Mark Ptashne - Publications

Affiliations: 
Memorial Sloan-Kettering Cancer Center, Rockville Centre, NY, United States 
Area:
Cell Signaling; Gene Regulation; Stem Cell Biology
Website:
http://www.mskcc.org/research/lab/mark-ptashne

195 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Wang X, Bryant G, Zhao A, Ptashne M. Nucleosome avidities and transcriptional silencing in yeast. Current Biology : Cb. 25: 1215-20. PMID 25891403 DOI: 10.1016/j.cub.2015.03.004  1
2014 Ptashne M. The chemistry of regulation of genes and other things. The Journal of Biological Chemistry. 289: 5417-35. PMID 24385432 DOI: 10.1074/jbc.X114.547323  1
2014 Ptashne M. Francois Jacob 1920-2013 Research in Microbiology. DOI: 10.1016/j.resmic.2014.05.038  1
2013 Berrozpe G, Bryant GO, Warpinski K, Ptashne M. Regulation of a mammalian gene bearing a CpG island promoter and a distal enhancer. Cell Reports. 4: 445-53. PMID 23911283 DOI: 10.1016/j.celrep.2013.07.001  1
2013 Ptashne M. Francois Jacob (1920-2013). Cell. 153: 1180-2. PMID 23901416  1
2013 Ptashne M. Epigenetics: core misconcept. Proceedings of the National Academy of Sciences of the United States of America. 110: 7101-3. PMID 23584020 DOI: 10.1073/pnas.1305399110  1
2013 Ptashne M. Faddish stuff: epigenetics and the inheritance of acquired characteristics. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1-2. PMID 23284163 DOI: 10.1096/fj.13-0101ufm  1
2012 Hammachi F, Morrison GM, Sharov AA, Livigni A, Narayan S, Papapetrou EP, O'Malley J, Kaji K, Ko MS, Ptashne M, Brickman JM. Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency. Cell Reports. 1: 99-109. PMID 22832160 DOI: 10.1016/j.celrep.2011.12.002  1
2011 Wang X, Bai L, Bryant GO, Ptashne M. Nucleosomes and the accessibility problem. Trends in Genetics : Tig. 27: 487-92. PMID 22019336 DOI: 10.1016/j.tig.2011.09.001  1
2011 Ptashne M. Principles of a switch. Nature Chemical Biology. 7: 484-7. PMID 21769089 DOI: 10.1038/nchembio.611  1
2011 Wang X, Bryant GO, Floer M, Spagna D, Ptashne M. An effect of DNA sequence on nucleosome occupancy and removal. Nature Structural & Molecular Biology. 18: 507-9. PMID 21378966 DOI: 10.1038/nsmb.2017  1
2010 Floer M, Wang X, Prabhu V, Berrozpe G, Narayan S, Spagna D, Alvarez D, Kendall J, Krasnitz A, Stepansky A, Hicks J, Bryant GO, Ptashne M. A RSC/nucleosome complex determines chromatin architecture and facilitates activator binding. Cell. 141: 407-18. PMID 20434983 DOI: 10.1016/j.cell.2010.03.048  1
2010 Wang X, Muratani M, Tansey WP, Ptashne M. Proteolytic instability and the action of nonclassical transcriptional activators. Current Biology : Cb. 20: 868-71. PMID 20417106 DOI: 10.1016/j.cub.2010.03.029  1
2010 Ptashne M, Hobert O, Davidson E. Questions over the scientific basis of epigenome project. Nature. 464: 487. PMID 20336114 DOI: 10.1038/464487c  1
2009 Ptashne M. Binding reactions: epigenetic switches, signal transduction and cancer. Current Biology : Cb. 19: R234-41. PMID 19321137 DOI: 10.1016/j.cub.2009.02.015  1
2009 Berry A, Cobb M, Conway Morris S, Coyne J, Hoekstra H, Lawrence P, May R, Nüsslein-Volhard C, Ptashne M, Ridley M, Zuk M. (Re)Reading The Origin (DOI:10.1016/j.cub.2008.12.033) Current Biology. 19: 448. DOI: 10.1016/j.cub.2009.02.042  1
2008 Floer M, Bryant GO, Ptashne M. HSP90/70 chaperones are required for rapid nucleosome removal upon induction of the GAL genes of yeast. Proceedings of the National Academy of Sciences of the United States of America. 105: 2975-80. PMID 18287040 DOI: 10.1073/pnas.0800053105  1
2008 Ptashne M. Transcription: a mechanism for short-term memory. Current Biology : Cb. 18: R25-7. PMID 18177708 DOI: 10.1016/j.cub.2007.11.017  1
2008 Ptashne M. Phage repressors Strategy of the Viral Genome. 141-153. DOI: 10.1002/9780470719824.ch8  1
2007 Ptashne M. Repressors. Current Biology : Cb. 17: R740-1. PMID 17803917 DOI: 10.1016/j.cub.2007.06.053  1
2007 Ptashne M. Words. Current Biology : Cb. 17: R533-5. PMID 17637347 DOI: 10.1016/j.cub.2007.05.071  1
2007 Ptashne M. On learning to write. Current Biology : Cb. 17: R394-5. PMID 17550758 DOI: 10.1016/j.cub.2007.04.013  1
2007 Ptashne M. On speaking, writing and inspiration. Current Biology : Cb. 17: R348-9. PMID 17502082 DOI: 10.1016/j.cub.2007.03.030  1
2007 Ptashne M. On the use of the word 'epigenetic'. Current Biology : Cb. 17: R233-6. PMID 17407749 DOI: 10.1016/j.cub.2007.02.030  1
2006 Ptashne M. Lambda's switch: lessons from a module swap. Current Biology : Cb. 16: R459-62. PMID 16782001 DOI: 10.1016/j.cub.2006.05.037  1
2005 Ptashne M. Regulation of transcription: from lambda to eukaryotes. Trends in Biochemical Sciences. 30: 275-9. PMID 15950866 DOI: 10.1016/j.tibs.2005.04.003  1
