| Year |
Citation |
Score |
| 2021 |
Mostert KJ, Sharma N, van der Zwaag M, Staats R, Koekemoer L, Anand R, Sibon OCM, Strauss E. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. Acs Chemical Biology. PMID 34582681 DOI: 10.1021/acschembio.1c00535 |
0.347 |
|
| 2020 |
Spry C, Barnard L, Kok M, Powell A, Mahesh D, Tjhin ET, Saliba KJ, Strauss E, de Villiers M. Towards a stable and potent coenzyme A-targeting antiplasmodial agent: structure-activity relationship studies of N-phenethyl-α-methyl-pantothenamide. Acs Infectious Diseases. PMID 32375471 DOI: 10.1021/Acsinfecdis.0C00075 |
0.372 |
|
| 2020 |
Sharma N, Ahalawat N, Sandhu P, Strauss E, Mondal J, Anand R. Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation. Science Advances. 6: eaay7919. PMID 32284973 DOI: 10.1126/Sciadv.Aay7919 |
0.378 |
|
| 2019 |
Domingo R, van der Westhuyzen R, Hamann AR, Mostert KJ, Barnard L, Paquet T, Tjhin ET, Saliba KJ, van Otterlo WAL, Strauss E. Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801. Medchemcomm. 10: 2118-2125. PMID 32206243 DOI: 10.1039/C9Md00312F |
0.402 |
|
| 2018 |
Guan J, Barnard L, Cresson J, Hoegl A, Chang JH, Strauss E, Auclair K. Probing the ligand preferences of the three types of bacterial pantothenate kinase. Bioorganic & Medicinal Chemistry. PMID 30429095 DOI: 10.1016/J.Bmc.2018.10.042 |
0.342 |
|
| 2018 |
Santolaria C, Velázquez D, Strauss E, Ariño J. Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function. Scientific Reports. 8: 14701. PMID 30279472 DOI: 10.1038/S41598-018-32979-X |
0.353 |
|
| 2018 |
Abidin MZ, Saravanan T, Zhang J, Tepper P, Strauss E, Poelarends GJ. Modular enzymatic cascade synthesis of vitamin B5 and its derivatives. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30192043 DOI: 10.1002/Chem.201804151 |
0.304 |
|
| 2018 |
Tjhin ET, Spry C, Sewell AL, Hoegl A, Barnard L, Sexton AE, Siddiqui G, Howieson VM, Maier AG, Creek DJ, Strauss E, Marquez R, Auclair K, Saliba KJ. Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues. Plos Pathogens. 14: e1006918. PMID 29614109 DOI: 10.1371/Journal.Ppat.1006918 |
0.363 |
|
| 2018 |
Barnard L, Mostert KJ, van Otterlo WAL, Strauss E. Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action. Acs Infectious Diseases. PMID 29332383 DOI: 10.1021/Acsinfecdis.7B00240 |
0.406 |
|
| 2017 |
de Villiers M, Spry C, Macuamule CJ, Barnard L, Wells G, Saliba KJ, Strauss E. Antiplasmodial mode of action of pantothenamides: pantothenate kinase serves as a metabolic activator, not as a target. Acs Infectious Diseases. PMID 28437604 DOI: 10.1021/Acsinfecdis.7B00024 |
0.385 |
|
| 2017 |
Goosen R, Strauss E. Simultaneous quantification of coenzyme A and its salvage pathway intermediates in in vitro and whole cell-sourced samples Rsc Advances. 7: 19717-19724. DOI: 10.1039/C7Ra00192D |
0.394 |
|
| 2017 |
Tshililo NO, Strazzulli A, Cobucci-Ponzano B, Maurelli L, Iacono R, Bedini E, Corsaro MM, Strauss E, Moracci M. The α-Thioglycoligase Derived from a GH89 α-N-Acetylglucosaminidase Synthesises α-N-Acetylglucosamine-Based Glycosides of Biomedical Interest Advanced Synthesis & Catalysis. 359: 663-676. DOI: 10.1002/Adsc.201601091 |
0.317 |
|
| 2016 |
Hughes SJ, Barnard L, Mottaghi K, Tempel W, Antoshchenko T, Hong BS, Allali-Hassani A, Smil D, Vedadi M, Strauss E, Park HW. Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product. Acs Infectious Diseases. 2: 627-641. PMID 27759386 DOI: 10.1021/Acsinfecdis.6B00090 |
0.39 |
|
| 2016 |
Sibon OC, Strauss E. Coenzyme A: to make it or uptake it? Nature Reviews. Molecular Cell Biology. PMID 27552973 DOI: 10.1038/Nrm.2016.110 |
0.335 |
|
| 2015 |
Abrie JA, Molero C, Ariño J, Strauss E. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Scientific Reports. 5: 15774. PMID 26514574 DOI: 10.1038/Srep15774 |
0.382 |
|
| 2015 |
