Wei-Chieh Cheng, Ph.D. - Publications

Affiliations: 
2002 University of California, Davis, Davis, CA 
Area:
Combinatorial chemistry, heterocyclic chemistry, understanding reaction mechanisms, solid phase organic synthesis, polymer chemistry, organic synthesis, reaction methodology, and structure elucidation

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Cheng WC, Wang JH, Yun WY, Li HY, Hu JM. Rapid preparation of (3R,4S,5R) polyhydroxylated pyrrolidine-based libraries to discover a pharmacological chaperone for treatment of Fabry disease. European Journal of Medicinal Chemistry. 126: 1-6. PMID 27744182 DOI: 10.1016/j.ejmech.2016.10.004  0.96
2016 Chen KT, Chen PT, Lin CK, Huang LY, Hu CM, Chang YF, Hsu HT, Cheng TR, Wu YT, Cheng WC. Structural Investigation of Park's Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors. Scientific Reports. 6: 31579. PMID 27531195 DOI: 10.1038/srep31579  0.96
2016 Cheng WC, Wang JH, Li HY, Lu SJ, Hu JM, Yun WY, Chiu CH, Yang WB, Chien YH, Hwu WL. Bioevaluation of sixteen ADMDP stereoisomers toward alpha-galactosidase A: Development of a new pharmacological chaperone for the treatment of Fabry disease and potential enhancement of enzyme replacement therapy efficiency. European Journal of Medicinal Chemistry. 123: 14-20. PMID 27474919 DOI: 10.1016/j.ejmech.2016.07.025  0.96
2016 Lin CK, Yun WY, Lin LT, Cheng WC. A concise approach to the synthesis of the unique N-mannosyl d-β-hydroxyenduracididine moiety in the mannopeptimycin series of natural products. Organic & Biomolecular Chemistry. PMID 27055669 DOI: 10.1039/c6ob00644b  0.96
2016 Liu Y, Yang M, Chen J, Yan D, Cheng W, Wang Y, Thygesen A, Chen R, Xing J, Wang Q, Ma Y. PCR-Based Seamless Genome Editing with High Efficiency and Fidelity in Escherichia coli. Plos One. 11: e0149762. PMID 27019283 DOI: 10.1371/journal.pone.0149762  0.44
2016 Cui H, Zhang J, Liu Y, Li Q, Li H, Zhang L, Hu Q, Cheng W, Luo Q, Li J, Li W, Wang J, Feng J, Li C, Northoff G. Differential alterations of resting-state functional connectivity in generalized anxiety disorder and panic disorder. Human Brain Mapping. PMID 26800659 DOI: 10.1002/hbm.23113  0.44
2016 Yin G, Cheng W, Dong Y, Dong H, Zhang W. Location recommendation using trajectory fingerprints and location similarity Harbin Gongcheng Daxue Xuebao/Journal of Harbin Engineering University. 37: 414-419. DOI: 10.11990/jheu.201506035  0.44
2016 Liu Y, Sun C, Yang Y, Zhou M, Zhan W, Cheng W. Automatic extraction of offshore platforms using time-series Landsat-8 Operational Land Imager data Remote Sensing of Environment. 175: 73-91. DOI: 10.1016/j.rse.2015.12.047  0.44
2016 Sun QJ, Cheng WQ, Liu YB, Wang JF, Cai CW, Feng JC. Microstructure and mechanical properties of ultrasonic assisted underwater wet welding joints Materials and Design. 103: 63-70. DOI: 10.1016/j.matdes.2016.04.019  0.4
2016 Cheng W, Sun DW, Pu H, Liu Y. Integration of spectral and textural data for enhancing hyperspectral prediction of K value in pork meat Lwt - Food Science and Technology. 72: 322-329. DOI: 10.1016/j.lwt.2016.05.003  0.32
2016 Li R, Liu Y, Cheng W, Zhang W, Xue G, Ognier S. Study on remediation of phenanthrene contaminated soil by pulsed dielectric barrier discharge plasma: The role of active species Chemical Engineering Journal. 296: 132-140. DOI: 10.1016/j.cej.2016.03.054  0.44
2015 Chen KT, Huang DY, Chiu CH, Lin WW, Liang PH, Cheng WC. Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 11984-8. PMID 26226896 DOI: 10.1002/chem.201501557  0.96
2015 Zuegg J, Muldoon C, Adamson G, McKeveney D, Le Thanh G, Premraj R, Becker B, Cheng M, Elliott AG, Huang JX, Butler MS, Bajaj M, Seifert J, Singh L, Galley NF, ... ... Cheng WC, et al. Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications. 6: 7719. PMID 26194781 DOI: 10.1038/ncomms8719  0.96
