Noel T. Southall, Ph.D. - Publications

Affiliations: 
2001 University of California, San Francisco, San Francisco, CA 
Area:
protein folding and stability

95 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Thorne N, Malik N, Shah S, Zhao J, Class B, Aguisanda F, Southall N, Xia M, McKew JC, Rao M, Zheng W. High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress. Stem Cells Translational Medicine. PMID 27034412 DOI: 10.5966/sctm.2015-0170  0.96
2016 Liao XH, Meena NP, Southall N, Liu L, Swaroop M, Zhang AL, Xiang JJ, Parent CA, Zheng W, Kimmel AR. A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration. Scientific Reports. 6: 22273. PMID 26956526 DOI: 10.1038/srep22273  0.96
2016 Hu X, Myhr C, Huang Z, Xiao J, Barnaeva E, Ho BA, Agoulnik IU, Ferrer M, Marugan JJ, Southall N, Agoulnik AI. Structural insights into the activation of human relaxin family peptide receptor 1 by small molecule agonists. Biochemistry. PMID 26866459 DOI: 10.1021/acs.biochem.5b01195  0.96
2015 Bernstock JD, Lee YJ, Peruzzotti-Jametti L, Southall N, Johnson KR, Maric D, Volpe G, Kouznetsova J, Zheng W, Pluchino S, Hallenbeck JM. A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26661196 DOI: 10.1177/0271678X15609939  0.96
2015 He S, Xiao J, Dulcey AE, Lin B, Rolt A, Hu Z, Hu X, Wang AQ, Xu X, Southall N, Ferrer M, Zheng W, Liang TJ, Marugan JJ. Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. Journal of Medicinal Chemistry. PMID 26599718 DOI: 10.1021/acs.jmedchem.5b00752  0.96
2015 Hu Z, Hu X, He S, Yim HJ, Xiao J, Swaroop M, Tanega C, Zhang YQ, Yi G, Kao CC, Marugan J, Ferrer M, Zheng W, Southall N, Liang TJ. Identification of Novel Anti-Hepatitis C Virus Agents by a Quantitative High Throughput Screen in a Cell-Based Infection Assay. Antiviral Research. PMID 26515788 DOI: 10.1016/j.antiviral.2015.10.018  0.96
2015 Huang Z, Myhr C, Bathgate RA, Ho BA, Bueno A, Hu X, Xiao J, Southall N, Barnaeva E, Agoulnik IU, Marugan JJ, Ferrer M, Agoulnik AI. Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290. Frontiers in Endocrinology. 6: 128. PMID 26347712 DOI: 10.3389/fendo.2015.00128  0.96
2015 He S, Jain P, Lin B, Ferrer M, Hu Z, Southall N, Hu X, Zheng W, Neuenswander B, Cho CH, Chen Y, Worlikar SA, Aubé J, Larock RC, Schoenen FJ, et al. High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors. Acs Combinatorial Science. PMID 26332742 DOI: 10.1021/acscombsci.5b00101  0.96
2015 Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, et al. Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays. Plos One. 10: e0130796. PMID 26177200 DOI: 10.1371/journal.pone.0130796  0.96
2015 Kumari D, Swaroop M, Southall N, Huang W, Zheng W, Usdin K. High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells. Stem Cells Translational Medicine. 4: 800-8. PMID 25999519 DOI: 10.5966/sctm.2014-0278  0.96
2015 He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang AQ, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer M, Zheng W, Chayama K, et al. Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection. Science Translational Medicine. 7: 282ra49. PMID 25855495 DOI: 10.1126/scitranslmed.3010286  0.96
2015 Yeung M, Hurren R, Nemr C, Wang X, Hershenfeld S, Gronda M, Liyanage S, Wu Y, Augustine J, Lee EA, Spagnuolo PA, Southall N, Chen C, Zheng W, Jeyaraju DV, et al. Mitochondrial DNA damage by bleomycin induces AML cell death. Apoptosis : An International Journal On Programmed Cell Death. 20: 811-20. PMID 25820141 DOI: 10.1007/s10495-015-1119-z  0.96
