magboo R, Mehl RA, Chin JW, Fox JM, Wallace S. Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling. Organic & Biomolecular Chemistry. PMID 28752889 DOI: 10.1039/C7Ob01707C  0.68
2016 Gu X, Wu Z, Huang Y, Wagner MA, Baleanu-Gogonea C, Mehl RA, Buffa JA, DiDonato AJ, Hazen LB, Fox PL, Gogonea V, Parks JS, DiDonato JA, Hazen SL. A systematic investigation of structure/function requirements for the apolipoprotein A-I - lecithin cholesterol acyltransferase interaction loop of HDL. The Journal of Biological Chemistry. PMID 26797122 DOI: 10.1074/Jbc.M115.696088  1
2015 Rauch BJ, Porter JJ, Mehl RA, Perona JJ. Improved incorporation of noncanonical amino acids by an engineered tRNATyr suppressor. Biochemistry. PMID 26694948 DOI: 10.1021/Acs.Biochem.5B01185  1
2015 Leisle L, Valiyaveetil F, Mehl RA, Ahern CA. Incorporation of Non-Canonical Amino Acids. Advances in Experimental Medicine and Biology. 869: 119-51. PMID 26381943 DOI: 10.1007/978-1-4939-2845-3_7  1
2015 Blizzard RJ, Backus DR, Brown W, Bazewicz CG, Li YI, Mehl RA. Ideal Bioorthogonal Reactions Using A Site-Specifically Encoded Tetrazine Amino Acid. Journal of the American Chemical Society. PMID 26237426 DOI: 10.1021/Jacs.5B03275  1
2015 Franco MC, Ricart KC, Gonzalez AS, Dennys CN, Nelson PA, Janes MS, Mehl RA, Landar A, Estevez AG. Nitration of Hsp90 on tyrosine 33 regulates mitochondrial metabolism. The Journal of Biological Chemistry. PMID 26085096 DOI: 10.1074/Jbc.M115.663278  1
2015 Kamber DN, Liang Y, Blizzard RJ, Liu F, Mehl RA, Houk KN, Prescher JA. 1,2,4-Triazines Are Versatile Bioorthogonal Reagents. Journal of the American Chemical Society. PMID 26084312 DOI: 10.1021/Jacs.5B05100  1
2015 Averick S, Mehl RA, Das SR, Matyjaszewski K. Well-defined biohybrids using reversible-deactivation radical polymerization procedures. Journal of Controlled Release : Official Journal of the Controlled Release Society. 205: 45-57. PMID 25483427 DOI: 10.1016/J.Jconrel.2014.11.030  1
2014 Darko A, Wallace S, Dmitrenko O, Machovina MM, Mehl RA, Chin JW, Fox JM. Conformationally Strained trans-Cyclooctene with Improved Stability and Excellent Reactivity in Tetrazine Ligation. Chemical Science. 5: 3770-3776. PMID 26113970 DOI: 10.1039/C4Sc01348D  0.68
2014 Cooley RB, Karplus PA, Mehl RA. Gleaning unexpected fruits from hard-won synthetases: probing principles of permissivity in non-canonical amino acid-tRNA synthetases. Chembiochem : a European Journal of Chemical Biology. 15: 1810-9. PMID 25044993 DOI: 10.1002/Cbic.201402180  1
2014 Averick S, Karácsony O, Mohin J, Yong X, Moellers NM, Woodman BF, Zhu W, Mehl RA, Balazs AC, Kowalewski T, Matyjaszewski K. Cooperative, reversible self-assembly of covalently pre-linked proteins into giant fibrous structures. Angewandte Chemie (International Ed. in English). 53: 8050-5. PMID 25044628 DOI: 10.1002/Anie.201402827  1
2014 Padmanarayana M, Hams N, Speight LC, Petersson EJ, Mehl RA, Johnson CP. Characterization of the lipid binding properties of Otoferlin reveals specific interactions between PI(4,5)P2 and the C2C and C2F domains. Biochemistry. 53: 5023-33. PMID 24999532 DOI: 10.1021/Bi5004469  1
