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Joshua A. Lees, Ph.D. - Publications

Affiliations: 
2010 Princeton University, Princeton, NJ 
Area:
intracellular trafficking in eukaryotes and cell-cell communication
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10/118 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Salter CG, Cai Y, Lo B, Helman G, Taylor H, McCartney A, Leslie JS, Accogoli A, Zara F, Traverso M, Fasham J, Lees JA, Ferla M, Chioza BA, Wenger O, et al. Biallelic PI4KA variants cause neurological, intestinal and immunological disease. Brain : a Journal of Neurology. PMID 34415310 DOI: 10.1093/brain/awab313  0.311
2020 Lees JA, Li P, Kumar N, Weisman LS, Reinisch KM. Insights into Lysosomal PI(3,5)P Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex. Molecular Cell. PMID 33098764 DOI: 10.1016/j.molcel.2020.10.003  0.66
2020 Lees JA, Reinisch KM. Inter-organelle lipid transfer: a channel model for Vps13 and chorein-N motif proteins. Current Opinion in Cell Biology. 65: 66-71. PMID 32213462 DOI: 10.1016/J.Ceb.2020.02.008  0.711
2020 Li P, Lees JA, Lusk CP, Reinisch KM. Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes. The Journal of Cell Biology. 219. PMID 32182622 DOI: 10.1083/Jcb.202001161  0.688
2019 Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ. ATG2 transports lipids to promote autophagosome biogenesis. The Journal of Cell Biology. PMID 30952800 DOI: 10.1083/Jcb.201811139  0.695
2018 Kumar N, Leonzino M, Hancock-Cerutti W, Horenkamp FA, Li P, Lees JA, Wheeler H, Reinisch KM, De Camilli P. VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites. The Journal of Cell Biology. PMID 30093493 DOI: 10.1083/Jcb.201807019  0.688
2017 Lees JA, Zhang Y, Oh MS, Schauder CM, Yu X, Baskin JM, Dobbs K, Notarangelo LD, De Camilli P, Walz T, Reinisch KM. Architecture of the human PI4KIIIα lipid kinase complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 29229838 DOI: 10.1073/Pnas.1718471115  0.672
2017 Lees JA, Messa M, Sun EW, Wheeler H, Torta F, Wenk MR, De Camilli P, Reinisch KM. Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion. Science (New York, N.Y.). 355. PMID 28209843 DOI: 10.1126/Science.Aah6171  0.653
2010 Lees JA, Yip CK, Walz T, Hughson FM. Molecular organization of the COG vesicle tethering complex. Nature Structural & Molecular Biology. 17: 1292-7. PMID 20972446 DOI: 10.1038/Nsmb.1917  0.611
2006 Bennett RP, Diner E, Sowden MP, Lees JA, Wedekind JE, Smith HC. APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic. Biochemical and Biophysical Research Communications. 350: 214-9. PMID 16999936 DOI: 10.1016/J.Bbrc.2006.09.032  0.329
Low-probability matches (unlikely to be authored by this person)
2001 Trimarchi JM, Fairchild B, Wen J, Lees JA. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proceedings of the National Academy of Sciences of the United States of America. 98: 1519-24. PMID 11171983 DOI: 10.1073/pnas.041597698  0.241
1993 Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K. The retinoblastoma protein binds to a family of E2F transcription factors. Molecular and Cellular Biology. 13: 7813-25. PMID 8246996 DOI: 10.1128/Mcb.13.12.7813  0.241
2001 Trimarchi JM, Fairchild B, Wen J, Lees JA. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex Proceedings of the National Academy of Sciences. 98: 1519-1524. DOI: 10.1073/Pnas.98.4.1519  0.24
2001 Gaubatz S, Lees JA, Lindeman GJ, Livingston DM. E2F4 is exported from the nucleus in a CRM1-dependent manner. Molecular and Cellular Biology. 21: 1384-92. PMID 11158323 DOI: 10.1128/Mcb.21.4.1384-1392.2001  0.239
