Hemant Khanna, Ph.D. - Publications

Affiliations: 
2002 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
design potent and specific "mechanism-based inhibitors" of selected target enzymes for use as drugs in the treatment of cancer and parasitic diseases

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Rao KN, Li L, Zhang W, Brush RS, Rajala RV, Khanna H. Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina. Human Molecular Genetics. PMID 26908598 DOI: 10.1093/hmg/ddw017  0.4
2015 Li L, Rao KN, Zheng-Le Y, Hurd TW, Lillo C, Khanna H. Loss of Retinitis Pigmentosa 2 (RP2) protein affects cone photoreceptor sensory cilium elongation in mice. Cytoskeleton (Hoboken, N.J.). PMID 26383048 DOI: 10.1002/cm.21255  0.4
2015 Mookherjee S, Hiriyanna S, Kaneshiro K, Li L, Li Y, Li W, Qian H, Li T, Khanna H, Colosi P, Swaroop A, Wu Z. Long-Term Rescue of Cone Photoreceptor Degeneration in Retinitis Pigmentosa 2 (RP2) Knockout Mice by Gene Replacement Therapy. Human Molecular Genetics. PMID 26358772 DOI: 10.1093/hmg/ddv354  0.4
2015 Li L, Anand M, Rao KN, Khanna H. Cilia in photoreceptors. Methods in Cell Biology. 127: 75-92. PMID 25837387 DOI: 10.1016/bs.mcb.2014.12.005  0.4
2015 Rao KN, Li L, Anand M, Khanna H. Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition Scientific Reports. 5. DOI: 10.1038/srep11137  0.4
2014 Subramanian B, Anand M, Khan NW, Khanna H. Loss of Raf-1 kinase inhibitory protein delays early-onset severe retinal ciliopathy in Cep290rd16 mouse. Investigative Ophthalmology & Visual Science. 55: 5788-94. PMID 25125607 DOI: 10.1167/iovs.14-14954  0.4
2013 Li L, Khan N, Hurd T, Ghosh AK, Cheng C, Molday R, Heckenlively JR, Swaroop A, Khanna H. Ablation of the X-linked retinitis pigmentosa 2 (Rp2) gene in mice results in opsin mislocalization and photoreceptor degeneration. Investigative Ophthalmology & Visual Science. 54: 4503-11. PMID 23745007 DOI: 10.1167/iovs.13-12140  0.4
2012 Khanna H, Baehr W. Retina ciliopathies: from genes to mechanisms and treatment. Vision Research. 75: 1. PMID 23206575 DOI: 10.1016/j.visres.2012.11.007  0.4
2012 Yildiz O, Khanna H. Ciliary signaling cascades in photoreceptors. Vision Research. 75: 112-6. PMID 22921640 DOI: 10.1016/j.visres.2012.08.007  0.4
2012 Anand M, Khanna H. Ciliary transition zone (TZ) proteins RPGR and CEP290: role in photoreceptor cilia and degenerative diseases. Expert Opinion On Therapeutic Targets. 16: 541-51. PMID 22563985 DOI: 10.1517/14728222.2012.680956  0.4
2012 Thompson DA, Khan NW, Othman MI, Chang B, Jia L, Grahek G, Wu Z, Hiriyanna S, Nellissery J, Li T, Khanna H, Colosi P, Swaroop A, Heckenlively JR. Rd9 is a naturally occurring mouse model of a common form of retinitis pigmentosa caused by mutations in RPGR-ORF15. Plos One. 7: e35865. PMID 22563472 DOI: 10.1371/journal.pone.0035865  0.4
2012 Luo N, West CC, Murga-Zamalloa CA, Sun L, Anderson RM, Wells CD, Weinreb RN, Travers JB, Khanna H, Sun Y. OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome. Human Molecular Genetics. 21: 3333-44. PMID 22543976 DOI: 10.1093/hmg/dds163  0.4
