German A. Gomez, Ph.D. - Related publications

Affiliations: 
2006 University of Pennsylvania, Philadelphia, PA, United States 
Area:
structure-mechanism of hydrolytic metalloenzymes
NOTE: We are testing a new system for identifying relevant work based on semantic analysis that identifies similarities between recently published papers and the current author's publications. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches.
50 most relevant papers in past 60 days:
Year Citation  Score
2021 Gerrard Wheeler MC, Arias CL, E Mello JDFR, Cirauqui Diaz N, Rodrigues CR, Drincovich MF, de Souza AMT, Alvarez CE. Structural insights into the allosteric site of Arabidopsis NADP-malic enzyme 2: role of the second sphere residues in the regulatory signal transmission. Plant Molecular Biology. PMID 34333694 DOI: 10.1007/s11103-021-01176-2   
2021 Wangpaiboon K, Laohawuttichai P, Kim SY, Mori T, Nakapong S, Pichyangkura R, Pongsawasdi P, Hakoshima T, Krusong K. A GH13 α-glucosidase from Weissella cibaria uncommonly acts on short-chain maltooligosaccharides. Acta Crystallographica. Section D, Structural Biology. 77: 1064-1076. PMID 34342279 DOI: 10.1107/S205979832100677X   
2021 Jia Q, Zeng H, Li H, Xiao N, Tang J, Gao S, Zhang J, Xie W. The C-terminal loop of guanosine deaminase is essential to catalysis. Chemical Communications (Cambridge, England). PMID 34477187 DOI: 10.1039/d1cc03042f   
2021 James MO. Enzyme Kinetics of PAPS-Sulfotransferase. Methods in Molecular Biology (Clifton, N.J.). 2342: 285-300. PMID 34272699 DOI: 10.1007/978-1-0716-1554-6_11   
2021 James MO. Enzyme Kinetics of PAPS-Sulfotransferase. Methods in Molecular Biology (Clifton, N.J.). 2342: 285-300. PMID 34272699 DOI: 10.1007/978-1-0716-1554-6_11   
2021 Padavattan S, Jos S, Gogoi H, Bagautdinov B. Crystal structure of enoyl-CoA hydratase from Thermus thermophilus HB8. Acta Crystallographica. Section F, Structural Biology Communications. 77: 148-155. PMID 33949975 DOI: 10.1107/S2053230X21004593   
2021 Currie MJ, Manjunath L, Horne CR, Rendle PM, Subramanian R, Friemann R, Fairbanks AJ, Muscroft-Taylor AC, North RA, Dobson RCJ. N-Acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization. The Journal of Biological Chemistry. 101113. PMID 34437902 DOI: 10.1016/j.jbc.2021.101113   
2021 Weiss AKH, Wurzer R, Klapec P, Eder MP, Loeffler JR, von Grafenstein S, Monteleone S, Liedl KR, Jansen-Dürr P, Gstach H. Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1). Molecules (Basel, Switzerland). 26. PMID 34443596 DOI: 10.3390/molecules26165009   
2021 Sugiura S, Nakano S, Niwa M, Hasebe F, Matsui D, Ito S. Catalytic Mechanism of Ancestral L-Lysine Oxidase Assigned by Sequence Data Mining. The Journal of Biological Chemistry. 101043. PMID 34358565 DOI: 10.1016/j.jbc.2021.101043   
2021 Marshall AC, Bruning JB. Engineering potassium activation into biosynthetic thiolase. The Biochemical Journal. PMID 34338286 DOI: 10.1042/BCJ20210455   
2021 Zhang X, Huang Z, Wang D, Zhang Y, Eser BE, Gu Z, Dai R, Gao R, Guo Z. A new thermophilic extradiol dioxygenase promises biodegradation of catecholic pollutants. Journal of Hazardous Materials. 422: 126860. PMID 34399224 DOI: 10.1016/j.jhazmat.2021.126860   