2015 Lin CK, Chen KT, Hu CM, Yun WY, Cheng WC. Synthesis of 1-C-Glycoside-Linked Lipid II Analogues Toward Bacterial Transglycosylase Inhibition. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 7511-9. PMID 25820317 DOI: 10.1002/chem.201406629  0.96
2015 Kuo RJ, Huang MH, Cheng WC, Lin CC, Wu YH. Application of a two-stage fuzzy neural network to a prostate cancer prognosis system. Artificial Intelligence in Medicine. 63: 119-33. PMID 25576196 DOI: 10.1016/j.artmed.2014.12.008  0.48
2015 Lin CK, Cheng LW, Li HY, Yun WY, Cheng WC. Synthesis of novel polyhydroxylated pyrrolidine-triazole/-isoxazole hybrid molecules. Organic & Biomolecular Chemistry. 13: 2100-7. PMID 25525831 DOI: 10.1039/c4ob01934b  0.96
2015 Chen PT, Lin CK, Tsai CJ, Huang DY, Nien FY, Lin WW, Cheng WC. Expeditious synthesis of enantiopure, orthogonally protected bis-α-amino acids (OPBAAs) and their use in a study of Nod1 stimulation. Chemistry, An Asian Journal. 10: 474-82. PMID 25504924 DOI: 10.1002/asia.201403173  0.96
2015 Cheng WC, Guo CW, Lin CK, Jiang YR. Synthesis and inhibition study of bicyclic iminosugar-based alkaloids, scaffolds, and libraries towards glucosidase Israel Journal of Chemistry. 55: 403-411. DOI: 10.1002/ijch.201400140  0.96
2014 Hsu CH, Schelwies M, Enck S, Huang LY, Huang SH, Chang YF, Cheng TJ, Cheng WC, Wong CH. Iminosugar C-glycoside analogues of α-D-GlcNAc-1-phosphate: synthesis and bacterial transglycosylase inhibition. The Journal of Organic Chemistry. 79: 8629-37. PMID 25137529 DOI: 10.1021/jo501340s  0.96
2014 Huang LY, Huang SH, Chang YC, Cheng WC, Cheng TJ, Wong CH. Enzymatic synthesis of lipid II and analogues. Angewandte Chemie (International Ed. in English). 53: 8060-5. PMID 24990652 DOI: 10.1002/anie.201402313  0.96
2014 Tseng YY, Liou JM, Hsu TL, Cheng WC, Wu MS, Wong CH. Development of bacterial transglycosylase inhibitors as new antibiotics: moenomycin A treatment for drug-resistant Helicobacter pylori. Bioorganic & Medicinal Chemistry Letters. 24: 2412-4. PMID 24775303 DOI: 10.1016/j.bmcl.2014.04.041  0.96
2013 Huang SH, Wu WS, Huang LY, Huang WF, Fu WC, Chen PT, Fang JM, Cheng WC, Cheng TJ, Wong CH. New continuous fluorometric assay for bacterial transglycosylase using Förster resonance energy transfer. Journal of the American Chemical Society. 135: 17078-89. PMID 24131464 DOI: 10.1021/ja407985m  0.96
2013 Cheng TJ, Chan TH, Tsou EL, Chang SY, Yun WY, Yang PJ, Wu YT, Cheng WC. From natural product-inspired pyrrolidine scaffolds to the development of new human Golgi α-mannosidase II inhibitors. Chemistry, An Asian Journal. 8: 2600-4. PMID 23943613 DOI: 10.1002/asia.201300680  0.96
2013 Pan YW, Guo CW, Tu HY, Tsai CW, Cheng WC. Solid-phase synthesis of diverse spiroisoxazolinodiketopiperazines. Acs Combinatorial Science. 15: 425-34. PMID 23889462 DOI: 10.1021/co4000248  0.96
2013 Cheng WC, Weng CY, Yun WY, Chang SY, Lin YC, Tsai FJ, Huang FY, Chen YR. Rapid modifications of N-substitution in iminosugars: development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease. Bioorganic & Medicinal Chemistry. 21: 5021-8. PMID 23880081 DOI: 10.1016/j.bmc.2013.06.054  0.96
2013 Chen KT, Kuan YC, Fu WC, Liang PH, Cheng TJ, Wong CH, Cheng WC. Rapid preparation of mycobacterium N-glycolyl Lipid I and Lipid II derivatives: a biocatalytic approach. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 834-8. PMID 23229320 DOI: 10.1002/chem.201203251  0.96
2012 Shih HW, Chang YF, Li WJ, Meng FC, Huang CY, Ma C, Cheng TJ, Wong CH, Cheng WC. Effect of the peptide moiety of Lipid II on bacterial transglycosylase. Angewandte Chemie (International Ed. in English). 51: 10123-6. PMID 22952114 DOI: 10.1002/anie.201204038  0.96