2005 Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, ... ... Ptashne M, et al. An open letter to Elias Zerhouni. Science (New York, N.Y.). 307: 1409-10. PMID 15746409 DOI: 10.1126/science.307.5714.1409c  1
2005 Ansari AZ, Ogirala A, Ptashne M. Transcriptional activating regions target attached substrates to a cyclin-dependent kinase. Proceedings of the National Academy of Sciences of the United States of America. 102: 2346-9. PMID 15687503 DOI: 10.1073/pnas.0409671102  1
2004 Cheng JX, Gandolfi M, Ptashne M. Activation of the Gal1 gene of yeast by pairs of 'non-classical' activators. Current Biology : Cb. 14: 1675-9. PMID 15380071 DOI: 10.1016/j.cub.2004.09.025  1
2004 Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, ... ... Ptashne M, et al. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Molecular Cell. 14: 553-7. PMID 15175151 DOI: 10.1016/j.molcel.2004.05.011  1
2004 Ptashne M. Two "what if" experiments. Cell. 116: S71-2, 2 p following. PMID 15055587  1
2003 Ptashne M. Regulated recruitment and cooperativity in the design of biological regulatory systems. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 361: 1223-34. PMID 12816608 DOI: 10.1098/rsta.2003.1195  1
2003 Bryant GO, Ptashne M. Independent recruitment in vivo by Gal4 of two complexes required for transcription. Molecular Cell. 11: 1301-9. PMID 12769853 DOI: 10.1016/S1097-2765(03)00144-8  1
2003 Saha S, Ansari AZ, Jarrell KA, Ptashne M, Jarell KA. RNA sequences that work as transcriptional activating regions. Nucleic Acids Research. 31: 1565-70. PMID 12595565 DOI: 10.1093/nar/gkg227  1
2003 Ptashne M, Gann A. Signal transduction. Imposing specificity on kinases. Science (New York, N.Y.). 299: 1025-7. PMID 12586931 DOI: 10.1126/science.1081519  1
2002 Cheng JX, Floer M, Ononaji P, Bryant G, Ptashne M. Responses of four yeast genes to changes in the transcriptional machinery are determined by their promoters. Current Biology : Cb. 12: 1828-32. PMID 12419182 DOI: 10.1016/S0960-9822(02)01257-5  1
2002 Ansari AZ, Koh SS, Zaman Z, Bongards C, Lehming N, Young RA, Ptashne M. Transcriptional activating regions target a cyclin-dependent kinase. Proceedings of the National Academy of Sciences of the United States of America. 99: 14706-9. PMID 12417740 DOI: 10.1073/pnas.232573899  1
2002 Arora PS, Ansari AZ, Best TP, Ptashne M, Dervan PB. Design of artificial transcriptional activators with rigid poly-L-proline linkers. Journal of the American Chemical Society. 124: 13067-71. PMID 12405833 DOI: 10.1021/ja0208355  1
2002 Lu Z, Ansari AZ, Lu X, Ogirala A, Ptashne M. A target essential for the activity of a nonacidic yeast transcriptional activator. Proceedings of the National Academy of Sciences of the United States of America. 99: 8591-6. PMID 12084920 DOI: 10.1073/pnas.092263499  1
2002 Cheng JX, Nevado J, Lu Z, Ptashne M. The TBP-inhibitory domain of TAF145 limits the effects of nonclassical transcriptional activators. Current Biology : Cb. 12: 934-7. PMID 12062059 DOI: 10.1016/S0960-9822(02)00866-7  1
2002 Zaman Z, Heid C, Ptashne M. Telomere looping permits repression "at a distance" in yeast. Current Biology : Cb. 12: 930-3. PMID 12062058 DOI: 10.1016/S0960-9822(02)00865-5  1
2001 Ptashne M, Gann A. Transcription initiation: imposing specificity by localization. Essays in Biochemistry. 37: 1-15. PMID 11758451  1
2001 Ansari AZ, Mapp AK, Nguyen DH, Dervan PB, Ptashne M. Towards a minimal motif for artificial transcriptional activators. Chemistry & Biology. 8: 583-92. PMID 11410377 DOI: 10.1016/S1074-5521(01)00037-0  1
2001 de Bruin D, Zaman Z, Liberatore RA, Ptashne M. Telomere looping permits gene activation by a downstream UAS in yeast. Nature. 409: 109-13. PMID 11343124 DOI: 10.1038/35051119  1
2001 Hidalgo P, Ansari AZ, Schmidt P, Hare B, Simkovich N, Farrell S, Shin EJ, Ptashne M, Wagner G. Recruitment of the transcriptional machinery through GAL11P: structure and interactions of the GAL4 dimerization domain. Genes & Development. 15: 1007-20. PMID 11316794 DOI: 10.1101/gad.873901  1
2001 Zaman Z, Ansari AZ, Koh SS, Young R, Ptashne M. Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression. Proceedings of the National Academy of Sciences of the United States of America. 98: 2550-4. PMID 11226276 DOI: 10.1073/pnas.041611198  1
2001 Ptashne M. Imposing specificity by regulated localization Proceedings of the Annual International Conference On Computational Molecular Biology, Recomb. 268.  1
2000 Mapp AK, Ansari AZ, Ptashne M, Dervan PB. Activation of gene expression by small molecule transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 97: 3930-5. PMID 10760265 DOI: 10.1073/pnas.97.8.3930  1
