Ethan C. Settembre, Ph.D. - Publications

2004 Cornell University, Ithaca, NY, United States 
structure and function of proteins using X-ray crystallography

33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Suphaphiphat P, Whittaker L, De Souza I, Daniels RS, Dormitzer PR, McCauley JW, Settembre EC. Antigenic characterization of influenza viruses produced using synthetic DNA and novel backbones. Vaccine. PMID 27219338 DOI: 10.1016/j.vaccine.2016.05.031  0.4
2015 Ciferri C, Chandramouli S, Leitner A, Donnarumma D, Cianfrocco MA, Gerrein R, Friedrich K, Aggarwal Y, Palladino G, Aebersold R, Norais N, Settembre EC, Carfi A. Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies. Plos Pathogens. 11: e1005230. PMID 26485028 DOI: 10.1371/journal.ppat.1005230  0.4
2015 Chandramouli S, Ciferri C, Nikitin PA, Caló S, Gerrein R, Balabanis K, Monroe J, Hebner C, Lilja AE, Settembre EC, Carfi A. Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody. Nature Communications. 6: 8176. PMID 26365435 DOI: 10.1038/ncomms9176  0.4
2015 Wen Y, Han L, Palladino G, Ferrari A, Xie Y, Carfi A, Dormitzer PR, Settembre EC. Conformationally selective biophysical assay for influenza vaccine potency determination. Vaccine. 33: 5342-9. PMID 26348403 DOI: 10.1016/j.vaccine.2015.08.077  0.4
2015 Prevato M, Ferlenghi I, Bonci A, Uematsu Y, Anselmi G, Giusti F, Bertholet S, Legay F, Telford JL, Settembre EC, Maione D, Cozzi R. Expression and Characterization of Recombinant, Tetrameric and Enzymatically Active Influenza Neuraminidase for the Setup of an Enzyme-Linked Lectin-Based Assay. Plos One. 10: e0135474. PMID 26280677 DOI: 10.1371/journal.pone.0135474  0.4
2015 Prevato M, Cozzi R, Pezzicoli A, Taddei AR, Ferlenghi I, Nandi A, Montomoli E, Settembre EC, Bertholet S, Bonci A, Legay F. An Innovative Pseudotypes-Based Enzyme-Linked Lectin Assay for the Measurement of Functional Anti-Neuraminidase Antibodies. Plos One. 10: e0135383. PMID 26267900 DOI: 10.1371/journal.pone.0135383  0.4
2015 Ciferri C, Chandramouli S, Donnarumma D, Nikitin PA, Cianfrocco MA, Gerrein R, Feire AL, Barnett SW, Lilja AE, Rappuoli R, Norais N, Settembre EC, Carfi A. Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes. Proceedings of the National Academy of Sciences of the United States of America. 112: 1767-72. PMID 25624487 DOI: 10.1073/pnas.1424818112  0.4
2014 Settembre EC, Dormitzer PR, Rappuoli R. Bringing influenza vaccines into the 21st century. Human Vaccines & Immunotherapeutics. 10: 600-4. PMID 24378716 DOI: 10.4161/hv.27600  0.4
2014 Geall AJ, Settembre EC, Ulmer JB. Using self-amplifying mRNA vaccines to facilitate a rapid response to pandemic influenza European Pharmaceutical Review. 19: 20-23.  0.4
2013 Hekele A, Bertholet S, Archer J, Gibson DG, Palladino G, Brito LA, Otten GR, Brazzoli M, Buccato S, Bonci A, Casini D, Maione D, Qi ZQ, Gill JE, Caiazza NC, ... ... Settembre EC, et al. Rapidly produced SAM(®) vaccine against H7N9 influenza is immunogenic in mice. Emerging Microbes & Infections. 2: e52. PMID 26038486 DOI: 10.1038/emi.2013.54  0.4
2013 Soriano EV, Zhang Y, Colabroy KL, Sanders JM, Settembre EC, Dorrestein PC, Begley TP, Ealick SE. Active-site models for complexes of quinolinate synthase with substrates and intermediates. Acta Crystallographica. Section D, Biological Crystallography. 69: 1685-96. PMID 23999292 DOI: 10.1107/S090744491301247X  0.4
2013 Chandramouli S, Medina-Selby A, Coit D, Schaefer M, Spencer T, Brito LA, Zhang P, Otten G, Mandl CW, Mason PW, Dormitzer PR, Settembre EC. Generation of a parvovirus B19 vaccine candidate. Vaccine. 31: 3872-8. PMID 23827313 DOI: 10.1016/j.vaccine.2013.06.062  0.4
2013 Schmidt AG, Xu H, Khan AR, O'Donnell T, Khurana S, King LR, Manischewitz J, Golding H, Suphaphiphat P, Carfi A, Settembre EC, Dormitzer PR, Kepler TB, Zhang R, Moody MA, et al. Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proceedings of the National Academy of Sciences of the United States of America. 110: 264-9. PMID 23175789 DOI: 10.1073/pnas.1218256109  0.4
2013 Estrozi LF, Settembre EC, Goret G, McClain B, Zhang X, Chen JZ, Grigorieff N, Harrison SC. Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles. Journal of Molecular Biology. 425: 124-32. PMID 23089332 DOI: 10.1016/j.jmb.2012.10.011  0.4
2011 Lo Surdo P, Bottomley MJ, Calzetta A, Settembre EC, Cirillo A, Pandit S, Ni YG, Hubbard B, Sitlani A, Carfí A. Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. Embo Reports. 12: 1300-5. PMID 22081141 DOI: 10.1038/embor.2011.205  0.4