2015 Wang W, Gao Q, Yang M, Zhang X, Yu L, Lawas M, Li X, Bryant-Genevier M, Southall NT, Marugan J, Ferrer M, Xu H. Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation. Proceedings of the National Academy of Sciences of the United States of America. 112: E1373-81. PMID 25733853 DOI: 10.1073/pnas.1419669112  0.96
2015 Howe EA, de Souza A, Lahr DL, Chatwin S, Montgomery P, Alexander BR, Nguyen DT, Cruz Y, Stonich DA, Walzer G, Rose JT, Picard SC, Liu Z, Rose JN, Xiang X, ... ... Southall N, et al. BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types. Nucleic Acids Research. 43: D1163-70. PMID 25477388 DOI: 10.1093/nar/gku1244  0.96
2015 Blevins MA, Kouznetsova J, Krueger AB, King R, Griner LM, Hu X, Southall N, Marugan JJ, Zhang Q, Ferrer M, Zhao R. Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression. Journal of Biomolecular Screening. 20: 663-72. PMID 25477201 DOI: 10.1177/1087057114561400  0.96
2015 Class B, Thorne N, Aguisanda F, Southall N, McKew JC, Zheng W. High-throughput viability assay using an autonomously bioluminescent cell line with a bacterial Lux reporter. Journal of Laboratory Automation. 20: 164-74. PMID 25447977 DOI: 10.1177/2211068214560608  0.96
2014 Kulakova L, Galkin A, Chen CZ, Southall N, Marugan JJ, Zheng W, Herzberg O. Discovery of novel antigiardiasis drug candidates. Antimicrobial Agents and Chemotherapy. 58: 7303-11. PMID 25267663 DOI: 10.1128/AAC.03834-14  0.96
2014 Hu X, Legler PM, Southall N, Maloney DJ, Simeonov A, Jadhav A. Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening. Journal of Computer-Aided Molecular Design. 28: 765-78. PMID 24958623 DOI: 10.1007/s10822-014-9758-7  0.96
2014 Aflaki E, Stubblefield BK, Maniwang E, Lopez G, Moaven N, Goldin E, Marugan J, Patnaik S, Dutra A, Southall N, Zheng W, Tayebi N, Sidransky E. Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs. Science Translational Medicine. 6: 240ra73. PMID 24920659 DOI: 10.1126/scitranslmed.3008659  0.96
2014 Hoskins JW, Ofori LO, Chen CZ, Kumar A, Sobczak K, Nakamori M, Southall N, Patnaik S, Marugan JJ, Zheng W, Austin CP, Disney MD, Miller BL, Thornton CA. Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects. Nucleic Acids Research. 42: 6591-602. PMID 24799433 DOI: 10.1093/nar/gku275  0.96
2014 Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade JA, Xiao J, Hu X, Dulcey AE, Han Y, Duan L, Titus S, Bryant-Genevier M, ... ... Southall NT, et al. Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor. Molecular Pharmacology. 86: 96-105. PMID 24755247 DOI: 10.1124/mol.113.090563  0.96
2014 Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, ... Southall N, et al. Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. The Journal of Biological Chemistry. 289: 16349-61. PMID 24755226 DOI: 10.1074/jbc.M114.566729  0.96
2014 Bhattacharyya N, Hu X, Chen CZ, Mathews Griner LA, Zheng W, Inglese J, Austin CP, Marugan JJ, Southall N, Neumann S, Northup JK, Ferrer M, Collins MT. A high throughput screening assay system for the identification of small molecule inhibitors of gsp. Plos One. 9: e90766. PMID 24667240 DOI: 10.1371/journal.pone.0090766  0.96
2014 Xiao J, Free RB, Barnaeva E, Conroy JL, Doyle T, Miller B, Bryant-Genevier M, Taylor MK, Hu X, Dulcey AE, Southall N, Ferrer M, Titus S, Zheng W, Sibley DR, et al. Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists. Journal of Medicinal Chemistry. 57: 3450-63. PMID 24666157 DOI: 10.1021/jm500126s  0.96