2003 Landsberg RL, Sero JE, Danielian PS, Yuan TL, Lee EY, Lees JA. The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity. Proceedings of the National Academy of Sciences of the United States of America. 100: 2456-61. PMID 12604789 DOI: 10.1073/Pnas.0138064100  0.238
1993 Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes & Development. 7: 1850-61. PMID 8405995 DOI: 10.1101/Gad.7.10.1850  0.229
1992 Helin K, Lees JA, Vidal M, Dyson N, Harlow E, Fattaey A. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell. 70: 337-50. PMID 1638634 DOI: 10.1016/0092-8674(92)90107-N  0.222
1995 Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA. In vivo association of E2F and DP family proteins. Molecular and Cellular Biology. 15: 2536-46. PMID 7739537 DOI: 10.1128/Mcb.15.5.2536  0.209
2021 Lees JA, Dias JM, Han S. Applications of Cryo-EM in small molecule and biologics drug design. Biochemical Society Transactions. 49: 2627-2638. PMID 34812853 DOI: 10.1042/BST20210444  0.209
1991 Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E. The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. The Embo Journal. 10: 4279-90. PMID 1756735 DOI: 10.1002/J.1460-2075.1991.Tb05006.X  0.208
1996 Moberg K, Starz MA, Lees JA. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Molecular and Cellular Biology. 16: 1436-49. PMID 8657117 DOI: 10.1128/Mcb.16.4.1436  0.207
1997 Verona R, Moberg K, Estes S, Starz M, Vernon JP, Lees JA. E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Molecular and Cellular Biology. 17: 7268-82. PMID 9372959 DOI: 10.1128/Mcb.17.12.7268  0.205
1992 Hu QJ, Lees JA, Buchkovich KJ, Harlow E. The retinoblastoma protein physically associates with the human cdc2 kinase. Molecular and Cellular Biology. 12: 971-80. PMID 1545827 DOI: 10.1128/Mcb.12.3.971  0.199
1994 Mittnacht S, Lees JA, Desai D, Harlow E, Morgan DO, Weinberg RA. Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. The Embo Journal. 13: 118-27. PMID 8306955 DOI: 10.1002/J.1460-2075.1994.Tb06241.X  0.198
1999 Brugarolas J, Moberg K, Boyd SD, Taya Y, Jacks T, Lees JA. Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation. Proceedings of the National Academy of Sciences of the United States of America. 96: 1002-7. PMID 9927683 DOI: 10.1073/Pnas.96.3.1002  0.198
1995 Zhu L, Enders G, Lees JA, Beijersbergen RL, Bernards R, Harlow E. The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. The Embo Journal. 14: 1904-13. PMID 7743997 DOI: 10.1002/J.1460-2075.1995.Tb07182.X  0.195
1997 Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L. Specific regulation of E2F family members by cyclin-dependent kinases. Molecular and Cellular Biology. 17: 3867-75. PMID 9199321 DOI: 10.1128/Mcb.17.7.3867  0.193
1994 Dynlacht BD, Flores O, Lees JA, Harlow E. Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes & Development. 8: 1772-86. PMID 7958856 DOI: 10.1101/Gad.8.15.1772  0.19
2013 Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA. The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes & Development. 27: 1003-15. PMID 23618872 DOI: 10.1101/Gad.211326.112  0.19
2009 Berman SD, West JC, Danielian PS, Caron AM, Stone JR, Lees JA. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proceedings of the National Academy of Sciences of the United States of America. 106: 14932-6. PMID 19706423 DOI: 10.1073/Pnas.0902408106  0.187