de Villiers M, Strauss E. Metabolism: Jump-starting CoA biosynthesis. Nature Chemical Biology. 11: 757-8. PMID 26379022 DOI: 10.1038/Nchembio.1912 |
0.336 |
|
| 2015 |
Macuamule CJ, Tjhin ET, Jana CE, Barnard L, Koekemoer L, de Villiers M, Saliba KJ, Strauss E. A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity. Antimicrobial Agents and Chemotherapy. 59: 3666-8. PMID 25845876 DOI: 10.1128/Aac.04970-14 |
0.307 |
|
| 2014 |
de Villiers M, Barnard L, Koekemoer L, Snoep JL, Strauss E. Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis. The Febs Journal. 281: 4731-53. PMID 25156889 DOI: 10.1111/Febs.13013 |
0.462 |
|
| 2014 |
Moolman WJ, de Villiers M, Strauss E. Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development. Biochemical Society Transactions. 42: 1080-6. PMID 25110006 DOI: 10.1042/Bst20140131 |
0.382 |
|
| 2014 |
Spry C, Saliba KJ, Strauss E. A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices. Analytical Biochemistry. 451: 76-8. PMID 24333332 DOI: 10.1016/J.Ab.2013.12.010 |
0.334 |
|
| 2013 |
de Villiers M, Macuamule C, Spry C, Hyun YM, Strauss E, Saliba KJ. Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity. Acs Medicinal Chemistry Letters. 4: 784-9. PMID 24900746 DOI: 10.1021/Ml400180D |
0.362 |
|
| 2013 |
Molero C, Petrényi K, González A, Carmona M, Gelis S, Abrie JA, Strauss E, Ramos J, Dombradi V, Hidalgo E, Ariño J. The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities. Molecular Microbiology. 90: 367-82. PMID 23962284 DOI: 10.1111/Mmi.12370 |
0.348 |
|
| 2013 |
Spry C, Macuamule C, Lin Z, Virga KG, Lee RE, Strauss E, Saliba KJ. Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated. Plos One. 8: e54974. PMID 23405100 DOI: 10.1371/Journal.Pone.0054974 |
0.377 |
|
| 2012 |
Wallace BD, Edwards JS, Wallen JR, Moolman WJ, van der Westhuyzen R, Strauss E, Redinbo MR, Claiborne A. Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights. Biochemistry. 51: 7699-711. PMID 22954034 DOI: 10.1021/Bi301026C |
0.448 |
|
| 2012 |
Lamprecht DA, Muneri NO, Eastwood H, Naidoo KJ, Strauss E, Jardine A. An enzyme-initiated Smiles rearrangement enables the development of an assay of MshB, the GlcNAc-Ins deacetylase of mycothiol biosynthesis. Organic & Biomolecular Chemistry. 10: 5278-88. PMID 22678300 DOI: 10.1039/C2Ob25429H |
0.44 |
|
| 2012 |
van der Westhuyzen R, Hammons JC, Meier JL, Dahesh S, Moolman WJ, Pelly SC, Nizet V, Burkart MD, Strauss E. The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis. Chemistry & Biology. 19: 559-71. PMID 22633408 DOI: 10.1016/J.Chembiol.2012.03.013 |
0.491 |
|
| 2012 |
Abrie JA, González A, Strauss E, Ariño J. Functional mapping of the disparate activities of the yeast moonlighting protein Hal3. The Biochemical Journal. 442: 357-68. PMID 22124281 DOI: 10.1042/Bj20111466 |
0.383 |
|
| 2010 |
van der Westhuyzen R, Strauss E. Michael acceptor-containing coenzyme A analogues as inhibitors of the atypical coenzyme A disulfide reductase from Staphylococcus aureus. Journal of the American Chemical Society. 132: 12853-5. PMID 20738089 DOI: 10.1021/Ja106204M |
0.425 |
|
| 2010 |
de Villiers J, Koekemoer L, Strauss E. 3-Fluoroaspartate and pyruvoyl-dependant aspartate decarboxylase: exploiting the unique characteristics of fluorine to probe reactivity and binding. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 10030-41. PMID 20645337 DOI: 10.1002/Chem.201000622 |
0.472 |
|
| 2010 |
Spry C, van Schalkwyk DA, Strauss E, Saliba KJ. Pantothenate utilization by plasmodium as a target for antimalarial chemotherapy Infectious Disorders - Drug Targets. 10: 200-216. PMID 20334619 DOI: 10.2174/187152610791163390 |
0.333 |
|
| 2010 |
Rootman I, de Villiers M, Brand LA, Strauss E. Creating cellulose-binding domain fusions of the coenzymea biosynthetic enzymes to enable reactor-based biotransformations Chemcatchem. 2: 1239-1251. DOI: 10.1002/Cctc.201000197 |
0.489 |
|
| 2010 |