2014 de Souza A, Bittker JA, Lahr DL, Brudz S, Chatwin S, Oprea TI, Waller A, Yang JJ, Southall N, Guha R, Schürer SC, Vempati UD, Southern MR, Dawson ES, Clemons PA, et al. An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines. Journal of Biomolecular Screening. 19: 614-627. PMID 24441647 DOI: 10.1177/1087057113517139  0.96
2014 Sun W, Tanaka TQ, Magle CT, Huang W, Southall N, Huang R, Dehdashti SJ, McKew JC, Williamson KC, Zheng W. Chemical signatures and new drug targets for gametocytocidal drug development. Scientific Reports. 4: 3743. PMID 24434750 DOI: 10.1038/srep03743  0.96
2014 Hu Z, Lan KH, He S, Swaroop M, Hu X, Southall N, Zheng W, Liang TJ. Novel cell-based hepatitis C virus infection assay for quantitative high-throughput screening of anti-hepatitis C virus compounds. Antimicrobial Agents and Chemotherapy. 58: 995-1004. PMID 24277038 DOI: 10.1128/AAC.02094-13  0.96
2014 Ketley A, Chen CZ, Li X, Arya S, Robinson TE, Granados-Riveron J, Udosen I, Morris GE, Holt I, Furling D, Chaouch S, Haworth B, Southall N, Shinn P, Zheng W, et al. High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Human Molecular Genetics. 23: 1551-62. PMID 24179176 DOI: 10.1093/hmg/ddt542  0.96
2013 Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, Thorsell A, Heilig M, Bell L, Zook M, Eskay B, Brimacombe KR, Austin CP. Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor. Journal of Medicinal Chemistry. 56: 9045-56. PMID 24171469 DOI: 10.1021/jm400904m  0.96
2013 Samie M, Wang X, Zhang X, Goschka A, Li X, Cheng X, Gregg E, Azar M, Zhuo Y, Garrity AG, Gao Q, Slaugenhaupt S, Pickel J, Zolov SN, Weisman LS, ... ... Southall N, et al. A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis. Developmental Cell. 26: 511-24. PMID 23993788 DOI: 10.1016/j.devcel.2013.08.003  0.96
2013 Sun W, Park YD, Sugui JA, Fothergill A, Southall N, Shinn P, McKew JC, Kwon-Chung KJ, Zheng W, Williamson PR. Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens Plos One. 8. PMID 23990907 DOI: 10.1371/journal.pone.0070506  0.96
2013 Rhyasen GW, Bolanos L, Fang J, Jerez A, Wunderlich M, Rigolino C, Mathews L, Ferrer M, Southall N, Guha R, Keller J, Thomas C, Beverly LJ, Cortelezzi A, Oliva EN, et al. Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. Cancer Cell. 24: 90-104. PMID 23845443 DOI: 10.1016/j.ccr.2013.05.006  0.96
2013 Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin CP, Schatz GC, Sobczak K, Thornton CA, et al. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. Nature Communications. 4: 2044. PMID 23806903 DOI: 10.1038/ncomms3044  0.96
2013 Xiao J, Huang Z, Chen CZ, Agoulnik IU, Southall N, Hu X, Jones RE, Ferrer M, Zheng W, Agoulnik AI, Marugan JJ. Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1. Nature Communications. 4: 1953. PMID 23764525 DOI: 10.1038/ncomms2953  0.96
2013 Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10132-42. PMID 23761908 DOI: 10.1523/JNEUROSCI.4742-12.2013  0.96
2013 Casson L, Howell L, Mathews LA, Ferrer M, Southall N, Guha R, Keller JM, Thomas C, Siskind LJ, Beverly LJ. Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. Plos One. 8: e54525. PMID 23342165 DOI: 10.1371/journal.pone.0054525  0.96
2013 Hu X, Vujanac M, Southall N, Erec Stebbins C. Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches Bioorganic and Medicinal Chemistry Letters. 23: 1056-1062. PMID 23294700 DOI: 10.1016/j.bmcl.2012.12.018  0.96
2013 Chen CZ, Southall N, Xiao J, Marugan JJ, Ferrer M, Hu X, Jones RE, Feng S, Agoulnik IU, Zheng W, Agoulnik AI. Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay. Journal of Biomolecular Screening. 18: 670-7. PMID 23212924 DOI: 10.1177/1087057112469406  0.96
