Laura M. Wingler, Ph.D. - Publications

2011 Chemistry Columbia University, New York, NY 
Chemical Complementation, Ribosome Chemistry, In Vivo Imaging

23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, et al. Rapid generation of potent antibodies by autonomous hypermutation in yeast. Biorxiv : the Preprint Server For Biology. PMID 33200136 DOI: 10.1101/2020.11.11.378778  0.6
2020 McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ. Synthetic nanobodies as angiotensin receptor blockers. Proceedings of the National Academy of Sciences of the United States of America. PMID 32753386 DOI: 10.1073/pnas.2009029117  1
2020 Wingler LM, Lefkowitz RJ. Conformational Basis of G Protein-Coupled Receptor Signaling Versatility. Trends in Cell Biology. PMID 32622699 DOI: 10.1016/j.tcb.2020.06.002  1
2020 Manglik A, Wingler LM, Rockman HA, Lefkowitz RJ. β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19. Circulation. PMID 32412788 DOI: 10.1161/CIRCULATIONAHA.120.048723  1
2020 Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science (New York, N.Y.). 367: 888-892. PMID 32079768 DOI: 10.1126/science.aay9813  1
2020 Suomivuori CM, Latorraca NR, Wingler LM, Eismann S, King MC, Kleinhenz ALW, Skiba MA, Staus DP, Kruse AC, Lefkowitz RJ, Dror RO. Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. Science (New York, N.Y.). 367: 881-887. PMID 32079767 DOI: 10.1126/science.aaz0326  1
2020 Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G. Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc. Nature. PMID 31945772 DOI: 10.1038/s41586-020-1954-0  1
2019 Staus DP, Wingler LM, Pichugin D, Prosser RS, Lefkowitz RJ. Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G protein-coupled receptors. The Journal of Biological Chemistry. PMID 31362983 DOI: 10.1074/jbc.AC119.009848  1
2019 Wingler LM, McMahon C, Staus DP, Lefkowitz RJ, Kruse AC. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell. PMID 30639100 DOI: 10.1016/j.cell.2018.12.006  1
2019 Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. PMID 30639099 DOI: 10.1016/j.cell.2018.12.005  1
2018 Choi M, Staus DP, Wingler LM, Ahn S, Pani B, Capel WD, Lefkowitz RJ. G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β-adrenergic receptor. Science Signaling. 11. PMID 30131371 DOI: 10.1126/scisignal.aar7084  1
2018 Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestrgaard M, Jin L, Zhao S, Wingler LM, Rambarat PK, Simhal RK, Xu TT, Sun LD, Shim PJ, Staus DP, et al. Small Molecule Positive Allosteric Modulators of the β-Adrenoceptor Isolated from DNA Encoded Libraries. Molecular Pharmacology. PMID 29769246 DOI: 10.1124/mol.118.111948  1
2018 Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ. Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581292 DOI: 10.1073/pnas.1722336115  1
2017 Paek J, Kalocsay M, Staus DP, Wingler L, Pascolutti R, Paulo JA, Gygi SP, Kruse AC. Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling. Cell. 169: 338-349.e11. PMID 28388415 DOI: 10.1016/j.cell.2017.03.028  0.76
2017 Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, et al. Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. Proceedings of the National Academy of Sciences of the United States of America. PMID 28130548 DOI: 10.1073/pnas.1620645114  1
2016 Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, et al. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature. PMID 27409812 DOI: 10.1038/nature18636  1
2016 Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, et al. Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor. Nature Chemical Biology. PMID 27398998 DOI: 10.1038/nchembio.2126  1
2014 Staus DP, Wingler LM, Strachan RT, Rasmussen SG, Pardon E, Ahn S, Steyaert J, Kobilka BK, Lefkowitz RJ. Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. Molecular Pharmacology. 85: 472-81. PMID 24319111 DOI: 10.1124/mol.113.089516  1
2013 Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, et al. Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor. Acs Medicinal Chemistry Letters. 4: 1005-1010. PMID 24454993 DOI: 10.1021/ml400312j  1
2013 Harton MD, Wingler LM, Cornish VW. Transcriptional regulation improves the throughput of three-hybrid counter selections in Saccharomyces cerevisiae. Biotechnology Journal. 8: 1485-91. PMID 24318638 DOI: 10.1002/biot.201300186  1
2013 Ostrov N, Wingler LM, Cornish VW. Gene assembly and combinatorial libraries in S. cerevisiae via reiterative recombination. Methods in Molecular Biology (Clifton, N.J.). 978: 187-203. PMID 23423898 DOI: 10.1007/978-1-62703-293-3_14  1
2011 Wingler LM, Cornish VW. Reiterative Recombination for the in vivo assembly of libraries of multigene pathways. Proceedings of the National Academy of Sciences of the United States of America. 108: 15135-40. PMID 21876185 DOI: 10.1073/pnas.1100507108  1
2011 Wingler LM, Cornish VW. A library approach for the discovery of customized yeast three-hybrid counter selections. Chembiochem : a European Journal of Chemical Biology. 12: 715-7. PMID 21404416 DOI: 10.1002/cbic.201000543  1
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