2012 Rachel RA, May-Simera HL, Veleri S, Gotoh N, Choi BY, Murga-Zamalloa C, McIntyre JC, Marek J, Lopez I, Hackett AN, Zhang J, Brooks M, den Hollander AI, Beales PL, Li T, ... ... Khanna H, et al. Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis. The Journal of Clinical Investigation. 122: 1233-45. PMID 22446187 DOI: 10.1172/JCI60981  0.4
2012 Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, Chiodo VA, Fajardo DS, Román AJ, Deng WT, Swider M, Alemán TS, Boye SL, Genini S, Swaroop A, et al. Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 109: 2132-7. PMID 22308428 DOI: 10.1073/pnas.1118847109  0.4
2012 Rachel RA, May-Simera HL, Veleri S, Gotoh N, Choi BY, Murga-Zamalloa C, McIntyre JC, Marek J, Lopez I, Hackett AN, Zhang J, Brooks M, Den Hollander AI, Beales PL, Li T, ... ... Khanna H, et al. Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis (Journal of Clinical Investigation (2012) 122, 4, (1233-1245) DOI: 10.1172/JCI60981) Journal of Clinical Investigation. 122: 3025. DOI: 10.1172/JCI65432  0.4
2011 Bian ZM, Elner SG, Khanna H, Murga-Zamalloa CA, Patil S, Elner VM. Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 52: 8646-56. PMID 21969293 DOI: 10.1167/iovs.11-7570  0.4
2011 Patil SB, Hurd TW, Ghosh AK, Murga-Zamalloa CA, Khanna H. Functional analysis of retinitis pigmentosa 2 (RP2) protein reveals variable pathogenic potential of disease-associated missense variants. Plos One. 6: e21379. PMID 21738648 DOI: 10.1371/journal.pone.0021379  0.4
2011 Murga-Zamalloa CA, Ghosh AK, Patil SB, Reed NA, Chan LS, Davuluri S, Peränen J, Hurd TW, Rachel RA, Khanna H. Accumulation of the Raf-1 kinase inhibitory protein (Rkip) is associated with Cep290-mediated photoreceptor degeneration in ciliopathies. The Journal of Biological Chemistry. 286: 28276-86. PMID 21685394 DOI: 10.1074/jbc.M111.237560  0.4
2011 Chakarova CF, Khanna H, Shah AZ, Patil SB, Sedmak T, Murga-Zamalloa CA, Papaioannou MG, Nagel-Wolfrum K, Lopez I, Munro P, Cheetham M, Koenekoop RK, Rios RM, Matter K, Wolfrum U, et al. TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein. Human Molecular Genetics. 20: 975-87. PMID 21159800 DOI: 10.1093/hmg/ddq543  0.4
2011 Yao J, Feathers KL, Khanna H, Thompson D, Tsilfidis C, Hauswirth WW, Heckenlively JR, Swaroop A, Zacks DN. XIAP therapy increases survival of transplanted rod precursors in a degenerating host retina. Investigative Ophthalmology & Visual Science. 52: 1567-72. PMID 20926819 DOI: 10.1167/iovs.10-5998  0.4
2010 Otto EA, Hurd TW, Airik R, Chaki M, Zhou W, Stoetzel C, Patil SB, Levy S, Ghosh AK, Murga-Zamalloa CA, van Reeuwijk J, Letteboer SJ, Sang L, Giles RH, Liu Q, ... ... Khanna H, et al. Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nature Genetics. 42: 840-50. PMID 20835237 DOI: 10.1038/ng.662  0.4
2010 Patil SB, Verma R, Venkatareddy M, Khanna H. Expression and localization of the ciliary disease protein retinitis pigmentosa GTPase regulator in mammalian kidney. Kidney International. 78: 622-3. PMID 20805823 DOI: 10.1038/ki.2010.252  0.4
2010 Hurd T, Zhou W, Jenkins P, Liu CJ, Swaroop A, Khanna H, Martens J, Hildebrandt F, Margolis B. The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development. Human Molecular Genetics. 19: 4330-44. PMID 20729296 DOI: 10.1093/hmg/ddq355  0.4