2013 Ribbens J, Whiteley G, Furuya H, Southall N, Hu X, Marugan J, Ferrer M, Maegawa GHB. A high-throughput screening assay using Krabbe disease patient cells Analytical Biochemistry. 434: 15-25. PMID 23138179 DOI: 10.1016/j.ab.2012.10.034  0.96
2013 Krueger AB, Dehdashti SJ, Southall N, Marugan JJ, Ferrer M, Li X, Ford HL, Zheng W, Zhao R. Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity. Journal of Biomolecular Screening. 18: 85-96. PMID 22820394 DOI: 10.1177/1087057112453936  0.96
2013 Xu M, Liu K, Swaroop M, Porter FD, Sidhu R, Firnkes S, Ory DS, Marugan JJ, Xiao J, Southall N, Pavan WJ, Davidson C, Walkley SU, Remaley AT, Baxa U, et al. δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders (Journal of Biological Chemistry (2012) 287, (39349-39360)) Journal of Biological Chemistry. 288: 296. DOI: 10.1074/jbc.A112.357707  0.96
2013 Free RB, Conroy JL, Roof RA, Doyle T, Han Y, Donthamsetti P, Javitch JA, Southall N, Emmitte K, Lindsley C, Ferrer M, Sibley DR. High-Throughput Screening for Modulators of the D2 Dopamine Receptor Yields Unique and Selective Pharmacological Chemotypes Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 115. DOI: 10.1016/B978-0-12-800044-1.00101-X  0.96
2012 Xu M, Liu K, Swaroop M, Porter FD, Sidhu R, Firnkes S, Finkes S, Ory DS, Marugan JJ, Xiao J, Southall N, Pavan WJ, Davidson C, Walkley SU, Remaley AT, et al. δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. The Journal of Biological Chemistry. 287: 39349-60. PMID 23035117 DOI: 10.1074/jbc.M112.357707  0.96
2012 Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Southall N, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/nchembio.1060  0.96
2012 Cunningham L, Finckbeiner S, Hyde RK, Southall N, Marugan J, Yedavalli VR, Dehdashti SJ, Reinhold WC, Alemu L, Zhao L, Yeh JR, Sood R, Pommier Y, Austin CP, Jeang KT, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proceedings of the National Academy of Sciences of the United States of America. 109: 14592-7. PMID 22912405 DOI: 10.1073/pnas.1200037109  0.96
2012 Xiao J, Westbroek W, Motabar O, Lea WA, Hu X, Velayati A, Zheng W, Southall N, Gustafson AM, Goldin E, Sidransky E, Liu K, Simeonov A, Tamargo RJ, Ribes A, et al. Discovery of a novel noniminosugar acid α glucosidase chaperone series. Journal of Medicinal Chemistry. 55: 7546-59. PMID 22834902 DOI: 10.1021/jm3005543  0.96
2012 Xu M, Liu K, Southall N, Marugan JJ, Remaley AT, Zheng W. A high-throughput sphingomyelinase assay using natural substrate Analytical and Bioanalytical Chemistry. 404: 407-414. PMID 22710568 DOI: 10.1007/s00216-012-6174-5  0.96
2012 Patnaik S, Zheng W, Choi JH, Motabar O, Southall N, Westbroek W, Lea WA, Velayati A, Goldin E, Sidransky E, Leister W, Marugan JJ. Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase. Journal of Medicinal Chemistry. 55: 5734-48. PMID 22646221 DOI: 10.1021/jm300063b  0.96
2012 Marugan JJ, Huang W, Motabar O, Zheng W, Xiao J, Patnaik S, Southall N, Westbroek W, Lea WA, Simeonov A, Goldin E, Debernardi MA, Sidransky E. Non-iminosugar glucocerebrosidase small molecule chaperones. Medchemcomm. 3: 56-60. PMID 22606365 DOI: 10.1039/C1MD00200G  0.96
2012 Goldin E, Zheng W, Motabar O, Southall N, Choi JH, Marugan J, Austin CP, Sidransky E. High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase. Plos One. 7: e29861. PMID 22272254 DOI: 10.1371/journal.pone.0029861  0.96
