Lark J. Perez, Ph.D. - Publications

2009 Yale University, New Haven, CT 
Organic Chemistry, Medicinal Chemistry

14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Capilato JN, Philippi SV, Reardon T, McConnell A, Oliver DC, Warren A, Adams JS, Wu C, Perez LJ. Development of a novel series of non-natural triaryl agonists and antagonists of the Pseudomonas aeruginosa LasR quorum sensing receptor. Bioorganic & Medicinal Chemistry. PMID 27825554 DOI: 10.1016/j.bmc.2016.10.021  0.4
2016 Wu B, Capilato J, Pham MP, Walker J, Spur B, Rodriguez A, Perez LJ, Yin K. Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginosa virulence through quorum sensing inhibition. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26965685 DOI: 10.1096/fj.201500029R  1
2015 O'Brien KT, Noto JG, Nichols-O'Neill L, Perez LJ. Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa. Acs Medicinal Chemistry Letters. 6: 162-7. PMID 25699144 DOI: 10.1021/ml500459f  1
2015 Lu HD, Spiegel AC, Hurley A, Perez LJ, Maisel K, Ensign LM, Hanes J, Bassler BL, Semmelhack MF, Prud'homme RK. Modulating Vibrio cholerae quorum-sensing-controlled communication using autoinducer-loaded nanoparticles. Nano Letters. 15: 2235-41. PMID 25651002 DOI: 10.1021/acs.nanolett.5b00151  1
2014 Werner KM, Perez LJ, Ghosh R, Semmelhack MF, Bassler BL. Caenorhabditis elegans recognizes a bacterial quorum-sensing signal molecule through the AWCON neuron. The Journal of Biological Chemistry. 289: 26566-73. PMID 25092291 DOI: 10.1074/jbc.M114.573832  1
2014 Perez LJ, Karagounis TK, Hurley A, Bassler BL, Semmelhack MF. Highly Potent, Chemically Stable Quorum Sensing Agonists for Vibrio Cholerae. Chemical Science (Royal Society of Chemistry : 2010). 5: 151-155. PMID 24436778 DOI: 10.1039/C3SC52572D  1
2012 Perez LJ, Ng WL, Marano P, Brook K, Bassler BL, Semmelhack MF. Role of the CAI-1 fatty acid tail in the Vibrio cholerae quorum sensing response. Journal of Medicinal Chemistry. 55: 9669-81. PMID 23092313 DOI: 10.1021/jm300908t  1
2012 Ng WL, Perez L, Cong J, Semmelhack MF, Bassler BL. Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios. Plos Pathogens. 8: e1002767. PMID 22761573 DOI: 10.1371/journal.ppat.1002767  1
2011 Bolitho ME, Perez LJ, Koch MJ, Ng WL, Bassler BL, Semmelhack MF. Small molecule probes of the receptor binding site in the Vibrio cholerae CAI-1 quorum sensing circuit. Bioorganic & Medicinal Chemistry. 19: 6906-18. PMID 22001326 DOI: 10.1016/j.bmc.2011.09.021  1
2011 Ng WL, Perez LJ, Wei Y, Kraml C, Semmelhack MF, Bassler BL. Signal production and detection specificity in Vibrio CqsA/CqsS quorum-sensing systems. Molecular Microbiology. 79: 1407-17. PMID 21219472 DOI: 10.1111/j.1365-2958.2011.07548.x  1
2011 Wei Y, Perez LJ, Ng WL, Semmelhack MF, Bassler BL. Mechanism of Vibrio cholerae autoinducer-1 biosynthesis. Acs Chemical Biology. 6: 356-65. PMID 21197957 DOI: 10.1021/cb1003652  1
2010 Ng WL, Wei Y, Perez LJ, Cong J, Long T, Koch M, Semmelhack MF, Wingreen NS, Bassler BL. Probing bacterial transmembrane histidine kinase receptor-ligand interactions with natural and synthetic molecules. Proceedings of the National Academy of Sciences of the United States of America. 107: 5575-80. PMID 20212168 DOI: 10.1073/pnas.1001392107  1
2009 Perez LJ, Shimp HL, Micalizio GC. Stereoselective synthesis of trisubstituted (E,E)-1,3-dienes by the site-selective reductive cross-coupling of internal alkynes with terminal alkynes: a fragment coupling reaction for natural product synthesis. The Journal of Organic Chemistry. 74: 7211-9. PMID 19722544 DOI: 10.1021/jo901451c  1
2008 Perez LJ, Micalizio GC. Titanium-mediated fragment union processes in complex molecule synthesis: Development of a branched reaction pathway of high step economy for the synthesis of complex and diverse polyketides Synthesis. 0627-0648. DOI: 10.1055/s-2008-1032160  1
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