2010 Murga-Zamalloa CA, Desai NJ, Hildebrandt F, Khanna H. Interaction of ciliary disease protein retinitis pigmentosa GTPase regulator with nephronophthisis-associated proteins in mammalian retinas. Molecular Vision. 16: 1373-81. PMID 20664800  0.4
2010 Murga-Zamalloa CA, Atkins SJ, Peranen J, Swaroop A, Khanna H. Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration. Human Molecular Genetics. 19: 3591-8. PMID 20631154 DOI: 10.1093/hmg/ddq275  0.4
2010 Jayasundera T, Branham KE, Othman M, Rhoades WR, Karoukis AJ, Khanna H, Swaroop A, Heckenlively JR. RP2 phenotype and pathogenetic correlations in X-linked retinitis pigmentosa. Archives of Ophthalmology (Chicago, Ill. : 1960). 128: 915-23. PMID 20625056 DOI: 10.1001/archophthalmol.2010.122  0.4
2010 Patzke S, Redick S, Warsame A, Murga-Zamalloa CA, Khanna H, Doxsey S, Stokke T. CSPP is a ciliary protein interacting with Nephrocystin 8 and required for cilia formation. Molecular Biology of the Cell. 21: 2555-67. PMID 20519441 DOI: 10.1091/mbc.E09-06-0503  0.4
2010 Murga-Zamalloa C, Swaroop A, Khanna H. Multiprotein complexes of Retinitis Pigmentosa GTPase regulator (RPGR), a ciliary protein mutated in X-linked Retinitis Pigmentosa (XLRP). Advances in Experimental Medicine and Biology. 664: 105-14. PMID 20238008 DOI: 10.1007/978-1-4419-1399-9_13  0.4
2010 O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Kärppä M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, ... ... Khanna H, et al. Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. The Journal of Clinical Investigation. 120: 791-802. PMID 20179356 DOI: 10.1172/JCI40076  0.4
2010 Paul E, Kielbasinski M, Sedivy JM, Murga-Zamalloa C, Khanna H, Klysik JE. Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse. Transgenic Research. 19: 691-701. PMID 19937380 DOI: 10.1007/s11248-009-9346-0  0.4
2010 Wu DM, Khanna H, Atmaca-Sonmez P, Sieving PA, Branham K, Othman M, Swaroop A, Daiger SP, Heckenlively JR. Long-term follow-up of a family with dominant X-linked retinitis pigmentosa. Eye (London, England). 24: 764-74. PMID 19893586 DOI: 10.1038/eye.2009.270  0.4
2010 Ghosh AK, Murga-Zamalloa CA, Chan L, Hitchcock PF, Swaroop A, Khanna H. Human retinopathy-associated ciliary protein retinitis pigmentosa GTPase regulator mediates cilia-dependent vertebrate development. Human Molecular Genetics. 19: 90-8. PMID 19815619 DOI: 10.1093/hmg/ddp469  0.4
2010 O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Kärppä M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, ... ... Khanna H, et al. Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy (Journal of Clinical Investigation (2010) 120, 3 (791-802) DOI: 10.1172/JCI40076) Journal of Clinical Investigation. 120: 1362. DOI: 10.1172/JCI40076C1  0.4
2009 Murga-Zamalloa CA, Swaroop A, Khanna H. RPGR-containing protein complexes in syndromic and non-syndromic retinal degeneration due to ciliary dysfunction. Journal of Genetics. 88: 399-407. PMID 20090203 DOI: 10.1007/s12041-009-0061-7  0.4
2009 Khanna H, Davis EE, Murga-Zamalloa CA, Estrada-Cuzcano A, Lopez I, den Hollander AI, Zonneveld MN, Othman MI, Waseem N, Chakarova CF, Maubaret C, Diaz-Font A, MacDonald I, Muzny DM, Wheeler DA, et al. A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies. Nature Genetics. 41: 739-45. PMID 19430481 DOI: 10.1038/ng.366  0.4