Strauss E, de Villiers M, Rootman I. Biocatalytic Production of Coenzyme A Analogues Chemcatchem. 2: 929-937. DOI: 10.1002/Cctc.201000139 |
0.442 |
|
| 2010 |
Strauss E. Coenzyme A biosynthesis and enzymology Comprehensive Natural Products Ii: Chemistry and Biology. 7: 351-410. |
0.331 |
|
| 2009 |
Ruiz A, González A, Muñoz I, Serrano R, Abrie JA, Strauss E, Ariño J. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nature Chemical Biology. 5: 920-8. PMID 19915539 DOI: 10.1038/Nchembio.243 |
0.464 |
|
| 2008 |
van Wyk M, Strauss E. Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization. Organic & Biomolecular Chemistry. 6: 4348-55. PMID 19005594 DOI: 10.1039/B811086G |
0.392 |
|
| 2008 |
Yang K, Strauss E, Huerta C, Zhang H. Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase. Biochemistry. 47: 1369-80. PMID 18186650 DOI: 10.1021/Bi7018578 |
0.4 |
|
| 2007 |
van Wyk M, Strauss E. One-pot preparation of coenzyme A analogues via an improved chemo-enzymatic synthesis of pre-CoA thioester synthons. Chemical Communications (Cambridge, England). 398-400. PMID 17220983 DOI: 10.1039/B613527G |
0.415 |
|
| 2006 |
Yang K, Eyobo Y, Brand LA, Martynowski D, Tomchick D, Strauss E, Zhang H. Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria. Journal of Bacteriology. 188: 5532-40. PMID 16855243 DOI: 10.1128/Jb.00469-06 |
0.449 |
|
| 2005 |
Brand LA, Strauss E. Characterization of a new pantothenate kinase isoform from Helicobacter pylori. The Journal of Biological Chemistry. 280: 20185-8. PMID 15795230 DOI: 10.1074/Jbc.C500044200 |
0.454 |
|
| 2005 |
Strauss E, Begley TP. The selectivity for cysteine over serine in coenzyme A biosynthesis. Chembiochem : a European Journal of Chemical Biology. 6: 284-6. PMID 15593134 DOI: 10.1002/Cbic.200400340 |
0.472 |
|
| 2004 |
Strauss E, Zhai H, Brand LA, McLafferty FW, Begley TP. Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent. Biochemistry. 43: 15520-33. PMID 15581364 DOI: 10.1021/Bi048340A |
0.668 |
|
| 2003 |
Manoj N, Strauss E, Begley TP, Ealick SE. Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. Structure (London, England : 1993). 11: 927-36. PMID 12906824 DOI: 10.1016/S0969-2126(03)00146-1 |
0.519 |
|
| 2003 |
Seravalli J, Gu W, Tam A, Strauss E, Begley TP, Cramer SP, Ragsdale SW. Functional copper at the acetyl-CoA synthase active site. Proceedings of the National Academy of Sciences of the United States of America. 100: 3689-94. PMID 12589021 DOI: 10.1073/Pnas.0436720100 |
0.459 |
|
| 2003 |
Strauss E, Begley TP. Stereochemical studies on phosphopantothenoylcysteine decarboxylase from Escherichia coli. Bioorganic & Medicinal Chemistry Letters. 13: 339-42. PMID 12565925 DOI: 10.1016/S0960-894X(02)01018-1 |
0.502 |
|
| 2002 |
Strauss E, Begley TP. The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme a, a coenzyme a antimetabolite. The Journal of Biological Chemistry. 277: 48205-9. PMID 12372838 DOI: 10.1074/Jbc.M204560200 |
0.588 |
|
| 2002 |
Ge Y, Lawhorn BG, ElNaggar M, Strauss E, Park JH, Begley TP, McLafferty FW. Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry. Journal of the American Chemical Society. 124: 672-8. PMID 11804498 DOI: 10.1021/Ja011335Z |
0.685 |
|
| 2001 |
Strauss E, Begley TP. Mechanistic studies on phosphopantothenoylcysteine decarboxylase. Journal of the American Chemical Society. 123: 6449-50. PMID 11427085 DOI: 10.1021/Ja016020Y |
0.462 |
|
| 2001 |
Strauss E, Kinsland C, Ge Y, McLafferty FW, Begley TP. Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria. The Journal of Biological Chemistry. 276: 13513-6. PMID 11278255 DOI: 10.1074/Jbc.C100033200 |
0.723 |
|
| 2001 |
Begley TP, Kinsland C, Strauss E. The biosynthesis of coenzyme A in bacteria. Vitamins and Hormones. 61: 157-71. PMID 11153265 DOI: 10.1016/S0083-6729(01)61005-7 |
0.702 |
|
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