John M. Pascal, Ph.D. - Publications

2000 University of Texas at Austin, Austin, Texas, U.S.A. 
Biochemistry: Structural Biology, Protein Engineering, And Drug Design

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Riccio AA, Cingolani G, Pascal JM. PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage. Nucleic Acids Research. PMID 26704974 DOI: 10.1093/Nar/Gkv1376  0.56
2015 Dawicki-McKenna JM, Langelier MF, DeNizio JE, Riccio AA, Cao CD, Karch KR, McCauley M, Steffen JD, Black BE, Pascal JM. PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain. Molecular Cell. PMID 26626480 DOI: 10.1016/J.Molcel.2015.10.013  0.56
2015 Eustermann S, Wu WF, Langelier MF, Yang JC, Easton LE, Riccio AA, Pascal JM, Neuhaus D. Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1. Molecular Cell. PMID 26626479 DOI: 10.1016/J.Molcel.2015.10.032  0.56
2015 Chan TO, Zhang J, Tiegs BC, Blumhof B, Yan L, Keny N, Penny M, Li X, Pascal JM, Armen RS, Rodeck U, Penn RB. Akt Kinase C-Terminal Modifications Control Activation Loop Dephosphorylation and Enhance Insulin Response. The Biochemical Journal. PMID 26201515 DOI: 10.1042/Bj20150325  0.56
2015 Pascal JM, Ellenberger T. The rise and fall of poly(ADP-ribose): An enzymatic perspective. Dna Repair. 32: 10-6. PMID 25963443 DOI: 10.1016/J.Dnarep.2015.04.008  0.56
2015 Gagné JP, Ethier C, Defoy D, Bourassa S, Langelier MF, Riccio AA, Pascal JM, Moon KM, Foster LJ, Ning Z, Figeys D, Droit A, Poirier GG. Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs. Dna Repair. 30: 68-79. PMID 25800440 DOI: 10.1016/J.Dnarep.2015.02.004  0.56
2014 Zhang M, Meng XY, Cui M, Pascal JM, Logothetis DE, Zhang JF. Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex. Nature Chemical Biology. 10: 753-9. PMID 25108821 DOI: 10.1038/Nchembio.1592  0.56
2014 Langelier MF, Riccio AA, Pascal JM. PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1. Nucleic Acids Research. 42: 7762-75. PMID 24928857 DOI: 10.1093/Nar/Gku474  0.56
2014 Patel MR, Bhatt A, Steffen JD, Chergui A, Murai J, Pommier Y, Pascal JM, Trombetta LD, Fronczek FR, Talele TT. Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors. Journal of Medicinal Chemistry. 57: 5579-601. PMID 24922587 DOI: 10.1021/Jm5002502  0.56
2014 Steffen JD, Tholey RM, Langelier MF, Planck JL, Schiewer MJ, Lal S, Bildzukewicz NA, Yeo CJ, Knudsen KE, Brody JR, Pascal JM. Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer. Cancer Research. 74: 31-7. PMID 24189460 DOI: 10.1158/0008-5472.Can-13-1701  0.56
2013 Steffen JD, Brody JR, Armen RS, Pascal JM. Structural Implications for Selective Targeting of PARPs. Frontiers in Oncology. 3: 301. PMID 24392349 DOI: 10.3389/Fonc.2013.00301  0.56
2013 Steffen JD, Pascal JM. New players to the field of ADP-ribosylation make the final cut. The Embo Journal. 32: 1205-7. PMID 23572078 DOI: 10.1038/Emboj.2013.83  0.56
2013 Zhang M, Pascal JM, Zhang JF. Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca²⁺-sensing and SK channel activation. Proceedings of the National Academy of Sciences of the United States of America. 110: 4828-33. PMID 23487779 DOI: 10.1073/Pnas.1220253110  0.56
2013 Karlberg T, Langelier MF, Pascal JM, Schüler H. Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling. Molecular Aspects of Medicine. 34: 1088-108. PMID 23458732 DOI: 10.1016/J.Mam.2013.02.002  0.56
2013 Langelier MF, Pascal JM. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis. Current Opinion in Structural Biology. 23: 134-43. PMID 23333033 DOI: 10.1016/J.Sbi.2013.01.003  0.56
2012 Schiewer MJ, Goodwin JF, Han S, Brenner JC, Augello MA, Dean JL, Liu F, Planck JL, Ravindranathan P, Chinnaiyan AM, McCue P, Gomella LG, Raj GV, Dicker AP, Brody JR, ... Pascal JM, et al. Dual roles of PARP-1 promote cancer growth and progression. Cancer Discovery. 2: 1134-49. PMID 22993403 DOI: 10.1158/2159-8290.Cd-12-0120  0.56
2012 Zhang M, Pascal JM, Schumann M, Armen RS, Zhang JF. Identification of the functional binding pocket for compounds targeting small-conductance Ca 2+ -activated potassium channels Nature Communications. 3. PMID 22929778 DOI: 10.1038/Ncomms2017  0.56
2012 Langelier MF, Planck JL, Roy S, Pascal JM. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1. Science (New York, N.Y.). 336: 728-32. PMID 22582261 DOI: 10.1126/Science.1216338  0.56
