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Fei You, Ph.D. - Publications

Affiliations: 
2003 Brown University, Providence, RI 
Area:
Natural product total synthesis
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20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Vlahov IR, Qi L, Santhapuram HKR, Felten A, Parham GL, Zou N, Wang K, You F, Vaughn JF, Hahn SJ, Klein HF, Kleindl PJ, Reddy J, Reno D, Nicoson J, et al. Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate. Bioorganic & Medicinal Chemistry Letters. 126987. PMID 32029324 DOI: 10.1016/J.Bmcl.2020.126987  0.552
2018 Rangasamy L, Chelvam V, Kanduluru AK, Srinivasarao M, Bandara AN, You F, Orellana E, Kasinski AL, Low PS. New mechanism for release of endosomal contents: osmotic lysis via nigericin-mediated K/Hexchange. Bioconjugate Chemistry. PMID 29446616 DOI: 10.1021/Acs.Bioconjchem.7B00714  0.313
2017 Vlahov IR, Qi L, Kleindl PJ, Santhapuram HK, Felten A, Parham GL, Wang K, You F, Vaughn JF, Hahn SJ, Klein HF, Vetzel M, Reddy JA, Nelson M, Nicoson J, et al. Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates. Bioconjugate Chemistry. PMID 29211454 DOI: 10.1021/Acs.Bioconjchem.7B00476  0.558
2016 You F, Jiang L, Zhang B, Lu Q, Zhou Q, Liao X, Wu H, Du K, Zhu Y, Meng H, Gong Z, Zong Y, Huang L, Lu M, Tang J, et al. Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells. Science China. Life Sciences. PMID 26961900 DOI: 10.1007/s11427-016-5024-7  0.414
2016 Vlahov I, You F, Kleindl P, Vetzel M, Reddy J, Leamon C. Abstract 4735: Designing novel warheads for targeted therapies: SAR and efficient strategies for the synthesis of analogues of tubulysin Cancer Research. 76: 4735-4735. DOI: 10.1158/1538-7445.Am2016-4735  0.356
2015 Lu Y, Parker N, Kleindl PJ, Cross VA, Wollak K, Westrick E, Stinnette TW, Gehrke MA, Wang K, Santhapuram HK, You F, Hahn SJ, Vaughn JF, Klein PJ, Vlahov IR, et al. Anti-Inflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus. Molecular Medicine (Cambridge, Mass.). PMID 26181632 DOI: 10.2119/Molmed.2015.00040  0.316
2015 Leamon CP, Reddy JA, Vlahov IR, You F, Klein HF, Kleindl PJ, Nelson M, Vetzel M, Klein PJ, Matherly LH, Gangjee A. Abstract 4488: Folate receptor targeted therapy using small molecule drug conjugates constructed with high affinity antifolate ligands Cancer Research. 75: 4488-4488. DOI: 10.1158/1538-7445.Am2015-4488  0.366
2015 Vlahov IR, You F, Klein HF, Kleindl PJ, Nelson M, Vetzel M, Reddy JA, Leamon CP, Matherly LH, Gangjee A. Abstract 4393: Design and synthesis of novel conjugates for targeting the folate receptor: Exploiting cytotoxic GARFTase inhibitors for delivering additional chemotherapeutic payloads to cancer cells Cancer Research. 75: 4393-4393. DOI: 10.1158/1538-7445.Am2015-4393  0.361
2014 Leamon CP, Vlahov IR, Reddy JA, Vetzel M, Santhapuram HK, You F, Bloomfield A, Dorton R, Nelson M, Kleindl P, Vaughn JF, Westrick E. Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship. Bioconjugate Chemistry. 25: 560-8. PMID 24564229 DOI: 10.1021/Bc400441S  0.36