2014 Horowitz S, Adhikari U, Dirk LM, Del Rizzo PA, Mehl RA, Houtz RL, Al-Hashimi HM, Scheiner S, Trievel RC. Manipulating unconventional CH-based hydrogen bonding in a methyltransferase via noncanonical amino acid mutagenesis. Acs Chemical Biology. 9: 1692-7. PMID 24914947 DOI: 10.1021/Cb5001185  1
2014 Wang K, Sachdeva A, Cox DJ, Wilf NM, Wilf NW, Lang K, Wallace S, Mehl RA, Chin JW. Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET. Nature Chemistry. 6: 393-403. PMID 24755590 DOI: 10.1038/Nchem.1919  0.68
2014 Cooley RB, Feldman JL, Driggers CM, Bundy TA, Stokes AL, Karplus PA, Mehl RA. Structural basis of improved second-generation 3-nitro-tyrosine tRNA synthetases. Biochemistry. 53: 1916-24. PMID 24611875 DOI: 10.1021/Bi5001239  1
2014 DiDonato JA, Aulak K, Huang Y, Wagner M, Gerstenecker G, Topbas C, Gogonea V, DiDonato AJ, Tang WH, Mehl RA, Fox PL, Plow EF, Smith JD, Fisher EA, Hazen SL. Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional. The Journal of Biological Chemistry. 289: 10276-92. PMID 24558038 DOI: 10.1074/Jbc.M114.556506  1
2014 Chatterjee D, Cooley RB, Boyd CD, Mehl RA, O’Toole GA, Sondermann H. Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP Elife. 3: 1-29. DOI: 10.7554/eLife.03650  1
2013 Speight LC, Muthusamy AK, Goldberg JM, Warner JB, Wissner RF, Willi TS, Woodman BF, Mehl RA, Petersson EJ. Efficient synthesis and in vivo incorporation of acridon-2-ylalanine, a fluorescent amino acid for lifetime and Förster resonance energy transfer/luminescence resonance energy transfer studies. Journal of the American Chemical Society. 135: 18806-14. PMID 24303933 DOI: 10.1021/Ja403247J  1
2013 Horowitz S, Dirk LM, Yesselman JD, Nimtz JS, Adhikari U, Mehl RA, Scheiner S, Houtz RL, Al-Hashimi HM, Trievel RC. Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases. Journal of the American Chemical Society. 135: 15536-48. PMID 24093804 DOI: 10.1021/Ja407140K  1
2013 Wu IL, Patterson MA, Carpenter Desai HE, Mehl RA, Giorgi G, Conticello VP. Multiple site-selective insertions of noncanonical amino acids into sequence-repetitive polypeptides. Chembiochem : a European Journal of Chemical Biology. 14: 968-78. PMID 23625817 DOI: 10.1002/Cbic.201300069  1
2013 Franco MC, Ye Y, Refakis CA, Feldman JL, Stokes AL, Basso M, Melero Fernández de Mera RM, Sparrow NA, Calingasan NY, Kiaei M, Rhoads TW, Ma TC, Grumet M, Barnes S, Beal MF, ... ... Mehl R, et al. Nitration of Hsp90 induces cell death. Proceedings of the National Academy of Sciences of the United States of America. 110: E1102-11. PMID 23487751 DOI: 10.1073/Pnas.1215177110  1
2013 Averick SE, Bazewicz CG, Woodman BF, Simakova A, Mehl RA, Matyjaszewski K. Protein-polymer hybrids: Conducting ARGET ATRP from a genetically encoded cleavable ATRP initiator European Polymer Journal. 49: 2919-2924. DOI: 10.1016/J.Eurpolymj.2013.04.015  1