2012 Zhang M, Abrams C, Wang L, Gizzi A, He L, Lin R, Chen Y, Loll PJ, Pascal JM, Zhang JF. Structural basis for calmodulin as a dynamic calcium sensor. Structure (London, England : 1993). 20: 911-23. PMID 22579256 DOI: 10.1016/J.Str.2012.03.019  0.56
2012 Chan TO, Pascal JM, Armen RS, Rodeck U. Autoregulation of kinase dephosphorylation by ATP binding to AGC protein kinases Cell Cycle. 11: 475-478. PMID 22262182 DOI: 10.4161/Cc.11.3.19059  0.56
2012 Liu C, Sanders JM, Pascal JM, Hou YM. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases. Rna (New York, N.Y.). 18: 213-21. PMID 22184460 DOI: 10.1261/Rna.029983.111  0.56
2011 Chan TO, Zhang J, Rodeck U, Pascal JM, Armen RS, Spring M, Dumitru CD, Myers V, Li X, Cheung JY, Feldman AM. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity Proceedings of the National Academy of Sciences of the United States of America. 108: E1120-E1127. PMID 22031698 DOI: 10.1073/Pnas.1109879108  0.56
2011 Langelier MF, Planck JL, Servent KM, Pascal JM. Purification of human PARP-1 and PARP-1 domains from Escherichia coli for structural and biochemical analysis. Methods in Molecular Biology (Clifton, N.J.). 780: 209-26. PMID 21870263 DOI: 10.1007/978-1-61779-270-0_13  0.56
2011 Langelier MF, Planck JL, Roy S, Pascal JM. Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity. The Journal of Biological Chemistry. 286: 10690-701. PMID 21233213 DOI: 10.1074/Jbc.M110.202507  0.56
2010 Langelier MF, Ruhl DD, Planck JL, Kraus WL, Pascal JM. The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction. The Journal of Biological Chemistry. 285: 18877-87. PMID 20388712 DOI: 10.1074/Jbc.M110.105668  0.56
2009 Song W, Pascal JM, Ellenberger T, Tomkinson AE. The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1. Dna Repair. 8: 912-9. PMID 19523882 DOI: 10.1016/J.Dnarep.2009.05.002  0.56
2008 Pascal JM. DNA and RNA ligases: structural variations and shared mechanisms. Current Opinion in Structural Biology. 18: 96-105. PMID 18262407 DOI: 10.1016/J.Sbi.2007.12.008  0.56
2008 Langelier MF, Servent KM, Rogers EE, Pascal JM. A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation. The Journal of Biological Chemistry. 283: 4105-14. PMID 18055453 DOI: 10.1074/Jbc.M708558200  0.56
2008 Langelier MF, Servent KM, Rogers EE, Pascal JM. A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation (Journal of Biological Chemistry (2008) 283, (4105-4114)) Journal of Biological Chemistry. 283: 22884.  0.56
2006 Pascal JM, Ellenberger T. RNA ligase does the AMP shuffle. Nature Structural & Molecular Biology. 13: 950-1. PMID 17082787 DOI: 10.1038/Nsmb1106-950  0.56
2006 Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T. A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Molecular Cell. 24: 279-91. PMID 17052461 DOI: 10.1016/J.Molcel.2006.08.015  0.56
2006 Chen X, Pascal J, Vijayakumar S, Wilson GM, Ellenberger T, Tomkinson AE. Human DNA Ligases I, III, and IV-Purification and New Specific Assays for These Enzymes Methods in Enzymology. 409: 39-52. PMID 16793394 DOI: 10.1016/S0076-6879(05)09003-8  0.56
2006 Tomkinson AE, Vijayakumar S, Pascal JM, Ellenberger T. DNA ligases: structure, reaction mechanism, and function. Chemical Reviews. 106: 687-99. PMID 16464020 DOI: 10.1021/Cr040498D  0.56
2004 Pascal JM, O'Brien PJ, Tomkinson AE, Ellenberger T. Human DNA ligase I completely encircles and partially unwinds nicked DNA. Nature. 432: 473-8. PMID 15565146 DOI: 10.1038/Nature03082  0.56
2002 Pascal JM, Hart PJ, Hecht NB, Robertus JD. Crystal structure of TB-RBP, a novel RNA-binding and regulating protein. Journal of Molecular Biology. 319: 1049-57. PMID 12079346 DOI: 10.1016/S0022-2836(02)00364-9  0.56
2001 Pascal JM, Chennathukuzhi VM, Hecht NB, Robertus JD. Mouse testis-brain RNA-binding protein (TB-RBP): expression, purification and crystal X-ray diffraction. Acta Crystallographica. Section D, Biological Crystallography. 57: 1692-4. PMID 11679747 DOI: 10.1107/S0907444901014548  0.56
2001 Pascal JM, Day PJ, Monzingo AF, Ernst SR, Robertus JD, Iglesias R, Pérez Y, Férreras JM, Citores L, Girbés T. 2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l. Proteins. 43: 319-26. PMID 11288182 DOI: 10.1002/Prot.1043  0.56
1996 Day PJ, Ernst SR, Frankel AE, Monzingo AF, Pascal JM, Molina-Svinth MC, Robertus JD. Structure and activity of an active site substitution of ricin A chain. Biochemistry. 35: 11098-103. PMID 8780513 DOI: 10.1021/Bi960880N  0.56
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