Michael Z. Wang, Ph.D. - Publications

2003 Duke University, Durham, NC 
protein folding and stability

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Zhu X, Farahat AA, Mattamana M, Joice A, Pandharkar T, Holt E, Banerjee M, Gragg JL, Hu L, Kumar A, Yang S, Wang MZ, Boykin DW, Werbovetz KA. Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents. Bioorganic & Medicinal Chemistry Letters. PMID 27048943 DOI: 10.1016/j.bmcl.2016.03.082  1
2015 Peng KW, Bacon J, Zheng M, Guo Y, Wang MZ. Ethnic variability in the expression of hepatic drug transporters: absolute quantification by an optimized targeted quantitative proteomic approach. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1045-55. PMID 25926430 DOI: 10.1124/dmd.115.063362  1
2015 Yang S, Peng KW, Wang MZ. A simple and sensitive assay for eflornithine quantification in rat brain using pre-column derivatization and UPLC-MS/MS detection. Biomedical Chromatography : Bmc. 29: 918-24. PMID 25365958 DOI: 10.1002/bmc.3374  1
2014 Van Horn KS, Zhu X, Pandharkar T, Yang S, Vesely B, Vanaerschot M, Dujardin JC, Rijal S, Kyle DE, Wang MZ, Werbovetz KA, Manetsch R. Antileishmanial activity of a series of N²,N⁴-disubstituted quinazoline-2,4-diamines. Journal of Medicinal Chemistry. 57: 5141-56. PMID 24874647 DOI: 10.1021/jm5000408  1
2014 Michaels S, Wang MZ. The revised human liver cytochrome P450 "Pie": absolute protein quantification of CYP4F and CYP3A enzymes using targeted quantitative proteomics. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1241-51. PMID 24816681 DOI: 10.1124/dmd.114.058040  1
2014 Yang S, Wenzler T, Miller PN, Wu H, Boykin DW, Brun R, Wang MZ. Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis. Antimicrobial Agents and Chemotherapy. 58: 4064-74. PMID 24798280 DOI: 10.1128/AAC.02605-14  1
2014 Ju W, Yang S, Ansede JH, Stephens CE, Bridges AS, Voyksner RD, Ismail MA, Boykin DW, Tidwell RR, Hall JE, Wang MZ. CYP1A1 and CYP1B1-mediated biotransformation of the antitrypanosomal methamidoxime prodrug DB844 forms novel metabolites through intramolecular rearrangement. Journal of Pharmaceutical Sciences. 103: 337-49. PMID 24186380 DOI: 10.1002/jps.23765  1
2013 Hu L, Patel A, Bondada L, Yang S, Wang MZ, Munde M, Wilson WD, Wenzler T, Brun R, Boykin DW. Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues. Bioorganic & Medicinal Chemistry. 21: 6732-41. PMID 24012380 DOI: 10.1016/j.bmc.2013.08.006  1
2013 Wenzler T, Yang S, Braissant O, Boykin DW, Brun R, Wang MZ. Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis. Antimicrobial Agents and Chemotherapy. 57: 5330-43. PMID 23959303 DOI: 10.1128/AAC.00398-13  1
2013 Thuita JK, Wolf KK, Murilla GA, Liu Q, Mutuku JN, Chen Y, Bridges AS, Mdachi RE, Ismail MA, Ching S, Boykin DW, Hall JE, Tidwell RR, Paine MF, Brun R, ... Wang MZ, et al. Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis. Plos Neglected Tropical Diseases. 7: e2230. PMID 23755309 DOI: 10.1371/journal.pntd.0002230  1
2013 Soeiro MN, Werbovetz K, Boykin DW, Wilson WD, Wang MZ, Hemphill A. Novel amidines and analogues as promising agents against intracellular parasites: a systematic review. Parasitology. 140: 929-51. PMID 23561006 DOI: 10.1017/S0031182013000292  1
2012 Thuita JK, Wang MZ, Kagira JM, Denton CL, Paine MF, Mdachi RE, Murilla GA, Ching S, Boykin DW, Tidwell RR, Hall JE, Brun R. Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis. Plos Neglected Tropical Diseases. 6: e1734. PMID 22848769 DOI: 10.1371/journal.pntd.0001734  1
2012 Zhu X, Liu Q, Yang S, Parman T, Green CE, Mirsalis JC, de Nazaré Correia Soeiro M, Mello de Souza E, da Silva CF, da Gama Jaen Batista D, Stephens CE, Banerjee M, Farahat AA, Munde M, Wilson WD, ... ... Wang MZ, et al. Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies. Antimicrobial Agents and Chemotherapy. 56: 3690-9. PMID 22508306 DOI: 10.1128/AAC.06404-11  1
2011 Brun R, Don R, Jacobs RT, Wang MZ, Barrett MP. Development of novel drugs for human African trypanosomiasis. Future Microbiology. 6: 677-91. PMID 21707314 DOI: 10.2217/fmb.11.44  1
2011 Yan GZ, Brouwer KL, Pollack GM, Wang MZ, Tidwell RR, Hall JE, Paine MF. Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models. The Journal of Pharmacology and Experimental Therapeutics. 337: 503-12. PMID 21320872 DOI: 10.1124/jpet.110.177220  1
2011 Reid CS, Patrick DA, He S, Fotie J, Premalatha K, Tidwell RR, Wang MZ, Liu Q, Gershkovich P, Wasan KM, Wenzler T, Brun R, Werbovetz KA. Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation. Bioorganic & Medicinal Chemistry. 19: 513-23. PMID 21112788 DOI: 10.1016/j.bmc.2010.11.003  1
2010 Feng J, Sun J, Wang MZ, Zhang Z, Kim ST, Zhu Y, Sun J, Xu J. Compilation of a comprehensive gene panel for systematic assessment of genes that govern an individual's drug responses. Pharmacogenomics. 11: 1403-25. PMID 21047203 DOI: 10.2217/pgs.10.99  1