2000 Torigoi E, Bennani-Baiti IM, Rosen C, Gonzalez K, Morcillo P, Ptashne M, Dorsett D. Chip interacts with diverse homeodomain proteins and potentiates bicoid activity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 97: 2686-91. PMID 10688916 DOI: 10.1073/pnas.050586397  1
2000 Lu X, Ansari AZ, Ptashne M. An artificial transcriptional activating region with unusual properties. Proceedings of the National Academy of Sciences of the United States of America. 97: 1988-92. PMID 10681438 DOI: 10.1073/pnas.040573197  1
1999 Brickman JM, Adam M, Ptashne M. Interactions between an HMG-1 protein and members of the Rel family. Proceedings of the National Academy of Sciences of the United States of America. 96: 10679-83. PMID 10485885 DOI: 10.1073/pnas.96.19.10679  1
1999 Nevado J, Gaudreau L, Adam M, Ptashne M. Transcriptional activation by artificial recruitment in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 2674-7. PMID 10077569 DOI: 10.1073/pnas.96.6.2674  1
1999 Gaudreau L, Keaveney M, Nevado J, Zaman Z, Bryant GO, Struhl K, Ptashne M. Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences. Proceedings of the National Academy of Sciences of the United States of America. 96: 2668-73. PMID 10077568 DOI: 10.1073/pnas.96.6.2668  1
1998 Zaman Z, Ansari AZ, Gaudreau L, Nevado J, Ptashne M. Gene transcription by recruitment. Cold Spring Harbor Symposia On Quantitative Biology. 63: 167-71. PMID 10384280  1
1998 Ptashne M, Gann A. Imposing specificity by localization: mechanism and evolvability Current Biology : Cb. 8: R897. PMID 9844213  0.01
1998 Ptashne M, Gann A. Imposing specificity by localization: mechanism and evolvability. Current Biology : Cb. 8: R812-22. PMID 9818164  1
1998 Ansari AZ, Reece RJ, Ptashne M. A transcriptional activating region with two contrasting modes of protein interaction. Proceedings of the National Academy of Sciences of the United States of America. 95: 13543-8. PMID 9811836 DOI: 10.1073/pnas.95.23.13543  1
1998 Gaudreau L, Adam M, Ptashne M. Activation of transcription in vitro by recruitment of the yeast RNA polymerase II holoenzyme. Molecular Cell. 1: 913-6. PMID 9660974  1
1998 Koh SS, Ansari AZ, Ptashne M, Young RA. An activator target in the RNA polymerase II holoenzyme. Molecular Cell. 1: 895-904. PMID 9660972  1
1998 Lehming N, Le Saux A, Schüller J, Ptashne M. Chromatin components as part of a putative transcriptional repressing complex. Proceedings of the National Academy of Sciences of the United States of America. 95: 7322-6. PMID 9636147 DOI: 10.1073/pnas.95.13.7322  1
1997 Ptashne M. 1997 Albert Lasker Award for Basic Medical Research. Control of gene transcription: an outline. Nature Medicine. 3: 1069-72. PMID 9334708 DOI: 10.1038/nm1097-1069  1
1997 Walters KJ, Dayie KT, Reece RJ, Ptashne M, Wagner G. Structure and mobility of the PUT3 dimer. Nature Structural Biology. 4: 744-50. PMID 9303003 DOI: 10.1038/nsb0997-744  1
1997 Ptashne M, Gann A. Transcriptional activation by recruitment. Nature. 386: 569-77. PMID 9121580 DOI: 10.1038/386569a0  1
1997 Gaudreau L, Schmid A, Blaschke D, Ptashne M, Hörz W. RNA polymerase II holoenzyme recruitment is sufficient to remodel chromatin at the yeast PHO5 promoter. Cell. 89: 55-62. PMID 9094714  1
1997 Whipple FW, Ptashne M, Hochschild A. The activation defect of a lambda cI positive control mutant. Journal of Molecular Biology. 265: 261-5. PMID 9018040 DOI: 10.1006/jmbi.1996.0735  1
1996 Farrell S, Simkovich N, Wu Y, Barberis A, Ptashne M. Gene activation by recruitment of the RNA polymerase II holoenzyme. Genes & Development. 10: 2359-67. PMID 8824594  1
1996 Wu Y, Reece RJ, Ptashne M. Quantitation of putative activator-target affinities predicts transcriptional activating potentials. The Embo Journal. 15: 3951-63. PMID 8670900  1
1996 Liang SD, Marmorstein R, Harrison SC, Ptashne M. DNA sequence preferences of GAL4 and PPR1: how a subset of Zn2 Cys6 binuclear cluster proteins recognizes DNA. Molecular and Cellular Biology. 16: 3773-80. PMID 8668194  1
1995 Barberis A, Pearlberg J, Simkovich N, Farrell S, Reinagel P, Bamdad C, Sigal G, Ptashne M. Contact with a component of the polymerase II holoenzyme suffices for gene activation. Cell. 81: 359-68. PMID 7736588 DOI: 10.1016/0092-8674(95)90389-5  1
1995 Astromoff A, Ptashne M. A variant of lambda repressor with an altered pattern of cooperative binding to DNA sites. Proceedings of the National Academy of Sciences of the United States of America. 92: 8110-4. PMID 7667253 DOI: 10.1073/pnas.92.18.8110  1
1995 Lehming N, McGuire S, Brickman JM, Ptashne M. Interactions of a Rel protein with its inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 92: 10242-6. PMID 7479760 DOI: 10.1073/pnas.92.22.10242  1