2021 Blain JM, Grote DL, Watkins SM, Goshu GM, Muller C, Gorman JL, Ranieri G, Walter RL, Hofstetter H, Horn JR, Hagen TJ. Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate. Bioorganic & Medicinal Chemistry Letters. 48: 128273. PMID 34298132 DOI: 10.1016/j.bmcl.2021.128273   
2021 Chan SI, Chang WH, Huang SH, Lin HH, Yu SS. Catalytic machinery of methane oxidation in particulate methane monooxygenase (pMMO). Journal of Inorganic Biochemistry. 225: 111602. PMID 34547604 DOI: 10.1016/j.jinorgbio.2021.111602   
2021 Bai Y, Parker EJ. Reciprocal allostery arising from a bi-enzyme assembly controls aromatic amino acid biosynthesis in Prevotella nigrescens. The Journal of Biological Chemistry. 101038. PMID 34343567 DOI: 10.1016/j.jbc.2021.101038   
2021 DeLaney C, Sheng Y, Pectol DC, Vantansever E, Zhang H, Bhuvanesh N, Salas I, Liu WR, Fierke CF, Darensbourg MY. Zinc thiotropolone combinations as inhibitors of the SARS-CoV-2 main protease. Dalton Transactions (Cambridge, England : 2003). PMID 34396374 DOI: 10.1039/d1dt02499j   
2021 Pandey S, Mahanta P, Berger BW, Acharya R. Structural insights into the mechanism of pH-selective substrate specificity of the polysaccharide lyase Smlt1473. The Journal of Biological Chemistry. 101014. PMID 34358563 DOI: 10.1016/j.jbc.2021.101014   
2021 Marshall SA, Payne KAP, Fisher K, Titchiner GR, Levy C, Hay S, Leys D. UbiD domain dynamics underpins aromatic decarboxylation. Nature Communications. 12: 5065. PMID 34417452 DOI: 10.1038/s41467-021-25278-z   
2021 Chua SMH, Wizrah MSI, Luo Z, Lim BYJ, Kappler U, Kobe B, Fraser JA. Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets. The Journal of Biological Chemistry. 101091. PMID 34416230 DOI: 10.1016/j.jbc.2021.101091   
2021 Bandyopadhyay A, Saxena AK. Structural and ATPase activity analysis of nucleotide binding domain of Rv3870 enzyme of M. tuberculosis ESX-1 system. International Journal of Biological Macromolecules. PMID 34428493 DOI: 10.1016/j.ijbiomac.2021.08.130   
2021 Gyebi GA, Elfiky AA, Ogunyemi OM, Ibrahim IM, Adegunloye AP, Adebayo JO, Olaiya CO, Ocheje JO, Fabusiwa MM. Structure-based virtual screening suggests inhibitors of 3-Chymotrypsin-Like Protease of SARS-CoV-2 from Vernonia amygdalina and Occinum gratissimum. Computers in Biology and Medicine. 136: 104671. PMID 34332348 DOI: 10.1016/j.compbiomed.2021.104671   
2021 Yildiz I. Computational Analysis of the Nicotine Oxidoreductase Mechanism by the ONIOM Method. Acs Omega. 6: 22422-22428. PMID 34497931 DOI: 10.1021/acsomega.1c03357   
2021 Miranda-Rojas S, Blanco-Esperguez K, Tuñón I, Kästner J, Mendizábal F. Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study. Biomolecules. 11. PMID 34356675 DOI: 10.3390/biom11071051   
2021 Prasher P, Sharma M. Medicinal chemistry of pyrophosphate mimics: A mini review. Drug Development Research. PMID 34506652 DOI: 10.1002/ddr.21877   
2021 Mori T, Zhai R, Ushimaru R, Matsuda Y, Abe I. Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI. Nature Communications. 12: 4417. PMID 34285212 DOI: 10.1038/s41467-021-24685-6   
2021 Bakunova AK, Nikolaeva AY, Rakitina TV, Isaikina TY, Khrenova MG, Boyko KM, Popov VO, Bezsudnova EY. The Uncommon Active Site of D-Amino Acid Transaminase from : Biochemical and Structural Insights into the New Enzyme. Molecules (Basel, Switzerland). 26. PMID 34443642 DOI: 10.3390/molecules26165053   
