Olafur T. Magnusson, Ph.D. - Publications

2001 University of Wisconsin, Madison, Madison, WI 
Mechanisms of enzyme and coenzyme action; stereochemistry and mechanisms of phospho- and nucleotidyl transferase action; structure and function of multienzyme complexes

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Day FR, Helgason H, Chasman DI, Rose LM, Loh PR, Scott RA, Helgason A, Kong A, Masson G, Magnusson OT, Gudbjartsson D, Thorsteinsdottir U, Buring JE, Ridker PM, Sulem P, et al. Physical and neurobehavioral determinants of reproductive onset and success. Nature Genetics. PMID 27089180 DOI: 10.1038/ng.3551  1
2016 Sveinbjornsson G, Gudbjartsson DF, Halldorsson BV, Kristinsson KG, Gottfredsson M, Barrett JC, Gudmundsson LJ, Blondal K, Gylfason A, Gudjonsson SA, Helgadottir HT, Jonasdottir A, Jonasdottir A, Karason A, Kardum LB, ... ... Magnusson OT, et al. HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nature Genetics. PMID 26829749 DOI: 10.1038/ng.3498  1
2016 Stacey SN, Kehr B, Gudmundsson J, Zink F, Jonasdottir A, Gudjonsson SA, Sigurdsson A, Halldorsson BV, Agnarsson BA, Benediktsdottir KR, Aben KK, Vermeulen SH, Cremers RG, Panadero A, Helfand BT, ... ... Magnusson OT, et al. Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer. Human Molecular Genetics. PMID 26740556 DOI: 10.1093/Hmg/Ddv622  1
2015 Helgason H, Rafnar T, Olafsdottir HS, Jonasson JG, Sigurdsson A, Stacey SN, Jonasdottir A, Tryggvadottir L, Alexiusdottir K, Haraldsson A, le Roux L, Gudmundsson J, Johannsdottir H, Oddsson A, Gylfason A, ... Magnusson OT, et al. Loss-of-function variants in ATM confer risk of gastric cancer. Nature Genetics. 47: 906-10. PMID 26098866 DOI: 10.1038/ng.3342  1
2015 Gudbjartsson DF, Sulem P, Helgason H, Gylfason A, Gudjonsson SA, Zink F, Oddson A, Magnusson G, Halldorsson BV, Hjartarson E, Sigurdsson GT, Kong A, Helgason A, Masson G, Magnusson OT, et al. Sequence variants from whole genome sequencing a large group of Icelanders. Scientific Data. 2: 150011. PMID 25977816 DOI: 10.1038/sdata.2015.11  1
2015 Stacey SN, Helgason H, Gudjonsson SA, Thorleifsson G, Zink F, Sigurdsson A, Kehr B, Gudmundsson J, Sulem P, Sigurgeirsson B, Benediktsdottir KR, Thorisdottir K, Ragnarsson R, Fuentelsaz V, Corredera C, ... ... Magnusson OT, et al. New basal cell carcinoma susceptibility loci. Nature Communications. 6: 6825. PMID 25855136 DOI: 10.1038/ncomms7825  1
2015 Gudbjartsson DF, Helgason H, Gudjonsson SA, Zink F, Oddson A, Gylfason A, Besenbacher S, Magnusson G, Halldorsson BV, Hjartarson E, Sigurdsson GT, Stacey SN, Frigge ML, Holm H, Saemundsdottir J, ... ... Magnusson OT, et al. Large-scale whole-genome sequencing of the Icelandic population. Nature Genetics. 47: 435-44. PMID 25807286 DOI: 10.1038/ng.3247  1
2015 Steinberg S, Stefansson H, Jonsson T, Johannsdottir H, Ingason A, Helgason H, Sulem P, Magnusson OT, Gudjonsson SA, Unnsteinsdottir U, Kong A, Helisalmi S, Soininen H, Lah JJ, et al. Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease. Nature Genetics. 47: 445-7. PMID 25807283 DOI: 10.1038/ng.3246  1
2015 Sulem P, Helgason H, Oddson A, Stefansson H, Gudjonsson SA, Zink F, Hjartarson E, Sigurdsson GT, Jonasdottir A, Jonasdottir A, Sigurdsson A, Magnusson OT, Kong A, Helgason A, Holm H, et al. Identification of a large set of rare complete human knockouts. Nature Genetics. 47: 448-52. PMID 25807282 DOI: 10.1038/ng.3243  1