2008 MacInnes AW, Amsterdam A, Whittaker CA, Hopkins N, Lees JA. Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations. Proceedings of the National Academy of Sciences of the United States of America. 105: 10408-13. PMID 18641120 DOI: 10.1073/Pnas.0805036105  0.187
1998 Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proceedings of the National Academy of Sciences of the United States of America. 95: 2850-5. PMID 9501179 DOI: 10.1073/Pnas.95.6.2850  0.186
2009 Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, Haigis K, Gulino A, Lees JA. Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell. 15: 184-94. PMID 19249677 DOI: 10.1016/J.Ccr.2009.01.026  0.178
2013 Landman AS, Danielian PS, Lees JA. Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation. Oncogene. 32: 4798-805. PMID 23146901 DOI: 10.1038/Onc.2012.496  0.169
2023 Lees JA, Dias JM, Rajamohan F, Fortin JP, O'Connor R, Kong JX, Hughes EAG, Fisher EL, Tuttle JB, Lovett G, Kormos BL, Unwalla RJ, Zhang L, Dechert Schmitt AM, Zhou D, et al. An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Nature Communications. 14: 5938. PMID 37741852 DOI: 10.1038/s41467-023-41646-3  0.168
2002 Fajas L, Landsberg RL, Huss-Garcia Y, Sardet C, Lees JA, Auwerx J. E2Fs regulate adipocyte differentiation. Developmental Cell. 3: 39-49. PMID 12110166 DOI: 10.1016/S1534-5807(02)00190-9  0.167
1999 Gil EB, Malone Link E, Liu LX, Johnson CD, Lees JA. Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene. Proceedings of the National Academy of Sciences of the United States of America. 96: 2925-30. PMID 10077613 DOI: 10.1073/Pnas.96.6.2925  0.167
2004 Aslanian A, Iaquinta PJ, Verona R, Lees JA. Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes & Development. 18: 1413-22. PMID 15175242 DOI: 10.1101/Gad.1196704  0.163
2010 Sansam CL, Cruz NM, Danielian PS, Amsterdam A, Lau ML, Hopkins N, Lees JA. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes & Development. 24: 183-94. PMID 20080954 DOI: 10.1101/Gad.1860310  0.162
2016 Guen VJ, Gamble C, Perez DE, Bourassa S, Zappel H, Gärtner J, Lees JA, Colas P. STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis Cell Cycle. 15: 678-688. DOI: 10.1080/15384101.2016.1147632  0.16
2010 Zhang J, Lee EY, Liu Y, Berman SD, Lodish HF, Lees JA. pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis. Cell Cycle (Georgetown, Tex.). 9: 371-6. PMID 20023434 DOI: 10.4161/Cc.9.2.10467  0.16
2008 Courel M, Friesenhahn L, Lees JA. E2f6 and Bmi1 cooperate in axial skeletal development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 1232-42. PMID 18366140 DOI: 10.1002/Dvdy.21516  0.158
1999 Weng LP, Smith WM, Dahia PL, Ziebold U, Gil E, Lees JA, Eng C. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. Cancer Research. 59: 5808-14. PMID 10582703  0.157
2010 Calo E, Quintero-Estades JA, Danielian PS, Nedelcu S, Berman SD, Lees JA. Rb regulates fate choice and lineage commitment in vivo. Nature. 466: 1110-4. PMID 20686481 DOI: 10.1038/Nature09264  0.154
2005 Iaquinta PJ, Aslanian A, Lees JA. Regulation of the Arf/p53 tumor surveillance network by E2F. Cold Spring Harbor Symposia On Quantitative Biology. 70: 309-16. PMID 16869767 DOI: 10.1101/Sqb.2005.70.050  0.153
2015 Nicolay BN, Danielian PS, Kottakis F, Lapek JD, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, et al. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. Genes & Development. 29: 1875-89. PMID 26314710 DOI: 10.1101/Gad.264127.115  0.151