2021 Chao RR, Lau IC, Coleman T, Churchman LR, Child SA, Lee JHZ, Bruning JB, De Voss JJ, Bell SG. The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalyst. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34350662 DOI: 10.1002/chem.202102757   
2021 Sartor P, Denkhaus L, Gerhardt S, Einsle O, Fetzner S. Structural basis of O-methylation of (2-heptyl-)1-hydroxyquinolin-4(1H)-one and related compounds by the heterocyclic toxin methyltransferase Rv0560c of Mycobacterium tuberculosis. Journal of Structural Biology. 107794. PMID 34506908 DOI: 10.1016/j.jsb.2021.107794   
2021 Becker D, Bharatam PV, Gohlke H. F/G Region Rigidity is Inversely Correlated to Substrate Promiscuity of Human CYP Isoforms Involved in Metabolism. Journal of Chemical Information and Modeling. 61: 4023-4030. PMID 34370479 DOI: 10.1021/acs.jcim.1c00558   
2021 Yeh CC, Pierides C, Jameson G, de Visser S. Structure and functional differences of cysteine and 3-mercaptopropionate dioxygenases. A computational study. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34310770 DOI: 10.1002/chem.202101878   
2021 Kummer MJ, Lee YS, Yuan M, Alkotaini B, Zhao J, Blumenthal E, Minteer SD. Substrate Channeling by a Rationally Designed Fusion Protein in a Biocatalytic Cascade. Jacs Au. 1: 1187-1197. PMID 34467357 DOI: 10.1021/jacsau.1c00180   
2021 Nguyen TM, Goto M, Noda S, Matsutani M, Hodoya Y, Kataoka N, Adachi O, Matsushita K, Yakushi T. The 5-ketofructose reductase of sp. strain CHM43 is a novel class in the shikimate dehydrogenase family. Journal of Bacteriology. JB0055820. PMID 34309403 DOI: 10.1128/JB.00558-20   
2021 Singh A, Fenwick RB, Dyson HJ, Wright PE. Role of Active Site Loop Dynamics in Mediating Ligand Release from Dihydrofolate Reductase. Biochemistry. PMID 34428034 DOI: 10.1021/acs.biochem.1c00461   
2021 Mota C, Diniz A, Coelho C, Santos-Silva T, Esmaeeli M, Leimkühler S, Cabrita EJ, Marcelo F, Romão MJ. Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case. Journal of Medicinal Chemistry. PMID 34415167 DOI: 10.1021/acs.jmedchem.1c01125   
2021 Martínez-Aldino IY, Villaseca-Murillo M, Morales-Jiménez J, Rivera-Chávez J. Absolute configuration and protein tyrosine phosphatase 1B inhibitory activity of xanthoepocin, a dimeric naphtopyrone from Penicillium sp. IQ-429. Bioorganic Chemistry. 115: 105166. PMID 34384957 DOI: 10.1016/j.bioorg.2021.105166   
2021 Su D, Zhang Y, Ulrich S, Barboiu M. Constitutional Dynamic Inhibition/Activation of Carbonic Anhydrases. Chempluschem. PMID 34327867 DOI: 10.1002/cplu.202100263   
2021 Gabrielli V, Muñoz-García JC, Pergolizzi G, de Andrade P, Khimyak Y, Field RA, Angulo J. Molecular recognition of natural and non-natural substrates by cellodextrin phosphorylase from Ruminiclostridium thermocellum investigated by NMR spectroscopy. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34436794 DOI: 10.1002/chem.202102039   
2021 Adjogatse E, Bennett J, Guo J, Erskine PT, Wood SP, Wren BW, Cooper JB. The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile. Acta Crystallographica. Section F, Structural Biology Communications. 77: 269-274. PMID 34341193 DOI: 10.1107/S2053230X21007135   