2012 Mehl RA. Engineered unnatural animals: tools for multicellular biochemistry. Chembiochem : a European Journal of Chemical Biology. 13: 186-8. PMID 22351958 DOI: 10.1002/Cbic.201100674  1
2012 Seitchik JL, Peeler JC, Taylor MT, Blackman ML, Rhoads TW, Cooley RB, Refakis C, Fox JM, Mehl RA. Genetically encoded tetrazine amino acid directs rapid site-specific in vivo bioorthogonal ligation with trans-cyclooctenes. Journal of the American Chemical Society. 134: 2898-901. PMID 22283158 DOI: 10.1021/Ja2109745  1
2012 Averick SE, Paredes E, Grahacharya D, Woodman BF, Miyake-Stoner SJ, Mehl RA, Matyjaszewski K, Das SR. A protein-polymer hybrid mediated by DNA. Langmuir : the Acs Journal of Surfaces and Colloids. 28: 1954-8. PMID 22224833 DOI: 10.1021/La204077V  1
2012 Libby RD, Mehl RA. Characterization of covalent Ene adduct intermediates in "hydride equivalent" transfers in a dihydropyridine model for NADH reduction reactions. Bioorganic Chemistry. 40: 57-66. PMID 22112981 DOI: 10.1016/J.Bioorg.2011.10.002  1
2012 Peeler JC, Mehl RA. Site-specific incorporation of unnatural amino acids as probes for protein conformational changes. Methods in Molecular Biology (Clifton, N.J.). 794: 125-34. PMID 21956560 DOI: 10.1007/978-1-61779-331-8_8  1
2012 Averick S, Simakova A, Park S, Konkolewicz D, Magenau AJD, Mehl RA, Matyjaszewski K. ATRP under biologically relevant conditions: Grafting from a protein Acs Macro Letters. 1: 6-10. DOI: 10.1021/Mz200020C  1
2011 Averick SE, Magenau AJD, Simakova A, Woodman BF, Seong A, Mehl RA, Matyjaszewski K. Covalently incorporated protein-nanogels using AGET ATRP in an inverse miniemulsion Polymer Chemistry. 2: 1476-1478. DOI: 10.1039/C1Py00050K  1
2010 Peeler JC, Woodman BF, Averick S, Miyake-Stoner SJ, Stokes AL, Hess KR, Matyjaszewski K, Mehl RA. Genetically encoded initiator for polymer growth from proteins. Journal of the American Chemical Society. 132: 13575-7. PMID 20839808 DOI: 10.1021/ja104493d  1
2010 Rowe L, Ensor M, Mehl R, Daunert S. Modulating the bioluminescence emission of photoproteins by in vivo site-directed incorporation of non-natural amino acids. Acs Chemical Biology. 5: 455-60. PMID 20230005 DOI: 10.1021/Cb9002909  1
2010 Miyake-Stoner SJ, Refakis CA, Hammill JT, Lusic H, Hazen JL, Deiters A, Mehl RA. Generating permissive site-specific unnatural aminoacyl-tRNA synthetases. Biochemistry. 49: 1667-77. PMID 20082521 DOI: 10.1021/Bi901947R  1
2010 Li C, Wang GF, Wang Y, Creager-Allen R, Lutz EA, Scronce H, Slade KM, Ruf RA, Mehl RA, Pielak GJ. Protein (19)F NMR in Escherichia coli. Journal of the American Chemical Society. 132: 321-7. PMID 20050707 DOI: 10.1021/Ja907966N  1
2009 Stokes AL, Miyake-Stoner SJ, Peeler JC, Nguyen DP, Hammer RP, Mehl RA. Enhancing the utility of unnatural amino acid synthetases by manipulating broad substrate specificity. Molecular Biosystems. 5: 1032-8. PMID 19668869 DOI: 10.1039/B904032C  1
2009 Taskent-Sezgin H, Chung J, Patsalo V, Miyake-Stoner SJ, Miller AM, Brewer SH, Mehl RA, Green DF, Raleigh DP, Carrico I. Interpretation of p-cyanophenylalanine fluorescence in proteins in terms of solvent exposure and contribution of side-chain quenchers: a combined fluorescence, IR and molecular dynamics study. Biochemistry. 48: 9040-6. PMID 19658436 DOI: 10.1021/Bi900938Z  1