2012 Huang CY, Shih HW, Lin LY, Tien YW, Cheng TJ, Cheng WC, Wong CH, Ma C. Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism. Proceedings of the National Academy of Sciences of the United States of America. 109: 6496-501. PMID 22493270 DOI: 10.1073/pnas.1203900109  0.96
2012 Hsu YC, Chen NC, Chen PC, Wang CC, Cheng WC, Wu HN. Identification of a small-molecule inhibitor of dengue virus using a replicon system. Archives of Virology. 157: 681-8. PMID 22249364 DOI: 10.1007/s00705-012-1224-z  0.96
2012 Shih HW, Chen KT, Cheng WC. One-pot synthesis of phosphate diesters and phosphonate monoesters via a combination of microwave-CCl 3CN-pyridine coupling conditions Tetrahedron Letters. 53: 243-246. DOI: 10.1016/j.tetlet.2011.11.032  0.96
2011 Meng FC, Chen KT, Huang LY, Shih HW, Chang HH, Nien FY, Liang PH, Cheng TJ, Wong CH, Cheng WC. Total synthesis of polyprenyl N-glycolyl lipid II as a mycobacterial transglycosylase substrate. Organic Letters. 13: 5306-9. PMID 21913698 DOI: 10.1021/ol2021687  0.96
2011 Shih HW, Chen KT, Cheng TJ, Wong CH, Cheng WC. A new synthetic approach toward bacterial transglycosylase substrates, Lipid II and Lipid IV. Organic Letters. 13: 4600-3. PMID 21797279 DOI: 10.1021/ol201806d  0.96
2011 Chang YF, Guo CW, Chan TH, Pan YW, Tsou EL, Cheng WC. Parallel synthesis of natural product-like polyhydroxylated pyrrolidine and piperidine alkaloids. Molecular Diversity. 15: 203-14. PMID 20563842 DOI: 10.1007/s11030-010-9255-4  0.96
2010 Cheng TJ, Wu YT, Yang ST, Lo KH, Chen SK, Chen YH, Huang WI, Yuan CH, Guo CW, Huang LY, Chen KT, Shih HW, Cheng YS, Cheng WC, Wong CH. High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase. Bioorganic & Medicinal Chemistry. 18: 8512-29. PMID 21075637 DOI: 10.1016/j.bmc.2010.10.036  0.96
2010 Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Cheng WC, Wu YT, Tsai MD, Cheng YS, Wong CH. High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity. Proceedings of the National Academy of Sciences of the United States of America. 107: 19151-6. PMID 20974907 DOI: 10.1073/pnas.1013592107  0.96
2010 Shih HW, Chen KT, Chen SK, Huang CY, Cheng TJ, Ma C, Wong CH, Cheng WC. Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors. Organic & Biomolecular Chemistry. 8: 2586-93. PMID 20485795 DOI: 10.1039/c000622j  0.96
2010 Liu CY, Guo CW, Chang YF, Wang JT, Shih HW, Hsu YF, Chen CW, Chen SK, Wang YC, Cheng TJ, Ma C, Wong CH, Fang JM, Cheng WC. Synthesis and evaluation of a new fluorescent transglycosylase substrate: lipid II-based molecule possessing a dansyl-C20 polyprenyl moiety. Organic Letters. 12: 1608-11. PMID 20187630 DOI: 10.1021/ol100338v  0.96
2010 Chan TH, Chang YF, Hsu JJ, Cheng WC. Straightforward synthesis of diverse 1-deoxyazapyranosides via stereocontrolled nucleophilic additions to six-membered cyclic nitrones European Journal of Organic Chemistry. 5555-5559. DOI: 10.1002/ejoc.201001045  0.96
2009 Sung MT, Lai YT, Huang CY, Chou LY, Shih HW, Cheng WC, Wong CH, Ma C. Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 106: 8824-9. PMID 19458048 DOI: 10.1073/pnas.0904030106  0.96
2009 Shih HW, Guo CW, Lo KH, Huang MY, Cheng WC. Solution-phase parallel synthesis of novel spirooxazolinoisoxazolines. Journal of Combinatorial Chemistry. 11: 281-7. PMID 19199644 DOI: 10.1021/cc800158t  0.96
2009 Tsou EL, Yeh YT, Liang PH, Cheng WC. A convenient approach toward the synthesis of enantiopure isomers of DMDP and ADMDP Tetrahedron. 65: 93-100. DOI: 10.1016/j.tet.2008.10.096  0.96
