David W. Konas, Ph.D. - Publications

Affiliations: 
2002 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
design potent and specific "mechanism-based inhibitors" of selected target enzymes for use as drugs in the treatment of cancer and parasitic diseases

11 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Konas DW, Seci D, Tamimi S. Synthesis of (L)-4-fluorotryptophan Synthetic Communications. 42: 144-152. DOI: 10.1080/00397911.2010.523154  1
2011 Konas DW, Feldman C, Anand B, Piemonte J, Garay C, Silverthorne E, Wunderlich SM. Laboratory analysis of vitamin C in vegetables served in eldercare facilities and evaluation of related public nutrient database information Topics in Clinical Nutrition. 26: 68-77. DOI: 10.1097/TIN.0b013e318209e266  1
2008 Ilagan RP, Tiso M, Konas DW, Hemann C, Durra D, Hille R, Stuehr DJ. Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins. The Journal of Biological Chemistry. 283: 19603-15. PMID 18487202 DOI: 10.1074/jbc.M802914200  1
2007 Ray SS, Sengupta R, Tiso M, Haque MM, Sahoo R, Konas DW, Aulak K, Regulski M, Tully T, Stuehr DJ, Ghosh S. Reductase domain of Drosophila melanogaster nitric-oxide synthase: redox transformations, regulation, and similarity to mammalian homologues. Biochemistry. 46: 11865-73. PMID 17900149 DOI: 10.1021/bi700805x  1
2006 Konas DW, Takaya N, Sharma M, Stuehr DJ. Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein. Biochemistry. 45: 12596-609. PMID 17029414 DOI: 10.1021/bi061011t  1
2005 Tiso M, Konas DW, Panda K, Garcin ED, Sharma M, Getzoff ED, Stuehr DJ. C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase. The Journal of Biological Chemistry. 280: 39208-19. PMID 16150731 DOI: 10.1074/jbc.M507775200  1
2004 Konas DW, Zhu K, Sharma M, Aulak KS, Brudvig GW, Stuehr DJ. The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain. The Journal of Biological Chemistry. 279: 35412-25. PMID 15180983 DOI: 10.1074/jbc.M400872200  1
2004 Panda K, Adak S, Konas D, Sharma M, Stuehr DJ. A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis. The Journal of Biological Chemistry. 279: 18323-33. PMID 14966111 DOI: 10.1074/jbc.M310391200  1
2002 Konas DW, Pankuch JJ, Coward JK. The synthesis of (2S)-4,4-difluoroglutamyl γ-peptides based on Garner's aldehyde and fluoro-reformatsky chemistry Synthesis. 2616-2626.  1
2001 Konas DW, Coward JK. Electrophilic fluorination of pyroglutamic acid derivatives: application of substrate-dependent reactivity and diastereoselectivity to the synthesis of optically active 4-fluoroglutamic acids. The Journal of Organic Chemistry. 66: 8831-42. PMID 11749613 DOI: 10.1021/jo0106804  1
1999 Konas DW, Coward JK. Synthesis of L-4,4-difluoroglutamic acid via electrophilic difluorination of a lactam. Organic Letters. 1: 2105-7. PMID 10836063  1
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