Todd C. Appleby, Ph.D. - Publications

Affiliations: 
2001 Cornell University, Ithaca, NY, United States 
Area:
structure and function of proteins using X-ray crystallography

24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Appleby TC, Perry JK, Murakami E, Barauskas O, Feng J, Cho A, Fox D, Wetmore DR, McGrath ME, Ray AS, Sofia MJ, Swaminathan S, Edwards TE. Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase. Science (New York, N.Y.). 347: 771-5. PMID 25678663 DOI: 10.1126/science.1259210  0.64
2014 Boyce SE, Tirunagari N, Niedziela-Majka A, Perry J, Wong M, Kan E, Lagpacan L, Barauskas O, Hung M, Fenaux M, Appleby T, Watkins WJ, Schmitz U, Sakowicz R. Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors. Plos One. 9: e84808. PMID 24416288 DOI: 10.1371/journal.pone.0084808  0.64
2014 Lazerwith SE, Lew W, Zhang J, Morganelli P, Liu Q, Canales E, Clarke MO, Doerffler E, Byun D, Mertzman M, Ye H, Chong L, Xu L, Appleby T, Chen X, et al. Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection. Journal of Medicinal Chemistry. 57: 1893-901. PMID 24144213 DOI: 10.1021/jm401420j  0.64
2013 Fenaux M, Eng S, Leavitt SA, Lee YJ, Mabery EM, Tian Y, Byun D, Canales E, Clarke MO, Doerffler E, Lazerwith SE, Lew W, Liu Q, Mertzman M, Morganelli P, ... ... Appleby TC, et al. Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase. Antimicrobial Agents and Chemotherapy. 57: 804-10. PMID 23183437 DOI: 10.1128/AAC.02052-12  0.64
2012 Canales E, Carlson JS, Appleby T, Fenaux M, Lee J, Tian Y, Tirunagari N, Wong M, Watkins WJ. Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 4288-92. PMID 22664130 DOI: 10.1016/j.bmcl.2012.05.025  0.64
2012 Sheng XC, Appleby T, Butler T, Cai R, Chen X, Cho A, Clarke MO, Cottell J, Delaney IV WE, Doerffler E, Link J, Ji M, Pakdaman R, Pyun HJ, Wu Q, et al. Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease Bioorganic and Medicinal Chemistry Letters. 22: 2629-2634. PMID 22366653 DOI: 10.1016/j.bmcl.2012.01.017  0.64
2012 Chan K, Cheng G, Beran RK, Yang H, Appleby TC, Pokrovskii MV, Mo H, Zhong W, Delaney WE. An adaptive mutation in NS2 is essential for efficient production of infectious 1b/2a chimeric hepatitis C virus in cell culture. Virology. 422: 224-34. PMID 22099378 DOI: 10.1016/j.virol.2011.10.022  0.64
2011 Appleby TC, Anderson R, Fedorova O, Pyle AM, Wang R, Liu X, Brendza KM, Somoza JR. Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV. Journal of Molecular Biology. 405: 1139-53. PMID 21145896 DOI: 10.1016/j.jmb.2010.11.034  0.64
2009 Iverson C, Larson G, Lai C, Yeh LT, Dadson C, Weingarten P, Appleby T, Vo T, Maderna A, Vernier JM, Hamatake R, Miner JN, Quart B. RDEA119/BAY 869766: A potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer Cancer Research. 69: 6839-6847. PMID 19706763 DOI: 10.1158/0008-5472.CAN-09-0679  0.64
2009 Appleby T, Shih IH, Zhong W. Viral RNA polymerase inhibitors Viral Genome Replication. 527-548. DOI: 10.1007/b135974_23  0.64
2007 Yan S, Appleby T, Larson G, Wu JZ, Hamatake RK, Hong Z, Yao N. Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study Bioorganic and Medicinal Chemistry Letters. 17: 1991-1995. PMID 17276060 DOI: 10.1016/j.bmcl.2007.01.024  0.64
