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Po-Ssu Huang, Ph.D. - Publications

Affiliations: 
2004 California Institute of Technology, Pasadena, CA 
Area:
Structural Biology
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Longwell CK, Hanna S, Hartrampf N, Sperberg RAP, Huang PS, Pentelute BL, Cochran JR. Identification of N-Terminally Diversified GLP-1R Agonists Using Saturation Mutagenesis and Chemical Design. Acs Chemical Biology. PMID 33307682 DOI: 10.1021/acschembio.0c00722  0.4
2020 Caldwell SJ, Haydon IC, Piperidou N, Huang PS, Bick MJ, Sjöström HS, Hilvert D, Baker D, Zeymer C. Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion. Proceedings of the National Academy of Sciences of the United States of America. PMID 33203677 DOI: 10.1073/pnas.2008535117  0.84
2020 Wayment-Steele HK, Kim DS, Choe CA, Nicol JJ, Wellington-Oguri R, Sperberg RAP, Huang PS, Das R. Theoretical basis for stabilizing messenger RNA through secondary structure design. Biorxiv : the Preprint Server For Biology. PMID 32869022 DOI: 10.1101/2020.08.22.262931  0.4
2020 Xu C, Lu P, Gamal El-Din TM, Pei XY, Johnson MC, Uyeda A, Bick MJ, Xu Q, Jiang D, Bai H, Reggiano G, Hsia Y, Brunette TJ, Dou J, Ma D, ... ... Huang PS, et al. Computational design of transmembrane pores. Nature. PMID 32848250 DOI: 10.1038/s41586-020-2646-5  0.84
2020 Kim JW, Marquez CP, Sperberg RAP, Wu J, Bae WG, Huang PS, Sweet-Cordero EA, Cochran JR. Engineering a potent receptor superagonist or antagonist from a novel IL-6 family cytokine ligand. Proceedings of the National Academy of Sciences of the United States of America. PMID 32522868 DOI: 10.1073/pnas.1922729117  0.4
2020 Leman JK, Weitzner BD, Lewis SM, Adolf-Bryfogle J, Alam N, Alford RF, Aprahamian M, Baker D, Barlow KA, Barth P, Basanta B, Bender BJ, Blacklock K, Bonet J, Boyken SE, ... ... Huang PS, et al. Macromolecular modeling and design in Rosetta: recent methods and frameworks. Nature Methods. PMID 32483333 DOI: 10.1038/s41592-020-0848-2  0.84
2020 Wei KY, Moschidi D, Bick MJ, Nerli S, McShan AC, Carter LP, Huang PS, Fletcher DA, Sgourakis NG, Boyken SE, Baker D. Computational design of closely related proteins that adopt two well-defined but structurally divergent folds. Proceedings of the National Academy of Sciences of the United States of America. PMID 32188784 DOI: 10.1073/pnas.1914808117  0.84
2019 Meier S, Bohnacker S, Klose CJ, Lopez A, Choe CA, Schmid PWN, Bloemeke N, Rührnößl F, Haslbeck M, Bieren JE, Sattler M, Huang PS, Feige MJ. The molecular basis of chaperone-mediated interleukin 23 assembly control. Nature Communications. 10: 4121. PMID 31511508 DOI: 10.1038/s41467-019-12006-x  0.4
2018 Dou J, Vorobieva AA, Sheffler W, Doyle LA, Park H, Bick MJ, Mao B, Foight GW, Lee MY, Gagnon LA, Carter L, Sankaran B, Ovchinnikov S, Marcos E, Huang PS, et al. De novo design of a fluorescence-activating β-barrel. Nature. PMID 30209393 DOI: 10.1038/s41586-018-0509-0  0.84
2017 Parmeggiani F, Huang PS. Designing repeat proteins: a modular approach to protein design. Current Opinion in Structural Biology. 45: 116-123. PMID 28267654 DOI: 10.1016/j.sbi.2017.02.001  0.4
2017 Ovchinnikov S, Park H, Varghese N, Huang PS, Pavlopoulos GA, Kim DE, Kamisetty H, Kyrpides NC, Baker D. Protein structure determination using metagenome sequence data. Science (New York, N.Y.). 355: 294-298. PMID 28104891 DOI: 10.1126/science.aah4043  0.84