2009 Miyake-Stoner SJ, Miller AM, Hammill JT, Peeler JC, Hess KR, Mehl RA, Brewer SH. Probing protein folding using site-specifically encoded unnatural amino acids as FRET donors with tryptophan. Biochemistry. 48: 5953-62. PMID 19492814 DOI: 10.1021/Bi900426D  1
2008 Neumann H, Hazen JL, Weinstein J, Mehl RA, Chin JW. Genetically encoding protein oxidative damage. Journal of the American Chemical Society. 130: 4028-33. PMID 18321101 DOI: 10.1021/Ja710100D  1
2008 Carrico ZM, Romanini DW, Mehl RA, Francis MB. Oxidative coupling of peptides to a virus capsid containing unnatural amino acids Chemical Communications. 1205-1207. PMID 18309418 DOI: 10.1039/B717826C  1
2007 Hammill JT, Miyake-Stoner S, Hazen JL, Jackson JC, Mehl RA. Preparation of site-specifically labeled fluorinated proteins for 19F-NMR structural characterization. Nature Protocols. 2: 2601-7. PMID 17948003 DOI: 10.1038/Nprot.2007.379  1
2007 Jackson JC, Hammill JT, Mehl RA. Site-specific incorporation of a (19)F-amino acid into proteins as an NMR probe for characterizing protein structure and reactivity. Journal of the American Chemical Society. 129: 1160-6. PMID 17263397 DOI: 10.1021/Ja064661T  1
2006 Jackson JC, Duffy SP, Hess KR, Mehl RA. Improving nature's enzyme active site with genetically encoded unnatural amino acids. Journal of the American Chemical Society. 128: 11124-7. PMID 16925430 DOI: 10.1021/Ja061099Y  1
2005 Farrell IS, Toroney R, Hazen JL, Mehl RA, Chin JW. Photo-cross-linking interacting proteins with a genetically encoded benzophenone. Nature Methods. 2: 377-84. PMID 16170867 DOI: 10.1038/Nmeth0505-377  1
2004 Lawhorn BG, Mehl RA, Begley TP. Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction. Organic & Biomolecular Chemistry. 2: 2538-46. PMID 15326535 DOI: 10.1039/B405429F  1
2003 Mehl RA, Anderson JC, Santoro SW, Wang L, Martin AB, King DS, Horn DM, Schultz PG. Generation of a bacterium with a 21 amino acid genetic code. Journal of the American Chemical Society. 125: 935-9. PMID 12537491 DOI: 10.1021/Ja0284153  1
2002 Mehl RA, Begley TP. Synthesis of 32P-labeled intermediates on the purine biosynthetic pathway Journal of Labelled Compounds and Radiopharmaceuticals. 45: 1097-1102. DOI: 10.1002/Jlcr.627  1
2001 Begley TP, Kinsland C, Mehl RA, Osterman A, Dorrestein P. The biosynthesis of nicotinamide adenine dinucleotides in bacteria. Vitamins and Hormones. 61: 103-19. PMID 11153263 DOI: 10.1016/S0083-6729(01)61003-3  1
2000 Mehl RA, Kinsland C, Begley TP. Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene. Journal of Bacteriology. 182: 4372-4. PMID 10894752 DOI: 10.1128/Jb.182.15.4372-4374.2000  1
1999 Mehl RA, Begley TP. Mechanistic studies on the repair of a novel DNA photolesion: the spore photoproduct. Organic Letters. 1: 1065-6. PMID 10825958 DOI: 10.1021/Ol9908676  1
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