2014 Sveinbjornsson G, Mikaelsdottir E, Palsson R, Indridason OS, Holm H, Jonasdottir A, Helgason A, Sigurdsson S, Jonasdottir A, Sigurdsson A, Eyjolfsson GI, Sigurdardottir O, Magnusson OT, Kong A, Masson G, et al. Rare mutations associating with serum creatinine and chronic kidney disease. Human Molecular Genetics. 23: 6935-43. PMID 25082825 DOI: 10.1093/hmg/ddu399  1
2014 Rafnar T, Sulem P, Thorleifsson G, Vermeulen SH, Helgason H, Saemundsdottir J, Gudjonsson SA, Sigurdsson A, Stacey SN, Gudmundsson J, Johannsdottir H, Alexiusdottir K, Petursdottir V, Nikulasson S, Geirsson G, ... ... Magnusson OT, et al. Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer. Human Molecular Genetics. 23: 5545-57. PMID 24861552 DOI: 10.1093/hmg/ddu264  1
2014 Styrkarsdottir U, Thorleifsson G, Helgadottir HT, Bomer N, Metrustry S, Bierma-Zeinstra S, Strijbosch AM, Evangelou E, Hart D, Beekman M, Jonasdottir A, Sigurdsson A, Eiriksson FF, Thorsteinsdottir M, Frigge ML, ... ... Magnusson OT, et al. Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. Nature Genetics. 46: 498-502. PMID 24728293 DOI: 10.1038/Ng.2957  1
2014 Steinthorsdottir V, Thorleifsson G, Sulem P, Helgason H, Grarup N, Sigurdsson A, Helgadottir HT, Johannsdottir H, Magnusson OT, Gudjonsson SA, Justesen JM, Harder MN, Jørgensen ME, Christensen C, Brandslund I, et al. Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes. Nature Genetics. 46: 294-8. PMID 24464100 DOI: 10.1038/ng.2882  1
2014 Komlósi K, Hadzsiev K, Garbes L, Martínez Carrera LA, Pál E, Sigurðsson JH, Magnusson O, Melegh B, Wirth B. Exome sequencing identifies Laing distal myopathy MYH7 mutation in a Roma family previously diagnosed with distal neuronopathy. Neuromuscular Disorders : Nmd. 24: 156-61. PMID 24300783 DOI: 10.1016/j.nmd.2013.10.010  1
2013 Gudmundsson J, Sulem P, Gudbjartsson DF, Masson G, Petursdottir V, Hardarson S, Gudjonsson SA, Johannsdottir H, Helgadottir HT, Stacey SN, Magnusson OT, Helgason H, Panadero A, van der Zanden LF, Aben KK, et al. A common variant at 8q24.21 is associated with renal cell cancer. Nature Communications. 4: 2776. PMID 24220699 DOI: 10.1038/ncomms3776  1
2013 Helgason H, Sulem P, Duvvari MR, Luo H, Thorleifsson G, Stefansson H, Jonsdottir I, Masson G, Gudbjartsson DF, Walters GB, Magnusson OT, Kong A, Rafnar T, Kiemeney LA, Schoenmaker-Koller FE, et al. A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration. Nature Genetics. 45: 1371-4. PMID 24036950 DOI: 10.1038/ng.2740  1
2013 Grarup N, Sulem P, Sandholt CH, Thorleifsson G, Ahluwalia TS, Steinthorsdottir V, Bjarnason H, Gudbjartsson DF, Magnusson OT, Sparsø T, Albrechtsen A, Kong A, Masson G, Tian G, Cao H, et al. Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets. Plos Genetics. 9: e1003530. PMID 23754956 DOI: 10.1371/Journal.Pgen.1003530  1
2013 Styrkarsdottir U, Thorleifsson G, Sulem P, Gudbjartsson DF, Sigurdsson A, Jonasdottir A, Jonasdottir A, Oddsson A, Helgason A, Magnusson OT, Walters GB, Frigge ML, Helgadottir HT, Johannsdottir H, Bergsteinsdottir K, et al. Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits. Nature. 497: 517-20. PMID 23644456 DOI: 10.1038/nature12124  1
2012 Gudmundsson J, Sulem P, Gudbjartsson DF, Masson G, Agnarsson BA, Benediktsdottir KR, Sigurdsson A, Magnusson OT, Gudjonsson SA, Magnusdottir DN, Johannsdottir H, Helgadottir HT, Stacey SN, Jonasdottir A, Olafsdottir SB, et al. A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. Nature Genetics. 44: 1326-9. PMID 23104005 DOI: 10.1038/Ng.2437  1
