Daniel P. Dowling, Ph.D. - Publications

University of Massachusetts, Boston, Boston, MA 
structure-mechanism of hydrolytic metalloenzymes

16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Grell TAJ, Bell BN, Nguyen C, Dowling DP, Bruender NA, Bandarian V, Drennan CL. Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity. Protein Science : a Publication of the Protein Society. PMID 30341796 DOI: 10.2210/Pdb6Nhl/Pdb  0.72
2017 Bruender NA, Grell TA, Dowling DP, McCarty RM, Drennan CL, Bandarian V. 7-Carboxy-7-deazaguanine synthase - A radical S-adenosyl-L-methionine enzyme with polar tendencies. Journal of the American Chemical Society. PMID 28045519 DOI: 10.1021/Jacs.6B11381  0.72
2016 Dowling DP, Kung Y, Croft AK, Taghizadeh K, Kelly WL, Walsh CT, Drennan CL. Structural elements of an NRPS cyclization domain and its intermodule docking domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791103 DOI: 10.1073/Pnas.1608615113  0.72
2016 Dowling DP, Miles ZD, Köhrer C, Maiocco SJ, Elliott SJ, Bandarian V, Drennan CL. Molecular basis of cobalamin-dependent RNA modification. Nucleic Acids Research. PMID 27638883 DOI: 10.1093/Nar/Gkw806  0.72
2014 Dowling DP, Bruender NA, Young AP, McCarty RM, Bandarian V, Drennan CL. Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nature Chemical Biology. 10: 106-12. PMID 24362703 DOI: 10.1038/Nchembio.1426  0.72
2012 Dowling DP, Vey JL, Croft AK, Drennan CL. Structural diversity in the AdoMet radical enzyme superfamily. Biochimica Et Biophysica Acta. 1824: 1178-95. PMID 22579873 DOI: 10.1016/J.Bbapap.2012.04.006  0.72
2012 Dowling DP, Croft AK, Drennan CL. Radical use of Rossmann and TIM barrel architectures for controlling coenzyme B12 chemistry. Annual Review of Biophysics. 41: 403-27. PMID 22577824 DOI: 10.1146/Annurev-Biophys-050511-102225  0.72
2011 Ilies M, Dowling DP, Lombardi PM, Christianson DW. Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8. Bioorganic & Medicinal Chemistry Letters. 21: 5854-8. PMID 21875805 DOI: 10.1016/J.Bmcl.2011.07.100  0.72
2011 Lombardi PM, Cole KE, Dowling DP, Christianson DW. Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes. Current Opinion in Structural Biology. 21: 735-43. PMID 21872466 DOI: 10.1016/J.Sbi.2011.08.004  0.72
2011 Cole KE, Dowling DP, Boone MA, Phillips AJ, Christianson DW. Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. Journal of the American Chemical Society. 133: 12474-7. PMID 21790156 DOI: 10.1021/Ja205972N  0.72
2011 Ilies M, Di Costanzo L, Dowling DP, Thorn KJ, Christianson DW. Binding of α,α-disubstituted amino acids to arginase suggests new avenues for inhibitor design. Journal of Medicinal Chemistry. 54: 5432-43. PMID 21728378 DOI: 10.1021/Jm200443B  0.72
2010 Dowling DP, Gattis SG, Fierke CA, Christianson DW. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function . Biochemistry. 49: 5048-56. PMID 20545365 DOI: 10.1021/Bi1005046  0.72
2010 Dowling DP, Ilies M, Olszewski KL, Portugal S, Mota MM, Llinás M, Christianson DW. Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection . Biochemistry. 49: 5600-8. PMID 20527960 DOI: 10.1021/Bi100390Z  0.72
2008 Dowling DP, Gantt SL, Gattis SG, Fierke CA, Christianson DW. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry. 47: 13554-63. PMID 19053282 DOI: 10.1021/Bi801610C  0.72
2008 Dowling DP, Di Costanzo L, Gennadios HA, Christianson DW. Evolution of the arginase fold and functional diversity. Cellular and Molecular Life Sciences : Cmls. 65: 2039-55. PMID 18360740 DOI: 10.1007/S00018-008-7554-Z  0.72
2006 Higham CS, Dowling DP, Shaw JL, Cetin A, Ziegler CJ, Farrell JR. Multidentate aminophenol ligands prepared with Mannich condensations Tetrahedron Letters. 47: 4419-4423. DOI: 10.1016/J.Tetlet.2006.04.077  0.72
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