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Timothy A. Wencewicz, Ph.D. - Publications

Affiliations: 
2011 University of Notre Dame, Notre Dame, IN, United States 
 2013- Chemistry Washington University, Saint Louis, St. Louis, MO 
Area:
chemical and enzymatic synthesis and study of biologically important, heteroatom-containing systems including amino acids, peptides, antibiotics, siderophores, and others
Website:
https://artsci.wustl.edu/faculty-staff/timothy-wencewicz
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yang J, Banas VS, Rivera GSM, Wencewicz TA. Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis. Acs Chemical Biology. PMID 37207292 DOI: 10.1021/acschembio.3c00167  0.611
2022 Yang J, Wencewicz TA. Reconstitution of Fimsbactin Biosynthesis from . Acs Chemical Biology. PMID 36122366 DOI: 10.1021/acschembio.2c00573  0.612
2022 Yang J, Banas VS, Patel KD, Rivera GSM, Mydy LS, Gulick AM, Wencewicz TA. An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD. The Journal of Biological Chemistry. 102166. PMID 35750210 DOI: 10.1016/j.jbc.2022.102166  0.631
2022 Yang J, Qi Y, Blodgett JAV, Wencewicz TA. Multifunctional P450 Monooxygenase CftA Diversifies the Clifednamide Pool through Tandem C-H Bond Activations. Journal of Natural Products. 85: 47-55. PMID 35086337 DOI: 10.1021/acs.jnatprod.1c00606  0.594
2021 Bohac TJ, Fang L, Banas VS, Giblin DE, Wencewicz TA. Synthetic Mimics of Native Siderophores Disrupt Iron Trafficking in . Acs Infectious Diseases. PMID 34110766 DOI: 10.1021/acsinfecdis.1c00119  0.327
2020 Endicott NP, Rivera GSM, Yang J, Wencewicz TA. Emergence of Ferrichelatase Activity in a Siderophore-Binding Protein Supports an Iron Shuttle in Bacteria. Acs Central Science. 6: 493-506. PMID 32341999 DOI: 10.1021/Acscentsci.9B01257  0.624
2019 Wencewicz TA. Crossroads of Antibiotic Resistance and Biosynthesis. Journal of Molecular Biology. PMID 31288031 DOI: 10.1016/J.Jmb.2019.06.033  0.33
2019 Markley JL, Fang L, Gasparrini AJ, Symister CT, Kumar H, Tolia NH, Dantas G, Wencewicz TA. Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes. Acs Infectious Diseases. PMID 30835428 DOI: 10.1021/Acsinfecdis.8B00349  0.338
2019 Bohac TJ, Fang L, Giblin DE, Wencewicz TA. Fimsbactin and Acinetobactin Compete for the Periplasmic Siderophore Binding Protein BauB in Pathogenic Acinetobacter baumannii. Acs Chemical Biology. PMID 30785725 DOI: 10.1021/Acschembio.8B01051  0.419
2019 Kreitler DF, Gemmell EM, Schaffer JE, Wencewicz TA, Gulick AM. The structural basis of N-acyl-alpha-amino-beta-lactone formation catalyzed by a nonribosomal peptide synthetase. Nature Communications. 10: 3432-3432. DOI: 10.2210/Pdb6N8E/Pdb  0.347
2018 Bailey DC, Bohac TJ, Shapiro JA, Giblin DE, Wencewicz TA, Gulick AM. Crystal Structure of the Siderophore Binding Protein BauB Bound to an Unusual 2:1 Complex Between Acinetobactin and Ferric Iron. Biochemistry. PMID 30406986 DOI: 10.1021/Acs.Biochem.8B00986  0.397
2018 Markley JL, Wencewicz TA. Tetracycline-Inactivating Enzymes. Frontiers in Microbiology. 9: 1058. PMID 29899733 DOI: 10.3389/Fmicb.2018.01058  0.36
2018 Rivera GSM, Beamish CR, Wencewicz TA. Immobilized FhuD2 Siderophore-Binding Protein Enables Purification of Salmycin Sideromycins from Streptomyces violaceus DSM 8286. Acs Infectious Diseases. PMID 29460625 DOI: 10.1021/Acsinfecdis.8B00015  0.414
2017 Patrick G, Fang L, Schaefer J, Singh S, Bowman G, Wencewicz TA. Mechanistic Basis for ATP-Dependent Inhibition of Glutamine Synthetase by Tabtoxinine-β-Lactam. Biochemistry. PMID 29039929 DOI: 10.1021/Acs.Biochem.7B00838  0.336
2017 Bohac TJ, Shapiro JA, Wencewicz TA. Rigid Oxazole Acinetobactin Analog Blocks Siderophore Cycling in Acinetobacter baumannii. Acs Infectious Diseases. PMID 28991447 DOI: 10.1021/Acsinfecdis.7B00146  0.361
2017 Endicott NP, Lee E, Wencewicz TA. Structural Basis for Xenosiderophore Utilization by the Human Pathogen Staphylococcus aureus. Acs Infectious Diseases. PMID 28505405 DOI: 10.1021/Acsinfecdis.7B00036  0.356