2021 Waidha K, Zurgil U, Ben-Zeev E, Gopas J, Rajendran S, Golan-Goldhirsh A. Inhibition of Cysteine Proteases by 6,6'-Dihydroxythiobinupharidine (DTBN) from . Molecules (Basel, Switzerland). 26. PMID 34443335 DOI: 10.3390/molecules26164743   
2021 Bose I, Zhao Y. Selective Hydrolysis of Aryl Esters under Acidic and Neutral Conditions by a Synthetic Aspartic Protease Mimic. Acs Catalysis. 11: 3938-3942. PMID 34422449 DOI: 10.1021/acscatal.1c00371   
2021 Jezewski AJ, Alden KM, Esan TE, DeBouver ND, Abendroth J, Bullen JC, Calhoun BM, Potts KT, Murante DM, Hagen TJ, Fox D, Krysan DJ. Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases. Acs Chemical Biology. PMID 34369755 DOI: 10.1021/acschembio.1c00484   
2021 Somma V, Calvio C, Rabuffetti M, Rama E, Speranza G, Morelli CF. An overall framework for the E. coli γ-glutamyltransferase-catalyzed transpeptidation reactions. Bioorganic Chemistry. 115: 105217. PMID 34364051 DOI: 10.1016/j.bioorg.2021.105217   
2021 Atasever Arslan B, Kaya B, Şahin O, Baday S, Saylan CC, Ülküseven B. The iron(III) and nickel(II) complexes with tetradentate thiosemicarbazones. Synthesis, experimental, theoretical characterization, and antiviral effect against SARS-CoV-2. Journal of Molecular Structure. 1246: 131166. PMID 34316082 DOI: 10.1016/j.molstruc.2021.131166   
2021 Douglas CD, Grandinetti L, Easton NM, Kuehm OP, Hayden JA, Hamilton MC, St Maurice M, Bearne SL. Slow-Onset, Potent Inhibition of Mandelate Racemase by 2-Formylphenylboronic Acid. An Unexpected Adduct Clasps with the Catalytic Machinery. Biochemistry. PMID 34339165 DOI: 10.1021/acs.biochem.1c00374   
2021 Reiberger R, Radilová K, Kráľ M, Zima V, Majer P, Brynda J, Dračínský M, Konvalinka J, Kožíšek M, Machara A. Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors. International Journal of Molecular Sciences. 22. PMID 34299354 DOI: 10.3390/ijms22147735   
2021 Guo Y, Li DF, Zheng J, Xu Y, Zhou NY. Single-component and two-component -nitrophenol monooxygenases: structural basis for their catalytic difference. Applied and Environmental Microbiology. AEM0117121. PMID 34469195 DOI: 10.1128/AEM.01171-21   
2021 Lou D, Liu X, Tan J. An Overview of 7α- and 7β-Hydroxysteroid Dehydrogenases: Structure, Specificity and Practical Application. Protein and Peptide Letters. PMID 34397319 DOI: 10.2174/0929866528666210816114032   
2021 Sen A, Gaded V, Jayapal P, Rajaraman G, Anand R. Insights into the Dual Shuttle Catalytic Mechanism of Guanine Deaminase. The Journal of Physical Chemistry. B. PMID 34324362 DOI: 10.1021/acs.jpcb.1c06127   
2021 Quirke JCK, Crich D. Side Chain Conformation Restriction in the Catalysis of Glycosidic Bond Formation by Leloir Glycosyltransferases, Glycoside Phosphorylases, and Transglycosidases. Acs Catalysis. 11: 5069-5078. PMID 34367723 DOI: 10.1021/acscatal.1c00896   
2021 Darrouzet E, Rinaldi C, Zambelli B, Ciurli S, Cavazza C. Revisiting the CooJ family, a potential chaperone for nickel delivery to [NiFe]‑carbon monoxide dehydrogenase. Journal of Inorganic Biochemistry. 225: 111588. PMID 34530332 DOI: 10.1016/j.jinorgbio.2021.111588   
2021 Korasick DA, Christgen SL, Qureshi IA, Becker DF, Tanner JJ. Probing the function of a ligand-modulated dynamic tunnel in bifunctional proline utilization A (PutA). Archives of Biochemistry and Biophysics. 109025. PMID 34506758 DOI: 10.1016/j.abb.2021.109025