2012 Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G, Gudjonsson SA, Sigurdsson A, Jonasdottir A, Jonasdottir A, Wong WS, Sigurdsson G, Walters GB, Steinberg S, Helgason H, ... ... Magnusson OT, et al. Rate of de novo mutations and the importance of father's age to disease risk. Nature. 488: 471-5. PMID 22914163 DOI: 10.1038/nature11396  1
2012 Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, ... ... Magnusson OT, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature. 488: 96-9. PMID 22801501 DOI: 10.1038/Nature11283  1
2011 Sulem P, Gudbjartsson DF, Walters GB, Helgadottir HT, Helgason A, Gudjonsson SA, Zanon C, Besenbacher S, Bjornsdottir G, Magnusson OT, Magnusson G, Hjartarson E, Saemundsdottir J, Gylfason A, Jonasdottir A, et al. Identification of low-frequency variants associated with gout and serum uric acid levels. Nature Genetics. 43: 1127-30. PMID 21983786 DOI: 10.1038/Ng.972  1
2011 Rafnar T, Gudbjartsson DF, Sulem P, Jonasdottir A, Sigurdsson A, Jonasdottir A, Besenbacher S, Lundin P, Stacey SN, Gudmundsson J, Magnusson OT, le Roux L, Orlygsdottir G, Helgadottir HT, Johannsdottir H, et al. Mutations in BRIP1 confer high risk of ovarian cancer. Nature Genetics. 43: 1104-7. PMID 21964575 DOI: 10.1038/ng.955  1
2011 Stacey SN, Sulem P, Jonasdottir A, Masson G, Gudmundsson J, Gudbjartsson DF, Magnusson OT, Gudjonsson SA, Sigurgeirsson B, Thorisdottir K, Ragnarsson R, Benediktsdottir KR, Nexø BA, Tjønneland A, Overvad K, et al. A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. Nature Genetics. 43: 1098-103. PMID 21946351 DOI: 10.1038/Ng.926  1
2011 Gurney ME, Burgin AB, Magnusson OT, Stewart LJ. Small molecule allosteric modulators of phosphodiesterase 4. Handbook of Experimental Pharmacology. 167-92. PMID 21695640 DOI: 10.1007/978-3-642-17969-3_7  1
2011 Holm H, Gudbjartsson DF, Sulem P, Masson G, Helgadottir HT, Zanon C, Magnusson OT, Helgason A, Saemundsdottir J, Gylfason A, Stefansdottir H, Gretarsdottir S, Matthiasson SE, Thorgeirsson GM, Jonasdottir A, et al. A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nature Genetics. 43: 316-20. PMID 21378987 DOI: 10.1038/ng.781  1
2010 Burgin AB, Magnusson OT, Singh J, Witte P, Staker BL, Bjornsson JM, Thorsteinsdottir M, Hrafnsdottir S, Hagen T, Kiselyov AS, Stewart LJ, Gurney ME. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nature Biotechnology. 28: 63-70. PMID 20037581 DOI: 10.1038/Nbt.1598  1
2009 Wecksler SR, Stoll S, Tran H, Magnusson OT, Wu SP, King D, Britt RD, Klinman JP. Pyrroloquinoline quinone biogenesis: Demonstration that PqqE from Klebsiella pneumoniae is a radical S-adenosyl-L-methionine enzyme Biochemistry. 48: 10151-10161. PMID 19746930 DOI: 10.1021/Bi900918B  1
2009 Davies DR, Mamat B, Magnusson OT, Christensen J, Haraldsson MH, Mishra R, Pease B, Hansen E, Singh J, Zembower D, Kim H, Kiselyov AS, Burgin AB, Gurney ME, Stewart LJ. Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. Journal of Medicinal Chemistry. 52: 4694-715. PMID 19618939 DOI: 10.1021/Jm900259H  1
2009 Singh J, Zeller W, Zhou N, Hategen G, Mishra R, Polozov A, Yu P, Onua E, Zhang J, Zembower D, Kiselyov A, Ramírez JL, Sigthorsson G, Bjornsson JM, Thorsteinsdottir M, ... ... Magnusson O, et al. Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding. Acs Chemical Biology. 4: 115-26. PMID 19193156 DOI: 10.1021/cb8002094  1