2010 Paine MF, Wang MZ, Generaux CN, Boykin DW, Wilson WD, De Koning HP, Olson CA, Pohlig G, Burri C, Brun R, Murilla GA, Thuita JK, Barrett MP, Tidwell RR. Diamidines for human African trypanosomiasis. Current Opinion in Investigational Drugs (London, England : 2000). 11: 876-83. PMID 20721830  1
2010 Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, et al. Novel arylimidamides for treatment of visceral leishmaniasis. Antimicrobial Agents and Chemotherapy. 54: 2507-16. PMID 20368397 DOI: 10.1128/AAC.00250-10  1
2008 Wang MZ, Wu JQ, Dennison JB, Bridges AS, Hall SD, Kornbluth S, Tidwell RR, Smith PC, Voyksner RD, Paine MF, Hall JE. A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes. Proteomics. 8: 4186-96. PMID 18792928 DOI: 10.1002/pmic.200800144  1
2008 Guo JY, Yamada A, Kajino T, Wu JQ, Tang W, Freel CD, Feng J, Chau BN, Wang MZ, Margolis SS, Yoo HY, Wang XF, Dunphy WG, Irusta PM, Hardwick JM, et al. Aven-dependent activation of ATM following DNA damage. Current Biology : Cb. 18: 933-42. PMID 18571408 DOI: 10.1016/j.cub.2008.05.045  1
2007 Wu JQ, Hansen DV, Guo Y, Wang MZ, Tang W, Freel CD, Tung JJ, Jackson PK, Kornbluth S. Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A. Proceedings of the National Academy of Sciences of the United States of America. 104: 16564-9. PMID 17881560 DOI: 10.1073/pnas.0707537104  1
2007 Wang MZ, Wu JQ, Bridges AS, Zeldin DC, Kornbluth S, Tidwell RR, Hall JE, Paine MF. Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 2067-75. PMID 17709372 DOI: 10.1124/dmd.107.016428  1
2007 Wu Q, Guo Y, Yamada A, Perry JA, Wang MZ, Araki M, Freel CD, Tung JJ, Tang W, Margolis SS, Jackson PK, Yamano H, Asano M, Kornbluth S. A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. Current Biology : Cb. 17: 213-24. PMID 17276914 DOI: 10.1016/j.cub.2006.12.045  1
2006 Wang MZ, Saulter JY, Usuki E, Cheung YL, Hall M, Bridges AS, Loewen G, Parkinson OT, Stephens CE, Allen JL, Zeldin DC, Boykin DW, Tidwell RR, Parkinson A, Paine MF, et al. CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1985-94. PMID 16997912 DOI: 10.1124/dmd.106.010587  1
2004 Howard BA, Zheng Z, Campa MJ, Wang MZ, Sharma A, Haura E, Herndon JE, Fitzgerald MC, Bepler G, Patz EF. Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer. Lung Cancer (Amsterdam, Netherlands). 46: 313-23. PMID 15541816 DOI: 10.1016/j.lungcan.2004.05.013  1
2004 Wang MZ, Shetty JT, Howard BA, Campa MJ, Patz EF, Fitzgerald MC. Thermodynamic analysis of cyclosporin a binding to cyclophilin a in a lung tumor tissue lysate. Analytical Chemistry. 76: 4343-8. PMID 15283571 DOI: 10.1021/ac049536j  1
2003 Howard BA, Wang MZ, Campa MJ, Corro C, Fitzgerald MC, Patz EF. Identification and validation of a potential lung cancer serum biomarker detected by matrix-assisted laser desorption/ionization-time of flight spectra analysis. Proteomics. 3: 1720-4. PMID 12973732 DOI: 10.1002/pmic.200300514  1
2003 Wang MZ, Howard B, Campa MJ, Patz EF, Fitzgerald MC. Analysis of human serum proteins by liquid phase isoelectric focusing and matrix-assisted laser desorption/ionization-mass spectrometry. Proteomics. 3: 1661-6. PMID 12973721 DOI: 10.1002/pmic.200300513  1
2003 Campa MJ, Wang MZ, Howard B, Fitzgerald MC, Patz EF. Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer. Cancer Research. 63: 1652-6. PMID 12670919  1
2003 Powell KD, Wang MZ, Silinski P, Ma L, Wales TE, Dai SY, Warner AH, Yang X, Fitzgerald MC. The accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic stability of proteins Analytica Chimica Acta. 496: 225-232. DOI: 10.1016/S0003-2670(03)01002-X  1
2002 Powell KD, Ghaemmaghami S, Wang MZ, Ma L, Oas TG, Fitzgerald MC. A general mass spectrometry-based assay for the quantitation of protein-ligand binding interactions in solution. Journal of the American Chemical Society. 124: 10256-7. PMID 12197709 DOI: 10.1021/ja026574g  1
2002 Fitzgerald MC, Powell KD, Wang MZ, Ma L, Ghaemmaghami S, Oas TG. A general mass spectrometry-based method for the quantitation of protein-ligand binding interactions in solution Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 395-396.  1
2002 Wang MZ, Campa M, Howard BA, Patz EF, Fitzgerald MC. A fractionation protocol to reduce signal suppression effects in the MALDI analysis of blood proteins Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 587-588.  1
2001 Wang MZ, Fitzgerald MC. A solid sample preparation method that reduces signal suppression effects in the MALDI analysis of peptides. Analytical Chemistry. 73: 625-31. PMID 11217772 DOI: 10.1021/ac0009090  1
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