2007 Iaquinta PJ, Lees JA. Life and death decisions by the E2F transcription factors. Current Opinion in Cell Biology. 19: 649-57. PMID 18032011 DOI: 10.1016/J.Ceb.2007.10.006  0.147
2000 Humbert PO, Rogers C, Ganiatsas S, Landsberg RL, Trimarchi JM, Dandapani S, Brugnara C, Erdman S, Schrenzel M, Bronson RT, Lees JA. E2F4 is essential for normal erythrocyte maturation and neonatal viability. Molecular Cell. 6: 281-91. PMID 10983976 DOI: 10.1016/S1097-2765(00)00029-0  0.146
2002 Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA, Dynlacht BD. E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell. 2: 463-72. PMID 12498715 DOI: 10.1016/S1535-6108(02)00207-6  0.146
2008 Danielian PS, Friesenhahn LB, Faust AM, West JC, Caron AM, Bronson RT, Lees JA. E2f3a and E2f3b make overlapping but different contributions to total E2f3 activity. Oncogene. 27: 6561-70. PMID 18663357 DOI: 10.1038/onc.2008.253  0.143
2007 Conboy CM, Spyrou C, Thorne NP, Wade EJ, Barbosa-Morais NL, Wilson MD, Bhattacharjee A, Young RA, Tavaré S, Lees JA, Odom DT. Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor. Plos One. 2: e1061. PMID 17957245 DOI: 10.1371/Journal.Pone.0001061  0.142
1994 Zhu L, Enders GH, Wu CL, Starz MA, Moberg KH, Lees JA, Dyson N, Harlow E. Growth suppression by members of the retinoblastoma protein family. Cold Spring Harbor Symposia On Quantitative Biology. 59: 75-84. PMID 7587134 DOI: 10.1101/Sqb.1994.059.01.011  0.142
1999 Perren A, Weng LP, Boag AH, Ziebold U, Thakore K, Dahia PL, Komminoth P, Lees JA, Mulligan LM, Mutter GL, Eng C. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. The American Journal of Pathology. 155: 1253-60. PMID 10514407 DOI: 10.1016/S0002-9440(10)65227-3  0.14
2001 Ziebold U, Reza T, Caron A, Lees JA. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes & Development. 15: 386-91. PMID 11230146 DOI: 10.1101/Gad.858801  0.138
2010 Miller ES, Berman SD, Yuan TL, Lees JA. Disruption of calvarial ossification in E2f4 mutant embryos correlates with increased proliferation and progenitor cell populations. Cell Cycle (Georgetown, Tex.). 9: 2620-8. PMID 20581455 DOI: 10.4161/Cc.9.13.12108  0.137
1989 Lees JA, Fawell SE, Parker MG. Identification of constitutive and steroid-dependent transactivation domains in the mouse oestrogen receptor. Journal of Steroid Biochemistry. 34: 33-9. PMID 2626027 DOI: 10.1016/0022-4731(89)90063-0  0.134
1990 Fawell SE, Lees JA, White R, Parker MG. Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor. Cell. 60: 953-62. PMID 2317866 DOI: 10.1016/0092-8674(90)90343-D  0.133
1992 Danielian PS, White R, Lees JA, Parker MG. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. The Embo Journal. 11: 1025-33. PMID 1372244  0.133
2006 Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes & Development. 20: 3117-29. PMID 17085480 DOI: 10.1101/Gad.1482106  0.132
1989 Lees JA, Fawell SE, Parker MG. Identification of two transactivation domains in the mouse oestrogen receptor. Nucleic Acids Research. 17: 5477-88. PMID 2762146 DOI: 10.1093/Nar/17.14.5477  0.132
2002 Trimarchi JM, Lees JA. Sibling rivalry in the E2F family. Nature Reviews. Molecular Cell Biology. 3: 11-20. PMID 11823794 DOI: 10.1038/Nrm714  0.131
2016 Danielian PS, Hess RA, Lees JA. E2f4 and E2f5 are essential for the development of the male reproductive system Cell Cycle. 15: 250-260. DOI: 10.1080/15384101.2015.1121350  0.126
1990 Lees JA, Oldham JD, Haresign W, Garnsworthy PC. The effect of patterns of rumen fermentation on the response by dairy cows to dietary protein concentration. The British Journal of Nutrition. 63: 177-86. PMID 2185824 DOI: 10.1079/BJN19900105  0.124