2016 Rose JC, Huang PS, Camp ND, Ye J, Leidal AM, Goreshnik I, Trevillian BM, Dickinson MS, Cunningham-Bryant D, Debnath J, Baker D, Wolf-Yadlin A, Maly DJ. A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. Nature Chemical Biology. PMID 27870838 DOI: 10.1038/nchembio.2244  0.84
2016 Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D. Corrigendum: Design of a hyperstable 60-subunit protein icosahedron. Nature. PMID 27760110 DOI: 10.1038/nature20108  0.84
2016 Huang PS, Boyken SE, Baker D. The coming of age of de novo protein design. Nature. 537: 320-327. PMID 27629638 DOI: 10.1038/nature19946  0.68
2016 Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, et al. Accurate de novo design of hyperstable constrained peptides. Nature. PMID 27626386 DOI: 10.1038/nature19791  0.84
2016 Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D. Design of a hyperstable 60-subunit protein icosahedron. Nature. PMID 27309817 DOI: 10.1038/nature18010  0.68
2016 Tian XQ, Yang YJ, Li Q, Huang PS, Li XD, Jin C, Qi K, Jiang LP, Chen GH. Globular Adiponectin Inhibits the Apoptosis of Mesenchymal Stem Cells Induced by Hypoxia and Serum Deprivation via the AdipoR1-Mediated Pathway. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 38: 909-925. PMID 26919192 DOI: 10.1159/000443044  0.32
2016 Huang PY, Xu ZH, Liu Y, Li XD, Liao H, Nian XY, Liu XG, Ou Cw, Xu DP. The clinical significance of nucleotide G1613A and C1653T mutations in the core promoter region of hepatitis B virus Medical Journal of Chinese People's Liberation Army. 41: 204-210. DOI: 10.11855/j.issn.0577-7402.2016.03.07  0.32
2015 Brunette TJ, Parmeggiani F, Huang PS, Bhabha G, Ekiert DC, Tsutakawa SE, Hura GL, Tainer JA, Baker D. Exploring the repeat protein universe through computational protein design. Nature. PMID 26675729 DOI: 10.1038/nature16162  0.68
2015 Huang PS, Feldmeier K, Parmeggiani F, Fernandez Velasco DA, Höcker B, Baker D. De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy. Nature Chemical Biology. PMID 26595462 DOI: 10.1038/nchembio.1966  0.4
2015 Mou Y, Huang PS, Hsu FC, Huang SJ, Mayo SL. Computational design and experimental verification of a symmetric protein homodimer. Proceedings of the National Academy of Sciences of the United States of America. 112: 10714-9. PMID 26269568 DOI: 10.1073/pnas.1505072112  0.6
2015 Mou Y, Huang PS, Thomas LM, Mayo SL. Using molecular dynamics simulations as an aid in the prediction of domain swapping of computationally designed protein variants. Journal of Molecular Biology. PMID 26101839 DOI: 10.1016/j.jmb.2015.06.006  0.6
2015 Park K, Shen BW, Parmeggiani F, Huang PS, Stoddard BL, Baker D. Control of repeat-protein curvature by computational protein design. Nature Structural & Molecular Biology. 22: 167-74. PMID 25580576 DOI: 10.1038/nsmb.2938  0.84
2015 Parmeggiani F, Huang PS, Vorobiev S, Xiao R, Park K, Caprari S, Su M, Seetharaman J, Mao L, Janjua H, Montelione GT, Hunt J, Baker D. A general computational approach for repeat protein design. Journal of Molecular Biology. 427: 563-75. PMID 25451037 DOI: 10.1016/j.jmb.2014.11.005  0.84
2015 Yu R, Huang P, Ren H, Xie Z, Wang C, Ma X. Ammonium removal by struvite precipitation with cheap magnesia Huagong Xuebao/Ciesc Journal. 66: 5040-5044. DOI: 10.11949/j.issn.0438-1157.20150857  0.32