1994 Lehming N, Thanos D, Brickman JM, Ma J, Maniatis T, Ptashne M. An HMG-like protein that can switch a transcriptional activator to a repressor. Nature. 371: 175-9. PMID 8072548 DOI: 10.1038/371175a0  1
1993 Barberis A, Müller CW, Harrison SC, Ptashne M. Delineation of two functional regions of transcription factor TFIIB. Proceedings of the National Academy of Sciences of the United States of America. 90: 5628-32. PMID 8516311  1
1993 Saha S, Brickman JM, Lehming N, Ptashne M. New eukaryotic transcriptional repressors. Nature. 363: 648-52. PMID 8510759 DOI: 10.1038/363648a0  1
1993 Reece RJ, Rickles RJ, Ptashne M. Overproduction and single-step purification of GAL4 fusion proteins from Escherichia coli. Gene. 126: 105-7. PMID 8472950 DOI: 10.1016/0378-1119(93)90596-U  1
1993 Baumann R, Grogan E, Ptashne M, Miller G. Changing Epstein-Barr viral ZEBRA protein into a more powerful activator enhances its capacity to disrupt latency. Proceedings of the National Academy of Sciences of the United States of America. 90: 4436-40. PMID 8389449  1
1993 Reece RJ, Ptashne M. Determinants of binding-site specificity among yeast C6 zinc cluster proteins. Science (New York, N.Y.). 261: 909-11. PMID 8346441  1
1992 Lamphier MS, Ptashne M. Multiple mechanisms mediate glucose repression of the yeast GAL1 gene. Proceedings of the National Academy of Sciences of the United States of America. 89: 5922-6. PMID 1631075  1
1992 Marmorstein R, Carey M, Ptashne M, Harrison SC. DNA recognition by GAL4: structure of a protein-DNA complex. Nature. 356: 408-14. PMID 1557122 DOI: 10.1038/356408a0  1
1992 Guarante L, Roberts TM, Ptashne M. A technique for expressing eukaryotic genes in bacteria. 1980. Biotechnology (Reading, Mass.). 24: 261-3. PMID 1422022  1
1991 Ptashne MS. Alfred P. Sloan, Jr. Prize. Gene regulation. Cancer. 67: 2422-7. PMID 2015541  1
1991 Ruden DM, Ma J, Li Y, Wood K, Ptashne M. Generating yeast transcriptional activators containing no yeast protein sequences. Nature. 350: 250-2. PMID 2005981 DOI: 10.1038/350250a0  1
1991 Sadowski I, Niedbala D, Wood K, Ptashne M. GAL4 is phosphorylated as a consequence of transcriptional activation. Proceedings of the National Academy of Sciences of the United States of America. 88: 10510-4. PMID 1961715 DOI: 10.1073/pnas.88.23.10510  1
1991 Ptashne M. Baltimore's unanswered questions [2] Nature. 353: 495.  1
1990 Carey M, Leatherwood J, Ptashne M. A potent GAL4 derivative activates transcription at a distance in vitro. Science (New York, N.Y.). 247: 710-2. PMID 2405489  1
1990 Lin YS, Carey M, Ptashne M, Green MR. How different eukaryotic transcriptional activators can cooperate promiscuously. Nature. 345: 359-61. PMID 2188137 DOI: 10.1038/345359a0  1
1990 Gill G, Sadowski I, Ptashne M. Mutations that increase the activity of a transcriptional activator in yeast and mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 2127-31. PMID 2179950 DOI: 10.1073/pnas.87.6.2127  1
1990 Carey M, Lin YS, Green MR, Ptashne M. A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives. Nature. 345: 361-4. PMID 2160609 DOI: 10.1038/345361a0  1
1990 Ptashne M, Gann AA. Activators and targets. Nature. 346: 329-31. PMID 2142753 DOI: 10.1038/346329a0  1
1990 Himmelfarb HJ, Pearlberg J, Last DH, Ptashne M. GAL11P: a yeast mutation that potentiates the effect of weak GAL4-derived activators. Cell. 63: 1299-309. PMID 2124519 DOI: 10.1016/0092-8674(90)90425-E  1
1989 Sadowski I, Ptashne M. A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Research. 17: 7539. PMID 2798115 DOI: 10.1093/nar/17.18.7539  1
1989 Bushman FD, Shang C, Ptashne M. A single glutamic acid residue plays a key role in the transcriptional activation function of lambda repressor. Cell. 58: 1163-71. PMID 2570642 DOI: 10.1016/0092-8674(89)90514-X  1
1989 Chasman DI, Leatherwood J, Carey M, Ptashne M, Kornberg RD. Activation of yeast polymerase II transcription by herpesvirus VP16 and GAL4 derivatives in vitro. Molecular and Cellular Biology. 9: 4746-9. PMID 2557540 DOI: 10.1128/MCB.9.11.4746  1
1989 Valenzuela D, Ptashne M. P22 repressor mutants deficient in co-operative binding and DNA loop formation. The Embo Journal. 8: 4345-50. PMID 2531662  1
1989 Ptashne M. How gene activators work. Scientific American. 260: 40-7. PMID 2521264  1
1989 Carey M, Kakidani H, Leatherwood J, Mostashari F, Ptashne M. An amino-terminal fragment of GAL4 binds DNA as a dimer. Journal of Molecular Biology. 209: 423-32. PMID 2511324 DOI: 10.1016/0022-2836(89)90007-7  1
1989 Driever W, Ma J, Nüsslein-Volhard C, Ptashne M. Rescue of bicoid mutant Drosophila embryos by bicoid fusion proteins containing heterologous activating sequences. Nature. 342: 149-54. PMID 2509940 DOI: 10.1038/342149a0  1