2008 Berman SD, Yuan TL, Miller ES, Lee EY, Caron A, Lees JA. The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development. Molecular Cancer Research : McR. 6: 1440-51. PMID 18819932 DOI: 10.1158/1541-7786.Mcr-08-0176  0.123
2009 Lee EY, Yuan TL, Danielian PS, West JC, Lees JA. E2F4 cooperates with pRB in the development of extra-embryonic tissues. Developmental Biology. 332: 104-15. PMID 19433082 DOI: 10.1016/J.Ydbio.2009.05.541  0.122
1989 Fawell SE, Lees JA, Parker MG. A proposed consensus steroid-binding sequence--a reply. Molecular Endocrinology (Baltimore, Md.). 3: 1002-5. PMID 2739652 DOI: 10.1210/Mend-3-6-1002  0.118
1990 Lees JA, Fawell SE, White R, Parker MG. A 22-amino-acid peptide restores DNA-binding activity to dimerization-defective mutants of the estrogen receptor. Molecular and Cellular Biology. 10: 5529-31. PMID 2398899 DOI: 10.1128/Mcb.10.10.5529  0.117
2001 Chapman AS, Foster ID, Lees JA, Hodgkinson RA, Jackson RH. Particulate phosphorus transport by sub-surface drainage from agricultural land in the UK. Environmental significance at the catchment and national scale. The Science of the Total Environment. 266: 95-102. PMID 11258839 DOI: 10.1016/S0048-9697(00)00734-8  0.117
2009 Lai K, Amsterdam A, Farrington S, Bronson RT, Hopkins N, Lees JA. Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 76-85. PMID 19097187 DOI: 10.1002/Dvdy.21815  0.116
2000 Perren A, Komminoth P, Saremaslani P, Matter C, Feurer S, Lees JA, Heitz PU, Eng C. Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells. The American Journal of Pathology. 157: 1097-103. PMID 11021813 DOI: 10.1016/S0002-9440(10)64624-X  0.115
2000 Humbert PO, Verona R, Trimarchi JM, Rogers C, Dandapani S, Lees JA. E2f3 is critical for normal cellular proliferation. Genes & Development. 14: 690-703. PMID 10733529  0.114
2015 Percival SM, Thomas HR, Amsterdam A, Carroll AJ, Lees JA, Yost HJ, Parant JM. Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome. Disease Models & Mechanisms. 8: 941-55. PMID 26044958 DOI: 10.1242/Dmm.019059  0.111
2007 Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell. 11: 175-89. PMID 17292828 DOI: 10.1016/J.Ccr.2006.11.024  0.111
2002 Cloud JE, Rogers C, Reza TL, Ziebold U, Stone JR, Picard MH, Caron AM, Bronson RT, Lees JA. Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo. Molecular and Cellular Biology. 22: 2663-72. PMID 11909960 DOI: 10.1128/Mcb.22.8.2663-2672.2002  0.11
2003 Baudino TA, Maclean KH, Brennan J, Parganas E, Yang C, Aslanian A, Lees JA, Sherr CJ, Roussel MF, Cleveland JL. Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. Molecular Cell. 11: 905-14. PMID 12718877 DOI: 10.1016/S1097-2765(03)00102-3  0.11
2008 Berman SD, Calo E, Landman AS, Danielian PS, Miller ES, West JC, Fonhoue BD, Caron A, Bronson R, Bouxsein ML, Mukherjee S, Lees JA. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proceedings of the National Academy of Sciences of the United States of America. 105: 11851-6. PMID 18697945 DOI: 10.1073/Pnas.0805462105  0.109
2000 Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Baak JP, Lees JA, Weng LP, Eng C. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. Journal of the National Cancer Institute. 92: 924-30. PMID 10841828 DOI: 10.1093/Jnci/92.11.924  0.104
1999 Charlesworth SM, Lees JA. Particulate-associated heavy metals in the urban environment: their transport from source to deposit, Coventry, UK. Chemosphere. 39: 833-48. PMID 10448560 DOI: 10.1016/S0045-6535(99)00017-X  0.104