2014 Huang PS, Oberdorfer G, Xu C, Pei XY, Nannenga BL, Rogers JM, DiMaio F, Gonen T, Luisi B, Baker D. High thermodynamic stability of parametrically designed helical bundles. Science (New York, N.Y.). 346: 481-5. PMID 25342806 DOI: 10.1126/science.1257481  0.68
2013 Schiffner T, Kong L, Duncan CJ, Back JW, Benschop JJ, Shen X, Huang PS, Stewart-Jones GB, DeStefano J, Seaman MS, Tomaras GD, Montefiori DC, Schief WR, Sattentau QJ. Immune focusing and enhanced neutralization induced by HIV-1 gp140 chemical cross-linking. Journal of Virology. 87: 10163-72. PMID 23843636 DOI: 10.1128/JVI.01161-13  0.68
2013 Jardine J, Julien JP, Menis S, Ota T, Kalyuzhniy O, McGuire A, Sok D, Huang PS, MacPherson S, Jones M, Nieusma T, Mathison J, Baker D, Ward AB, Burton DR, et al. Rational HIV immunogen design to target specific germline B cell receptors. Science (New York, N.Y.). 340: 711-6. PMID 23539181 DOI: 10.1126/science.1234150  0.68
2013 Yu Y, Zhu J, Huang PS, Wang JH, Pullen N, Springer TA. Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop. The Journal of Biological Chemistry. 288: 6284-94. PMID 23297416 DOI: 10.1074/jbc.M112.413153  0.68
2011 Azoitei ML, Correia BE, Ban YE, Carrico C, Kalyuzhniy O, Chen L, Schroeter A, Huang PS, McLellan JS, Kwong PD, Baker D, Strong RK, Schief WR. Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold. Science (New York, N.Y.). 334: 373-6. PMID 22021856 DOI: 10.1126/science.1209368  0.68
2011 Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science (New York, N.Y.). 334: 1097-103. PMID 21998254 DOI: 10.1126/science.1213256  0.68
2011 Huang PS, Ban YE, Richter F, Andre I, Vernon R, Schief WR, Baker D. RosettaRemodel: a generalized framework for flexible backbone protein design. Plos One. 6: e24109. PMID 21909381 DOI: 10.1371/journal.pone.0024109  0.68
2011 Correia BE, Holmes MA, Huang PS, Strong RK, Schief WR. High-resolution structure prediction of a circular permutation loop. Protein Science : a Publication of the Protein Society. 20: 1929-34. PMID 21898647 DOI: 10.1002/pro.725  0.68
2011 van Montfort T, Melchers M, Isik G, Menis S, Huang PS, Matthews K, Michael E, Berkhout B, Schief WR, Moore JP, Sanders RW. A chimeric HIV-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (GM-CSF) domain induces enhanced antibody and T cell responses. The Journal of Biological Chemistry. 286: 22250-61. PMID 21515681 DOI: 10.1074/jbc.M111.229625  0.68
2010 Smagghe BJ, Huang PS, Ban YE, Baker D, Springer TA. Modulation of integrin activation by an entropic spring in the {beta}-knee. The Journal of Biological Chemistry. 285: 32954-66. PMID 20670939 DOI: 10.1074/jbc.M110.145177  0.68
2007 Huang PS, Love JJ, Mayo SL. A de novo designed protein protein interface. Protein Science : a Publication of the Protein Society. 16: 2770-4. PMID 18029425 DOI: 10.1110/ps.073125207  0.68
2005 Huang PS, Love JJ, Mayo SL. Adaptation of a fast Fourier transform-based docking algorithm for protein design. Journal of Computational Chemistry. 26: 1222-32. PMID 15962277 DOI: 10.1002/jcc.20252  0.68
2004 Shukla UJ, Marino H, Huang PS, Mayo SL, Love JJ. A designed protein interface that blocks fibril formation. Journal of the American Chemical Society. 126: 13914-5. PMID 15506739 DOI: 10.1021/ja0456858  0.68
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