1988 Hollis M, Valenzuela D, Pioli D, Wharton R, Ptashne M. A repressor heterodimer binds to a chimeric operator. Proceedings of the National Academy of Sciences of the United States of America. 85: 5834-8. PMID 3413061  1
1988 Gill G, Ptashne M. Negative effect of the transcriptional activator GAL4. Nature. 334: 721-4. PMID 3412449 DOI: 10.1038/334721a0  1
1988 Koudelka GB, Harbury P, Harrison SC, Ptashne M. DNA twisting and the affinity of bacteriophage 434 operator for bacteriophage 434 repressor. Proceedings of the National Academy of Sciences of the United States of America. 85: 4633-7. PMID 3387430 DOI: 10.1073/pnas.85.13.4633  1
1988 Harrison SC, Anderson JE, Koudelka GB, Mondragon A, Subbiah S, Wharton RP, Wolberger C, Ptashne M. Recognition of DNA sequences by the repressor of bacteriophage 434. Biophysical Chemistry. 29: 31-7. PMID 3359001 DOI: 10.1016/0301-4622(88)87022-4  1
1988 Aggarwal AK, Rodgers DW, Drottar M, Ptashne M, Harrison SC. Recognition of a DNA operator by the repressor of phage 434: a view at high resolution. Science (New York, N.Y.). 242: 899-907. PMID 3187531 DOI: 10.1126/science.3187531  1
1988 Wolberger C, Dong YC, Ptashne M, Harrison SC. Structure of a phage 434 Cro/DNA complex. Nature. 335: 789-95. PMID 3185709 DOI: 10.1038/335789a0  1
1988 Ma J, Ptashne M. Converting a eukaryotic transcriptional inhibitor into an activator. Cell. 55: 443-6. PMID 3180218 DOI: 10.1016/0092-8674(88)90030-X  1
1988 Ma J, Przibilla E, Hu J, Bogorad L, Ptashne M. Yeast activators stimulate plant gene expression. Nature. 334: 631-3. PMID 3165494 DOI: 10.1038/334631a0  1
1988 Ruden DM, Ma J, Ptashne M. No strict alignment is required between a transcriptional activator binding site and the "TATA box" of a yeast gene. Proceedings of the National Academy of Sciences of the United States of America. 85: 4262-6. PMID 3132708  1
1988 Fischer JA, Giniger E, Maniatis T, Ptashne M. GAL4 activates transcription in Drosophila. Nature. 332: 853-6. PMID 3128741 DOI: 10.1038/332853a0  1
1988 Giniger E, Ptashne M. Cooperative DNA binding of the yeast transcriptional activator GAL4. Proceedings of the National Academy of Sciences of the United States of America. 85: 382-6. PMID 3124106  1
1988 Ptashne M. How eukaryotic transcriptional activators work. Nature. 335: 683-9. PMID 3050531 DOI: 10.1038/335683a0  1
1988 Sadowski I, Ma J, Triezenberg S, Ptashne M. GAL4-VP16 is an unusually potent transcriptional activator. Nature. 335: 563-4. PMID 3047590 DOI: 10.1038/335563a0  1
1988 Lin YS, Carey MF, Ptashne M, Green MR. GAL4 derivatives function alone and synergistically with mammalian activators in vitro. Cell. 54: 659-64. PMID 3044607 DOI: 10.1016/S0092-8674(88)80010-2  1
1988 Hochschild A, Ptashne M. Interaction at a distance between lambda repressors disrupts gene activation. Nature. 336: 353-7. PMID 2973565 DOI: 10.1038/336353a0  1
1988 Bushman FD, Ptashne M. Turning lambda Cro into a transcriptional activator. Cell. 54: 191-7. PMID 2968842 DOI: 10.1016/0092-8674(88)90551-X  1
1988 Kakidani H, Ptashne M. GAL4 activates gene expression in mammalian cells. Cell. 52: 161-7. PMID 2830021 DOI: 10.1016/0092-8674(88)90504-1  1
1988 Harrison SC, Ptashne M, Anderson JE, Dong YC, Drottar M, Koudelka GB, Mondragon A, Subbiah S, Wharton RP, Wolberger C. Recognition of DNA sequences by the repressor and Cro proteins of bacteriophage 434 Bulletin De L'Institut Pasteur. 86: 55-64.  1
1987 Wharton RP, Ptashne M. A new-specificity mutant of 434 repressor that defines an amino acid-base pair contact. Nature. 326: 888-91. PMID 3553961 DOI: 10.1038/326888a0  1
1987 Koudelka GB, Harrison SC, Ptashne M. Effect of non-contacted bases on the affinity of 434 operator for 434 repressor and Cro. Nature. 326: 886-8. PMID 3553960 DOI: 10.1038/326886a0  1
1987 Anderson JE, Ptashne M, Harrison SC. Structure of the repressor-operator complex of bacteriophage 434. Nature. 326: 846-52. PMID 3553959 DOI: 10.1038/326846a0  1
1987 Giniger E, Ptashne M. Transcription in yeast activated by a putative amphipathic alpha helix linked to a DNA binding unit. Nature. 330: 670-2. PMID 3317067 DOI: 10.1038/330670a0  1
1987 Ma J, Ptashne M. The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80. Cell. 50: 137-42. PMID 3297349 DOI: 10.1016/0092-8674(87)90670-2  1
1987 Gill G, Ptashne M. Mutants of GAL4 protein altered in an activation function. Cell. 51: 121-6. PMID 3115592 DOI: 10.1016/0092-8674(87)90016-X  1
1987 Ma J, Ptashne M. A new class of yeast transcriptional activators. Cell. 51: 113-9. PMID 3115591 DOI: 10.1016/0092-8674(87)90015-8  1
1987 Ma J, Ptashne M. Deletion analysis of GAL4 defines two transcriptional activating segments. Cell. 48: 847-53. PMID 3028647 DOI: 10.1016/0092-8674(87)90081-X  1