2008 King JC, Moskowitz IP, Burgon PG, Ahmad F, Stone JR, Seidman JG, Lees JA. E2F3 plays an essential role in cardiac development and function. Cell Cycle (Georgetown, Tex.). 7: 3775-80. PMID 19029823 DOI: 10.4161/Cc.7.23.7240  0.103
2015 McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD. Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide. Cancer Research. PMID 26025730 DOI: 10.1158/0008-5472.Can-14-3616  0.103
2009 Amsterdam A, Lai K, Komisarczuk AZ, Becker TS, Bronson RT, Hopkins N, Lees JA. Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma. Molecular Cancer Research : McR. 7: 841-50. PMID 19531571 DOI: 10.1158/1541-7786.Mcr-08-0555  0.103
2009 Parisi T, Bronson RT, Lees JA. Inhibition of pituitary tumors in Rb mutant chimeras through E2f4 loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis. Oncogene. 28: 500-8. PMID 18997819 DOI: 10.1038/Onc.2008.406  0.1
2000 Gimm O, Perren A, Weng LP, Marsh DJ, Yeh JJ, Ziebold U, Gil E, Hinze R, Delbridge L, Lees JA, Mutter GL, Robinson BG, Komminoth P, Dralle H, Eng C. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. The American Journal of Pathology. 156: 1693-700. PMID 10793080 DOI: 10.1016/S0002-9440(10)65040-7  0.099
2000 Gimm O, Attié-Bitach T, Lees JA, Vekemans M, Eng C. Expression of the PTEN tumour suppressor protein during human development. Human Molecular Genetics. 9: 1633-9. PMID 10861290 DOI: 10.1093/Hmg/9.11.1633  0.097
2007 Danielian PS, Bender Kim CF, Caron AM, Vasile E, Bronson RT, Lees JA. E2f4 is required for normal development of the airway epithelium. Developmental Biology. 305: 564-76. PMID 17383628 DOI: 10.1016/J.Ydbio.2007.02.037  0.096
2007 Parisi T, Yuan TL, Faust AM, Caron AM, Bronson R, Lees JA. Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues. Molecular and Cellular Biology. 27: 2283-93. PMID 17210634 DOI: 10.1128/Mcb.01854-06  0.092
2012 Ravi A, Gurtan AM, Kumar MS, Bhutkar A, Chin C, Lu V, Lees JA, Jacks T, Sharp PA. Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. Cancer Cell. 21: 848-55. PMID 22698408 DOI: 10.1016/J.Ccr.2012.04.037  0.09
2012 Jimènez Berrocoso A, Huber BT, MacLeod KG, Petrizzo MR, Lees JA, Wendler I, Coxall H, Mweneinda AK, Falzoni F, Birch H, Singano JM, Haynes S, Cotton L, Wendler J, Bown PR, et al. Lithostratigraphy, biostratigraphy and chemostratigraphy of Upper Cretaceous and Paleogene sediments from southern Tanzania: Tanzania Drilling Project Sites 27-35 Journal of African Earth Sciences. 70: 36-57. DOI: 10.1016/J.Jafrearsci.2012.05.006  0.09
2021 Vogel AB, Kanevsky I, Che Y, Swanson KA, Muik A, Vormehr M, Kranz LM, Walzer KC, Hein S, Güler A, Loschko J, Maddur MS, Ota-Setlik A, Tompkins K, Cole J, ... ... Lees JA, et al. Immunogenic BNT162b vaccines protect rhesus macaques from SARS-CoV-2. Nature. PMID 33524990 DOI: 10.1038/s41586-021-03275-y  0.089
2010 Jiménez Berrocoso A, MacLeod KG, Huber BT, Lees JA, Wendler I, Bown PR, Mweneinda AK, Isaza Londoño C, Singano JM. Lithostratigraphy, biostratigraphy and chemostratigraphy of Upper Cretaceous sediments from southern Tanzania: Tanzania drilling project sites 21-26 Journal of African Earth Sciences. 57: 47-69. DOI: 10.1016/j.jafrearsci.2009.07.010  0.088
2014 Maynard MA, Ferretti R, Hilgendorf KI, Perret C, Whyte P, Lees JA. Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer. Oncogene. 33: 3742-7. PMID 23955081 DOI: 10.1038/Onc.2013.333  0.087
