Year |
Citation |
Score |
2023 |
Viering BL, Balogh H, Cox CF, Kirpekar OK, Akers AL, Federico VA, Valenzano GZ, Stempel R, Pickett HL, Lundin PM, Blackledge MS, Miller HB. Loratadine Combats Methicillin-Resistant by Modulating Virulence, Antibiotic Resistance, and Biofilm Genes. Acs Infectious Diseases. 10: 232-250. PMID 38153409 DOI: 10.1021/acsinfecdis.3c00616 |
0.484 |
|
2023 |
Liu C, Zhang H, Peng X, Blackledge MS, Furlani RE, Li H, Su Z, Melander RJ, Melander C, Michalek S, Wu H. Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator. Mbio. e0013723. PMID 37074183 DOI: 10.1128/mbio.00137-23 |
0.732 |
|
2022 |
Lundin PM, Fiser BL, Blackledge MS, Pickett HL, Copeland AL. Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation. Pharmaceutics. 14. PMID 36015238 DOI: 10.3390/pharmaceutics14081613 |
0.387 |
|
2022 |
Viering B, Cunningham T, King A, Blackledge MS, Miller HB. Brominated Carbazole with Antibiotic Adjuvant Activity Displays Pleiotropic Effects in MRSA's Transcriptome. Acs Chemical Biology. 17: 1239-1248. PMID 35467845 DOI: 10.1021/acschembio.2c00168 |
0.467 |
|
2022 |
Berndsen R, Cunningham T, Kaelin L, Callender M, Boldog WD, Viering B, King A, Labban N, Pollock JA, Miller HB, Blackledge MS. Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA. Acs Medicinal Chemistry Letters. 13: 483-491. PMID 35295086 DOI: 10.1021/acsmedchemlett.1c00680 |
0.719 |
|
2021 |
King A, Blackledge MS. Evaluation of Small Molecule Kinase Inhibitors as Novel Antimicrobial and Antibiofilm Agents. Chemical Biology & Drug Design. PMID 34581492 DOI: 10.1111/cbdd.13962 |
0.453 |
|
2020 |
Miller H, Blackledge M. Beta‐lactam Antibiotic Potentiation in MRSA Using Small Molecule Adjuvants The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04408 |
0.451 |
|
2019 |
Cutrona N, Gillard KR, Ulrich RJ, Seemann M, Miller HB, Blackledge MS. From antihistamine to anti-infective: Loratadine inhibits regulatory PASTA kinases in Staphylococci to reduce biofilm formation and potentiate β-lactam antibiotics and vancomycin in resistant strains of S. aureus. Acs Infectious Diseases. PMID 31132246 DOI: 10.1021/Acsinfecdis.9B00096 |
0.72 |
|
2018 |
Robb AJ, Vinogradov S, Danell AS, Anderson E, Blackledge MS, Melander C, Hvastkovs EG. Electrochemical Detection of Small Molecule Induced Biofilm Dispersion. Electrochimica Acta. 268: 276-282. PMID 30504968 DOI: 10.1016/J.Electacta.2018.02.113 |
0.589 |
|
2018 |
Gillard K, Miller HB, Blackledge MS. Tricyclic Amine Antidepressants Suppress β-lactam Resistance in Methicillin-Resistant Staphylococcus aureus (MRSA) by Repressing mRNA Levels of Key Resistance Genes. Chemical Biology & Drug Design. PMID 29953721 DOI: 10.1111/Cbdd.13361 |
0.561 |
|
2018 |
Wilson TJ, Blackledge MS, Vigueira PA. Resensitization of methicillin-resistant Staphylococcus aureus by amoxapine, an FDA-approved antidepressant. Heliyon. 4: e00501. PMID 29349359 DOI: 10.1016/J.Heliyon.2017.E00501 |
0.525 |
|
2017 |
Jeon AB, Obregón-Henao A, Ackart DF, Podell BK, Belardinelli JM, Jackson M, Nguyen TV, Blackledge MS, Melander RJ, Melander C, Johnson BK, Abramovitch RB, Basaraba RJ. 2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability. Plos One. 12: e0180925. PMID 28749949 DOI: 10.1371/Journal.Pone.0180925 |
0.634 |
|
2017 |
Garcia SS, Blackledge MS, Michalek S, Su L, Ptacek T, Eipers P, Morrow C, Lefkowitz EJ, Melander C, Wu H. Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome. Journal of Dental Research. 22034517698096. PMID 28571487 DOI: 10.1177/0022034517698096 |
0.613 |
|
2017 |
Nguyen TV, Blackledge MS, Lindsey EA, Minrovic BM, Ackart DF, Jeon AB, Obregón-Henao A, Melander RJ, Basaraba RJ, Melander C. The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors. Angewandte Chemie (International Ed. in English). PMID 28247991 DOI: 10.1002/Anie.201612006 |
0.672 |
|
2015 |
Stowe SD, Thompson RJ, Peng L, Su Z, Blackledge MS, Draughn GL, Coe WH, Johannes E, Lapham VK, Mackenzie J, Melander C, Cavanagh J. Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii. Current Drug Delivery. 12: 223-30. PMID 25348099 DOI: 10.2174/1567201811666140924125740 |
0.664 |
|
2013 |
Blackledge MS, Worthington RJ, Melander C. Biologically inspired strategies for combating bacterial biofilms. Current Opinion in Pharmacology. 13: 699-706. PMID 23871261 DOI: 10.1016/J.Coph.2013.07.004 |
0.651 |
|
2013 |
Worthington RJ, Blackledge MS, Melander C. Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence. Future Medicinal Chemistry. 5: 1265-84. PMID 23859207 DOI: 10.4155/Fmc.13.58 |
0.694 |
|
2013 |
Blackledge MS, Melander C. Programmable DNA-binding small molecules. Bioorganic & Medicinal Chemistry. 21: 6101-14. PMID 23665141 DOI: 10.1016/J.Bmc.2013.04.023 |
0.518 |
|
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