1987 Irwin N, Ptashne M. Mutants of the catabolite activator protein of Escherichia coli that are specifically deficient in the gene-activation function. Proceedings of the National Academy of Sciences of the United States of America. 84: 8315-9. PMID 2825186  1
1986 Hochschild A, Ptashne M. Homologous interactions of λ repressor and λ Cro with the λ operator Cell. 44: 925-933. PMID 3955653 DOI: 10.1016/0092-8674(86)90015-2  1
1986 Hochschild A, Ptashne M. Cooperative binding of λ repressors to sites separated by integral turns of the DNA helix Cell. 44: 681-687. PMID 3948245 DOI: 10.1016/0092-8674(86)90833-0  1
1986 Griffith J, Hochschild A, Ptashne M. DNA loops induced by cooperative binding of lambda repressor. Nature. 322: 750-2. PMID 3748156 DOI: 10.1038/322750a0  1
1986 Bushman FD, Ptashne M. Activation of transcription by the bacteriophage 434 repressor. Proceedings of the National Academy of Sciences of the United States of America. 83: 9353-7. PMID 3467310 DOI: 10.1073/pnas.83.24.9353  1
1986 Silver PA, Brent R, Ptashne M. DNA binding is not sufficient for nuclear localization of regulatory proteins in Saccharomyces cerevisiae. Molecular and Cellular Biology. 6: 4763-6. PMID 3099172  1
1986 Sharon J, Gefter ML, Manser T, Ptashne M. Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibody. Proceedings of the National Academy of Sciences of the United States of America. 83: 2628-31. PMID 3085101  1
1986 Keegan L, Gill G, Ptashne M. Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein. Science (New York, N.Y.). 231: 699-704. PMID 3080805  1
1986 Ptashne M. Gene regulation by proteins acting nearby and at a distance. Nature. 322: 697-701. PMID 3018583 DOI: 10.1038/322697a0  1
1986 Hochschild A, Douhan J, Ptashne M. How lambda repressor and lambda Cro distinguish between OR1 and OR3. Cell. 47: 807-16. PMID 2946418 DOI: 10.1016/0092-8674(86)90523-4  1
1986 Wharton RP, Ptashne M. An α-helix determines the DNA-binding specificity of a repressor Trends in Biochemical Sciences. 11: 71-73. DOI: 10.1016/0968-0004(86)90268-9  1
1985 Bushman FD, Anderson JE, Harrison SC, Ptashne M. Ethylation interference and X-ray crystallography identify similar interactions between 434 repressor and operator Nature. 316: 651-653. PMID 4033762 DOI: 10.1038/316651a0  1
1985 Wharton RP, Ptashne M. Changing the binding specificity of a repressor by redesigning an alpha-helix. Nature. 316: 601-5. PMID 4033758 DOI: 10.1038/316601a0  1
1985 Anderson JE, Ptashne M, Harrison SC. A phage repressor-operator complex at 7 Å resolution Nature. 316: 596-601. PMID 4033757  1
1985 Brent R, Ptashne M. A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor Cell. 43: 729-736. PMID 3907859 DOI: 10.1016/0092-8674(85)90246-6  1
1985 Giniger E, Varnum SM, Ptashne M. Specific DNA binding of GAL4, a positive regulatory protein of yeast. Cell. 40: 767-74. PMID 3886158 DOI: 10.1016/0092-8674(85)90336-8  1
1985 Eliason JL, Weiss MA, Ptashne M. NH2-terminal arm of phage λ repressor contributes energy and specificity to repressor binding and determines the effects of operator mutations Proceedings of the National Academy of Sciences of the United States of America. 82: 2339-2343. PMID 3157988 DOI: 10.1073/pnas.82.8.2339  1
1984 Wharton RP, Brown EL, Ptashne M. Substituting an alpha-helix switches the sequence-specific DNA interactions of a repressor. Cell. 38: 361-9. PMID 6540625 DOI: 10.1016/0092-8674(84)90491-4  1
1984 West RW, Yocum RR, Ptashne M. Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASG. Molecular and Cellular Biology. 4: 2467-78. PMID 6392852  1
1984 Brent R, Ptashne M. A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene Nature. 312: 612-615. PMID 6390216  1
1984 Yocum RR, Hanley S, West R, Ptashne M. Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae Molecular and Cellular Biology. 4: 1985-1998. PMID 6390181  1
1984 Kimelman D, Lucher LA, Brackmann KH, Symington JS, Ptashne M, Green M. Synthesis in Escherichia coli of human adenovirus type 12 transforming proteins encoded by early region 1A 13S mRNA and 12S mRNA Proceedings of the National Academy of Sciences of the United States of America. 81: 6300-6304. PMID 6387701 DOI: 10.1073/pnas.81.20.6300  1
1984 Ptashne M. DNA-binding proteins Nature. 308: 753-754. PMID 6371545 DOI: 10.1038/308753c0  1
1984 Anderson J, Ptashne M, Harrison SC. Cocrystals of the DNA-binding domain of phage 434 repressor and a synthetic phage 434 operator Proceedings of the National Academy of Sciences of the United States of America. 81: 1307-1311. PMID 6369323  1