2004 Amsterdam A, Sadler KC, Lai K, Farrington S, Bronson RT, Lees JA, Hopkins N. Many ribosomal protein genes are cancer genes in zebrafish. Plos Biology. 2: E139. PMID 15138505 DOI: 10.1371/Journal.Pbio.0020139  0.085
2012 Schlüter N, Kutscher M, Smith AB, Jagt JWM, Lees JA. Late Cretaceous phymosomatids and the true identity of Cidarites granulosus Goldfuss, 1829 (Echinoidea, Phymosomatoida) Zootaxa. 17-30.  0.083
2010 Zhang G, Hoersch S, Amsterdam A, Whittaker CA, Lees JA, Hopkins N. Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proceedings of the National Academy of Sciences of the United States of America. 107: 16940-5. PMID 20837522 DOI: 10.1073/Pnas.1011548107  0.083
1987 White R, Lees JA, Needham M, Ham J, Parker M. Structural organization and expression of the mouse estrogen receptor. Molecular Endocrinology (Baltimore, Md.). 1: 735-44. PMID 2484714 DOI: 10.1210/Mend-1-10-735  0.078
2013 Zhang G, Hoersch S, Amsterdam A, Whittaker CA, Beert E, Catchen JM, Farrington S, Postlethwait JH, Legius E, Hopkins N, Lees JA. Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery. Plos Genetics. 9: e1003734. PMID 24009526 DOI: 10.1371/Journal.Pgen.1003734  0.078
1999 Lees JA, Weinberg RA. Tossing monkey wrenches into the clock: new ways of treating cancer. Proceedings of the National Academy of Sciences of the United States of America. 96: 4221-3. PMID 10200241 DOI: 10.1073/Pnas.96.8.4221  0.075
2003 Ziebold U, Lee EY, Bronson RT, Lees JA. E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. Molecular and Cellular Biology. 23: 6542-52. PMID 12944480 DOI: 10.1128/Mcb.23.18.6542-6552.2003  0.073
2001 Winter LT, Foster ID, Charlesworth SM, Lees JA. Floodplain lakes as sinks for sediment-associated contaminants--a new source of proxy hydrological data? The Science of the Total Environment. 266: 187-94. PMID 11258816 DOI: 10.1016/S0048-9697(00)00745-2  0.072
2015 Jiménez Berrocoso Á, Huber BT, MacLeod KG, Petrizzo MR, Lees JA, Wendler I, Coxall H, Mweneinda AK, Falzoni F, Birch H, Haynes SJ, Bown PR, Robinson SA, Singano JM. The Lindi Formation (upper Albian-Coniacian) and Tanzania Drilling Project Sites 36-40 (Lower Cretaceous to Paleogene): Lithostratigraphy, biostratigraphy and chemostratigraphy Journal of African Earth Sciences. 101: 282-308. DOI: 10.1016/j.jafrearsci.2014.09.017  0.067
2015 Nicolay BN, Danielian PS, Kottakis F, Lapek JD, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, et al. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation Genes and Development. 29: 1875-1889. DOI: 10.1101/gad.264127.115  0.06
2015 Parisi T, Bronson RT, Lees JA. Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer. Oncogene. PMID 25745996 DOI: 10.1038/Onc.2015.30  0.056
2014 Linnert C, Robinson SA, Lees JA, Bown PR, Pérez-Rodríguez I, Petrizzo MR, Falzoni F, Littler K, Arz JA, Russell EE. Evidence for global cooling in the Late Cretaceous. Nature Communications. 5: 4194. PMID 24937202 DOI: 10.1038/Ncomms5194  0.054
2008 Dovey JS, Zacharek SJ, Kim CF, Lees JA. Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proceedings of the National Academy of Sciences of the United States of America. 105: 11857-62. PMID 18697930 DOI: 10.1073/Pnas.0803574105  0.046
2010 Walaszczyk I, Wood CJ, Lees JA, Peryt D, Voigt S, Wiese F. The salzgitter-salder quarry (lower saxony, germany) and słupia nadbrzeżna river cliff section (central poland): A proposed candidate composite global boundary stratotype section and point for the coniacian stage (upper cretaceous) Acta Geologica Polonica. 60: 445-447.  0.045
