Patrick A. Frantom, Ph.D. - Publications

2005 Texas A & M University, College Station, TX, United States 
catalytic and regulatory mechanisms of enzymes

22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.


Year Citation  Score
2016 Kumar G, Johnson JL, Frantom PA. Improving functional annotation in the DRE-TIM metallolyase superfamily through identification of active site fingerprints. Biochemistry. PMID 26935545 DOI: 10.1021/acs.biochem.5b01193  1
2016 Scalfani VF, Frantom PA, Woski SA. Replacing the Traditional Graduate Chemistry Literature Seminar with a Chemical Research Literacy Course Journal of Chemical Education. 93: 482-487. DOI: 10.1021/acs.jchemed.5b00512  1
2015 Dai Y, Kim D, Dong G, Busenlehner LS, Frantom PA, Outten FW. SufE D74R Substitution Alters Active Site Loop Dynamics To Further Enhance SufE Interaction with the SufS Cysteine Desulfurase. Biochemistry. 54: 4824-33. PMID 26171726 DOI: 10.1021/acs.biochem.5b00663  1
2014 Kumar G, Guan S, Frantom PA. Biochemical characterization of the retaining glycosyltransferase glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics. 564: 120-7. PMID 25317963 DOI: 10.1016/  1
2014 Frantom PA, Birman Y, Hays BN, Casey AK. An evolutionarily conserved alternate metal ligand is important for activity in α-isopropylmalate synthase from Mycobacterium tuberculosis. Biochimica Et Biophysica Acta. 1844: 1784-9. PMID 25064783 DOI: 10.1016/j.bbapap.2014.07.013  1
2014 Kumar G, Frantom PA. Evolutionarily distinct versions of the multidomain enzyme α-isopropylmalate synthase share discrete mechanisms of V-type allosteric regulation. Biochemistry. 53: 4847-56. PMID 24991690 DOI: 10.1021/bi500702u  1
2014 Casey AK, Hicks MA, Johnson JL, Babbitt PC, Frantom PA. Mechanistic and bioinformatic investigation of a conserved active site helix in α-isopropylmalate synthase from Mycobacterium tuberculosis, a member of the DRE-TIM metallolyase superfamily. Biochemistry. 53: 2915-25. PMID 24720347 DOI: 10.1021/bi500246z  1
2013 Casey AK, Schwalm EL, Hays BN, Frantom PA. V-type allosteric inhibition is described by a shift in the rate-determining step for α-isopropylmalate synthase from Mycobacterium tuberculosis. Biochemistry. 52: 6737-9. PMID 24033269 DOI: 10.1021/bi401186v  1
2012 Casey AK, Baugh J, Frantom PA. The slow-onset nature of allosteric inhibition in α-isopropylmalate synthase from Mycobacterium tuberculosis is mediated by a flexible loop. Biochemistry. 51: 4773-5. PMID 22662746 DOI: 10.1021/bi300671u  1
2012 Frantom PA. Structural and functional characterization of α-isopropylmalate synthase and citramalate synthase, members of the LeuA dimer superfamily. Archives of Biochemistry and Biophysics. 519: 202-9. PMID 22033339 DOI: 10.1016/  1
2010 Frantom PA, Coward JK, Blanchard JS. UDP-(5F)-GlcNAc acts as a slow-binding inhibitor of MshA, a retaining glycosyltransferase. Journal of the American Chemical Society. 132: 6626-7. PMID 20411981 DOI: 10.1021/ja101231a  1
2010 Frantom PA, Blanchard JS. Bisubstrate analog inhibitors Comprehensive Natural Products Ii: Chemistry and Biology. 8: 689-717.  1
2009 Wang W, Hu T, Frantom PA, Zheng T, Gerwe B, Del Amo DS, Garret S, Seidel RD, Wu P. Chemoenzymatic synthesis of GDP-L-fucose and the Lewis X glycan derivatives. Proceedings of the National Academy of Sciences of the United States of America. 106: 16096-101. PMID 19805264 DOI: 10.1073/pnas.0908248106  1
2009 Frantom PA, Zhang HM, Emmett MR, Marshall AG, Blanchard JS. Mapping of the allosteric network in the regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis by the feedback inhibitor L-leucine: solution-phase H/D exchange monitored by FT-ICR mass spectrometry. Biochemistry. 48: 7457-64. PMID 19606873 DOI: 10.1021/bi900851q  1
2009 De Carvalho LPS, Frantom PA, Argyrou A, Blanchard JS. Kinetic evidence for interdomain communication in the allosteric regulation of α-isopropylmalate synthase from Mycobacterium tuberculosis Biochemistry. 48: 1996-2004. PMID 19166329 DOI: 10.1021/bi801707t  1
2009 Fan F, Vetting MW, Frantom PA, Blanchard JS. Structures and mechanisms of the mycothiol biosynthetic enzymes Current Opinion in Chemical Biology. 13: 444-452. DOI: 10.1016/j.cbpa.2009.07.018  1
2008 Vetting MW, Frantom PA, Blanchard JS. Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: Substrate-assisted catalysis Journal of Biological Chemistry. 283: 15834-15844. PMID 18390549 DOI: 10.1074/jbc.M801017200  1
2007 Eser BE, Barr EW, Frantom PA, Saleh L, Bollinger JM, Krebs C, Fitzpatrick PF. Direct spectroscopic evidence for a high-spin Fe(IV) intermediate in tyrosine hydroxylase. Journal of the American Chemical Society. 129: 11334-5. PMID 17715926 DOI: 10.1021/ja074446s  1
2006 Frantom PA, Seravalli J, Ragsdale SW, Fitzpatrick PF. Reduction and oxidation of the active site iron in tyrosine hydroxylase: kinetics and specificity. Biochemistry. 45: 2372-9. PMID 16475826 DOI: 10.1021/bi0680072  1
2003 Frantom PA, Fitzpatrick PF. Uncoupled forms of tyrosine hydroxylase unmask kinetic isotope effects on chemical steps. Journal of the American Chemical Society. 125: 16190-1. PMID 14692751 DOI: 10.1021/ja0383165  1
2002 Frantom PA, Pongdee R, Sulikowski GA, Fitzpatrick PF. Intrinsic deuterium isotope effects on benzylic hydroxylation by tyrosine hydroxylase. Journal of the American Chemical Society. 124: 4202-3. PMID 11960436 DOI: 10.1021/ja025602s  1
1999 Blanchard CZ, Lee YM, Frantom PA, Waldrop GL. Mutations at four active site residues of biotin carboxylase abolish substrate-induced synergism by biotin Biochemistry. 38: 3393-3400. PMID 10079084 DOI: 10.1021/bi982660a  1
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