2008 Heptinstall S, Espinosa DI, Manolopoulos P, Glenn JR, White AE, Johnson A, Dovlatova N, Fox SC, May JA, Hermann D, Magnusson O, Stefansson K, Hartman D, Gurney M. DG-041 inhibits the EP3 prostanoid receptor--a new target for inhibition of platelet function in atherothrombotic disease. Platelets. 19: 605-13. PMID 19012178 DOI: 10.1080/09537100802351073  1
2007 Magnusson OT, Rosefigura JM, Toyama H, Schwarzenbacher R, Klinman JP. Pyrroloquinoline quinone biogenesis: Characterization of PqqC and its H84N and H84A active site variants Biochemistry. 46: 7174-7186. PMID 17523676 DOI: 10.1021/Bi700162N  1
2006 Mansoorabadi SO, Magnusson OT, Poyner RR, Frey PA, Reed GH. Analysis of the Cob(II)alamin-5'-deoxy-3',4'-anhydroadenosyl radical triplet spin system in the active site of diol dehydrase. Biochemistry. 45: 14362-70. PMID 17128975 DOI: 10.1021/Bi061586Q  1
2004 Magnusson OT, Toyama H, Saeki M, Rojas A, Reed JC, Liddington RC, Klinman JP, Schwarzenbacher R. Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone Proceedings of the National Academy of Sciences of the United States of America. 101: 7913-7918. PMID 15148379 DOI: 10.1073/Pnas.0402640101  1
2004 Magnusson OT, Toyama H, Saeki M, Schwarzenbacher R, Klinman JP. The Structure of a Biosynthetic Intermediate of Pyrroloquinoline Quinone (PQQ) and Elucidation of the Final Step of PQQ Biosynthesis Journal of the American Chemical Society. 126: 5342-5343. PMID 15113189 DOI: 10.1021/Ja0493852  1
2003 Frey PA, Magnusson OT. S-Adenosylmethionine: a wolf in sheep's clothing, or a rich man's adenosylcobalamin? Chemical Reviews. 103: 2129-48. PMID 12797826 DOI: 10.1021/Cr020422M  1
2002 Arnórsdottir J, Smáradóttir RB, Magnússon OT, Thorbjarnardóttir SH, Eggertsson G, Kristjánsson MM. Characterization of a cloned subtilisin-like serine proteinase from a psychrotrophic Vibrio species. European Journal of Biochemistry / Febs. 269: 5536-46. PMID 12423352 DOI: 10.1046/j.1432-1033.2002.03259.x  1
2002 Magnusson OT, Frey PA. Facile hydrogen-deuterium exchange at the 5'-position of an analogue of S-adenosyl-l-methionine. Bioorganic Chemistry. 30: 53-61. PMID 11955002 DOI: 10.1006/Bioo.2001.1223  1
2002 Magnusson OT, Frey PA. Interactions of diol dehydrase and 3',4'-anhydroadenosylcobalamin: suicide inactivation by electron transfer. Biochemistry. 41: 1695-702. PMID 11814365 DOI: 10.1021/Bi011947W  1
2001 Magnusson OT, Reed GH, Frey PA. Characterization of an allylic analogue of the 5'-deoxyadenosyl radical: an intermediate in the reaction of lysine 2,3-aminomutase. Biochemistry. 40: 7773-82. PMID 11425303 DOI: 10.1021/Bi0104569  1
2001 LoBrutto R, Bandarian V, Magnusson OT, Chen X, Schramm VL, Reed GH. 5'-Deoxyadenosine contacts the substrate radical intermediate in the active site of ethanolamine ammonia-lyase: 2H and 13C electron nuclear double resonance studies. Biochemistry. 40: 9-14. PMID 11141051 DOI: 10.1021/Bi001865S  1
2000 Magnusson OT, Frey PA. Synthesis and characterization of 3',4'-anhydroadenosylcobalamin: A coenzyme B12 analogue with unusual properties Journal of the American Chemical Society. 122: 8807-8813. DOI: 10.1021/Ja0013780  1
2000 Magnusson OT, Frey PA. Synthesis and characterization of 3′,4′-anhydroadenosylcobalamin: A coenzyme B12 analogue with unusual properties Journal of the American Chemical Society. 122: X.  1
1999 Magnusson OT, Reed GH, Frey PA. Spectroscopic evidence for the participation of an allylic analogue of the 5'-deoxyadenosyl radical in the reaction of lysine 2,3-aminomutase [22] Journal of the American Chemical Society. 121: 9764-9765. DOI: 10.1021/Ja9925507  1
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