2023 Che Y, Gribenko AV, Song X, Handke LD, Efferen KS, Tompkins K, Kodali S, Nunez L, Prasad AK, Phelan LM, Ammirati M, Yu X, Lees JA, Chen W, Martinez L, et al. Rational Design of a Highly Immunogenic Prefusion-Stabilized F Glycoprotein Antigen for a Respiratory Syncytial Virus Vaccine. Science Translational Medicine. eade6422. PMID 37023209 DOI: 10.1126/scitranslmed.ade6422  0.034
2006 Carter JA, Lees JA, Gona JK, Murira G, Rimba K, Neville BG, Newton CR. Severe falciparum malaria and acquired childhood language disorder. Developmental Medicine and Child Neurology. 48: 51-7. PMID 16359594 DOI: 10.1017/S0012162206000107  0.031
1986 Fischer KF, Lees JA, Newman JH. Hypoglycemia in hospitalized patients. Causes and outcomes. The New England Journal of Medicine. 315: 1245-50. PMID 3534567 DOI: 10.1056/NEJM198611133152002  0.029
2012 Walaszczyk I, Lees JA, Peryt D, Cobban WA, Wood CJ. Testing the congruence of the macrofossil versus microfossil record in the Turonian-Coniacian boundary succession of the Wagon Mound-Springer composite section (NE New Mexico, USA) Acta Geologica Polonica. 62: 581-594.  0.028
1985 Lees JA, Falk RM, Stone WJ, McDougal WS. Pyocystis, pyonephrosis and perinephric abscess in end stage renal disease. The Journal of Urology. 134: 716-9. PMID 4032579 DOI: 10.1016/S0022-5347(17)47404-0  0.026
2016 Ferretti R, Bhutkar A, McNamara MC, Lees JA. BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance Genes and Development. 30: 18-33. DOI: 10.1101/gad.267757.115  0.025
2015 Cain AK, Lees JA. Using genomics to combat infectious diseases on a global scale. Genome Biology. 16: 250. PMID 26581564 DOI: 10.1186/s13059-015-0822-y  0.021
2005 Carter JA, Lees JA, Murira GM, Gona J, Neville BG, Newton CR. Issues in the development of cross-cultural assessments of speech and language for children. International Journal of Language & Communication Disorders / Royal College of Speech & Language Therapists. 40: 385-401. PMID 16195197 DOI: 10.1080/13682820500057301  0.016
2014 Denne RA, Hinote RE, Breyer JA, Kosanke TH, Lees JA, Engelhardt-Moore N, Spaw JM, Tur N. The Cenomanian-Turonian Eagle Ford Group of South Texas: Insights on timing and paleoceanographic conditions from geochemistry and micropaleontologic analyses Palaeogeography, Palaeoclimatology, Palaeoecology. 413: 2-28. DOI: 10.1016/j.palaeo.2014.05.029  0.016
1998 Ellis RJ, Cosby RL, Lees JA. Pulmonary embolus masquerading as pneumonia in a patient with Hodgkin's disease and nephrotic syndrome. Southern Medical Journal. 91: 283-6. PMID 9521373 DOI: 10.1097/00007611-199803000-00016  0.015
2005 Carter JA, Ross AJ, Neville BG, Obiero E, Katana K, Mung'ala-Odera V, Lees JA, Newton CR. Developmental impairments following severe falciparum malaria in children. Tropical Medicine & International Health : Tm & Ih. 10: 3-10. PMID 15655008 DOI: 10.1111/j.1365-3156.2004.01345.x  0.015
2012 Pérez-Rodríguez I, Lees JA, Larrasoaña JC, Arz JA, Arenillas I. Planktonic foraminiferal and calcareous nannofossil biostratigraphy and magnetostratigraphy of the uppermost Campanian and Maastrichtian at Zumaia, northern Spain Cretaceous Research. 37: 100-126. DOI: 10.1016/j.cretres.2012.03.011  0.01
1997 Neville BG, Harkness WF, Cross JH, Cass HC, Burch VC, Lees JA, Taylor DC. Surgical treatment of severe autistic regression in childhood epilepsy. Pediatric Neurology. 16: 137-40. PMID 9090688  0.01
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