2008 Tsou EL, Chen SY, Yang MH, Wang SC, Cheng TR, Cheng WC. Synthesis and biological evaluation of a 2-aryl polyhydroxylated pyrrolidine alkaloid-based library. Bioorganic & Medicinal Chemistry. 16: 10198-204. PMID 19008111 DOI: 10.1016/j.bmc.2008.10.063  0.96
2008 Chang YF, Liu CY, Guo CW, Wang YC, Fang JM, Cheng WC. Solid-phase organic synthesis of polyisoprenoid alcohols with traceless sulfone linker. The Journal of Organic Chemistry. 73: 7197-203. PMID 18707172 DOI: 10.1021/jo8010182  0.96
2008 Cheng TJ, Sung MT, Liao HY, Chang YF, Chen CW, Huang CY, Chou LY, Wu YD, Chen YH, Cheng YS, Wong CH, Ma C, Cheng WC. Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 105: 431-6. PMID 18182485 DOI: 10.1073/pnas.0710868105  0.96
2008 Huang CM, Liu RS, Wu TS, Cheng WC. Structural establishment of polygalatenosides A and B by total synthesis Tetrahedron Letters. 49: 2895-2898. DOI: 10.1016/j.tetlet.2008.03.032  0.96
2008 Shih HW, Cheng WC. Solution-phase parallel synthesis of highly diverse spiroisoxazolinohydantoins Tetrahedron Letters. 49: 1008-1011. DOI: 10.1016/j.tetlet.2007.12.008  0.96
2008 Chang YF, Jiang YR, Cheng WC. Traceless sulfone linker cleavage triggered by ozonolysis: solid-phase synthesis of diverse α-β-unsaturated carbonyl compounds Tetrahedron Letters. 49: 543-547. DOI: 10.1016/j.tetlet.2007.11.064  0.96
2006 Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nature Chemical Biology. 2: 434-41. PMID 16829954 DOI: 10.1038/nchembio804  0.96
2006 Liang PH, Cheng WC, Lee YL, Yu HP, Wu YT, Lin YL, Wong CH. Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis. Chembiochem : a European Journal of Chemical Biology. 7: 165-73. PMID 16397876 DOI: 10.1002/cbic.200500321  0.96
2005 Sawkar AR, Adamski-Werner SL, Cheng WC, Wong CH, Beutler E, Zimmer KP, Kelly JW. Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles. Chemistry & Biology. 12: 1235-44. PMID 16298303 DOI: 10.1016/j.chembiol.2005.09.007  0.96
2004 Best MD, Brik A, Chapman E, Lee LV, Cheng WC, Wong CH. Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening. Chembiochem : a European Journal of Chemical Biology. 5: 811-9. PMID 15174164 DOI: 10.1002/cbic.200300841  0.96
2002 Sawkar AR, Cheng WC, Beutler E, Wong CH, Balch WE, Kelly JW. Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 15428-33. PMID 12434014 DOI: 10.1073/pnas.192582899  0.96
2002 Cheng WC, Liu Y, Wong M, Olmstead MM, Lam KS, Kurth MJ. Stereoselective synthesis of unnatural spiroisoxazolinoproline-based amino acids and derivatives. The Journal of Organic Chemistry. 67: 5673-7. PMID 12153267 DOI: 10.1021/jo025611j  0.96
2002 Cheng WC, Kurth MJ. The sulfone linker in solid-phase synthesis: preparation of 3,5-disubstituted cyclopent-2-enones. The Journal of Organic Chemistry. 67: 4387-91. PMID 12076132 DOI: 10.1021/jo0256843  0.96
2002 Cheng WC, Wong M, Olmstead MM, Kurth MJ. Solid-phase synthesis of novel isoxazolocyclobutanones and isoxazolinocyclobutenones. Organic Letters. 4: 741-4. PMID 11869116  0.96
2002 Cheng WC, Lin CC, Kurth MJ. Dimsyl anion in the monoalkylation of solid-phase alkyl sulfones Tetrahedron Letters. 43: 2967-2970. DOI: 10.1016/S0040-4039(02)00423-9  0.96
2002 Cheng WC, Kurth MJ. The zincke reaction. A review Organic Preparations and Procedures International. 34: 585-608.  0.96
2001 Cheng WC, Olmstead MM, Kurth MJ. Vinyl sulfones in solid-phase synthesis: preparation of 4,5,6,7-tetrahydroisoindole derivatives. The Journal of Organic Chemistry. 66: 5528-33. PMID 11485478 DOI: 10.1021/jo0156823  0.96
1999 Cheng WC, Halm C, Evarts JB, Olmstead MM, Kurth MJ. Allylic sulfones in solid-phase synthesis: Preparation of cyclobutylidenes Journal of Organic Chemistry. 64: 8557-8562. DOI: 10.1021/jo990954b  0.96
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