2011 Di Giovine P, Settembre EC, Bhargava AK, Luftig MA, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C, Carfi A. Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1. Plos Pathogens. 7: e1002277. PMID 21980294 DOI: 10.1371/journal.ppat.1002277  0.4
2011 Swanson KA, Settembre EC, Shaw CA, Dey AK, Rappuoli R, Mandl CW, Dormitzer PR, Carfi A. Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers. Proceedings of the National Academy of Sciences of the United States of America. 108: 9619-24. PMID 21586636 DOI: 10.1073/pnas.1106536108  0.4
2011 Settembre EC, Dormitzer PR, Rappuoli R. Learning from the 2009 H1N1 pandemic: prospects for more broadly effective influenza vaccines. Journal of Molecular Cell Biology. 3: 144-6. PMID 21430014 DOI: 10.1093/jmcb/mjq046  0.4
2011 Settembre EC, Chen JZ, Dormitzer PR, Grigorieff N, Harrison SC. Atomic model of an infectious rotavirus particle. The Embo Journal. 30: 408-16. PMID 21157433 DOI: 10.1038/emboj.2010.322  0.4
2010 Suphaphiphat P, Franti M, Hekele A, Lilja A, Spencer T, Settembre E, Palmer G, Crotta S, Tuccino AB, Keiner B, Trusheim H, Balabanis K, Sackal M, Rothfeder M, Mandl CW, et al. Mutations at positions 186 and 194 in the HA gene of the 2009 H1N1 pandemic influenza virus improve replication in cell culture and eggs. Virology Journal. 7: 157. PMID 20630098 DOI: 10.1186/1743-422X-7-157  0.4
2010 Settembre EC, Dormitzer PR, Rappuoli R. H1N1: can a pandemic cycle be broken? Science Translational Medicine. 2: 24ps14. PMID 20375006 DOI: 10.1126/scitranslmed.3000948  0.4
2010 Paul D, O'Leary SE, Rajashankar K, Bu W, Toms A, Settembre EC, Sanders JM, Begley TP, Ealick SE. Glycal formation in crystals of uridine phosphorylase. Biochemistry. 49: 3499-509. PMID 20364833 DOI: 10.1021/bi902073b  0.4
2010 McClain B, Settembre E, Temple BR, Bellamy AR, Harrison SC. X-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution. Journal of Molecular Biology. 397: 587-99. PMID 20122940 DOI: 10.1016/j.jmb.2010.01.055  0.4
2010 Nkolola JP, Peng H, Settembre EC, Freeman M, Grandpre LE, Devoy C, Lynch DM, La Porte A, Simmons NL, Bradley R, Montefiori DC, Seaman MS, Chen B, Barouch DH. Breadth of neutralizing antibodies elicited by stable, homogeneous clade A and clade C HIV-1 gp140 envelope trimers in guinea pigs. Journal of Virology. 84: 3270-9. PMID 20053749 DOI: 10.1128/JVI.02252-09  0.4
2009 Aoki ST, Settembre EC, Trask SD, Greenberg HB, Harrison SC, Dormitzer PR. Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab. Science (New York, N.Y.). 324: 1444-7. PMID 19520960 DOI: 10.1126/science.1170481  0.4
2009 Chen JZ, Settembre EC, Aoki ST, Zhang X, Bellamy AR, Dormitzer PR, Harrison SC, Grigorieff N. Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proceedings of the National Academy of Sciences of the United States of America. 106: 10644-8. PMID 19487668 DOI: 10.1073/pnas.0904024106  0.4
2008 Zhang X, Settembre E, Xu C, Dormitzer PR, Bellamy R, Harrison SC, Grigorieff N. Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction. Proceedings of the National Academy of Sciences of the United States of America. 105: 1867-72. PMID 18238898 DOI: 10.1073/pnas.0711623105  0.4
2005 Bu W, Settembre EC, el Kouni MH, Ealick SE. Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines. Acta Crystallographica. Section D, Biological Crystallography. 61: 863-72. PMID 15983408 DOI: 10.1107/S0907444905007882  0.4
2004 Settembre EC, Chittuluru JR, Mill CP, Kappock TJ, Ealick SE. Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE). Acta Crystallographica. Section D, Biological Crystallography. 60: 1753-60. PMID 15388921 DOI: 10.1107/S090744490401858X  0.4
2004 Settembre EC, Dorrestein PC, Zhai H, Chatterjee A, McLafferty FW, Begley TP, Ealick SE. Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex. Biochemistry. 43: 11647-57. PMID 15362849 DOI: 10.1021/bi0488911  0.4
2004 Lee JE, Settembre EC, Cornell KA, Riscoe MK, Sufrin JR, Ealick SE, Howell PL. Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design. Biochemistry. 43: 5159-69. PMID 15122881 DOI: 10.1021/bi035492h  0.4
2003 Settembre E, Begley TP, Ealick SE. Structural biology of enzymes of the thiamin biosynthesis pathway. Current Opinion in Structural Biology. 13: 739-47. PMID 14675553 DOI: 10.1016/  0.4
2003 Settembre EC, Dorrestein PC, Park JH, Augustine AM, Begley TP, Ealick SE. Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis. Biochemistry. 42: 2971-81. PMID 12627963 DOI: 10.1021/bi026916v  0.4
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