2008 Tsang WY, Bossard C, Khanna H, Peränen J, Swaroop A, Malhotra V, Dynlacht BD. CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease. Developmental Cell. 15: 187-97. PMID 18694559 DOI: 10.1016/j.devcel.2008.07.004  0.4
2008 Siffroi-Fernandez S, Felder-Schmittbuhl MP, Khanna H, Swaroop A, Hicks D. FGF19 exhibits neuroprotective effects on adult mammalian photoreceptors in vitro. Investigative Ophthalmology & Visual Science. 49: 1696-704. PMID 18385093 DOI: 10.1167/iovs.07-1272  0.4
2008 He S, Parapuram SK, Hurd TW, Behnam B, Margolis B, Swaroop A, Khanna H. Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies. Vision Research. 48: 366-76. PMID 17904189 DOI: 10.1016/j.visres.2007.08.005  0.4
2007 Chakarova CF, Papaioannou MG, Khanna H, Lopez I, Waseem N, Shah A, Theis T, Friedman J, Maubaret C, Bujakowska K, Veraitch B, Abd El-Aziz MM, Prescott de Q, Parapuram SK, Bickmore WA, et al. Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy. American Journal of Human Genetics. 81: 1098-103. PMID 17924349 DOI: 10.1086/521953  0.4
2007 McEwen DP, Koenekoop RK, Khanna H, Jenkins PM, Lopez I, Swaroop A, Martens JR. Hypomorphic CEP290/NPHP6 mutations result in anosmia caused by the selective loss of G proteins in cilia of olfactory sensory neurons. Proceedings of the National Academy of Sciences of the United States of America. 104: 15917-22. PMID 17898177 DOI: 10.1073/pnas.0704140104  0.4
2007 Cideciyan AV, Aleman TS, Jacobson SG, Khanna H, Sumaroka A, Aguirre GK, Schwartz SB, Windsor EA, He S, Chang B, Stone EM, Swaroop A. Centrosomal-ciliary gene CEP290/NPHP6 mutations result in blindness with unexpected sparing of photoreceptors and visual brain: implications for therapy of Leber congenital amaurosis. Human Mutation. 28: 1074-83. PMID 17554762 DOI: 10.1002/humu.20565  0.4
2007 Oh EC, Khan N, Novelli E, Khanna H, Strettoi E, Swaroop A. Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. Proceedings of the National Academy of Sciences of the United States of America. 104: 1679-84. PMID 17242361 DOI: 10.1073/pnas.0605934104  0.4
2006 Khanna H, Akimoto M, Siffroi-Fernandez S, Friedman JS, Hicks D, Swaroop A. Retinoic acid regulates the expression of photoreceptor transcription factor NRL. The Journal of Biological Chemistry. 281: 27327-34. PMID 16854989 DOI: 10.1074/jbc.M605500200  0.4
2006 Sayer JA, Otto EA, O'Toole JF, Nurnberg G, Kennedy MA, Becker C, Hennies HC, Helou J, Attanasio M, Fausett BV, Utsch B, Khanna H, Liu Y, Drummond I, Kawakami I, et al. The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nature Genetics. 38: 674-81. PMID 16682973 DOI: 10.1038/ng1786  0.4
2006 Chang B, Khanna H, Hawes N, Jimeno D, He S, Lillo C, Parapuram SK, Cheng H, Scott A, Hurd RE, Sayer JA, Otto EA, Attanasio M, O'Toole JF, Jin G, et al. In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse. Human Molecular Genetics. 15: 1847-57. PMID 16632484 DOI: 10.1093/hmg/ddl107  0.4
2005 Khanna H, Hurd TW, Lillo C, Shu X, Parapuram SK, He S, Akimoto M, Wright AF, Margolis B, Williams DS, Swaroop A. RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins. The Journal of Biological Chemistry. 280: 33580-7. PMID 16043481 DOI: 10.1074/jbc.M505827200  0.4