1984 Silver PA, Keegan LP, Ptashne M. Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization. Proceedings of the National Academy of Sciences of the United States of America. 81: 5951-5. PMID 6091123  1
1983 Amann E, Brosius J, Ptashne M. Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli Gene. 25: 167-178. PMID 6363212 DOI: 10.1016/0378-1119(83)90222-6  1
1983 Lewis M, Jeffrey A, Wang J, Ladner R, Ptashne M, Pabo CO. Structure of the operator-binding domain of bacteriophage lambda repressor: implications for DNA recognition and gene regulation. Cold Spring Harbor Symposia On Quantitative Biology. 47: 435-40. PMID 6305562  1
1983 Hochschild A, Irwin N, Ptashne M. Repressor structure and the mechanism of positive control Cell. 32: 319-325. PMID 6218886 DOI: 10.1016/0092-8674(83)90451-8  1
1983 Long ME, Lee CK, Griffith WL, Compere AL, Holleman JW, Simonson LG, Lamberts BL, Fenton DM, Goldstein J, Dawson EC, Roman JDH, Weemen BKV, Matsumura E, lshikawa H, Misaki H, ... ... Ptashne M, et al. Patents and literature Applied Biochemistry and Biotechnology. 8: 69-84. DOI: 10.1007/BF02798349  1
1982 Zinn K, Mellon P, Ptashne M, Maniatis T. Regulated expression of an extrachromosomal human beta-interferon gene in mouse cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 4897-901. PMID 6956899  1
1982 Kenyon CJ, Brent R, Ptashne M, Walker GC. Regulation of damage-inducible genes in Escherichia coli Journal of Molecular Biology. 160: 445-457. PMID 6818350 DOI: 10.1016/0022-2836(82)90307-2  1
1982 Poteete AR, Ptashne M. Control of transcription by the bacteriophage P22 repressor Journal of Molecular Biology. 157: 21-48. PMID 6809952 DOI: 10.1016/0022-2836(82)90511-3  1
1982 Sauer RT, Ross MJ, Ptashne M. Cleavage of the lambda and P22 repressors by recA protein. The Journal of Biological Chemistry. 257: 4458-62. PMID 6461657  1
1982 Ptashne M, Johnson AD, Pabo CO. A genetic switch in a bacterial virus. Scientific American. 247: 128-30, 132, 134-40. PMID 6216590  1
1982 Guarente L, Nye JS, Hochschild A, Ptashne M. Mutant λ phage repressor with a specific defect in its positive control function Proceedings of the National Academy of Sciences of the United States of America. 79: 2236-2239. PMID 6212933 DOI: 10.1073/pnas.79.7.2236  1
1981 Brent R, Ptashne M. Mechanism of action of the lexA gene product Proceedings of the National Academy of Sciences of the United States of America. 78: 4204-4208. PMID 7027256  1
1981 Johnson AD, Poteete AR, Lauer G, Sauer RT, Ackers GK, Ptashne M. lambda Repressor and cro--components of an efficient molecular switch. Nature. 294: 217-23. PMID 6457992 DOI: 10.1038/294217a0  1
1981 Lauer G, Pastrana R, Sherley J, Ptashne M. Construction of overproducers of the bacteriophage 434 repressor and cro proteins Journal of Molecular and Applied Genetics. 1: 139-147. PMID 6286819  1
1981 Guarente L, Ptashne M. Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America. 78: 2199-2203. PMID 6264467  1
1980 Brent R, Ptashne M. The lexA gene product represses its own promoter Proceedings of the National Academy of Sciences of the United States of America. 77: 1932-1936. PMID 6990417  1
1980 Meyer BJ, Ptashne M. Gene regulation at the right operator (OR) of bacteriophage lambda. III. lambda repressor directly activates gene transcription. Journal of Molecular Biology. 139: 195-205. PMID 6447796 DOI: 10.1016/0022-2836(80)90304-6  1
1980 Meyer BJ, Maurer R, Ptashne M. Gene regulation at the right operator (OR) of bacteriophage lambda. II. OR1, OR2, and OR3: their roles in mediating the effects of repressor and cro. Journal of Molecular Biology. 139: 163-94. PMID 6447795 DOI: 10.1016/0022-2836(80)90303-4  1
1980 Maurer R, Meyer BJ, Ptashne M. Gene regulation at the right operator (OR) of bacteriophage λ. I. OR3 and autogenous negative control by repressor Journal of Molecular Biology. 139: 147-161. PMID 6447794 DOI: 10.1016/0022-2836(80)90302-2  1
1980 Poteete AR, Ptashne M, Ballivet M, Eisen H. Operator sequences of bacteriophages P22 and 21 Journal of Molecular Biology. 137: 81-91. PMID 6445008 DOI: 10.1016/0022-2836(80)90158-8  1
1980 Ptashne M, Jeffrey A, Johnson AD, Maurer R, Meyer BJ, Pabo CO, Roberts TM, Sauer RT. How the lambda repressor and cro work. Cell. 19: 1-11. PMID 6444544 DOI: 10.1016/0092-8674(80)90383-9  1
1980 Guarente L, Lauer G, Roberts TM, Ptashne M. Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit β-globin Cell. 20: 543-553. PMID 6248249 DOI: 10.1016/0092-8674(80)90640-6  1
1980 Taniguchi T, Guarente L, Roberts TM, Kimelman D, Douhan J, Ptashne M. Expression of the human fibroblast interferon gene in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 77: 5230-5233. PMID 6159642 DOI: 10.1073/pnas.77.9.5230  1