2012 Chen CZ, Sobczak K, Hoskins J, Southall N, Marugan JJ, Zheng W, Thornton CA, Austin CP. Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1. Analytical and Bioanalytical Chemistry. 402: 1889-98. PMID 22218462 DOI: 10.1007/s00216-011-5604-0  0.96
2012 Motabar O, Goldin E, Leister W, Liu K, Southall N, Huang W, Marugan JJ, Sidransky E, Zheng W. A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide Analytical and Bioanalytical Chemistry. 402: 731-739. PMID 22033823 DOI: 10.1007/s00216-011-5496-z  0.96
2011 Englund EE, Neumann S, Eliseeva E, McCoy JG, Titus S, Zheng W, Southall N, Shin P, Leister W, Thomas CJ, Inglese J, Austin CP, Gershengorn MC, Huang W. The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists. Medchemcomm. 2: 1016-1020. PMID 22408719 DOI: 10.1039/C1MD00145K  0.96
2011 Geng H, Whiteley G, Ribbens J, Zheng W, Southall N, Hu X, Marugan JJ, Ferrer M, Maegawa GH. Novel patient cell-based HTS assay for identification of small molecules for a lysosomal storage disease. Plos One. 6: e29504. PMID 22216298 DOI: 10.1371/journal.pone.0029504  0.96
2011 Xiao J, Marugan JJ, Zheng W, Titus S, Southall N, Cherry JJ, Evans M, Androphy EJ, Austin CP. Discovery, synthesis, and biological evaluation of novel SMN protein modulators. Journal of Medicinal Chemistry. 54: 6215-33. PMID 21819082 DOI: 10.1021/jm200497t  0.96
2011 Huang R, Southall N, Wang Y, Yasgar A, Shinn P, Jadhav A, Nguyen DT, Austin CP. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Science Translational Medicine. 3: 80ps16. PMID 21525397 DOI: 10.1126/scitranslmed.3001862  0.96
2011 Xia M, Shahane SA, Huang R, Titus SA, Shum E, Zhao Y, Southall N, Zheng W, Witt KL, Tice RR, Austin CP. Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicology and Applied Pharmacology. 252: 250-8. PMID 21362439 DOI: 10.1016/j.taap.2011.02.016  0.96
2011 Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP. Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. Journal of Medicinal Chemistry. 54: 1033-58. PMID 21250698 DOI: 10.1021/jm1008902  0.96
2011 Chen CZ, Kulakova L, Southall N, Marugan JJ, Galkin A, Austin CP, Herzberg O, Zheng W. High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements. Antimicrobial Agents and Chemotherapy. 55: 667-75. PMID 21078930 DOI: 10.1128/AAC.00618-10  0.96
2010 McCoy JG, Marugan JJ, Liu K, Zheng W, Southall N, Huang W, Heilig M, Austin CP. Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor. Acs Chemical Neuroscience. 1: 559-574. PMID 21116448 DOI: 10.1021/cn100040h  0.96
2010 Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/j.bmcl.2010.04.015  0.96
2010 Liu K, Southall N, Titus SA, Inglese J, Eskay RL, Shinn P, Austin CP, Heilig MA, Zheng W. A multiplex calcium assay for identification of GPCR agonists and antagonists. Assay and Drug Development Technologies. 8: 367-79. PMID 20230302 DOI: 10.1089/adt.2009.0245  0.96
2010 Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Sidransky E, Aungst RA, Liu K, Sadhukhan SK, Austin CP. Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators. European Journal of Medicinal Chemistry. 45: 1880-97. PMID 20206419 DOI: 10.1016/j.ejmech.2010.01.027  0.96
2010 Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. 53: 1048-55. PMID 20017496 DOI: 10.1021/jm901577g  0.96
2009 Veith H, Southall N, Huang R, James T, Fayne D, Artemenko N, Shen M, Inglese J, Austin CP, Lloyd DG, Auld DS. Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries. Nature Biotechnology. 27: 1050-5. PMID 19855396 DOI: 10.1038/nbt.1581  0.96