2007 Cheney IW, Yan S, Appleby T, Walker H, Vo T, Yao N, Hamatake R, Hong Z, Wu JZ. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase Bioorganic and Medicinal Chemistry Letters. 17: 1679-1683. PMID 17251021 DOI: 10.1016/j.bmcl.2006.12.086  0.64
2007 Yan S, Appleby T, Gunic E, Shim JH, Tasu T, Kim H, Rong F, Chen H, Hamatake R, Wu JZ, Hong Z, Yao N. Isothiazoles as active-site inhibitors of HCV NS5B polymerase. Bioorganic & Medicinal Chemistry Letters. 17: 28-33. PMID 17049853 DOI: 10.1016/j.bmcl.2006.10.002  0.64
2007 Yan S, Larson G, Wu JZ, Appleby T, Ding Y, Hamatake R, Hong Z, Yao N. Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure Bioorganic and Medicinal Chemistry Letters. 17: 63-67. PMID 17049849 DOI: 10.1016/j.bmcl.2006.09.095  0.64
2006 El Abdellaoui H, Varaprasad CVNS, Barawkar D, Chakravarty S, Maderna A, Tam R, Chen H, Allan M, Wu JZ, Appleby T, Yan S, Zhang W, Lang S, Yao N, Hamatake R, et al. Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors Bioorganic and Medicinal Chemistry Letters. 16: 5561-5566. PMID 16934458 DOI: 10.1016/j.bmcl.2006.08.048  0.64
2006 Yan S, Appleby T, Larson G, Wu JZ, Hamatake R, Hong Z, Yao N. Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors Bioorganic and Medicinal Chemistry Letters. 16: 5888-5891. PMID 16934455 DOI: 10.1016/j.bmcl.2006.08.056  0.64
2005 Appleby TC, Larson G, Cheney IW, Walker H, Wu JZ, Zhong W, Hong Z, Yao N. Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative. Acta Crystallographica. Section D, Biological Crystallography. 61: 278-84. PMID 15735337 DOI: 10.1107/S0907444904032937  0.64
2005 Appleby TC, Luecke H, Shim JH, Wu JZ, Cheney IW, Zhong W, Vogeley L, Hong Z, Yao N. Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer. Journal of Virology. 79: 277-88. PMID 15596823 DOI: 10.1128/JVI.79.1.277-288.2005  0.64
2003 Walker MP, Appleby TC, Zhong W, Lau JY, Hong Z. Hepatitis C virus therapies: current treatments, targets and future perspectives. Antiviral Chemistry & Chemotherapy. 14: 1-21. PMID 12790512  0.64
2001 Appleby TC, Mathews II, Porcelli M, Cacciapuoti G, Ealick SE. Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus. The Journal of Biological Chemistry. 276: 39232-42. PMID 11489901 DOI: 10.1074/jbc.M105694200  0.64
2000 Begley TP, Appleby TC, Ealick SE. The structural basis for the remarkable catalytic proficiency of orotidine 5'-monophosphate decarboxylase. Current Opinion in Structural Biology. 10: 711-8. PMID 11114509 DOI: 10.1016/S0959-440X(00)00148-2  0.64
2000 Appleby TC, Kinsland C, Begley TP, Ealick SE. The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase. Proceedings of the National Academy of Sciences of the United States of America. 97: 2005-10. PMID 10681442 DOI: 10.1073/pnas.259441296  0.64
1999 Appleby TC, Erion MD, Ealick SE. The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis. Structure (London, England : 1993). 7: 629-41. PMID 10404592 DOI: 10.1016/S0969-2126(99)80084-7  0.64
1998 Deacon AM, Appleby T, Bilderback DH, Ealick SE, Fontes E, Thiel DJ. Protein crystallography using a multilayer monochromator. Journal of Synchrotron Radiation. 5: 494-6. PMID 15263556 DOI: 10.1107/S0909049597017275  0.64
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