2014 Wang K, Hahn S, Santhapuram H, Qi L, Kleindl P, Vaughn J, You F, Reddy J, Dorton R, Leamon C, Vlahov I. Abstract 4462: Structure-activity relationship studies for PSMA-targeted tubulysin conjugates Cancer Research. 74: 4462-4462. DOI: 10.1158/1538-7445.Am2014-4462  0.364
2013 Piao D, Basavapathruni A, Iyidogan P, Dai G, Hinz W, Ray AS, Murakami E, Feng JY, You F, Dutschman GE, Austin DJ, Parker KA, Anderson KS. Bifunctional inhibition of HIV-1 reverse transcriptase: a first step in designing a bifunctional triphosphate. Bioorganic & Medicinal Chemistry Letters. 23: 1511-8. PMID 23380374 DOI: 10.1016/J.Bmcl.2012.12.015  0.607
2013 Vlahov I, Qi L, You F, Hahn S, Santhapuram HK, Wang K, Kleindl P, Vaughn J, Vetzel M, Reddy J, Leamon C. Abstract 4499: Total synthesis of tubulysins: A new chemical reaction leads to analogues with enhanced cytotoxicity. Cancer Research. 73: 4499-4499. DOI: 10.1158/1538-7445.Am2013-4499  0.334
2012 Vlahov I, You F, Dorton R, Westrick E, Reddy J, Leamon CP. Abstract 1929: Antifolates as folate receptor targeting ligands: Design and synthesis of their conjugates with cytotoxic agents Cancer Research. 72: 1929-1929. DOI: 10.1158/1538-7445.Am2012-1929  0.368
2011 Vlahov IR, You F, Santhapuram HK, Wang Y, Vaughn JF, Hahn SJ, Kleindl PJ, Fan M, Leamon CP. Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation. Bioorganic & Medicinal Chemistry Letters. 21: 1202-5. PMID 21236665 DOI: 10.1016/J.Bmcl.2010.12.085  0.362
2011 Leamon CP, Vlahov IR, Reddy JA, Vetzel M, Santhapuram HK, You F, Bloomfield A, Dorton R, Nelson M, Kleindl P, Vaughn J, Westrick E. Abstract 2518: Structure-activity relationships of folate-vinca alkaloid conjugates Cancer Research. 71: 2518-2518. DOI: 10.1158/1538-7445.Am2011-2518  0.355
2010 Vlahov IR, Vite GD, Kleindl PJ, Wang Y, Santhapuram HK, You F, Howard SJ, Kim SH, Lee FF, Leamon CP. Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid. Bioorganic & Medicinal Chemistry Letters. 20: 4578-81. PMID 20594844 DOI: 10.1016/J.Bmcl.2010.06.016  0.364
2010 Vlahov IR, Santhapuram HKR, Wang Y, You F, Kleindl PJ, Fan M, Vaughn JF, Han SJ, Leamon CP. Abstract 5515: Design and synthesis of releasable folate-drug conjugates possessing optimized carbohydrate-based spacer units Cancer Research. 70: 5515-5515. DOI: 10.1158/1538-7445.Am10-5515  0.39
2009 Leamon CP, You F, Santhapuram HK, Fan M, Vlahov IR. Properties influencing the relative binding affinity of pteroate derivatives and drug conjugates thereof to the folate receptor. Pharmaceutical Research. 26: 1315-23. PMID 19189203 DOI: 10.1007/S11095-009-9840-3  0.306
2007 Lu Y, You F, Vlahov I, Westrick E, Fan M, Low PS, Leamon CP. Folate-targeted dinitrophenyl hapten immunotherapy: effect of linker chemistry on antitumor activity and allergic potential. Molecular Pharmaceutics. 4: 695-706. PMID 17784727 DOI: 10.1021/Mp070050B  0.325
2007 Vlahov IR, Santhapuram HK, Wang Y, Kleindl PJ, You F, Howard SJ, Westrick E, Reddy JA, Leamon CP. An assembly concept for the consecutive introduction of unsymmetrical disulfide bonds: synthesis of a releasable multidrug conjugate of folic acid. The Journal of Organic Chemistry. 72: 5968-72. PMID 17602528 DOI: 10.1021/Jo070411Z  0.352
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