2009 Parham F, Austin C, Southall N, Huang R, Tice R, Portier C. Dose-response modeling of high-throughput screening data. Journal of Biomolecular Screening. 14: 1216-27. PMID 19828774 DOI: 10.1177/1087057109349355  0.96
2009 Thomas CJ, Auld DS, Huang R, Huang W, Jadhav A, Johnson RL, Leister W, Maloney DJ, Marugan JJ, Michael S, Simeonov A, Southall N, Xia M, Zheng W, Inglese J, et al. The pilot phase of the NIH Chemical Genomics Center. Current Topics in Medicinal Chemistry. 9: 1181-93. PMID 19807664 DOI: 10.2174/156802609789753644  0.96
2009 Huang R, Southall N, Xia M, Cho MH, Jadhav A, Nguyen DT, Inglese J, Tice RR, Austin CP. Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 385-93. PMID 19805409 DOI: 10.1093/toxsci/kfp231  0.96
2009 Wang Z, Zheng M, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin CP, Zheng W, Xie Z, Sun Y. Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Research. 69: 6556-64. PMID 19679550 DOI: 10.1158/0008-5472.CAN-09-0891  0.96
2009 Johnson RL, Huang R, Jadhav A, Southall N, Wichterman J, MacArthur R, Xia M, Bi K, Printen J, Austin CP, Inglese J. A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries. Molecular Biosystems. 5: 1039-50. PMID 19668870 DOI: 10.1039/b902021g  0.96
2009 Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 12471-6. PMID 19592511 DOI: 10.1073/pnas.0904506106  0.96
2009 Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W. A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Analytical Biochemistry. 394: 30-8. PMID 19583963 DOI: 10.1016/j.ab.2009.07.003  0.96
2009 Zhu PJ, Hobson JP, Southall N, Qiu C, Thomas CJ, Lu J, Inglese J, Zheng W, Leppla SH, Bugge TH, Austin CP, Liu S. Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorganic & Medicinal Chemistry. 17: 5139-45. PMID 19540764 DOI: 10.1016/j.bmc.2009.05.054  0.96
2009 Shi ZD, Motabar O, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase. Analytical and Bioanalytical Chemistry. 394: 1903-9. PMID 19521690 DOI: 10.1007/s00216-009-2879-5  0.96
2009 MacArthur R, Leister W, Veith H, Shinn P, Southall N, Austin CP, Inglese J, Auld DS. Monitoring compound integrity with cytochrome P450 assays and qHTS. Journal of Biomolecular Screening. 14: 538-46. PMID 19483146 DOI: 10.1177/1087057109336954  0.96
2009 Motabar O, Shi ZD, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. A new resorufin-based alpha-glucosidase assay for high-throughput screening. Analytical Biochemistry. 390: 79-84. PMID 19371716 DOI: 10.1016/j.ab.2009.04.010  0.96
2009 Auld DS, Zhang YQ, Southall NT, Rai G, Landsman M, MacLure J, Langevin D, Thomas CJ, Austin CP, Inglese J. A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. Journal of Medicinal Chemistry. 52: 1450-8. PMID 19215089 DOI: 10.1021/jm8014525  0.96
2009 Yi F, Zhu P, Southall N, Inglese J, Austin CP, Zheng W, Regan L. An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction. Journal of Biomolecular Screening. 14: 273-81. PMID 19211782 DOI: 10.1177/1087057108330114  0.96
2009 Xia M, Huang R, Guo V, Southall N, Cho MH, Inglese J, Austin CP, Nirenberg M. Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory. Proceedings of the National Academy of Sciences of the United States of America. 106: 2412-7. PMID 19196967 DOI: 10.1073/pnas.0813020106  0.96
2008 Titus SA, Li X, Southall N, Lu J, Inglese J, Brasch M, Austin CP, Zheng W. A cell-based PDE4 assay in 1536-well plate format for high-throughput screening. Journal of Biomolecular Screening. 13: 609-18. PMID 18591513 DOI: 10.1177/1087057108319977  0.96