2005 Shu X, Fry AM, Tulloch B, Manson FD, Crabb JW, Khanna H, Faragher AJ, Lennon A, He S, Trojan P, Giessl A, Wolfrum U, Vervoort R, Swaroop A, Wright AF. RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin. Human Molecular Genetics. 14: 1183-97. PMID 15772089 DOI: 10.1093/hmg/ddi129  0.4
2005 Otto EA, Loeys B, Khanna H, Hellemans J, Sudbrak R, Fan S, Muerb U, O'Toole JF, Helou J, Attanasio M, Utsch B, Sayer JA, Lillo C, Jimeno D, Coucke P, et al. Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin. Nature Genetics. 37: 282-8. PMID 15723066 DOI: 10.1038/ng1520  0.4
2004 Friedman JS, Khanna H, Swain PK, Denicola R, Cheng H, Mitton KP, Weber CH, Hicks D, Swaroop A. The minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts with TATA-binding protein. The Journal of Biological Chemistry. 279: 47233-41. PMID 15328344 DOI: 10.1074/jbc.M408298200  0.4
2004 Park MS, Hill CM, Li Y, Hardy RK, Khanna H, Khang YH, Raushel FM. Catalytic properties of the PepQ prolidase from Escherichia coli. Archives of Biochemistry and Biophysics. 429: 224-30. PMID 15313226 DOI: 10.1016/j.abb.2004.06.022  0.4
2004 Cheng H, Khanna H, Oh EC, Hicks D, Mitton KP, Swaroop A. Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors. Human Molecular Genetics. 13: 1563-75. PMID 15190009 DOI: 10.1093/hmg/ddh173  0.4
2003 Mitton KP, Swain PK, Khanna H, Dowd M, Apel IJ, Swaroop A. Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. Human Molecular Genetics. 12: 365-73. PMID 12566383 DOI: 10.1093/hmg/ddg035  0.4
2001 Khanna H, Singh Y. War against anthrax. Molecular Medicine (Cambridge, Mass.). 7: 795-6. PMID 11844866  0.4
2001 Khanna H, Gupta PK, Singh A, Chandra R, Singh Y. Participation of residue F552 in domain III of the protective antigen in the biological activity of anthrax lethal toxin. Biological Chemistry. 382: 941-6. PMID 11501759 DOI: 10.1515/BC.2001.117  0.4
2001 Khanna H, Chopra AP, Arora N, Chaudhry A, Singh Y. Role of residues constituting the 2beta1 strand of domain II in the biological activity of anthrax protective antigen. Fems Microbiology Letters. 199: 27-31. PMID 11356563 DOI: 10.1016/S0378-1097(01)00152-5  0.4
2001 Singh Y, Khanna H, Chopra AP, Mehra V. A dominant negative mutant of Bacillus anthracis protective antigen inhibits anthrax toxin action in vivo. The Journal of Biological Chemistry. 276: 22090-4. PMID 11278644 DOI: 10.1074/jbc.M010222200  0.4
2001 Mehra V, Khanna H, Chandra R, Singh Y. Anthrax-toxin-mediated delivery of a 19 kDa antigen of Mycobacterium tuberculosis into the cytosol of mammalian cells. Biotechnology and Applied Biochemistry. 33: 71-4. PMID 11277858 DOI: 10.1042/BA20000072  0.4
2000 Sharma M, Khanna H, Arora N, Singh Y. Anthrax toxin-mediated delivery of cholera toxin-A subunit into the cytosol of mammalian cells. Biotechnology and Applied Biochemistry. 32: 69-72. PMID 10918040  0.4
1998 Xu T, Khanna H, Coward JK. The design, synthesis, and initial evaluation of benzophenone-containing peptides as potential photoaffinity labels of oligosaccharyltransferase. Bioorganic & Medicinal Chemistry. 6: 1821-34. PMID 9839012 DOI: 10.1016/S0968-0896(98)00135-7  0.4
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