Gregory R. Hoffman, Ph.D. - Publications

Affiliations: 
2002 Cornell University, Ithaca, NY, United States 
Area:
Signal Transduction Mechanisms

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 DeJesus R, Moretti F, McAllister G, Wang Z, Bergman P, Liu S, Frias E, Alford J, Reece-Hoyes JS, Lindeman A, Kelliher J, Russ C, Knehr J, Carbone W, Beibel M, ... ... Hoffman GR, et al. Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62. Elife. 5. PMID 27351204 DOI: 10.7554/eLife.17290  0.96
2016 Mavrakis KJ, McDonald ER, Schlabach MR, Billy E, Hoffman GR, deWeck A, Ruddy DA, Venkatesan K, Yu J, McAllister G, Stump M, deBeaumont R, Ho S, Yue Y, Liu Y, et al. Disordered methionine metabolism in MTAP/CDKN2A deleted cancers leads to dependence on PRMT5. Science (New York, N.Y.). PMID 26912361 DOI: 10.1126/science.aad5944  0.96
2015 Eng CH, Wang Z, Tkach D, Toral-Barza L, Ugwonali S, Liu S, Fitzgerald SL, George E, Frias E, Cochran N, De Jesus R, McAllister G, Hoffman GR, Bray K, Lemon L, et al. Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy. Proceedings of the National Academy of Sciences of the United States of America. PMID 26677873 DOI: 10.1073/pnas.1515617113  0.96
2015 Lantermann AB, Chen D, McCutcheon KJ, Hoffman GR, Frias E, Ruddy DA, Rakiec DP, Korn JM, McAllister G, Stegmeier F, Meyer MJ, Sharma SV. Inhibition of casein kinase 1 alpha prevents acquired drug resistance to erlotinib in EGFR-mutant non-small cell lung cancer. Cancer Research. PMID 26490646 DOI: 10.1158/0008-5472.CAN-15-1113  0.96
2015 Li J, Csibi A, Yang S, Hoffman GR, Li C, Zhang E, Yu JJ, Blenis J. Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E21-9. PMID 25524627 DOI: 10.1073/pnas.1417015112  0.96
2014 Hoffman GR, Rahal R, Buxton F, Xiang K, McAllister G, Frias E, Bagdasarian L, Huber J, Lindeman A, Chen D, Romero R, Ramadan N, Phadke T, Haas K, Jaskelioff M, et al. Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. Proceedings of the National Academy of Sciences of the United States of America. 111: 3128-33. PMID 24520176 DOI: 10.1073/pnas.1316793111  0.96
2013 Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson RL, Cantley LC, Choo AY, Blenis J. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Molecular Cell. 49: 172-85. PMID 23142078 DOI: 10.1016/j.molcel.2012.10.003  0.96
2011 Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science (New York, N.Y.). 332: 1322-6. PMID 21659605 DOI: 10.1126/science.1199484  0.96
2010 Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J. A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Developmental Cell. 18: 1041-52. PMID 20627085 DOI: 10.1016/j.devcel.2010.05.005  0.96
2010 Hoffman GR, Moerke NJ, Hsia M, Shamu CE, Blenis J. A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique. Assay and Drug Development Technologies. 8: 186-99. PMID 20085456 DOI: 10.1089/adt.2009.0213  0.96
2008 DeRegis CJ, Rahl PB, Hoffman GR, Cerione RA, Collins RN. Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function. Bmc Cell Biology. 9: 3. PMID 18211691 DOI: 10.1186/1471-2121-9-3  0.96
2007 Abraira VE, Hyun N, Tucker AF, Coling DE, Brown MC, Lu C, Hoffman GR, Goodrich LV. Changes in Sef levels influence auditory brainstem development and function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4273-82. PMID 17442811 DOI: 10.1523/JNEUROSCI.3477-06.2007  0.96
2004 Korlach J, Baird DW, Heikal AA, Gee KR, Hoffman GR, Webb WW. Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled gamma-phosphate-linked GTP analogs. Proceedings of the National Academy of Sciences of the United States of America. 101: 2800-5. PMID 14973186 DOI: 10.1073/pnas.0308579100  0.96
2003 Hoffman GR, Rahl PB, Collins RN, Cerione RA. Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain. Molecular Cell. 12: 615-25. PMID 14527408 DOI: 10.1016/j.molcel.2003.08.002  0.96
2002 Hoffman GR, Cerione RA. Signaling to the Rho GTPases: networking with the DH domain. Febs Letters. 513: 85-91. PMID 11911885 DOI: 10.1016/S0014-5793(01)03310-5  0.96
2001 Hoffman GR, Cerione RA. Rac inserts its way into the immune response. Nature Immunology. 2: 194-6. PMID 11224514 DOI: 10.1038/85240  0.96
2000 Hoffman GR, Cerione RA. Flipping the switch: the structural basis for signaling through the CRIB motif. Cell. 102: 403-6. PMID 10966102  0.96
2000 Hoffman GR, Nassar N, Cerione RA. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell. 100: 345-56. PMID 10676816  0.96
1998 Nassar N, Hoffman GR, Manor D, Clardy JC, Cerione RA. Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nature Structural Biology. 5: 1047-52. PMID 9846874 DOI: 10.1038/4156  0.96
1998 Hoffman GR, Nassar N, Oswald RE, Cerione RA. Fluoride activation of the Rho family GTP-binding protein Cdc42Hs. The Journal of Biological Chemistry. 273: 4392-9. PMID 9468490 DOI: 10.1074/jbc.273.8.4392  0.96
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