2008 Auld DS, Southall NT, Jadhav A, Johnson RL, Diller DJ, Simeonov A, Austin CP, Inglese J. Characterization of chemical libraries for luciferase inhibitory activity. Journal of Medicinal Chemistry. 51: 2372-86. PMID 18363348 DOI: 10.1021/jm701302v  0.96
2008 Simeonov A, Jadhav A, Thomas CJ, Wang Y, Huang R, Southall NT, Shinn P, Smith J, Austin CP, Auld DS, Inglese J. Fluorescence spectroscopic profiling of compound libraries. Journal of Medicinal Chemistry. 51: 2363-71. PMID 18363325 DOI: 10.1021/jm701301m  0.96
2008 Xia M, Huang R, Witt KL, Southall N, Fostel J, Cho MH, Jadhav A, Smith CS, Inglese J, Portier CJ, Tice RR, Austin CP. Compound cytotoxicity profiling using quantitative high-throughput screening. Environmental Health Perspectives. 116: 284-91. PMID 18335092 DOI: 10.1289/ehp.10727  0.96
2008 Huang R, Southall N, Cho MH, Xia M, Inglese J, Austin CP. Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chemical Research in Toxicology. 21: 659-67. PMID 18281954 DOI: 10.1021/tx700365e  0.96
2008 Skoumbourdis AP, Huang R, Southall N, Leister W, Guo V, Cho MH, Inglese J, Nirenberg M, Austin CP, Xia M, Thomas CJ. Identification of a potent new chemotype for the selective inhibition of PDE4. Bioorganic & Medicinal Chemistry Letters. 18: 1297-303. PMID 18243697 DOI: 10.1016/j.bmcl.2008.01.028  0.96
2008 Titus S, Neumann S, Zheng W, Southall N, Michael S, Klumpp C, Yasgar A, Shinn P, Thomas CJ, Inglese J, Gershengorn MC, Austin CP. Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. Journal of Biomolecular Screening. 13: 120-7. PMID 18216391 DOI: 10.1177/1087057107313786  0.96
2008 Xie Y, Deng S, Thomas CJ, Liu Y, Zhang YQ, Rinderspacher A, Huang W, Gong G, Wyler M, Cayanis E, Aulner N, Többen U, Chung C, Pampou S, Southall N, et al. Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorganic & Medicinal Chemistry Letters. 18: 329-35. PMID 18024113 DOI: 10.1016/j.bmcl.2007.10.100  0.96
2007 Davis RE, Zhang YQ, Southall N, Staudt LM, Austin CP, Inglese J, Auld DS. A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor. Assay and Drug Development Technologies. 5: 85-103. PMID 17355202 DOI: 10.1089/adt.2006.048  0.96
2006 Southall NT, Ajay. Kinase patent space visualization using chemical replacements. Journal of Medicinal Chemistry. 49: 2103-9. PMID 16539399 DOI: 10.1021/jm051201m  0.96
2002 Southall NT, Dill KA. Potential of mean force between two hydrophobic solutes in water. Biophysical Chemistry. 101: 295-307. PMID 12488009 DOI: 10.1016/S0301-4622(02)00167-9  0.96
2002 Hribar B, Southall NT, Vlachy V, Dill KA. How ions affect the structure of water. Journal of the American Chemical Society. 124: 12302-11. PMID 12371874 DOI: 10.1021/ja026014h  0.96
2002 Urbi T, Vlachy V, Kalyuzhnyi YV, Southall NT, Dill KA. A two-dimensional model of water: Solvation of nonpolar solutes Journal of Chemical Physics. 116: 723-729. DOI: 10.1063/1.1427307  0.96
2002 Southall NT, Dill KA, Haymet ADJ. A view of the hydrophobic effect Journal of Physical Chemistry B. 106: 521-533. DOI: 10.1021/jp015514e  0.96
2000 Urbič T, Vlachy V, Kalyuzhnyi YV, Southall NT, Dill KA. A two-dimensional model of water: Theory and computer simulations Journal of Chemical Physics. 112: 2843-2848. DOI: 10.1063/1.480928  0.96
2000 Southall NT, Dill KA. The mechanism of hydrophobic solvation depends on solute radius Journal of Physical Chemistry B. 104: 1326-1331.  0.96
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