1979 Sauer RT, Pabo CO, Meyer BJ, Ptashne M, Backman KC. Regulatory functions of the lambda repressor reside in the amino-terminal domain. Nature. 279: 396-400. PMID 16068162 DOI: 10.1038/279396a0  1
1979 Roberts TM, Kacich R, Ptashne M. A general method for maximizing the expression of a cloned gene Proceedings of the National Academy of Sciences of the United States of America. 76: 760-764. PMID 370836  1
1979 Pabo CO, Sauer RT, Sturtevant JM, Ptashne M. The lambda repressor contains two domains. Proceedings of the National Academy of Sciences of the United States of America. 76: 1608-12. PMID 287002 DOI: 10.1073/pnas.76.4.1608  1
1979 Roberts TM, Bikel I, Yocum RR, Livingston DM, Ptashne M. Synthesis of simian virus 40 t antigen in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 76: 5596-5600. PMID 230483 DOI: 10.1073/pnas.76.11.5596  1
1979 Johnson AD, Meyer BJ, Ptashne M. Interactions between DNA-bound repressors govern regulation by the lambda phage repressor. Proceedings of the National Academy of Sciences of the United States of America. 76: 5061-5. PMID 159452 DOI: 10.1073/pnas.76.10.5061  1
1978 Backman K, Ptashne M. Maximizing gene expression on a plasmid using recombination in vitro Cell. 13: 65-71. PMID 340049 DOI: 10.1016/0092-8674(78)90138-1  1
1978 Johnson A, Meyer BJ, Ptashne M. Mechanism of action of the cro protein of bacteriophage lambda. Proceedings of the National Academy of Sciences of the United States of America. 75: 1783-7. PMID 273909  1
1978 Adelstein RS, Pershan PS, Ptashne M, Fink G, Temin HM, Hershey AD, Caspari E, Yanofsky C, Rhoades MM, Owen RD, Fresco J, Henderson AS. Moscow genetics Congress [2] Science. 201: 675.  1
1977 Humayun Z, Kleid D, Ptashne M. Sites of contact between λ operators and λ repressor Nucleic Acids Research. 4: 1595-1607. PMID 896470  1
1977 Humayun Z, Jeffrey A, Ptashne M. Completed DNA sequences and organization of repressor-binding sites in the operators of phage lambda Journal of Molecular Biology. 112: 265-277. PMID 875019 DOI: 10.1016/S0022-2836(77)80143-5  1
1977 Ptashne M, Mosing G, Nash HA. Integration and excision of DNA molecules Hoppe-Seyler's Zeitschrift Fur Physiologische Chemie. 358: 417-423.  1
1976 Ptashne M, Gilbert W, Baltimore D, Gefter M, Steitz J, Bishop M, Guthrie C, Boyer H, Sobell H, Abelson J, Alberts B. The "sunday seminar". Science (New York, N.Y.). 191: 245. PMID 17832131 DOI: 10.1126/science.191.4224.245  1
1976 Maniatis T, Ptashne M. A DNA operator-repressor system. Scientific American. 234: 64-6, 71-6. PMID 1251177  1
1976 Backman K, Ptashne M, Gilbert W. Construction of plasmids carrying the cI gene of bacteriophage lambda. Proceedings of the National Academy of Sciences of the United States of America. 73: 4174-8. PMID 1069307  1
1976 Kleid D, Humayun Z, Jeffrey A, Ptashne M. Novel properties of a restriction endonuclease isolated from Haemophilus parahaemolyticus Proceedings of the National Academy of Sciences of the United States of America. 73: 293-297. PMID 1061131  1
1976 Ptashne M, Backman K, Humayun MZ, Jeffrey A, Maurer R, Meyer B, Sauer RT. Autoregulation and function of a repressor in bacteriophage lambda. Science (New York, N.Y.). 194: 156-61. PMID 959843 DOI: 10.1126/science.959843  1
1975 Maniatis T, Ptashne M, Backman K, Kield D, Flashman S, Jeffrey A, Maurer R. Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda. Cell. 5: 109-13. PMID 1095210 DOI: 10.1016/0092-8674(75)90018-5  1
1975 Meyer BJ, Kleid DG, Ptashne M. Lambda repressor turns off transcription of its own gene. Proceedings of the National Academy of Sciences of the United States of America. 72: 4785-89. PMID 1061069  1
1974 Maniatis T, Ptashne M, Barrell BG, Donelson J. Sequence of a repressor-binding site in the DNA of bacteriophage lamda. Nature. 250: 394-7. PMID 4854243 DOI: 10.1038/250394A0  1
1974 Maurer R, Maniatis T, Ptashne M. Promoters are in the operators in phage lambda. Nature. 249: 221-3. PMID 4598033  1
1974 Maniatis T, Ptashne M, Maurer R. Control elements in the DNA of bacteriophage lambda. Cold Spring Harbor Symposia On Quantitative Biology. 38: 857-68. PMID 4545512  1
1973 Ptashne M. Repressor, operators, and promoters in bacteriophage lambda Harvey Lectures. 143-171. PMID 4618262  1
1973 Maniatis T, Ptashne M. Structure of the lambda operators. Nature. 246: 133-6. PMID 4586104 DOI: 10.1038/246133A0  1
1973 Maniatis T, Ptashne M. Multiple repressor binding at the operators in bacteriophage lambda. Proceedings of the National Academy of Sciences of the United States of America. 70: 1531-5. PMID 4514322  1
1970 Ptashne M, Gilbert W. Genetic repressors. Scientific American. 222: 36-44. PMID 4910866  1
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