2017 Schaffer JE, Reck MR, Prasad NK, Wencewicz TA. β-Lactone formation during product release from a nonribosomal peptide synthetase. Nature Chemical Biology. PMID 28504677 DOI: 10.1038/Nchembio.2374  0.34
2017 Park J, Gasparrini AJ, Reck MR, Symister CT, Elliott JL, Vogel JP, Wencewicz TA, Dantas G, Tolia NH. Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes. Nature Chemical Biology. PMID 28481346 DOI: 10.1038/Nchembio.2376  0.382
2017 Shapiro JA, Wencewicz TA. Structure-function studies of acinetobactin analogs. Metallomics : Integrated Biometal Science. PMID 28440833 DOI: 10.1039/C7Mt00064B  0.361
2016 Wencewicz TA. New antibiotics from Nature's chemical inventory. Bioorganic & Medicinal Chemistry. PMID 27658795 DOI: 10.1016/J.Bmc.2016.09.014  0.354
2016 Shapiro JA, Wencewicz TA. Acinetobactin Isomerization Enables Adaptive Iron Acquisition in Acinetobacter baumannii through pH-Triggered Siderophore Swapping. Acs Infectious Diseases. 2: 157-68. PMID 27624967 DOI: 10.1021/Acsinfecdis.5B00145  0.329
2016 Hart KM, Reck M, Bowman GR, Wencewicz TA. Tabtoxinine-β-lactam is a "stealth" β-lactam antibiotic that evades β-lactamase-mediated antibiotic resistance Medchemcomm. 7: 118-127. DOI: 10.1039/C5Md00325C  0.328
2015 Forsberg KJ, Patel S, Wencewicz TA, Dantas G. The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes. Chemistry & Biology. PMID 26097034 DOI: 10.1016/J.Chembiol.2015.05.017  0.336
2014 Walsh CT, Wencewicz TA. Prospects for new antibiotics: a molecule-centered perspective. The Journal of Antibiotics. 67: 7-22. PMID 23756684 DOI: 10.1038/Ja.2013.49  0.492
2013 Wencewicz TA, Miller MJ. Biscatecholate-monohydroxamate mixed ligand siderophore-carbacephalosporin conjugates are selective sideromycin antibiotics that target Acinetobacter baumannii. Journal of Medicinal Chemistry. 56: 4044-52. PMID 23614627 DOI: 10.1021/Jm400265K  0.521
2013 Wencewicz TA, Long TE, Möllmann U, Miller MJ. Trihydroxamate siderophore-fluoroquinolone conjugates are selective sideromycin antibiotics that target Staphylococcus aureus. Bioconjugate Chemistry. 24: 473-86. PMID 23350642 DOI: 10.1021/Bc300610F  0.545
2013 Walsh CT, Wencewicz TA. Flavoenzymes: versatile catalysts in biosynthetic pathways. Natural Product Reports. 30: 175-200. PMID 23051833 DOI: 10.1039/C2Np20069D  0.452
2012 Wencewicz TA, Walsh CT. Pseudomonas syringae self-protection from tabtoxinine-β-lactam by ligase TblF and acetylase Ttr. Biochemistry. 51: 7712-25. PMID 22994681 DOI: 10.1021/Bi3011384  0.421
2012 Wencewicz TA, Oliver AG, Miller MJ. Iron(III)-templated macrolactonization of trihydroxamate siderophores. Organic Letters. 14: 4390-3. PMID 22906163 DOI: 10.1021/Ol301869X  0.498
2011 Wencewicz TA, Yang B, Rudloff JR, Oliver AG, Miller MJ. N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry. Journal of Medicinal Chemistry. 54: 6843-58. PMID 21859126 DOI: 10.1021/Jm200794R  0.633
2010 Yan S, Miller MJ, Wencewicz TA, Möollmann U. Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. Medchemcomm. 1: 145-148. PMID 27087912 DOI: 10.1039/C0Md00015A  0.489
2010 Mayfield JA, Frederick RE, Streit BR, Wencewicz TA, Ballou DP, DuBois JL. Comprehensive spectroscopic, steady state, and transient kinetic studies of a representative siderophore-associated flavin monooxygenase. The Journal of Biological Chemistry. 285: 30375-88. PMID 20650894 DOI: 10.1074/Jbc.M110.157578  0.373
2010 Yan S, Miller MJ, Wencewicz TA, Möllmann U. Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. Bioorganic & Medicinal Chemistry Letters. 20: 1302-5. PMID 20031407 DOI: 10.1016/J.Bmcl.2009.10.018  0.524
2010 Yan S, Miller MJ, Wencewicz TA, Möllmann U. Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates Medchemcomm. 1: 145-148. DOI: 10.1039/c0md00015a  0.396
2009 Wencewicz TA, Möllmann U, Long TE, Miller MJ. Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin "Trojan Horse" antibiotics and synthetic desferridanoxamine-antibiotic conjugates. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 22: 633-48. PMID 19221879 DOI: 10.1007/S10534-009-9218-3  0.48
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